Blast-Search of mutated query peptide against human proteome |
BLASTP 2.2.15 [Oct-15-2006] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= User_input (9 letters) Database: HUMAN_PROTEOME_FASTA 71,491 sequences; 45,948,801 total letters Searching..................................................doneScore E Sequences producing significant alignments: (bits) Value NP_055455 18 1482 XP_006712938 18 1482 XP_006712937 18 1482 XP_006712936 18 1482 XP_005247034 18 1482 NP_054888 18 1935 NP_001278017 17 2528 NP_114157 17 2528 NP_001005354 17 2528 XP_006723474 17 2528 XP_005259362 17 2528 NP_060927 17 2528 NP_060697 17 4312 XP_006726835 17 4312 XP_003960810 17 4312 XP_006723017 17 4312 XP_003960002 17 4312 XP_003960940 17 4312 NP_653082 16 5631 NP_000163 16 5631 NP_997716 16 5631 NP_001130015 16 5631 NP_004526 16 5631 NP_001257449 16 5631 NP_055807 16 5631 NP_055568 16 5631 NP_001244953 16 5631 XP_005267488 16 5631 XP_005267487 16 5631 XP_005271905 16 5631 XP_005271904 16 5631 XP_005271903 16 5631 NP_001269389 16 7355 NP_003613 16 7355 NP_001185845 16 7355 NP_803193 16 7355 NP_001185844 16 7355 XP_006719224 16 7355 XP_006719223 16 7355 XP_006719222 16 7355 XP_005253573 16 7355 XP_005253572 16 7355 XP_005253571 16 7355 XP_005253568 16 7355 XP_005253567 16 7355 XP_005253566 16 7355 XP_005253565 16 7355 XP_005253564 16 7355 XP_005253563 16 7355 XP_005253562 16 7355 NP_056477 15 9605 NP_001275563 15 9605 NP_060652 15 9605 NP_001070966 15 9605 NP_001275560 15 9605 NP_001275562 15 9605 NP_001275561 15 9605 NP_001275564 15 9605 NP_899631 15 9605 NP_899630 15 9605 NP_003707 15 9605 XP_006722034 15 9605 XP_006713441 15 9605 XP_006713440 15 9605 XP_006713439 15 9605 XP_006713438 15 9605 XP_006713437 15 9605 XP_006713436 15 9605 XP_006713435 15 9605 XP_006713434 15 9605 XP_006713433 15 9605 XP_006713432 15 9605 XP_006713431 15 9605 XP_006713430 15 9605 XP_006713429 15 9605 XP_006713428 15 9605 XP_006713427 15 9605 XP_006713426 15 9605 XP_006713425 15 9605 XP_006712050 15 9605 XP_005264311 15 9605 XP_006712049 15 9605 NP_056248 15 9605>NP_055455 Length = 1199 Score = 18.1 bits (35), Expect = 1482 Identities = 7/8 (87%), Positives = 8/8 (100%) Query: 2 AQKMKKAH 9 AQKMKKA+ Sbjct: 976 AQKMKKAY 983>XP_006712938 Length = 1138 Score = 18.1 bits (35), Expect = 1482 Identities = 7/8 (87%), Positives = 8/8 (100%) Query: 2 AQKMKKAH 9 AQKMKKA+ Sbjct: 976 AQKMKKAY 983>XP_006712937 Length = 1199 Score = 18.1 bits (35), Expect = 1482 Identities = 7/8 (87%), Positives = 8/8 (100%) Query: 2 AQKMKKAH 9 AQKMKKA+ Sbjct: 976 AQKMKKAY 983>XP_006712936 Length = 1199 Score = 18.1 bits (35), Expect = 1482 Identities = 7/8 (87%), Positives = 8/8 (100%) Query: 2 AQKMKKAH 9 AQKMKKA+ Sbjct: 976 AQKMKKAY 983>XP_005247034 Length = 1199 Score = 18.1 bits (35), Expect = 1482 Identities = 7/8 (87%), Positives = 8/8 (100%) Query: 2 AQKMKKAH 9 AQKMKKA+ Sbjct: 976 AQKMKKAY 983>NP_054888 Length = 265 Score = 17.7 bits (34), Expect = 1935 Identities = 7/9 (77%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 AAQ MKKA+ Sbjct: 152 AAQSMKKAY 160>NP_001278017 Length = 2912 Score = 17.3 bits (33), Expect = 2528 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 AQKMKKAH 9 AQK+KK H Sbjct: 1224 AQKLKKKH 1231>NP_114157 Length = 2873 Score = 17.3 bits (33), Expect = 2528 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 AQKMKKAH 9 AQK+KK H Sbjct: 1185 AQKLKKKH 1192>NP_001005354 Length = 98 Score = 17.3 bits (33), Expect = 2528 Identities = 6/7 (85%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 +KMKKAH Sbjct: 61 KKMKKAH 67>XP_006723474 Length = 2737 Score = 17.3 bits (33), Expect = 2528 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 AQKMKKAH 9 AQK+KK H Sbjct: 1049 AQKLKKKH 1056>XP_005259362 Length = 2855 Score = 17.3 bits (33), Expect = 2528 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 AQKMKKAH 9 AQK+KK H Sbjct: 1167 AQKLKKKH 1174>NP_060927 Length = 148 Score = 17.3 bits (33), Expect = 2528 Identities = 6/7 (85%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 +KMKKAH Sbjct: 111 KKMKKAH 117>NP_060697 Length = 1052 Score = 16.5 bits (31), Expect = 4312 Identities = 6/9 (66%), Positives = 7/9 (77%) Query: 1 AAQKMKKAH 9 A QKM K+H Sbjct: 55 AMQKMAKSH 63>XP_006726835 Length = 498 Score = 16.5 bits (31), Expect = 4312 Identities = 6/9 (66%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 +AQK +KAH Sbjct: 179 SAQKHEKAH 187>XP_003960810 Length = 539 Score = 16.5 bits (31), Expect = 4312 Identities = 6/9 (66%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 +AQK +KAH Sbjct: 220 SAQKHEKAH 228>XP_006723017 Length = 498 Score = 16.5 bits (31), Expect = 4312 Identities = 6/9 (66%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 +AQK +KAH Sbjct: 179 SAQKHEKAH 187>XP_003960002 Length = 539 Score = 16.5 bits (31), Expect = 4312 Identities = 6/9 (66%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 +AQK +KAH Sbjct: 220 SAQKHEKAH 228>XP_003960940 Length = 539 Score = 16.5 bits (31), Expect = 4312 Identities = 6/9 (66%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 +AQK +KAH Sbjct: 220 SAQKHEKAH 228>NP_653082 Length = 350 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 +K+KKAH Sbjct: 272 EKIKKAH 278>NP_000163 Length = 350 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 +K+KKAH Sbjct: 272 EKIKKAH 278>NP_997716 Length = 227 Score = 16.2 bits (30), Expect = 5631 Identities = 6/7 (85%), Positives = 7/7 (100%) Query: 1 AAQKMKK 7 AAQK+KK Sbjct: 172 AAQKLKK 178>NP_001130015 Length = 179 Score = 16.2 bits (30), Expect = 5631 Identities = 6/7 (85%), Positives = 7/7 (100%) Query: 1 AAQKMKK 7 AAQK+KK Sbjct: 124 AAQKLKK 130>NP_004526 Length = 1121 Score = 16.2 bits (30), Expect = 5631 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 AA+K+ K+H Sbjct: 514 AAEKLAKSH 522>NP_001257449 Length = 1068 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 AQKMKKAH 9 A+KM+K H Sbjct: 452 AEKMRKEH 459>NP_055807 Length = 1078 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 AQKMKKAH 9 A+KM+K H Sbjct: 452 AEKMRKEH 459>NP_055568 Length = 1282 Score = 16.2 bits (30), Expect = 5631 Identities = 6/7 (85%), Positives = 7/7 (100%) Query: 2 AQKMKKA 8 +QKMKKA Sbjct: 1219 SQKMKKA 1225>NP_001244953 Length = 868 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K+AH Sbjct: 834 QKLKEAH 840>XP_005267488 Length = 1078 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 AQKMKKAH 9 A+KM+K H Sbjct: 452 AEKMRKEH 459>XP_005267487 Length = 1078 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 AQKMKKAH 9 A+KM+K H Sbjct: 452 AEKMRKEH 459>XP_005271905 Length = 1219 Score = 16.2 bits (30), Expect = 5631 Identities = 6/7 (85%), Positives = 7/7 (100%) Query: 2 AQKMKKA 8 +QKMKKA Sbjct: 1156 SQKMKKA 1162>XP_005271904 Length = 1219 Score = 16.2 bits (30), Expect = 5631 Identities = 6/7 (85%), Positives = 7/7 (100%) Query: 2 AQKMKKA 8 +QKMKKA Sbjct: 1156 SQKMKKA 1162>XP_005271903 Length = 1282 Score = 16.2 bits (30), Expect = 5631 Identities = 6/7 (85%), Positives = 7/7 (100%) Query: 2 AQKMKKA 8 +QKMKKA Sbjct: 1219 SQKMKKA 1225>NP_001269389 Length = 587 Score = 15.8 bits (29), Expect = 7355 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 2 AQKMKKAH 9 AQK++K H Sbjct: 168 AQKLEKMH 175>NP_003613 Length = 1005 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 286 QKMKKA 291>NP_001185845 Length = 980 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 275 QKMKKA 280>NP_803193 Length = 1011 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 306 QKMKKA 311>NP_001185844 Length = 858 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 153 QKMKKA 158>XP_006719224 Length = 991 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 286 QKMKKA 291>XP_006719223 Length = 580 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 317 QKMKKA 322>XP_006719222 Length = 883 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 164 QKMKKA 169>XP_005253573 Length = 991 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 275 QKMKKA 280>XP_005253572 Length = 994 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 275 QKMKKA 280>XP_005253571 Length = 1002 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 286 QKMKKA 291>XP_005253568 Length = 1014 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 306 QKMKKA 311>XP_005253567 Length = 1025 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 317 QKMKKA 322>XP_005253566 Length = 1025 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 306 QKMKKA 311>XP_005253565 Length = 1026 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 317 QKMKKA 322>XP_005253564 Length = 1033 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 317 QKMKKA 322>XP_005253563 Length = 1036 