PRRDB 2.0 :
Pattern Recognition Receptor Database
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C-Type Lectins (CTLs/CLRs)
Gram negative binding Proteins(GNBPs)
1,3-β-D-Glucan Pattern Recognition Protein(GRPs)
Lectins
Mannose Receptors (MRs)
Nod like Receptors (NLRs)
Peptidoglycan Recognition Proteins (PGRPs)
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Browse result page of PRRDB 2.0
PRRID
Name of Ligand
Source of ligand
Sequence of Ligand
Length of Ligand
Type of Ligand
Occurence
Role of Ligand
Name of Receptor
Type of Reeptor
Source of the Receptor
Localization
Domain
Sequence of Receptor
Swiss prot ID
Length of receptor
Function of Receptor
Assay used
PMID
Year of publication
Pubchem assay
PRRID_0280
Curdlan
Click for more detail
Alcaligenes faecalis(Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
Curdlan is a pure dectin-1 agonist and induces TNF-alpha production in human PBMCs and macrophages.
Dectin-1
C type Lectin (CTL/CLR)
Human
PBMCs and monocyte-derived macrophages.
NA
Q9BXN2.fasta
Q9BXN2
247
It is resoonsible for the immuno-inflammation in the host cell.
ELISA
18549457
2008
Pubchem Assay
PRRID_0280
Curdlan
Click for more detail
Alcaligenes faecalis(Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
Curdlan is a pure dectin-1 agonist and induces TNF-alpha production in human PBMCs and macrophages.
Dectin-1
C type Lectin (CTL/CLR)
Human
PBMCs and monocyte-derived macrophages.
NA
Q9BXN2.fasta
Q9BXN2
247
It is resoonsible for the immuno-inflammation in the host cell.
ELISA
18549457
2008
Pubchem Assay
PRRID_0847
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins
Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer
Toll-like receptor (TLR)
Human
NA
Leucine-rich Repeat (LRR) Domain
NA
NA
NA
It coauses the inflammation
NA
20740341
2010
NA
PRRID_0847
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins
Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer
Toll-like receptor (TLR)
Human
NA
Leucine-rich Repeat (LRR) Domain
NA
NA
NA
It coauses the inflammation
NA
20740341
2010
NA
PRRID_0848
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
NA
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
dendritic cells, macrophages and lymphocytes
Leucine-rich Repeat (LRR) Domain
O60603.fasta
O60603
784
NA
NA
20713100
2010
Pubchem Assay
PRRID_0848
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
NA
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
dendritic cells, macrophages and lymphocytes
Leucine-rich Repeat (LRR) Domain
O60603.fasta
O60603
784
NA
NA
20713100
2010
Pubchem Assay
PRRID_0849
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
Lung's endothelial cell
Leucine-rich Repeat (LRR) Domain
Q9QUN7.fasta
Q9QUN7
784
It has the role in the inflammation.
NA
20706658
2010
Pubchem Assay
PRRID_0849
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
Lung's endothelial cell
Leucine-rich Repeat (LRR) Domain
Q9QUN7.fasta
Q9QUN7
784
It has the role in the inflammation.
NA
20706658
2010
Pubchem Assay
PRRID_0850
Zymosan
Click for more detail
gram-positive bacteria and yeast
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
Their bindng leads to the secretion of the proinflammatory cytokines through NF-KB pathways
Toll-like receptor 2/6 (TLR2/6)
Toll-like receptor (TLR)
Human
cerebral endothelial cell line hCMEC/D3
Leucine-rich Repeat (LRR) Domain
NA
NA
NA
It's activation causes tight junction disruption in CECs
NA
20637248
2010
NA
PRRID_0850
Zymosan
Click for more detail
gram-positive bacteria and yeast
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
Their bindng leads to the secretion of the proinflammatory cytokines through NF-KB pathways
Toll-like receptor 2/6 (TLR2/6)
Toll-like receptor (TLR)
Human
cerebral endothelial cell line hCMEC/D3
Leucine-rich Repeat (LRR) Domain
NA
NA
NA
It's activation causes tight junction disruption in CECs
NA
20637248
2010
NA
PRRID_0851
Zymosan
Click for more detail
S. cerevisiae (Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector
Toll-like receptor 9 (TLR9)
Toll-like receptor (TLR)
Human
Cell surface
Leucine-rich Repeat (LRR) Domain
Q9NR96.fasta
Q9NR96
1032
It leadsto the secretion of the proinfalmmatory cytokines
NA
20620129
2010
Pubchem Assay
PRRID_0851
Zymosan
Click for more detail
S. cerevisiae (Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector
Toll-like receptor 9 (TLR9)
Toll-like receptor (TLR)
Human
Cell surface
Leucine-rich Repeat (LRR) Domain
Q9NR96.fasta
Q9NR96
1032
It leadsto the secretion of the proinfalmmatory cytokines
NA
20620129
2010
Pubchem Assay
PRRID_0852
β -1,3-glucan
Click for more detail
Fungi
C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O
NA
Glucan
Natural
NA
PGRP-S2
Peptidoglycan Recognition Receptor (PGRPs)
Chlamys farreri
mantle, gill, kidney and gonad
NA
Q9VYX7.fasta
Q9VYX7
203
It has the role in the inflammation.
