Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1482
NP_001075109                                                           18    1482
NP_001129386                                                           18    1935
NP_001271169                                                           17    2528
NP_001271171                                                           17    2528
XP_005269965                                                           17    2528
XP_006717958                                                           17    2528
XP_006717957                                                           17    2528
NP_001026                                                              17    3301
XP_006711873                                                           17    3301
XP_006711871                                                           17    3301
XP_006711870                                                           17    3301
XP_006711869                                                           17    3301
XP_006711868                                                           17    3301
XP_006711867                                                           17    3301
XP_006711866                                                           17    3301
XP_006711865                                                           17    3301
NP_003283                                                              16    5631
NP_001273708                                                           16    5631
NP_115669                                                              16    5631
NP_002882                                                              16    5631
NP_001139120                                                           16    5631
XP_006720692                                                           16    5631
XP_006720691                                                           16    5631
XP_006720690                                                           16    5631
XP_005254635                                                           16    5631
XP_005252325                                                           16    5631
XP_006717365                                                           16    5631
XP_005252324                                                           16    5631
XP_005245528                                                           16    5631
NP_001171564                                                           16    7355
NP_078875                                                              16    7355
NP_115979                                                              16    7355
NP_001229828                                                           16    7355
NP_001005498                                                           16    7355
NP_001005366                                                           16    7355
XP_005257727                                                           16    7355
XP_006722145                                                           16    7355
XP_006722144                                                           16    7355
XP_006722143                                                           16    7355
XP_006722142                                                           16    7355
XP_005257726                                                           16    7355
XP_005254018                                                           16    7355
XP_005254013                                                           16    7355
XP_005254012                                                           16    7355
XP_005254011                                                           16    7355
NP_001135780                                                           16    7355
NP_004516                                                              15    9605
NP_002196                                                              15    9605
NP_002448                                                              15    9605
NP_056372                                                              15    9605
NP_003105                                                              15    9605
NP_757367                                                              15    9605
NP_001229698                                                           15    9605
NP_001229696                                                           15    9605
NP_056255                                                              15    9605
NP_001035902                                                           15    9605
NP_003887                                                              15    9605
NP_005483                                                              15    9605
NP_001268659                                                           15    9605
XP_005260696                                                           15    9605
XP_006716683                                                           15    9605
XP_006716682                                                           15    9605
XP_005266968                                                           15    9605
XP_005266967                                                           15    9605
XP_005266964                                                           15    9605
XP_006715114                                                           15    9605
XP_006715113                                                           15    9605
XP_006712591                                                           15    9605
XP_006712589                                                           15    9605
XP_005264687                                                           15    9605
XP_006712190                                                           15    9605
NP_258441                                                              15    9605
NP_036479                                                              15    9605
>NP_008835
          Length = 4128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AEARSDCSE 9
            AEARSD SE
Sbjct: 2959 AEARSDYSE 2967
>NP_001075109
          Length = 4097

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AEARSDCSE 9
            AEARSD SE
Sbjct: 2959 AEARSDYSE 2967
>NP_001129386
          Length = 1503

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    AEARSDCSE 9
            AEA S+CSE
Sbjct: 1020 AEALSNCSE 1028
>NP_001271169
          Length = 1047

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EARSDCS 8
           EARS+CS
Sbjct: 803 EARSECS 809
>NP_001271171
          Length = 474

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EARSDCS 8
           EARS+CS
Sbjct: 230 EARSECS 236
>XP_005269965
          Length = 474

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EARSDCS 8
           EARS+CS
Sbjct: 230 EARSECS 236
>XP_006717958
          Length = 493

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EARSDCS 8
           EARS+CS
Sbjct: 249 EARSECS 255
>XP_006717957
          Length = 493

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EARSDCS 8
           EARS+CS
Sbjct: 249 EARSECS 255
>NP_001026
          Length = 4967

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    AEARSDCSE 9
            AEAR D SE
Sbjct: 3342 AEARGDMSE 3350
>XP_006711873
          Length = 4954

