Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              21     175
NP_001120972                                                           21     175
XP_006716052                                                           21     175
XP_006716051                                                           21     175
NP_031377                                                              17    2528
XP_005262913                                                           17    2528
NP_056234                                                              17    3301
XP_005274542                                                           17    3301
NP_001189162                                                           17    4312
NP_001073996                                                           17    4312
XP_005268880                                                           17    4312
XP_005268879                                                           17    4312
XP_006712602                                                           17    4312
NP_000188                                                              16    5631
XP_006720282                                                           16    5631
XP_006720281                                                           16    5631
XP_006720280                                                           16    5631
XP_006720279                                                           16    5631
XP_005267972                                                           16    5631
XP_005267971                                                           16    5631
XP_006720278                                                           16    5631
XP_005267970                                                           16    5631
XP_006717157                                                           16    5631
NP_065766                                                              16    5631
NP_001103132                                                           16    7355
NP_073752                                                              16    7355
NP_006528                                                              16    7355
NP_001243631                                                           16    7355
XP_005254873                                                           16    7355
XP_006720855                                                           16    7355
XP_006720854                                                           16    7355
XP_006720853                                                           16    7355
XP_006720852                                                           16    7355
XP_005254660                                                           16    7355
NP_056344                                                              15    9605
NP_003245                                                              15    9605
NP_060026                                                              15    9605
NP_001019387                                                           15    9605
NP_940880                                                              15    9605
NP_001019386                                                           15    9605
NP_612373                                                              15    9605
NP_054868                                                              15    9605
XP_006726692                                                           15    9605
XP_006721060                                                           15    9605
XP_005250342                                                           15    9605
XP_006715519                                                           15    9605
XP_005263395                                                           15    9605
XP_006714166                                                           15    9605
XP_006714164                                                           15    9605
XP_006714163                                                           15    9605
XP_006714162                                                           15    9605
XP_006714161                                                           15    9605
XP_006714160                                                           15    9605
XP_005262823                                                           15    9605
XP_005245087                                                           15    9605
XP_005245086                                                           15    9605
XP_005245085                                                           15    9605
XP_005245084                                                           15    9605
XP_005245968                                                           15    9605
XP_005245967                                                           15    9605
XP_005245966                                                           15    9605
XP_005245965                                                           15    9605
XP_005245961                                                           15    9605
XP_006710768                                                           15    9605
XP_006710767                                                           15    9605
XP_005245960                                                           15    9605
XP_005245959                                                           15    9605
XP_005245958                                                           15    9605
XP_005245957                                                           15    9605
XP_006710063                                                           15    9605
>NP_000236
          Length = 1390

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           IQSEVHCI
Sbjct: 154 IQSEVHCI 161
>NP_001120972
          Length = 1408

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           IQSEVHCI
Sbjct: 154 IQSEVHCI 161
>XP_006716052
          Length = 1409

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           IQSEVHCI
Sbjct: 173 IQSEVHCI 180
>XP_006716051
          Length = 1427

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           IQSEVHCI
Sbjct: 173 IQSEVHCI 180
>NP_031377
          Length = 1228

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    IQSEVHC 8
            I SE+HC
Sbjct: 1177 INSEIHC 1183
>XP_005262913
          Length = 1193

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    IQSEVHC 8
            I SE+HC
Sbjct: 1142 INSEIHC 1148
>NP_056234
          Length = 2828

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  IQSEVHC 8
          + SEVHC
Sbjct: 35 VPSEVHC 41
>XP_005274542
          Length = 2853

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  IQSEVHC 8
          + SEVHC
Sbjct: 60 VPSEVHC 66
>NP_001189162
          Length = 611

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AIQSEVHCI 9
          +IQSE+ CI
Sbjct: 9  SIQSEMPCI 17
>NP_001073996
          Length = 2116

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    AIQSEVHC 8
            A+Q EV+C
Sbjct: 1705 ALQDEVYC 1712
>XP_005268880
          Length = 652

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AIQSEVHCI 9
          +IQSE+ CI
Sbjct: 50 SIQSEMPCI 58
>XP_005268879
          Length = 670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AIQSEVHCI 9
          +IQSE+ CI
Sbjct: 68 SIQSEMPCI 76
>XP_006712602
          Length = 2142

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    AIQSEVHC 8
            A+Q EV+C
Sbjct: 1731 ALQDEVYC 1738
>NP_000188
          Length = 310

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IQSEVHC 8
           IQS +HC
Sbjct: 150 IQSLIHC 156
>XP_006720282
          Length = 891

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IQSEVHC 8
           +QSE++C
Sbjct: 420 LQSEIYC 426
>XP_006720281
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IQSEVHC 8
           +QSE++C
Sbjct: 466 LQSEIYC 472
>XP_006720280
          Length = 945

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IQSEVHC 8
           +QSE++C
Sbjct: 474 LQSEIYC 480
>XP_006720279
          Length = 1191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IQSEVHC 8
           +QSE++C
Sbjct: 720 LQSEIYC 726
>XP_005267972
          Length = 1325

