Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0280Curdlan

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Alcaligenes faecalis(Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalCurdlan is a pure dectin-1 agonist and induces TNF-alpha production in human PBMCs and macrophages.Dectin-1C type Lectin (CTL/CLR)HumanPBMCs and monocyte-derived macrophages.NAQ9BXN2.fastaQ9BXN2247It is resoonsible for the immuno-inflammation in the host cell.ELISA185494572008Pubchem Assay
PRRID_0280Curdlan

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Alcaligenes faecalis(Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalCurdlan is a pure dectin-1 agonist and induces TNF-alpha production in human PBMCs and macrophages.Dectin-1C type Lectin (CTL/CLR)HumanPBMCs and monocyte-derived macrophages.NAQ9BXN2.fastaQ9BXN2247It is resoonsible for the immuno-inflammation in the host cell.ELISA185494572008Pubchem Assay
PRRID_0847Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimerToll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAIt coauses the inflammationNA207403412010NA
PRRID_0847Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimerToll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAIt coauses the inflammationNA207403412010NA
PRRID_0848Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0848Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0849Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0849Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0850Zymosan

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gram-positive bacteria and yeastC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalTheir bindng leads to the secretion of the proinflammatory cytokines through NF-KB pathwaysToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)Humancerebral endothelial cell line hCMEC/D3Leucine-rich Repeat (LRR) DomainNANANAIt's activation causes tight junction disruption in CECsNA206372482010NA
PRRID_0850Zymosan

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gram-positive bacteria and yeastC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalTheir bindng leads to the secretion of the proinflammatory cytokines through NF-KB pathwaysToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)Humancerebral endothelial cell line hCMEC/D3Leucine-rich Repeat (LRR) DomainNANANAIt's activation causes tight junction disruption in CECsNA206372482010NA
PRRID_0851Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0851Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0852β -1,3-glucan

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FungiC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlucanNaturalNAPGRP-S2Peptidoglycan Recognition Receptor (PGRPs)Chlamys farrerimantle, gill, kidney and gonadNAQ9VYX7.fastaQ9VYX7203It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0852β -1,3-glucan

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FungiC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlucanNaturalNAPGRP-S2Peptidoglycan Recognition Receptor (PGRPs)Chlamys farrerimantle, gill, kidney and gonadNAQ9VYX7.fastaQ9VYX7203It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0859β -1,3-glucan

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Vibrio harveyi (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlucanNaturalNAGNBPGram-negative Bacteria-binding Protein (GNBPs)Artemia sinicaNANANANANAHave cytoprotective effectNA206991042010NA
PRRID_0859β -1,3-glucan

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Vibrio harveyi (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlucanNaturalNAGNBPGram-negative Bacteria-binding Protein (GNBPs)Artemia sinicaNANANANANAHave cytoprotective effectNA206991042010NA
PRRID_0972Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784plays a fundamental role in pathogen recognition and activation of innate immunityNA219825582011Pubchem Assay
PRRID_0972Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784plays a fundamental role in pathogen recognition and activation of innate immunityNA219825582011Pubchem Assay
PRRID_0973Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMyeloid cells, dendritic cells, microglia, astrocytesNAQ9Y2C9.fastaQ9Y2C9796significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0973Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMyeloid cells, dendritic cells, microglia, astrocytesNAQ9Y2C9.fastaQ9Y2C9796significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0974Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0974Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0975Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 6 (TLR6)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0975Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 6 (TLR6)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_1166Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses RT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1166Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses RT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1167Zymosan

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Various pathogens (others)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs Q9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1167Zymosan