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    AEARSDCSE 9
            AEAR D SE
Sbjct: 3341 AEARGDMSE 3349
>XP_006711871
          Length = 4906

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    AEARSDCSE 9
            AEAR D SE
Sbjct: 3273 AEARGDMSE 3281
>XP_006711870
          Length = 4965

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    AEARSDCSE 9
            AEAR D SE
Sbjct: 3352 AEARGDMSE 3360
>XP_006711869
          Length = 4973

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    AEARSDCSE 9
            AEAR D SE
Sbjct: 3352 AEARGDMSE 3360
>XP_006711868
          Length = 4975

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    AEARSDCSE 9
            AEAR D SE
Sbjct: 3342 AEARGDMSE 3350
>XP_006711867
          Length = 4977

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    AEARSDCSE 9
            AEAR D SE
Sbjct: 3352 AEARGDMSE 3360
>XP_006711866
          Length = 4984

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    AEARSDCSE 9
            AEAR D SE
Sbjct: 3351 AEARGDMSE 3359
>XP_006711865
          Length = 4985

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    AEARSDCSE 9
            AEAR D SE
Sbjct: 3352 AEARGDMSE 3360
>NP_003283
          Length = 2363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    EARSDCSE 9
            +AR DC E
Sbjct: 1063 QARRDCQE 1070
>NP_001273708
          Length = 991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EARSDCSE 9
           ++RSDC E
Sbjct: 550 KSRSDCRE 557
>NP_115669
          Length = 1013

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EARSDCSE 9
           ++RSDC E
Sbjct: 572 KSRSDCRE 579
>NP_002882
          Length = 1273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           EA+ DC E
Sbjct: 364 EAKPDCEE 371
>NP_001139120
          Length = 1257

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           EA+ DC E
Sbjct: 364 EAKPDCEE 371
>XP_006720692
          Length = 1270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           EA+ DC E
Sbjct: 364 EAKPDCEE 371
>XP_006720691
          Length = 1182

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           EA+ DC E
Sbjct: 364 EAKPDCEE 371
>XP_006720690
          Length = 1245

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           EA+ DC E
Sbjct: 364 EAKPDCEE 371
>XP_005254635
          Length = 1280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           EA+ DC E
Sbjct: 364 EAKPDCEE 371
>XP_005252325
          Length = 1036

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EARSDCSE 9
           ++RSDC E
Sbjct: 595 KSRSDCRE 602
>XP_006717365
          Length = 1062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EARSDCSE 9
           ++RSDC E
Sbjct: 621 KSRSDCRE 628
>XP_005252324
          Length = 1076

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EARSDCSE 9
           ++RSDC E
Sbjct: 635 KSRSDCRE 642
>XP_005245528
          Length = 2439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    EARSDCSE 9
            +AR DC E
Sbjct: 1139 QARRDCQE 1146
>NP_001171564
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  AEARSDCS 8
          A AR DCS
Sbjct: 10 ALARQDCS 17
>NP_078875
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RSDCSE 9
           R DCSE
Sbjct: 513 RKDCSE 518
>NP_115979
          Length = 1336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AEARSDCSE 9
           A+ RS+C E
Sbjct: 764 AKRRSECEE 772
>NP_001229828
          Length = 933

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           E+R DC E
Sbjct: 243 ESRQDCVE 250
>NP_001005498
          Length = 827

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RSDCSE 9
           R DCSE
Sbjct: 484 RKDCSE 489
>NP_001005366
          Length = 1265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AEARSDCSE 9
           A+ RS+C E
Sbjct: 733 AKRRSECEE 741
>XP_005257727
          Length = 827

