Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           18    1135
NP_000242                                                              18    1135
XP_005264389                                                           18    1135
NP_009098                                                              17    3301
NP_001276018                                                           17    4312
NP_079048                                                              17    4312
NP_001276019                                                           17    4312
NP_001276017                                                           17    4312
XP_006710967                                                           17    4312
XP_005271277                                                           17    4312
XP_005271276                                                           17    4312
XP_005271275                                                           17    4312
XP_005271273                                                           17    4312
NP_004527                                                              16    5631
NP_075043                                                              16    5631
XP_006725522                                                           16    5631
XP_006725521                                                           16    5631
XP_006725519                                                           16    5631
XP_006725518                                                           16    5631
XP_006725517                                                           16    5631
XP_006725516                                                           16    5631
XP_005276859                                                           16    5631
XP_005276858                                                           16    5631
XP_006726285                                                           16    5631
XP_006726284                                                           16    5631
XP_006726283                                                           16    5631
XP_006726282                                                           16    5631
XP_005248581                                                           16    5631
XP_006714693                                                           16    5631
XP_006714692                                                           16    5631
XP_006714691                                                           16    5631
XP_006714690                                                           16    5631
XP_006714689                                                           16    5631
NP_056060                                                              16    7355
NP_055616                                                              16    7355
XP_006715101                                                           16    7355
XP_006715100                                                           16    7355
XP_005249021                                                           16    7355
XP_006715099                                                           16    7355
XP_006715098                                                           16    7355
XP_006715097                                                           16    7355
XP_006715096                                                           16    7355
XP_006711879                                                           16    7355
NP_000713                                                              15    9605
NP_002385                                                              15    9605
XP_006716183                                                           15    9605
XP_005250631                                                           15    9605
XP_005250630                                                           15    9605
XP_006716182                                                           15    9605
XP_005250629                                                           15    9605
XP_005250627                                                           15    9605
XP_006716181                                                           15    9605
>NP_001245210
          Length = 868

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEMLETTSI 9
           AEMLET SI
Sbjct: 661 AEMLETASI 669
>NP_000242
          Length = 934

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEMLETTSI 9
           AEMLET SI
Sbjct: 727 AEMLETASI 735
>XP_005264389
          Length = 921

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AEMLETTSI 9
           AEMLET SI
Sbjct: 727 AEMLETASI 735
>NP_009098
          Length = 1325

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AEMLETTS 8
           AEM+ETT+
Sbjct: 283 AEMIETTN 290
>NP_001276018
          Length = 1123

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           EM+ETTS
Sbjct: 288 EMIETTS 294
>NP_079048
          Length = 1142

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           EM+ETTS
Sbjct: 288 EMIETTS 294
>NP_001276019
          Length = 1142

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           EM+ETTS
Sbjct: 288 EMIETTS 294
>NP_001276017
          Length = 1142

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           EM+ETTS
Sbjct: 288 EMIETTS 294
>XP_006710967
          Length = 481

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           EM+ETTS
Sbjct: 288 EMIETTS 294
>XP_005271277
          Length = 951

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           EM+ETTS
Sbjct: 97  EMIETTS 103
>XP_005271276
          Length = 1067

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           EM+ETTS
Sbjct: 213 EMIETTS 219
>XP_005271275
          Length = 1067

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           EM+ETTS
Sbjct: 213 EMIETTS 219
>XP_005271273
          Length = 1130

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           EM+ETTS
Sbjct: 288 EMIETTS 294
>NP_004527
          Length = 1403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>NP_075043
          Length = 1241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 204 ELLETTS 210
>XP_006725522
          Length = 765

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_006725521
          Length = 792

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_006725519
          Length = 1139

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 102 ELLETTS 108
>XP_006725518
          Length = 1219

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 182 ELLETTS 188
>XP_006725517
          Length = 1348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_006725516
          Length = 1352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_005276859
          Length = 765

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_005276858
          Length = 792

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_006726285
          Length = 1139

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 102 ELLETTS 108
>XP_006726284
          Length = 1219

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 182 ELLETTS 188
>XP_006726283
          Length = 1348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_006726282
          Length = 1352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_005248581
          Length = 765

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_006714693
          Length = 792

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_006714692
          Length = 1139

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 102 ELLETTS 108
>XP_006714691
          Length = 1219

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 182 ELLETTS 188
>XP_006714690
          Length = 1348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>XP_006714689
          Length = 1352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EMLETTS 8
           E+LETTS
Sbjct: 366 ELLETTS 372
>NP_056060
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AEMLETTS 8
            AEM+ET S
Sbjct: 1079 AEMIETKS 1086
>NP_055616
          Length = 2137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEMLETTS 8
           A MLETT+
Sbjct: 202 AHMLETTT 209
>XP_006715101
          Length = 1150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AEMLETTS 8
            AEM+ET S
Sbjct: 1079 AEMIETKS 1086
>XP_006715100
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AEMLETTS 8
            AEM+ET S
Sbjct: 1080 AEMIETKS 1087
>XP_005249021
          Length = 1155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AEMLETTS 8
            AEM+ET S
Sbjct: 1100 AEMIETKS 1107
>XP_006715099
          Length = 1156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AEMLETTS 8
            AEM+ET S
Sbjct: 1101 AEMIETKS 1108
>XP_006715098
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AEMLETTS 8
            AEM+ET S
Sbjct: 1100 AEMIETKS 1107
>XP_006715097
          Length = 1171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AEMLETTS 8
            AEM+ET S
Sbjct: 1100 AEMIETKS 1107
>XP_006715096
          Length = 1172

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AEMLETTS 8
            AEM+ET S
Sbjct: 1101 AEMIETKS 1108
>XP_006711879
          Length = 1364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEMLETTS 8
           A MLETT+
Sbjct: 202 AHMLETTT 209
>NP_000713
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEMLETTS 8
           +EMLET S
Sbjct: 277 SEMLETLS 284
>NP_002385
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AEMLETTS 8
          AEM+ET S
Sbjct: 65 AEMIETGS 72
>XP_006716183
          Length = 1071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEMLETTS 8
           +EMLET S
Sbjct: 238 SEMLETLS 245
>XP_005250631
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEMLETTS 8
           +EMLET S
Sbjct: 277 SEMLETLS 284
>XP_005250630
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEMLETTS 8
           +EMLET S
Sbjct: 277 SEMLETLS 284
>XP_006716182
          Length = 1085

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEMLETTS 8
           +EMLET S
Sbjct: 252 SEMLETLS 259
>XP_005250629
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEMLETTS 8
           +EMLET S
Sbjct: 277 SEMLETLS 284
>XP_005250627
          Length = 1103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEMLETTS 8
           +EMLET S
Sbjct: 277 SEMLETLS 284
>XP_006716181
          Length = 1110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AEMLETTS 8
           +EMLET S
Sbjct: 277 SEMLETLS 284
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.111    0.245 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 367,595
Number of extensions: 409
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package