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 317 QKMKKA 322>XP_005253562 Length = 1036 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 QKMKKA 8 QKMKKA Sbjct: 317 QKMKKA 322>NP_056477 Length = 1749 Score = 15.4 bits (28), Expect = 9605 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 AAQ++ +AH Sbjct: 1186 AAQRVAEAH 1194>NP_001275563 Length = 562 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 QKMKKAH 9 QKM+ AH Sbjct: 32 QKMRTAH 38>NP_060652 Length = 562 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 QKMKKAH 9 QKM+ AH Sbjct: 32 QKMRTAH 38>NP_001070966 Length = 562 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 QKMKKAH 9 QKM+ AH Sbjct: 32 QKMRTAH 38>NP_001275560 Length = 564 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 QKMKKAH 9 QKM+ AH Sbjct: 34 QKMRTAH 40>NP_001275562 Length = 562 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 QKMKKAH 9 QKM+ AH Sbjct: 32 QKMRTAH 38>NP_001275561 Length = 562 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 QKMKKAH 9 QKM+ AH Sbjct: 32 QKMRTAH 38>NP_001275564 Length = 562 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 QKMKKAH 9 QKM+ AH Sbjct: 32 QKMRTAH 38>NP_899631 Length = 1314 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 368 QKLKRSH 374>NP_899630 Length = 1274 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 368 QKLKRSH 374>NP_003707 Length = 1353 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 368 QKLKRSH 374>XP_006722034 Length = 564 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 QKMKKAH 9 QKM+ AH Sbjct: 34 QKMRTAH 40>XP_006713441 Length = 1125 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713440 Length = 1127 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713439 Length = 1134 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713438 Length = 1148 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713437 Length = 1154 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713436 Length = 1164 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713435 Length = 1174 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713434 Length = 1180 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713433 Length = 1183 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713432 Length = 1184 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713431 Length = 1190 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713430 Length = 1197 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713429 Length = 1203 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713428 Length = 1206 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713427 Length = 1207 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713426 Length = 1210 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006713425 Length = 1213 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 7/7 (100%) Query: 3 QKMKKAH 9 QK+K++H Sbjct: 198 QKLKRSH 204>XP_006712050 Length = 1716 Score = 15.4 bits (28), Expect = 9605 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 AAQ++ +AH Sbjct: 1186 AAQRVAEAH 1194>XP_005264311 Length = 1727 Score = 15.4 bits (28), Expect = 9605 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 AAQ++ +AH Sbjct: 1164 AAQRVAEAH 1172>XP_006712049 Length = 1728 Score = 15.4 bits (28), Expect = 9605 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 AAQKMKKAH 9 AAQ++ +AH Sbjct: 1165 AAQRVAEAH 1173>NP_056248 Length = 226 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 6/8 (75%) Query: 2 AQKMKKAH 9 A KM+K H Sbjct: 179 ASKMRKEH 186Database: HUMAN_PROTEOME_FASTA Posted date: May 26, 2014 10:46 AM Number of letters in database: 45,948,801 Number of sequences in database: 71,491 Lambda K H 0.310 0.105 0.270 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 71491 Number of Hits to DB: 445,971 Number of extensions: 915 Number of successful extensions: 83 Number of sequences better than 10000.0: 83 Number of HSP's gapped: 83 Number of HSP's successfully gapped: 83 Length of query: 9 Length of database: 45,948,801 Length adjustment: 0 Effective length of query: 9 Effective length of database: 45,948,801 Effective search space: 413539209 Effective search space used: 413539209 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 28 (15.8 bits) S2: 28 (15.4 bits)
CANCERTOPE | Raghava's Group | IMTECH | CSIR | CRDD | GPSR Package |