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RSDCSE 9
           R DCSE
Sbjct: 484 RKDCSE 489
>XP_006722145
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RSDCSE 9
           R DCSE
Sbjct: 508 RKDCSE 513
>XP_006722144
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RSDCSE 9
           R DCSE
Sbjct: 508 RKDCSE 513
>XP_006722143
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RSDCSE 9
           R DCSE
Sbjct: 508 RKDCSE 513
>XP_006722142
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RSDCSE 9
           R DCSE
Sbjct: 508 RKDCSE 513
>XP_005257726
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RSDCSE 9
           R DCSE
Sbjct: 513 RKDCSE 518
>XP_005254018
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AEARSDCSE 9
           A+ RS+C E
Sbjct: 204 AKRRSECEE 212
>XP_005254013
          Length = 1299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AEARSDCSE 9
           A+ RS+C E
Sbjct: 727 AKRRSECEE 735
>XP_005254012
          Length = 1305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AEARSDCSE 9
           A+ RS+C E
Sbjct: 733 AKRRSECEE 741
>XP_005254011
          Length = 1334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AEARSDCSE 9
           A+ RS+C E
Sbjct: 764 AKRRSECEE 772
>NP_001135780
          Length = 2156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   EARSDCSE 9
           ++R DCS+
Sbjct: 454 DSRQDCSD 461
>NP_004516
          Length = 4655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   AEARSDCSE 9
           ++ R DCS+
Sbjct: 97  SDERQDCSQ 105
>NP_002196
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   ARSDCSE 9
           AR DC E
Sbjct: 580 AREDCRE 586
>NP_002448
          Length = 5179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AEARSDCSE 9
           AEA +DC +
Sbjct: 231 AEAFADCQD 239
>NP_056372
          Length = 1954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AEARSDCS 8
           A  RS+CS
Sbjct: 309 ASVRSECS 316
>NP_003105
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           EA+ DC +
Sbjct: 675 EAKQDCDQ 682
>NP_757367
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           EA+ DC +
Sbjct: 675 EAKQDCDQ 682
>NP_001229698
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EARSDCS 8
          +ARS CS
Sbjct: 56 QARSSCS 62
>NP_001229696
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EARSDCS 8
          +ARS CS
Sbjct: 56 QARSSCS 62
>NP_056255
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EARSDCS 8
          +ARS CS
Sbjct: 56 QARSSCS 62
>NP_001035902
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4  RSDCS 8
          RSDCS
Sbjct: 16 RSDCS 20
>NP_003887
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4  RSDCS 8
          RSDCS
Sbjct: 39 RSDCS 43
>NP_005483
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  ARSDC 7
          ARSDC
Sbjct: 91 ARSDC 95
>NP_001268659
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  ARSDC 7
          ARSDC
Sbjct: 91 ARSDC 95
>XP_005260696
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  ARSDC 7
          ARSDC
Sbjct: 91 ARSDC 95
>XP_006716683
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           EA+ DC +
Sbjct: 633 EAKQDCDQ 640
>XP_006716682
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   EARSDCSE 9
           EA+ DC +
Sbjct: 675 EAKQDCDQ 682
>XP_005266968
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EARSDCS 8
          +ARS CS
Sbjct: 56 QARSSCS 62
>XP_005266967
          Length = 987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EARSDCS 8
          +ARS CS
Sbjct: 56 QARSSCS 62
>XP_005266964
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EARSDCS 8
          +ARS CS
Sbjct: 56 QARSSCS 62
>XP_006715114
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  AEARSDC 7
          AEA  DC
Sbjct: 12 AEAEEDC 18
>XP_006715113
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  AEARSDC 7
          AEA  DC
Sbjct: 12 AEAEEDC 18
>XP_006712591
          Length = 3308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   AEARSDCSE 9
           ++ R DCS+
Sbjct: 97  SDERQDCSQ 105
>XP_006712589
          Length = 4660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   AEARSDCSE 9
           ++ R DCS+
Sbjct: 97  SDERQDCSQ 105
>XP_005264687
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4  RSDCS 8
          RSDCS
Sbjct: 39 RSDCS 43
>XP_006712190
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4  RSDCS 8
          RSDCS
Sbjct: 39 RSDCS 43
>NP_258441
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1 AEARSDC 7
         AEA  DC
Sbjct: 2 AEAEEDC 8
>NP_036479
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  AEARSDC 7
          AEA  DC
Sbjct: 12 AEAEEDC 18
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.108    0.295 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 636,053
Number of extensions: 710
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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