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IDSequenceNameNature of peptide or cargoAssayTissue permeabilityTissue SamplePUBMED ID
1117pGlu-HWSYwLRPGTriptorelinLuteinizing hormone releasing hormone (LHRH) superagonistFranz diffusion cell, HPLC64.9±8.8% degradedInterior skin surface of dermatomed skin (DS) of porcine19486932
1118pGlu-HWSYwLRPGTriptorelinLuteinizing hormone releasing hormone (LHRH) superagonistFranz diffusion cell, HPLC15±4.1% degradedInterior skin surface of heat separated epidermis (HSE) of porcine19486932
1119pGlu-HWSYwLRPGTriptorelinLuteinizing hormone releasing hormone (LHRH) superagonistFranz diffusion cell, HPLC100% degradedInterior skin surface of full thickness skin (FTS) of porcine19486932
1120pGlu-HWSYwLRPGTriptorelinLuteinizing hormone releasing hormone (LHRH) superagonistFranz diffusion cell, HPLC87.8±4.4% degradedInterior skin surface of dermatomed skin (DS) of porcine19486932
1121pGlu-HWSYwLRPGTriptorelinLuteinizing hormone releasing hormone (LHRH) superagonistFranz diffusion cell, HPLC51.3±6% degradedInterior skin surface of heat separated epidermis (HSE) of porcine19486932
1199pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux= 2.37 ± 0.94 µg h−1 cm−2 at 100% DCHuman cadaver skin14757511
1200pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux= 9.87 ± 4.91 µg h−1 cm−2 at 75% pulsed DCHuman cadaver skin14757511
1201pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux= 5.57 ± 2.27 µg h−1 cm−2 at 50% pulsed DCHuman cadaver skin14757511
1202pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux= 1.21 ± 0.76 µg h−1 cm−2 at 75%+/25%− ACHuman cadaver skin14757511
1203pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux= 0.006 ± 0.004 µg h−1 cm−2 at 50%+/50%− ACHuman cadaver skin14757511
1204pGlu-HWSY-D-2-Nal-LRPGNafarelinPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCNafarelin flux= 1.99 ± 2.04 µg h−1 cm−2 at 100% DCHuman cadaver skin14757511
1205pGlu-HWSY-D-2-Nal-LRPGNafarelinPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCNafarelin flux= 6.47 ± 0.87 µg h−1 cm−2 at 75% DCHuman cadaver skin14757511
1206pGlu-HWSY-D-2-Nal-LRPGNafarelinPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCNafarelin flux= 0.96 ± 0.79 µg h−1 cm−2 at 50% pulsed DCHuman cadaver skin14757511
1207pGlu-HWSY-D-2-Nal-LRPGNafarelinPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCNafarelin flux= 3.33 ± 1.04 µg h−1 cm−2 at 75%+/25%- ACHuman cadaver skin14757511
1208pGlu-HWSY-D-2-Nal-LRPGNafarelinPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCNafarelin flux= 0.15 ± 0.09 µg h−1 cm−2 at 50%+/50%- ACHuman cadaver skin14757511
1209pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux= 12.39 ± 5.32 µg h−1 cm−2 at 75% pulsed DC (500 Hz)Epidermis of human cadaver skin14757511
1210pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux= 5.97 ± 3.20 µg h−1 cm−2 at 50% pulsed DC (500 Hz)Epidermis of human cadaver skin14757511
1211pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux=9.07 ± 4.28 µg h−1 cm−2 at 25% pulsed DC (500 Hz)Epidermis of human cadaver skin14757511
1212pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux= 8.70±3.56 µg h−1 cm−2 at 75% pulsed DC (5 Hz)Epidermis of human cadaver skin14757511
1213pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux= 7.31±1.94 µg h−1 cm−2 at 50% pulsed DC (5 Hz)Epidermis of human cadaver skin14757511
1214pGlu-HWSYGLRPGLHRHPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.HPLCLHRH flux= 9.35±1.98 µg h−1 cm−2 at 25% pulsed DC (5 Hz)Epidermis of human cadaver skin14757511
1229pGlu-HPThyrotropin-releasing hormone (TRH)TRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-11.1 ± 0.7, Basal skin blood flow(PU)-378 ± 47, Heart rate(min-1)-424 ± 26, Respiratory rate(min-1)-113 ± 8, pH-7.38 ± 0.02, pCO2(kPa)-7.07 ± 0.37 and pO2(kPa)-7.91 ± 0.25Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1230pGlu-HPThyrotropin-releasing hormone (TRH)TRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-10.8 ± 1.0, Basal skin blood flow(PU)-421 ± 4, Heart rate(min-1)-417 ± 23, Respiratory rate(min-1)-118 ± 6, pH-7.39 ± 0.01, pCO2(kPa)-6.82 ± 0.27 and pO2(kPa)-8.43 ± 0.24Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1231pGlu-HPThyrotropin-releasing hormone (TRH)TRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-10.5 ± 1.0, Basal skin blood flow(PU)-454 ± 23, Heart rate(min-1)-423 ± 23, Respiratory rate(min-1)-123 ± 6, pH-7.40 ± 0.02, pCO2(pKa)-6.46 ± 0.31 and pO2(pKa)-9.87 ± 1.49Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1232pGlu-HPThyrotropin-releasing hormone (TRH)TRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-9.5 ± 0.8, Basal skin blood flow(PU)-348 ± 62, Heart rate(min-1)-419 ± 26, Respiratory rate(min-1)-115 ± 7, pH-7.37 ± 0.02, pCO2(pKa)-7.05 ± 0.56 and pO2(pKa)-7.39 ± 0.33Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1233pGlu-HPThyrotropin-releasing hormone (TRH)TRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-11.3 ± 0.7, Basal skin blood flow(PU)-370 ± 55, Heart rate(min-1)-329 ± 12, Respiratory rate(min-1)-89 ± 5, pH-7.33 ± 0.01, pCO2(pKa)-8.31 ± 0.25 and pO2(pKa)-9.24 ± 1.03Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1234pGlu-HPThyrotropin-releasing hormone (TRH)TRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-9.9 ± 0.8, Basal skin blood flow(PU)-358 ± 47, Heart rate(min-1)-349 ± 15, Respiratory rate(min-1)-101 ± 5, pH-7.33 ± 0.01, pCO2(pKa)-7.85 ± 0.23 and pO2(pKa)-9.30 ± 0.71Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1235pGlu-HPThyrotropin-releasing hormone (TRH)TRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-9.0 ± 0.5, Basal skin blood flow(PU)-287 ± 51, Heart rate(min-1)-353 ± 14, Respiratory rate(min-1)-98 ± 4, pH-7.33 ± 0.01, pCO2(pKa)-7.72 ± 0.34 and pO2(pKa)-8.43 ± 0.63Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1236pGlu-HPThyrotropin-releasing hormone (TRH)TRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-8.2 ± 0.4, Basal skin blood flow(PU)-244 ± 50, Heart rate(min-1)-359 ± 11, Respiratory rate(min-1)-91 ± 9, pH-7.35 ± 0.02, pCO2(pKa)-6.89 ± 0.33 and pO2(pKa)-10.8 ± 1.55Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1237pGlu-3-methyl-HPM-TRHTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of M-TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-11.2 ± 0.2, Basal skin blood flow(PU)-380 ± 44, Heart rate(min-1)-387 ± 18, Respiratory rate(min-1)-105 ± 10, pH-7.36 ± 0.03, pCO2(pKa)-7.42 ± 0.49 and pO2(pKa)-8.32 ± 0.70Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1238pGlu-3-methyl-HPM-TRHTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of M-TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-10.5 ± 0.5, Basal skin blood flow(PU)-305 ± 72, Heart rate(min-1)-385 ± 3, Respiratory rate(min-1)-113 ± 5, pH-7.39 ± 0.01, pCO2(pKa)-6.72 ± 0.08 and pO2(pKa)-7.99 ± 0.60Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1239pGlu-3-methyl-HPM-TRHTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of M-TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-10.1 ± 0.5, Basal skin blood flow(PU)-259 ± 69, Heart rate(min-1)-378 ± 4, Respiratory rate(min-1)-110 ± 8, pH-7.41 ± 0.01, pCO2(pKa)-6.51 ± 0.04 and pO2(pKa)-8.44 ± 0.46Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1240pGlu-3-methyl-HPM-TRHTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of M-TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-9.9 ± 0.8, Basal skin blood flow(PU)-202 ± 71, Heart rate(min-1)-372 ± 17, Respiratory rate(min-1)-101 ± 4, pH-7.40 ± 0.01, pCO2(pKa)-6.58 ± 0.20 and pO2(pKa)-8.73 ± 0.60Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1241pGlu-3-methyl-HPM-TRHTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of M-TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-11.0 ± 0.31, Basal skin blood flow(PU)-382 ± 32, Heart rate(min-1)-400 ± 8, Respiratory rate(min-1)-116 ± 7, pH-7.35 ± 0.01, pCO2(pKa)-7.73 ± 0.24 and pO2(pKa)-9.59 ± 1.04Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1242pGlu-3-methyl-HPM-TRHTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of M-TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-10.7 ± 0.31, Basal skin blood flow(PU)-294 ± 42, Heart rate(min-1)-404 ± 10, Respiratory rate(min-1)-116 ± 7, pH-7.36 ± 0.01, pCO2(pKa)-7.14 ± 0.22 and pO2(pKa)-8.57 ± 0.31Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1243pGlu-3-methyl-HPM-TRHTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of M-TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-10.3 ± 0.33, Basal skin blood flow(PU)-213 ± 48, Heart rate(min-1)-407 ± 13, Respiratory rate(min-1)-107 ± 9, pH-7.38 ± 0.01, pCO2(pKa)-6.62 ± 0.24 and pO2(pKa)-10.6 ± 1.13Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1244pGlu-3-methyl-HPM-TRHTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effectsCardiovascular parameters and blood gas values determined by collecting blood at different time intervalsOn application of M-TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-9.8 ± 0.52, Basal skin blood flow(PU)-212 ± 54, Heart rate(min-1)-412 ± 8, Respiratory rate(min-1)-102 ± 13, pH-7.38 ± 0.01, pCO2(pKa)-6.52 ± 0.22 and pO2(pKa)-9.33 ± 0.58Stratum corneum of the abdominal area of male Sprague-Dawley rats11179600