NA
20713100
2010
Pubchem Assay
PRRID_0852
β -1,3-glucan
Click for more detail
Fungi
C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O
NA
Glucan
Natural
NA
PGRP-S2
Peptidoglycan Recognition Receptor (PGRPs)
Chlamys farreri
mantle, gill, kidney and gonad
NA
Q9VYX7.fasta
Q9VYX7
203
It has the role in the inflammation.
NA
20713100
2010
Pubchem Assay
PRRID_0859
β -1,3-glucan
Click for more detail
Vibrio harveyi (Bacteria)
C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O
NA
Glucan
Natural
NA
GNBP
Gram-negative Bacteria-binding Protein (GNBPs)
Artemia sinica
NA
NA
NA
NA
NA
Have cytoprotective effect
NA
20699104
2010
NA
PRRID_0859
β -1,3-glucan
Click for more detail
Vibrio harveyi (Bacteria)
C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O
NA
Glucan
Natural
NA
GNBP
Gram-negative Bacteria-binding Protein (GNBPs)
Artemia sinica
NA
NA
NA
NA
NA
Have cytoprotective effect
NA
20699104
2010
NA
PRRID_0972
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons
NA
O60603.fasta
O60603
784
plays a fundamental role in pathogen recognition and activation of innate immunity
NA
21982558
2011
Pubchem Assay
PRRID_0972
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons
NA
O60603.fasta
O60603
784
plays a fundamental role in pathogen recognition and activation of innate immunity
NA
21982558
2011
Pubchem Assay
PRRID_0973
Zymosan
Click for more detail
S. cerevisiae (Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 6 (TLR6)
Toll-like receptor (TLR)
Human
Myeloid cells, dendritic cells, microglia, astrocytes
NA
Q9Y2C9.fasta
Q9Y2C9
796
significant role in the pathogenesis of severe inflammatory responses
NA
21982558
2011
Pubchem Assay
PRRID_0973
Zymosan
Click for more detail
S. cerevisiae (Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 6 (TLR6)
Toll-like receptor (TLR)
Human
Myeloid cells, dendritic cells, microglia, astrocytes
NA
Q9Y2C9.fasta
Q9Y2C9
796
significant role in the pathogenesis of severe inflammatory responses
NA
21982558
2011
Pubchem Assay
PRRID_0974
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
NA
NA
NA
NA
NA
NA
plays a fundamental role in pathogen recognition and activation of innate immunity
NA
21955443
2011
NA
PRRID_0974
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
NA
NA
NA
NA
NA
NA
plays a fundamental role in pathogen recognition and activation of innate immunity
NA
21955443
2011
NA
PRRID_0975
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 6 (TLR6)
Toll-like receptor (TLR)
NA
NA
NA
NA
NA
NA
significant role in the pathogenesis of severe inflammatory responses
NA
21955443
2011
NA
PRRID_0975
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 6 (TLR6)
Toll-like receptor (TLR)
NA
NA
NA
NA
NA
NA
significant role in the pathogenesis of severe inflammatory responses
NA
21955443
2011
NA
PRRID_1166
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
testis, epididymis, vasa deferens, prostate and prepuce
NA
O60603.fasta
O60603
784
significant role in the pathogenesis of severe inflammatory responses
RT-PCR, Quantitative real-time PCR
23998272
2013
Pubchem_assay
PRRID_1166
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
testis, epididymis, vasa deferens, prostate and prepuce
NA
O60603.fasta
O60603
784
significant role in the pathogenesis of severe inflammatory responses
RT-PCR, Quantitative real-time PCR
23998272
2013
Pubchem_assay
PRRID_1167
Zymosan
Click for more detail
Various pathogens (others)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, DCs, B-lymphocytes
extracellular domains of leucine-rich repeat motifs
Q9QUN7.fasta
Q9QUN7
784
significant role in the pathogenesis of severe inflammatory responses
NA
23985302
2013
Pubchem_assay
PRRID_1167
Zymosan
Click for more detail
Various pathogens (others)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, DCs, B-lymphocytes
extracellular domains of leucine-rich repeat motifs
Q9QUN7.fasta
Q9QUN7
784
significant role in the pathogenesis of severe inflammatory responses
NA
23985302
2013
Pubchem_assay
PRRID_1168
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, DCs, B-lymphocytes
extracellular domains of leucine-rich repeat motifs
Q9QUN7.fasta
Q9QUN7
784
significant role in the pathogenesis of severe inflammatory responses
NA
23985302
2013
Pubchem_assay
PRRID_1168
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, DCs, B-lymphocytes
extracellular domains of leucine-rich repeat motifs
Q9QUN7.fasta
Q9QUN7
784
significant role in the pathogenesis of severe inflammatory responses
NA
23985302
2013
Pubchem_assay
PRRID_1170
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 6 /2 (TLR6/2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Cell Surface (Exogenous)
NA
NA
NA
fundamental role in pathogen recognition and activation of innate immunity.
