Browse result page of TopicalPdb


Please click on the ID to see detailed information about each entry.

The total number entries retrieved from this search are
IDSequenceNameNature of peptide or cargoAssayTissue permeabilityTissue SamplePUBMED ID
1393TCapsaicinRepeated capsaicin applications are assumed to cause desensitization of the nasal mucosa and a decreased secretory responseImmunocytochemistry, electron microscopyThe number of goblet cells was increased in the nasal region. CGRP-Iike activity was decreased in biopsies taken from the test sides of the paranasal sinuses when compared to control.Nasal mucosa of New Zealand White rabbits8737771
1396TCapsaicinNociceptive responses to various noxious stimuli are inhibited or abolished in capsaicin-treated animals. This effect is presumed to arise from the toxic action of capsaicin and the consequent neurodegeneration of C-fibre nociceptors.Pain response evaluated by a visual analogue scaleCapsaicin (50 nmol, 50 µl) produced a remarkable pain response (considered as 100 in the VAS), sneezing and secretion of copious flow of nasal fluid. Capsaicin applications were performed every day for 5-7 days until the painful response reported by each subject was reduced by about 80%Nostrils of human subjects8443036
1398TCapsaicinAffects not only sensory nerves but impacts on THI sympathetic nerves in the nasal mucosaImmunocytochemistryIn the nasal mucosa of toluene diisocyanate sensitized guinea pigs, substance P (SP)- and tyrosine hydroxylase (TH)-like immunoreactive (SPI and THI) fibers seemed to decrease after capsaicin applicationNasal mucosa of guinea pigs7680838
1399TCapsaicinCapsaicin, the pungent ingredient of red peppers, when applied into the nasal mucosa induces violent sneezing, vasodilation and increases vascular permeability.Visual analogue scale method was used to measure burning and painful sensation on application of capsaicin.The application of capsaicin into the human nasal mucosa was immediately followed by a painful sensation that was described by all the subjects as burning. A variable number of sneezes (from I up to 8) also occurred.Human nasal mucosa3370386
1400TCapsaicinCapsaicin activates sensory nerve endings in the nose and the paranasal sinuses, thereby stimulating protective reflexes involved in sneezing and in increased vasopermeability and stimulate mucociliary activityThe amount of nasal mucosa secreted in response to capsaicin was weighed.Capsaicin stimulated the secretion of nasal fluid in a dose-dependent manner when administered as a single dose.Nasal mucosa of rats2480171
1608TCapsaicinCapsaicin increases calcitonin gene-related peptide (CGRP) release from sensory neurons by stimulating vanilloid receptor-1Immunoassay.Dermal IGF level increased to approximately 2000 ng/g tissueMice skin17307377