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IQSEVHC 8
           +QSE++C
Sbjct: 906 LQSEIYC 912
>XP_005267971
          Length = 1344

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IQSEVHC 8
           +QSE++C
Sbjct: 906 LQSEIYC 912
>XP_006720278
          Length = 1349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IQSEVHC 8
           +QSE++C
Sbjct: 906 LQSEIYC 912
>XP_005267970
          Length = 1377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IQSEVHC 8
           +QSE++C
Sbjct: 906 LQSEIYC 912
>XP_006717157
          Length = 256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IQSEVHC 8
           IQS +HC
Sbjct: 96  IQSLIHC 102
>NP_065766
          Length = 1364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IQSEVHC 8
           +QSE++C
Sbjct: 893 LQSEIYC 899
>NP_001103132
          Length = 4284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AIQSEVH 7
            A+QSE+H
Sbjct: 3080 ALQSELH 3086
>NP_073752
          Length = 1460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IQSEVHCI 9
          +QS+V CI
Sbjct: 57 VQSKVDCI 64
>NP_006528
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           +Q+EV+C+
Sbjct: 318 LQNEVNCL 325
>NP_001243631
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           +Q+EV+C+
Sbjct: 274 LQNEVNCL 281
>XP_005254873
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           +Q+EV+C+
Sbjct: 149 LQNEVNCL 156
>XP_006720855
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           +Q+EV+C+
Sbjct: 149 LQNEVNCL 156
>XP_006720854
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           +Q+EV+C+
Sbjct: 233 LQNEVNCL 240
>XP_006720853
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           +Q+EV+C+
Sbjct: 296 LQNEVNCL 303
>XP_006720852
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IQSEVHCI 9
           +Q+EV+C+
Sbjct: 318 LQNEVNCL 325
>XP_005254660
          Length = 1460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IQSEVHCI 9
          +QS+V CI
Sbjct: 57 VQSKVDCI 64
>NP_056344
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   QSEVHC 8
           QSE HC
Sbjct: 359 QSEGHC 364
>NP_003245
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IQSEVHCI 9
           +QS  HC+
Sbjct: 162 LQSGTHCL 169
>NP_060026
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>NP_001019387
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 189 QNEVYCL 195
>NP_940880
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   QSEVHC 8
           QSE HC
Sbjct: 331 QSEWHC 336
>NP_001019386
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>NP_612373
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  AIQSEVHCI 9
          ++QS  HC+
Sbjct: 28 SLQSAEHCL 36
>NP_054868
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   AIQSEVH 7
           A+Q+E+H
Sbjct: 201 ALQAEIH 207
>XP_006726692
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   AIQSEVH 7
           A+Q E+H
Sbjct: 369 AVQGEIH 375
>XP_006721060
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   AIQSEVH 7
           A+Q E+H
Sbjct: 400 AVQGEIH 406
>XP_005250342
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   AIQSEVH 7
           A+Q+E+H
Sbjct: 201 ALQAEIH 207
>XP_006715519
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   QSEVHC 8
           QSE HC
Sbjct: 349 QSEGHC 354
>XP_005263395
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  AIQSEVHCI 9
          ++QS  HC+
Sbjct: 28 SLQSAEHCL 36
>XP_006714166
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  AIQSEVH 7
          +IQSE+H
Sbjct: 69 SIQSELH 75
>XP_006714164
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  AIQSEVH 7
          +IQSE+H
Sbjct: 10 SIQSELH 16
>XP_006714163
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  AIQSEVH 7
          +IQSE+H
Sbjct: 10 SIQSELH 16
>XP_006714162
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  AIQSEVH 7
          +IQSE+H
Sbjct: 10 SIQSELH 16
>XP_006714161
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  AIQSEVH 7
          +IQSE+H
Sbjct: 19 SIQSELH 25
>XP_006714160
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  AIQSEVH 7
          +IQSE+H
Sbjct: 69 SIQSELH 75
>XP_005262823
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  AIQSEVH 7
          +IQSE+H
Sbjct: 69 SIQSELH 75
>XP_005245087
          Length = 2708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    QSEVHCI 9
            Q+E HC+
Sbjct: 2673 QNEQHCL 2679
>XP_005245086
          Length = 2714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    QSEVHCI 9
            Q+E HC+
Sbjct: 2668 QNEQHCL 2674
>XP_005245085
          Length = 2718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    QSEVHCI 9
            Q+E HC+
Sbjct: 2673 QNEQHCL 2679
>XP_005245084
          Length = 2719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    QSEVHCI 9
            Q+E HC+
Sbjct: 2673 QNEQHCL 2679
>XP_005245968
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 189 QNEVYCL 195
>XP_005245967
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>XP_005245966
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>XP_005245965
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>XP_005245961
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>XP_006710768
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>XP_006710767
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>XP_005245960
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>XP_005245959
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>XP_005245958
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>XP_005245957
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   QSEVHCI 9
           Q+EV+C+
Sbjct: 286 QNEVYCL 292
>XP_006710063
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   AIQSEVH 7
           A+Q E+H
Sbjct: 400 AVQGEIH 406
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.132    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 584,403
Number of extensions: 746
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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