NA
23985302
2013
NA
PRRID_1170
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 6 /2 (TLR6/2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Cell Surface (Exogenous)
NA
NA
NA
fundamental role in pathogen recognition and activation of innate immunity.
NA
23985302
2013
NA
PRRID_1171
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 6 /2 (TLR6/2)
Toll-like receptor (TLR)
Human
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Cell Surface (Exogenous)
NA
NA
NA
fundamental role in pathogen recognition and activation of innate immunity.
NA
23985302
2013
NA
PRRID_1171
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
elicit innate immune response
Toll-like receptor 6 /2 (TLR6/2)
Toll-like receptor (TLR)
Human
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Cell Surface (Exogenous)
NA
NA
NA
fundamental role in pathogen recognition and activation of innate immunity.
NA
23985302
2013
NA
PRRID_1676
Zymosan
Click for more detail
S. cerevisiae (Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
activates macrophages via TLR2.
Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)
Toll-like receptor (TLR)
Human
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Cell Surface (Exogenous)
NA
NA
NA
TLR2 cooperates with TLR6 and CD14 in response to zymosan
NA
24830024
2014
NA
PRRID_1676
Zymosan
Click for more detail
S. cerevisiae (Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
activates macrophages via TLR2.
Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)
Toll-like receptor (TLR)
Human
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Cell Surface (Exogenous)
NA
NA
NA
TLR2 cooperates with TLR6 and CD14 in response to zymosan
NA
24830024
2014
NA
PRRID_1677
Zymosan
Click for more detail
S. cerevisiae (Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
activates macrophages via TLR2.
Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Cell Surface (Exogenous)
NA
NA
NA
TLR2 cooperates with TLR6 and CD14 in response to zymosan
NA
24830024
2014
NA
PRRID_1677
Zymosan
Click for more detail
S. cerevisiae (Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
activates macrophages via TLR2.
Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Cell Surface (Exogenous)
NA
NA
NA
TLR2 cooperates with TLR6 and CD14 in response to zymosan
NA
24830024
2014
NA
PRRID_1678
Zymosan
Click for more detail
S. cerevisiae (Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
mast cells
cell surface
O60603.fasta
O60603
784
significant role in the pathogenesis of severe inflammatory responses
Real-time PCR
24818634
2014
Pubchem_assay
PRRID_1678
Zymosan
Click for more detail
S. cerevisiae (Bacteria)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
mast cells
cell surface
O60603.fasta
O60603
784
significant role in the pathogenesis of severe inflammatory responses
Real-time PCR
24818634
2014
Pubchem_assay
PRRID_1679
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
cell surface
Q9QUN7.fasta
Q9QUN7
784
Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia
NA
24807166
2014
Pubchem_assay
PRRID_1679
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
cell surface
Q9QUN7.fasta
Q9QUN7
784
Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia
NA
24807166
2014
Pubchem_assay
PRRID_1680
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
cell surface
O60603.fasta
O60603
784
Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia
NA
24807166
2014
Pubchem_assay
PRRID_1680
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
cell surface
O60603.fasta
O60603
784
Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia
NA
24807166
2014
Pubchem_assay
PRRID_1681
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
human MSCs (hMSCs) and murine MSCs (mMSCs)
cell surface
Q9QUN7.fasta
Q9QUN7
784
TLR2 cooperates with TLR6 and CD14 in response to zymosan
NA
24780395
2014
Pubchem_assay
PRRID_1681
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
human MSCs (hMSCs) and murine MSCs (mMSCs)
cell surface
Q9QUN7.fasta
Q9QUN7
784
TLR2 cooperates with TLR6 and CD14 in response to zymosan
NA
24780395
2014
Pubchem_assay
PRRID_1682
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
human MSCs (hMSCs) and murine MSCs (mMSCs)
cell surface