1245pGlu-HPThyrotropin-releasing hormone (TRH)It is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND)Radioimmunoassay and Liquid Scintillation TechniquePermeability coefficient (Kp)= 18.4*105 cm/h, Cumulative amount= 24.9± 1.7 µg/cm2, Enhancement factor (EF) =3.4Human epidermal membrane10205635
1246pGlu-HPThyrotropin-releasing hormone (TRH)It is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND)Radioimmunoassay and Liquid Scintillation TechniquePermeability coefficient (Kp)= 16.6*105 cm/h, Cumulative amount= 18.5± 2.1 µg/cm2, Enhancement factor (EF) =3.1Human epidermal membrane10205635
1247pGlu-HPThyrotropin-releasing hormone (TRH)It is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND)Radioimmunoassay and Liquid Scintillation TechniquePermeability coefficient (Kp)= 5.4*105 cm/h, Cumulative amount= 7.8± 1.7 µg/cm2, Enhancement factor (EF) =0Human epidermal membrane10205635
1248pGlu-3-methyl-HPM-TRHAnalogue of TRH i.e. M-TRH is a potent analogue and stimulates the release of TSH from the pituitary seven to eight times that of the parental tripeptide.Liquid Scintillation TechniquePermeability coefficient (Kp)= 32.0*105 cm/h, Cumulative amount= 41.5±4.9 µg/cm2, Enhancement factor (EF) =4.7Human epidermal membrane10205635
1249pGlu-3-methyl-HPM-TRHAnalogue of TRH i.e. M-TRH is a potent analogue and stimulates the release of TSH from the pituitary seven to eight times that of the parental tripeptide.Liquid Scintillation TechniquePermeability coefficient (Kp)=20.2*105 cm/h, Cumulative amount= 20.4± 3.6µg/cm2, Enhancement factor (EF) =3.0Human epidermal membrane10205635
1250pGlu-3-methyl-HPM-TRHAnalogue of TRH i.e. M-TRH is a potent analogue and stimulates the release of TSH from the pituitary seven to eight times that of the parental tripeptide.Liquid Scintillation TechniquePermeability coefficient (Kp)= 6.8*105 cm/h, Cumulative amount= 8.6± 1.0 µg/cm2, Enhancement factor (EF) =0Human epidermal membrane10205635
1345pGlu-EDSGEpidermal pentapeptideIt induces a moderate but long-lasting inhibition of epidermal cell proliferation when given at low (picomol) doses but stimulates epidermal cell proliferation at higher dosesColcemid-arrested mitoses and labelled cells were counted per 12 mm of interfollicular epidermis in 5 pm paraffin sections stationed with haematoxylin in the former and dipcoated with NTB 2 emulsion and incubated for 3 weeks at 0-4 ͦC for later. The statistical evaluations were made according to the Wilcoxon's rank sum test.Significant mitotic rate inhibition initially and on day 7 after an overshoot on day 6Back skin of female hairless mice (hr/hr)1977237
1346pGlu-EDSGEpidermal pentapeptideIt induces a moderate but long-lasting inhibition of epidermal cell proliferation when given at low (picomol) doses but stimulates epidermal cell proliferation at higher dosesColcemid-arrested mitoses and labelled cells were counted per 12 mm of interfollicular epidermis in 5 pm paraffin sections stationed with haematoxylin in the former and dipcoated with NTB 2 emulsion and incubated for 3 weeks at 0-4 ͦC for later. The statistical evaluations were made according to the Wilcoxon's rank sum test.Initial increase in mitotic rate, peaking on day 2, from day 2 to day 10, mitotic rate was lower than normal.Back skin of female hairless mice (hr/hr)1977237
1347pGlu-EDSGEpidermal pentapeptideIt induces a moderate but long-lasting inhibition of epidermal cell proliferation when given at low (picomol) doses but stimulates epidermal cell proliferation at higher dosesColcemid-arrested mitoses and labelled cells were counted per 12 mm of interfollicular epidermis in 5 pm paraffin sections stationed with haematoxylin in the former and dipcoated with NTB 2 emulsion and incubated for 3 weeks at 0-4 ͦC for later. The statistical evaluations were made according to the Wilcoxon's rank sum test.The mitotic rate was strongly increased with peaks at days 1, 3 and 6 (twice the control value).Back skin of female hairless mice (hr/hr)1977237
1401Pyr-QRLGNQWAVGHLMBombesinIt may act as secretagogue in human nasal mucosa in vivoAnterior rhinomanimetry, Nasal provocation, Lowrys methodBombesin stimulates nasal secretion from submucosal glands and possibly epithelial cell without affecting vascular permeability. Total protein secretion was increased after 100 nmol (P=0.041) and 1000 nmol (P=0.009) of bombesin compared with baseline, significant lysozyme (24±3 µg/ml, P<0.05) secretion occurred after 1000 nmol.Nasal mucosa of humans1733281