Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1935
XP_006716142                                                           18    1935
XP_005250088                                                           18    1935
XP_006716141                                                           18    1935
XP_005250085                                                           18    1935
XP_006716140                                                           18    1935
XP_005250084                                                           18    1935
XP_005250083                                                           18    1935
XP_005250082                                                           18    1935
NP_001226                                                              17    3301
NP_001193943                                                           17    3301
XP_006718792                                                           17    3301
XP_006718791                                                           17    3301
XP_006718790                                                           17    3301
NP_003775                                                              17    4312
NP_001248760                                                           17    4312
NP_001248759                                                           17    4312
NP_001035237                                                           17    4312
XP_006722625                                                           17    4312
NP_001026                                                              16    5631
NP_065128                                                              16    5631
NP_001135943                                                           16    5631
NP_055244                                                              16    5631
NP_065770                                                              16    5631
XP_005263206                                                           16    5631
XP_005263205                                                           16    5631
XP_005247419                                                           16    5631
XP_006711873                                                           16    5631
XP_006711872                                                           16    5631
XP_006711871                                                           16    5631
XP_006711870                                                           16    5631
XP_006711869                                                           16    5631
XP_006711868                                                           16    5631
XP_006711867                                                           16    5631
XP_006711866                                                           16    5631
XP_006711865                                                           16    5631
NP_001001670                                                           16    7355
NP_612429                                                              16    7355
XP_005267356                                                           16    7355
NP_006149                                                              15    9605
NP_056080                                                              15    9605
NP_001165980                                                           15    9605
NP_001165988                                                           15    9605
NP_001276881                                                           15    9605
NP_001276880                                                           15    9605
NP_001008401                                                           15    9605
XP_005246453                                                           15    9605
XP_006712435                                                           15    9605
>NP_733751
          Length = 4911

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           AD SKADVS
Sbjct: 774 ADISKADVS 782
>XP_006716142
          Length = 4927

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           AD SKADVS
Sbjct: 775 ADISKADVS 783
>XP_005250088
          Length = 4928

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           AD SKADVS
Sbjct: 775 ADISKADVS 783
>XP_006716141
          Length = 4959

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           AD SKADVS
Sbjct: 775 ADISKADVS 783
>XP_005250085
          Length = 4979

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           AD SKADVS
Sbjct: 775 ADISKADVS 783
>XP_006716140
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           AD SKADVS
Sbjct: 775 ADISKADVS 783
>XP_005250084
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           AD SKADVS
Sbjct: 775 ADISKADVS 783
>XP_005250083
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           AD SKADVS
Sbjct: 774 ADISKADVS 782
>XP_005250082
          Length = 4983

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           AD SKADVS
Sbjct: 775 ADISKADVS 783
>NP_001226
          Length = 418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DKSKADVS 9
           DK+KAD+S
Sbjct: 331 DKNKADLS 338
>NP_001193943
          Length = 418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DKSKADVS 9
           DK+KAD+S
Sbjct: 331 DKNKADLS 338
>XP_006718792
          Length = 418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DKSKADVS 9
           DK+KAD+S
Sbjct: 331 DKNKADLS 338
>XP_006718791
          Length = 418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DKSKADVS 9
           DK+KAD+S
Sbjct: 331 DKNKADLS 338
>XP_006718790
          Length = 418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DKSKADVS 9
           DK+KAD+S
Sbjct: 331 DKNKADLS 338
>NP_003775
          Length = 380

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DKSKADVS 9
           D+SKAD+S
Sbjct: 301 DESKADLS 308
>NP_001248760
          Length = 363

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DKSKADVS 9
           D+SKAD+S
Sbjct: 284 DESKADLS 291
>NP_001248759
          Length = 380

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DKSKADVS 9
           D+SKAD+S
Sbjct: 301 DESKADLS 308
>NP_001035237
          Length = 380

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DKSKADVS 9
           D+SKAD+S
Sbjct: 301 DESKADLS 308
>XP_006722625
          Length = 380

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DKSKADVS 9
           D+SKAD+S
Sbjct: 301 DESKADLS 308
>NP_001026
          Length = 4967

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKSKADV 8
           DK KADV
Sbjct: 318 DKEKADV 324
>NP_065128
          Length = 462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           ADK K+D++
Sbjct: 101 ADKMKSDIT 109
>NP_001135943
          Length = 462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           ADK K+D++
Sbjct: 101 ADKMKSDIT 109
>NP_055244
          Length = 984

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADKSKADVS 9
           +DKS  DVS
Sbjct: 731 SDKSNTDVS 739
>NP_065770
          Length = 2036

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ADKSKADV 8
            AD+ KADV
Sbjct: 1103 ADEDKADV 1110
>XP_005263206
          Length = 462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           ADK K+D++
Sbjct: 101 ADKMKSDIT 109
>XP_005263205
          Length = 462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ADKSKADVS 9
           ADK K+D++
Sbjct: 101 ADKMKSDIT 109
>XP_005247419
          Length = 1014

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ADKSKADVS 9
           +DKS  DVS
Sbjct: 761 SDKSNTDVS 769
>XP_006711873
          Length = 4954

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKSKADV 8
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711872
          Length = 2735

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKSKADV 8
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711871
          Length = 4906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKSKADV 8
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711870
          Length = 4965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKSKADV 8
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711869
          Length = 4973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKSKADV 8
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711868
          Length = 4975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKSKADV 8
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711867
          Length = 4977

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKSKADV 8
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711866
          Length = 4984

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKSKADV 8
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711865
          Length = 4985

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DKSKADV 8
           DK KADV
Sbjct: 318 DKEKADV 324
>NP_001001670
          Length = 1576

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KSKADVS 9
           KSKAD+S
Sbjct: 930 KSKADLS 936
>NP_612429
          Length = 5795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KSKADVS 9
            K+KADVS
Sbjct: 4162 KAKADVS 4168
>XP_005267356
          Length = 5695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KSKADVS 9
            K+KADVS
Sbjct: 4062 KAKADVS 4068
>NP_006149
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DKSKADVS 9
           DK  AD+S
Sbjct: 338 DKQNADIS 345
>NP_056080
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ADKSKA 6
           ADKSKA
Sbjct: 720 ADKSKA 725
>NP_001165980
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ADKSKA 6
           ADKSKA
Sbjct: 720 ADKSKA 725
>NP_001165988
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ADKSKA 6
           ADKSKA
Sbjct: 720 ADKSKA 725
>NP_001276881
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ADKSKADV 8
           ADK K DV
Sbjct: 239 ADKYKCDV 246
>NP_001276880
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ADKSKADV 8
           ADK K DV
Sbjct: 239 ADKYKCDV 246
>NP_001008401
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ADKSKADV 8
           ADK K DV
Sbjct: 239 ADKYKCDV 246
>XP_005246453
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ADKSKA 6
           ADKSKA
Sbjct: 662 ADKSKA 667
>XP_006712435
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ADKSKA 6
           ADKSKA
Sbjct: 720 ADKSKA 725
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.287    0.103    0.236 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,295
Number of extensions: 917
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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