Bhasin, M., Singh, H., Raghava, G. P. S.
Institute of Microbial Technology Sector 39A, Chandigarh, India
The MHCBN is a comprehensive database of Major Histocompatibility Complex (MHC) binding and non-binding peptides. It is a curated database where the entries are compiled from published literature. Each entry in database consists the following information i) peptide sequence ii) MHC-peptide binding strength iii) potential of T-cell activation iv) sequence & structure of MHC molecule & associated proteins and v) internal & external hypertext data links. The MHCBN have number of online web tools for the analysis and retrieval of data from the database. These tools allow users to i) search the relevant information, ii) perform BLAST search against antigens and MHC sequences, iii) create allele specific data set and iv) submit data online. The server provides option to map the peptides in MHCBN database on a query protein sequence. This option would be very useful in locating the MHC binders/non-binders and T-cell epitopes in user?s antigen sequence. The latest version of MHCBN contains 16598 entries that include 14816 binders, 1782 non-binders and 5456 T-cell epitope entries. The database also maintains i) 2825 sequences & 676 structures of proteins having matching peptide, ii) 928 publication references, iii) 91 structure of MHC proteins and iv) 1457 sequence of MHC proteins. The server provides the hypertext link to major databases like SWISSPROT, PDB, IMGT/HLA-DB, PubMed and ENTREZ. The MHCBN database and its applications are freely available at http://www.imtech.res.in/raghava/mhcbn/.
Authors are thankful to CSIR and Department of Biotechnology (DBT), Govt. of India, for financial assistance.
Category Protein Databases