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Various pathogens (others)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs Q9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1168Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs Q9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1168Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs Q9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1170Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1170Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1171Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1171Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1676Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalactivates macrophages via TLR2.Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANATLR2 cooperates with TLR6 and CD14 in response to zymosanNA248300242014NA
PRRID_1676Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalactivates macrophages via TLR2.Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANATLR2 cooperates with TLR6 and CD14 in response to zymosanNA248300242014NA
PRRID_1677Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalactivates macrophages via TLR2.Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANATLR2 cooperates with TLR6 and CD14 in response to zymosanNA248300242014NA
PRRID_1677Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalactivates macrophages via TLR2.Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANATLR2 cooperates with TLR6 and CD14 in response to zymosanNA248300242014NA
PRRID_1678Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmast cellscell surfaceO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responsesReal-time PCR248186342014Pubchem_assay
PRRID_1678Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmast cellscell surfaceO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responsesReal-time PCR248186342014Pubchem_assay
PRRID_1679Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellscell surfaceQ9QUN7.fastaQ9QUN7784Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemiaNA248071662014Pubchem_assay
PRRID_1679Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellscell surfaceQ9QUN7.fastaQ9QUN7784Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemiaNA248071662014Pubchem_assay
PRRID_1680Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellscell surfaceO60603.fastaO60603784Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemiaNA248071662014Pubchem_assay
PRRID_1680Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellscell surfaceO60603.fastaO60603784Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemiaNA248071662014Pubchem_assay
PRRID_1681Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micehuman MSCs (hMSCs) and murine MSCs (mMSCs)cell surfaceQ9QUN7.fastaQ9QUN7784TLR2 cooperates with TLR6 and CD14 in response to zymosanNA247803952014Pubchem_assay
PRRID_1681Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micehuman MSCs (hMSCs) and murine MSCs (mMSCs)cell surfaceQ9QUN7.fastaQ9QUN7784TLR2 cooperates with TLR6 and CD14 in response to zymosanNA247803952014Pubchem_assay
PRRID_1682Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanhuman MSCs (hMSCs) and murine MSCs (mMSCs)cell surfaceO60603.fastaO60603784TLR2 cooperates with TLR6 and CD14 in response to zymosanNA247803952014Pubchem_assay
PRRID_1682Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanhuman MSCs (hMSCs) and murine MSCs (mMSCs)cell surfaceO60603.fastaO60603784TLR2 cooperates with TLR6 and CD14 in response to zymosanNA247803952014Pubchem_assay
PRRID_1683Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domainQ9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responsesELISA247572872014Pubchem_assay
PRRID_1683Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domainQ9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responsesELISA247572872014Pubchem_assay
PRRID_1684Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domainO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responsesELISA247572872014Pubchem_assay
PRRID_1684Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domainO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responsesELISA247572872014Pubchem_assay
PRRID_1685Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domains of leucine-rich repeat motifsQ9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responsesNA247543202014Pubchem_assay
PRRID_1685Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domains of leucine-rich repeat motifsQ9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responsesNA247543202014Pubchem_assay
PRRID_1686Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domains of leucine-rich repeat motifsO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responsesNA247543202014Pubchem_assay
PRRID_1686Zymosan

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Fungi(Yeast)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsextracellular domains of leucine-rich repeat motifsO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responsesNA247543202014Pubchem_assay
PRRID_1954Beta glucans

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Candida albicans(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlucanNaturalActivation of CLEC7ACLEC7AC type Lectin (CTL/CLR)HumanNANAQ9BXN2.fastaQ9BXN2247critical functions in host defense against Candida albicans invasionNA288241662017Pubchem_assay
PRRID_1954Beta glucans

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Candida albicans(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlucanNaturalActivation of CLEC7ACLEC7AC type Lectin (CTL/CLR)HumanNANAQ9BXN2.fastaQ9BXN2247critical functions in host defense against Candida albicans invasionNA288241662017Pubchem_assay
PRRID_2696Zymosan

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Fungi(Yeast)NANAGlucanNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290283692017Pubchem_assay
PRRID_2696Zymosan

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Fungi(Yeast)NANAGlucanNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290283692017Pubchem_assay
PRRID_2697Zymosan

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Fungi(Yeast)NANAGlucanNaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANANondepleted zymosan also binds TLR2NA281676512017NA
PRRID_2697Zymosan

Click for more detail

Fungi(Yeast)NANAGlucanNaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANANondepleted zymosan also binds TLR2NA281676512017NA