Browse result page of TopicalPdb


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IDSequenceNameNature of peptide or cargoAssayTissue permeabilityTissue SamplePUBMED ID
1019KETWWETWWTEWSQP
KKKRKV
Pep-1Cell penetrating peptideIn vivo imagingSignificant permeability of the peptide can be seen in in vivo imagesMouse skin cells23601371
1122GIGKFLKKAKKFG
KAFVKILKK
PexigananAntimicrobial, Diabetic Foot UlcersWound healing, infection progression, and the number of amputations required were calculated statisticallyClinical improvement rates were (85%–90%), Overall microbiological eradication rates (42%–47%)Diabetic Foot Ulcers18990064
1127GIGKFLHSAKKFGKA
FVGEIMNS
MagaininAntimicrobialFranz diffusion cellThe results suggest that positively charged magainin facilitated transdermal transport of negatively charged fluorescein due to electrostatic attraction at pH 7.4 and results in 35 fold increase in the permeation of maganine by the NLS control formulation (i.e., from an average of 0.037μg to 1.302 μg of fluorescein), but as the attraction decreased with increasing pH, the skin permeability enhancement decreased as wellHuman cadaver skin18601987
1128GIGKFLHSAKKFGKA
FVGEIMNS
MagaininAntimicrobialFranz diffusion cellThe results suggest that positively charged magainin facilitated transdermal transport of positively charged granisetron due to electrostatic attraction at pH 10 and results in 92–fold increase in the permeation of magnine (i.e., from and average of 2.23 μg to 205.55 μg of granisetron), but as the attraction decreased with decreasing pH, the skin permeability enhancement decreased as wellHuman cadaver skin18601987
1129GIGKFLHSAKKFGKA
FVGEIMNS
MagaininAntimicrobialMulti-photon excitation microscopyThe increase in permeation of fluorescein Faciliated by magnine can be seen the the microscopic imagesHuman cadaver skin18601987
1130GIGKFLHSAKKFGKA
FVGEIMNS
MagaininAntimicrobialMulti-photon excitation microscopyThe increase in permeation of granisetron faciliated by magnine can be seen the the microscopic imagesHuman cadaver skin18601987
1139GIGKFLHSAKKFGKA
FVGEIMNS
MagaininAntimicrobialFranz cell system, Multi-photon microscopySkin permeability 1.5x 103cm/h in presence of chemical enhancer,C o-administration of magainin and NLS-ethanol led to extensive magainin penetration throughout the stratum corneum which could be easily visualised in the microscopic imagesHuman cadaver skin17628164
1198RQIKIWFQNRRMKWK
KSIINFEKL
ANTP-OVA8 (OVA257–264 linked to Antennapedia transduction sequence)ANTP-OVA8 enhances the delivery of the antigen through the skin and promotes the generation of CTLHistochemical stainingPenetration of the antigen across skin surface with strong staining of all skin tissue layers. The penetration was rapid and detectable at 30 minTape-stripped ears of mice15121311
1289GrGDIPASSKGGGGS
rLLLLLLr
RGD peptide matrixActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer siteAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 57% (32 patients)Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle8080985
1290GrGDIPASSKGGGGS
rLLLLLLr
RGD peptide matrixActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer siteAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 55% (23 patients)Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle8080985
1291GrGDIPASSKGGGGS
rLLLLLLr
RGD peptide matrixActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer siteAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 54% (21 patients)Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle8080985
1292GrGDIPASSKGGGGS
rLLLLLLr
RGD peptide matrixActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer siteAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 56% (20 patients)Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle8080985
1293GrGDIPASSKGGGGS
rLLLLLLr
RGD peptide matrixActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer siteAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 58% (16 patients)Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle8080985
1294GrGDIPASSKGGGGS
rLLLLLLr
RGD peptide matrixActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer siteAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 61% (14 patients)Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle8080985
1357AGYKPDEGKRGDACE
GDSGGPFV
TRAP-508Thromboplastin activation product of prothrombin with high clotting and esterase activity.Histological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength.41% increase in breaking strength, P< 0.001, at 500 pmol/cm, histology demonstrated a more advanced state of healing, ratio test/saline control of incisional breaking strength is 1.37±0.39A single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose.1373740
1358AGYKPDEGKRGDACE
GDSGGPFV
TRAP-508bThromboplastin activation product of prothrombin with high clotting and esterase activity.Histological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength.Increased breaking strength > 80% over control values at day 7, P<0.001A single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose.1373740
1359AGYKPDEGKRGDACE
GDSGGPFV
TRAP-508bThromboplastin activation product of prothrombin with high clotting and esterase activity.Histological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength.39% increase over control breaking strength(P < 0.001)A single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose.1373740
1360AGYKPDEGKRGDACE
GDSGGPFV
TRAP-508bThromboplastin activation product of prothrombin with high clotting and esterase activity.Histological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength.18% increase over control breaking strength (P< 0.002)A single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose.1373740
1404AGYKPDEGKRGDACE
GDSGGPFV
TRAP 508 (Thrombin receptor-activating peptide)Mimics many effects of thrombinAngiography and histologyAfter 7 days, incisions treated with a single application of alpha-thrombin(10 pmol or 0.3310 micro gram/cm of incision) showed a 26% increase in breaking strength over those treated with PBS alone with a P value of <0.013. But, a single application of TRAP-508 worked even better than thrombin increasing breaking strength 41% over controls (P<0.001, at 500 pmol/cm).Mice skin1373740
1434AEKKDEGPYRMEHFR
WGSPPKD
β-MSH (β-Melanocyte-stimulating hormone)MSH stimulate the production and release of melanin (a process referred to as melanogenesis) by melanocytes in skin and hair. MSH actions in the brain have effects on appetite and sexual arousal.Osmolarity and tear volume measurementsOsmolarity measurements: t=0 min., β-MSH/Buffer=310/311mOsm/l; t=6 min., β-MSH/Buffer=301.5/306mOsm/l; t=16 min., β-MSH/Buffer=306/308mOsm/l; Volume measurement: β-MSH/Buffer= 14µl/56.1µlEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory duct2365569
1545GRKKRRQRRRPPQ-P
DALKSRTLR
μ-N2-10-2 (HIV-Nμ) (μ-calpain peptide )Not mentionedImmunofluorescence,TUNEL stainingTUNEL positive cells reduced by 50% in HIV-nu traeted retinascornea of the eye22885154