Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001276866                                                           18    1935
NP_004439                                                              18    1935
NP_001276865                                                           18    1935
NP_001005862                                                           18    1935
XP_005257197                                                           18    1935
XP_006721828                                                           18    1935
NP_899200                                                              17    4312
XP_005247134                                                           17    4312
NP_000254                                                              16    5631
NP_115613                                                              15    9605
NP_001264900                                                           15    9605
NP_001296                                                              15    9605
NP_057617                                                              15    9605
XP_006719047                                                           15    9605
XP_005253746                                                           15    9605
NP_001092254                                                           15    9605
NP_001935                                                              15    9605
>NP_001276866
          Length = 1055

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAVGILLVV 9
           A VGILLVV
Sbjct: 657 AVVGILLVV 665
>NP_004439
          Length = 1255

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAVGILLVV 9
           A VGILLVV
Sbjct: 657 AVVGILLVV 665
>NP_001276865
          Length = 1240

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAVGILLVV 9
           A VGILLVV
Sbjct: 642 AVVGILLVV 650
>NP_001005862
          Length = 1225

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAVGILLVV 9
           A VGILLVV
Sbjct: 627 AVVGILLVV 635
>XP_005257197
          Length = 1225

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAVGILLVV 9
           A VGILLVV
Sbjct: 627 AVVGILLVV 635
>XP_006721828
          Length = 1336

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AAVGILLVV 9
           A VGILLVV
Sbjct: 738 AVVGILLVV 746
>NP_899200
          Length = 1261

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AAVGILLVV 9
           AAVG++L++
Sbjct: 276 AAVGVILIM 284
>XP_005247134
          Length = 1286

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AAVGILLVV 9
           AAVG++L++
Sbjct: 276 AAVGVILIM 284
>NP_000254
          Length = 743

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  AAVGILLV 8
          AAVG+LL+
Sbjct: 8  AAVGVLLL 15
>NP_115613
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  AVGILLVV 9
          AVG+LL++
Sbjct: 20 AVGLLLIM 27
>NP_001264900
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  AVGILLVV 9
          AVG+LL++
Sbjct: 20 AVGLLLIM 27
>NP_001296
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AAVGILLVV 9
          AA+G+LL V
Sbjct: 91 AALGVLLSV 99
>NP_057617
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VGILLVV 9
           +G+LLVV
Sbjct: 126 IGVLLVV 132
>XP_006719047
          Length = 106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VGILLVV 9
          +G+LLVV
Sbjct: 44 IGVLLVV 50
>XP_005253746
          Length = 135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VGILLVV 9
          +G+LLVV
Sbjct: 73 IGVLLVV 79
>NP_001092254
          Length = 154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AAVGILLVV 9
           AAVG +LVV
Sbjct: 104 AAVGHVLVV 112
>NP_001935
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AAVGILLV 8
           AA+G+LL+
Sbjct: 619 AAIGLLLL 626
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.153    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 357,366
Number of extensions: 448
Number of successful extensions: 17
Number of sequences better than 10000.0: 17
Number of HSP's gapped: 17
Number of HSP's successfully gapped: 17
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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