Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0053	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8549669	1996	NA
PRRID_0053	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8549669	1996	NA
PRRID_0054	N-Pam-S-Lau2CSK4 Click for more detail	Synthetic (others)	NA	NA	Lipopeptides	Synthetic	Immunostimulant	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8549669	1996	NA
PRRID_0054	N-Pam-S-Lau2CSK4 Click for more detail	Synthetic (others)	NA	NA	Lipopeptides	Synthetic	Immunostimulant	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8549669	1996	NA
PRRID_0097	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0097	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0098	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0098	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0105	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0105	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0219	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0219	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0375	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	NA	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	MALP-2-induced degradation of I	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	lung epithelial cells (small airway lung epithelial (SALE))	NA	O60603.fasta	O60603	784	This induces the inflammatory response.	NF-kappaB-luciferase reporter assays	19265130	2009	Pubchem Assay
PRRID_0375	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	NA	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	MALP-2-induced degradation of I	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	lung epithelial cells (small airway lung epithelial (SALE))	NA	O60603.fasta	O60603	784	This induces the inflammatory response.	NF-kappaB-luciferase reporter assays	19265130	2009	Pubchem Assay
PRRID_0463	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	NA
PRRID_0463	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	NA
PRRID_0670	macrophage-activating lipopeptide Click for more detail	Mycoplasma fermentans (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	20713100	2010	Pubchem Assay
PRRID_0670	macrophage-activating lipopeptide Click for more detail	Mycoplasma fermentans (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	20713100	2010	Pubchem Assay
PRRID_0721	Diacylated Lipopeptide Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0721	Diacylated Lipopeptide Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0723	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-Œ∫B which results in secretion of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	embryonic mouse telencephalon and NPC	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	its activation inhibits NPC proliferation and decreases cell proliferation.	NA	20456021	2010	Pubchem Assay
PRRID_0723	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-Œ∫B which results in secretion of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	embryonic mouse telencephalon and NPC	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	its activation inhibits NPC proliferation and decreases cell proliferation.	NA	20456021	2010	Pubchem Assay
PRRID_0724	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	It mediates the effect through a TLR2/PI3K/Aktdependent mechanism.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Heart	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It induces induce cardioprotection against ischaemia/reperfusion injury	EMSA	20421349	2010	Pubchem Assay
PRRID_0724	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	It mediates the effect through a TLR2/PI3K/Aktdependent mechanism.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Heart	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It induces induce cardioprotection against ischaemia/reperfusion injury	EMSA	20421349	2010	Pubchem Assay
PRRID_0818	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 2 (TLR2)-Toll-like receptor (TLR1 dimer)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It coauses the inflammation	NA	20740341	2010	NA
PRRID_0818	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 2 (TLR2)-Toll-like receptor (TLR1 dimer)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It coauses the inflammation	NA	20740341	2010	NA
PRRID_0819	Triacylated lipopeptides Click for more detail	Bacteria and Mycobacteria	NA	NA	Lipopeptides	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	NA
PRRID_0819	Triacylated lipopeptides Click for more detail	Bacteria and Mycobacteria	NA	NA	Lipopeptides	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	NA
PRRID_0966	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Myeloid cells, T, B and NK cells, microglia, astrocytes	NA	Q15399.fasta	Q15399	786	NA	NA	21982558	2011	Pubchem Assay
PRRID_0966	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Myeloid cells, T, B and NK cells, microglia, astrocytes	NA	Q15399.fasta	Q15399	786	NA	NA	21982558	2011	Pubchem Assay
PRRID_0967	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	21955443	2011	NA
PRRID_0967	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	21955443	2011	NA
PRRID_0983	CBLB613 Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	reduced radiation-induced cytopenia and increased bone marrow cellularity in irradiated mice	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	CD2F1 Mice	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	22175300	2012	NA
PRRID_0983	CBLB613 Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	reduced radiation-induced cytopenia and increased bone marrow cellularity in irradiated mice	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	CD2F1 Mice	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	22175300	2012	NA