O60603.fasta
O60603
784
TLR2 cooperates with TLR6 and CD14 in response to zymosan
NA
24780395
2014
Pubchem_assay
PRRID_1682
Zymosan
Click for more detail
Fungi
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
human MSCs (hMSCs) and murine MSCs (mMSCs)
cell surface
O60603.fasta
O60603
784
TLR2 cooperates with TLR6 and CD14 in response to zymosan
NA
24780395
2014
Pubchem_assay
PRRID_1683
Zymosan
Click for more detail
Fungi(Yeast)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain
Q9QUN7.fasta
Q9QUN7
784
significant role in the pathogenesis of severe inflammatory responses
ELISA
24757287
2014
Pubchem_assay
PRRID_1683
Zymosan
Click for more detail
Fungi(Yeast)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain
Q9QUN7.fasta
Q9QUN7
784
significant role in the pathogenesis of severe inflammatory responses
ELISA
24757287
2014
Pubchem_assay
PRRID_1684
Zymosan
Click for more detail
Fungi(Yeast)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain
O60603.fasta
O60603
784
significant role in the pathogenesis of severe inflammatory responses
ELISA
24757287
2014
Pubchem_assay
PRRID_1684
Zymosan
Click for more detail
Fungi(Yeast)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain
O60603.fasta
O60603
784
significant role in the pathogenesis of severe inflammatory responses
ELISA
24757287
2014
Pubchem_assay
PRRID_1685
Zymosan
Click for more detail
Fungi(Yeast)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
extracellular domains of leucine-rich repeat motifs
Q9QUN7.fasta
Q9QUN7
784
significant role in the pathogenesis of severe inflammatory responses
NA
24754320
2014
Pubchem_assay
PRRID_1685
Zymosan
Click for more detail
Fungi(Yeast)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
extracellular domains of leucine-rich repeat motifs
Q9QUN7.fasta
Q9QUN7
784
significant role in the pathogenesis of severe inflammatory responses
NA
24754320
2014
Pubchem_assay
PRRID_1686
Zymosan
Click for more detail
Fungi(Yeast)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
extracellular domains of leucine-rich repeat motifs
O60603.fasta
O60603
784
significant role in the pathogenesis of severe inflammatory responses
NA
24754320
2014
Pubchem_assay
PRRID_1686
Zymosan
Click for more detail
Fungi(Yeast)
C(C1C(C(C(C(O1)O)O)O)O)O
NA
Glucan
Natural
induction of proinflammatory cytokines
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Human
monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
extracellular domains of leucine-rich repeat motifs
O60603.fasta
O60603
784
significant role in the pathogenesis of severe inflammatory responses
NA
24754320
2014
Pubchem_assay
PRRID_1954
Beta glucans
Click for more detail
Candida albicans(fungi)
C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O
NA
Glucan
Natural
Activation of CLEC7A
CLEC7A
C type Lectin (CTL/CLR)
Human
NA
NA
Q9BXN2.fasta
Q9BXN2
247
critical functions in host defense against Candida albicans invasion
NA
28824166
2017
Pubchem_assay
PRRID_1954
Beta glucans
Click for more detail
Candida albicans(fungi)
C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O
NA
Glucan
Natural
Activation of CLEC7A
CLEC7A
C type Lectin (CTL/CLR)
Human
NA
NA
Q9BXN2.fasta
Q9BXN2
247
critical functions in host defense against Candida albicans invasion
NA
28824166
2017
Pubchem_assay
PRRID_2696
Zymosan
Click for more detail
Fungi(Yeast)
NA
NA
Glucan
Natural
NA
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
NA
Leucine-rich Repeat (LRR) Domain
Q9QUN7.fasta
Q9QUN7
784
NA
NA
29028369
2017
Pubchem_assay
PRRID_2696
Zymosan
Click for more detail
Fungi(Yeast)
NA
NA
Glucan
Natural
NA
Toll-like receptor 2 (TLR2)
Toll-like receptor (TLR)
Mice
NA
Leucine-rich Repeat (LRR) Domain
Q9QUN7.fasta
Q9QUN7
784
NA
NA
29028369
2017
Pubchem_assay
PRRID_2697
Zymosan
Click for more detail
Fungi(Yeast)
NA
NA
Glucan
Natural
Immunostimulant
Dectin-1 (Clec7a)
Syk-coupled CLR
Infection model
NA
NA
NA
NA
NA
Nondepleted zymosan also binds TLR2
NA
28167651
2017
NA
PRRID_2697
Zymosan
Click for more detail
Fungi(Yeast)
NA
NA
Glucan
Natural
Immunostimulant
Dectin-1 (Clec7a)
Syk-coupled CLR
Infection model
NA
NA
NA
NA
NA
Nondepleted zymosan also binds TLR2
NA
28167651
2017
NA
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