PRRID_1162	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1162	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1164	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1164	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1190	Braun‚Äôs lipoprotein Click for more detail	NA	NA	NA	Lipopeptides	Synthetic	NA	Rac1	Pattern recognition receptor (PRR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1190	Braun‚Äôs lipoprotein Click for more detail	NA	NA	NA	Lipopeptides	Synthetic	NA	Rac1	Pattern recognition receptor (PRR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1241	dipalmitoyl-S-glyceryl cysteine (Pam2Cys) Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipopeptides	Synthetic	provide immunostimulatory activity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1241	dipalmitoyl-S-glyceryl cysteine (Pam2Cys) Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipopeptides	Synthetic	provide immunostimulatory activity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1303	GAS lipoprotein (group A streptococcus) Click for more detail	Streptococcus pyogenes (Bacteria)	NA	NA	Lipopeptides	Synthetic	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1303	GAS lipoprotein (group A streptococcus) Click for more detail	Streptococcus pyogenes (Bacteria)	NA	NA	Lipopeptides	Synthetic	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1385	J14 Click for more detail	NA	NA	NA	Lipopeptides	Synthetic	chimeric peptide with the protective conformational M protein antigen enclosed within peptide sequences that encourage an Œ±-helical conformation	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1385	J14 Click for more detail	NA	NA	NA	Lipopeptides	Synthetic	chimeric peptide with the protective conformational M protein antigen enclosed within peptide sequences that encourage an Œ±-helical conformation	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1474	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1474	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1475	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1475	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1476	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1476	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1477	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1477	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1478	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1478	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1522	Pam3CSK3 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	mimic parts of bacterial lipoproteins	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	TLR2 forms a heterodimer with TLR1 in response to Pam3CSK4 leading to the recruitment of the adaptor proteins MAL and MYD88 and the activation of IL1 receptor-associated kinase 4 (IRAK4), IRAK1, and TNF receptor-associated factor 6	Real-time PCR	24736205	2014	NA
PRRID_1522	Pam3CSK3 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	mimic parts of bacterial lipoproteins	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	TLR2 forms a heterodimer with TLR1 in response to Pam3CSK4 leading to the recruitment of the adaptor proteins MAL and MYD88 and the activation of IL1 receptor-associated kinase 4 (IRAK4), IRAK1, and TNF receptor-associated factor 6	Real-time PCR	24736205	2014	NA
PRRID_1527	Pam3CSK4 Click for more detail	Salmonella typhimurium(Bacteria)	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q9DD78.fasta	Q9DD78	793	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1527	Pam3CSK4 Click for more detail	Salmonella typhimurium(Bacteria)	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q9DD78.fasta	Q9DD78	793	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1528	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	induce apoptosis in monocytes	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	bone marrow stromal cells (BMSCs)	cell surface	NA	NA	NA	TLR1/2 triggering may be of therapeutic use to decrease cellular resistance to the cytotoxic action of chemotherapeutic agents.	Fluorometric Adhesion Assay, Drug Cytotoxicity Assay, Apoptosis Assay	24794258	2014	NA
PRRID_1528	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	induce apoptosis in monocytes	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	bone marrow stromal cells (BMSCs)	cell surface	NA	NA	NA	TLR1/2 triggering may be of therapeutic use to decrease cellular resistance to the cytotoxic action of chemotherapeutic agents.	Fluorometric Adhesion Assay, Drug Cytotoxicity Assay, Apoptosis Assay	24794258	2014	NA
PRRID_1654	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1654	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1655	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1655	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1656	tripalmitoyl-S-glycerol cysteine (Pam3Cys) Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)O	NA	Lipopeptides	Synthetic	provide immunostimulatory activity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1656	tripalmitoyl-S-glycerol cysteine (Pam3Cys) Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)O	NA	Lipopeptides	Synthetic	provide immunostimulatory activity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_2658	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	cell surface	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	NA	NA	29263932	2017	Pubchem_assay
PRRID_2658	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	cell surface	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	NA	NA	29263932	2017	Pubchem_assay
PRRID_2659	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	cell surface	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29263932	2017	Pubchem_assay
PRRID_2659	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	cell surface	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29263932	2017	Pubchem_assay
PRRID_2660	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	Induce IL-Ôòæ production in human tonsillar B cells	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	NA	NA	29028369	2017	Pubchem_assay
PRRID_2660	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	Induce IL-Ôòæ production in human tonsillar B cells	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	NA	NA	29028369	2017	Pubchem_assay

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