Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0340polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticStilmulation leads to the activation of the IRF3.RIG-1Rig-like receptor (RLR)HumanPrimary Human KeratinocytesNAO95786.fastaO95786925It is responsible for the antiviral defense status.ELISA186849602008Pubchem Assay
PRRID_0340polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticStilmulation leads to the activation of the IRF3.RIG-1Rig-like receptor (RLR)HumanPrimary Human KeratinocytesNAO95786.fastaO95786925It is responsible for the antiviral defense status.ELISA186849602008Pubchem Assay
PRRID_0341polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticStilmulation leads to the activation of the IRF3 and NF-MDA5Rig-like receptor (RLR)HumanPrimary Human KeratinocytesNAQ53TB6.fastaQ53TB6435It is responsible for the antiviral defense status.ELISA186849602008Pubchem Assay
PRRID_0341polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticStilmulation leads to the activation of the IRF3 and NF-MDA5Rig-like receptor (RLR)HumanPrimary Human KeratinocytesNAQ53TB6.fastaQ53TB6435It is responsible for the antiviral defense status.ELISA186849602008Pubchem Assay
PRRID_0343polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticPoly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.RIG-1Rig-like receptor (RLR)HumanMesothelial cellsNAO95786.fastaO95786925It leads to the inflammation and infection of mesothelial cells.ELISA190057392008Pubchem Assay
PRRID_0343polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticPoly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.RIG-1Rig-like receptor (RLR)HumanMesothelial cellsNAO95786.fastaO95786925It leads to the inflammation and infection of mesothelial cells.ELISA190057392008Pubchem Assay
PRRID_0344polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticPoly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.MDA5Rig-like receptor (RLR)HumanMesothelial cellsNAQ53TB6.fastaQ53TB6435It leads to the inflammation and infection of mesothelial cells.ELISA190057392008Pubchem Assay
PRRID_0344polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticPoly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.MDA5Rig-like receptor (RLR)HumanMesothelial cellsNAQ53TB6.fastaQ53TB6435It leads to the inflammation and infection of mesothelial cells.ELISA190057392008Pubchem Assay
PRRID_0354Viral RNA

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Murine norovirus-1 (virus)NANANucleic AcidNaturalUpon stimulation, it leads to the production of IFN-alpha, IL-6, MCP-1, TNFalpha and IFN-beta.MDA5Rig-like receptor (RLR)MiceBone marrow-derived DCNAQ8R5F7.fastaQ8R5F71025MDA5 limits MNV-1 replication.ELISA186361032008Pubchem Assay
PRRID_0354Viral RNA

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Murine norovirus-1 (virus)NANANucleic AcidNaturalUpon stimulation, it leads to the production of IFN-alpha, IL-6, MCP-1, TNFalpha and IFN-beta.MDA5Rig-like receptor (RLR)MiceBone marrow-derived DCNAQ8R5F7.fastaQ8R5F71025MDA5 limits MNV-1 replication.ELISA186361032008Pubchem Assay
PRRID_04023pRNA

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NANANANucleic AcidSyntheticTheir binding leads to the enhanced production of IFN-RIG-1Rig-like receptor (RLR)HumanNK cellsNAO95786.fastaO95786925It resulted in direct activation NK cells leading to high IFN-γ production in synergy with mDC-released soluble mediators induced by dsRNANA206394882010Pubchem Assay
PRRID_04023pRNA

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NANANANucleic AcidSyntheticTheir binding leads to the enhanced production of IFN-RIG-1Rig-like receptor (RLR)HumanNK cellsNAO95786.fastaO95786925It resulted in direct activation NK cells leading to high IFN-γ production in synergy with mDC-released soluble mediators induced by dsRNANA206394882010Pubchem Assay
PRRID_04035'-triphosphated RNA

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VirusNANANucleic AcidNaturalNARIG-1Rig-like receptor (RLR)Mice (Murine)CytoplasmNAQ6Q899.fastaQ6Q899926NANA207395192010Pubchem Assay
PRRID_04035'-triphosphated RNA

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VirusNANANucleic AcidNaturalNARIG-1Rig-like receptor (RLR)Mice (Murine)CytoplasmNAQ6Q899.fastaQ6Q899926NANA207395192010Pubchem Assay
PRRID_0472dsRNA

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VirusNANANucleic AcidNaturalNARIG-1Rig-like receptor (RLR)Mice (Murine)CytoplasmNAQ6Q899.fastaQ6Q899926NANA207395192010Pubchem Assay
PRRID_0472dsRNA

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VirusNANANucleic AcidNaturalNARIG-1Rig-like receptor (RLR)Mice (Murine)CytoplasmNAQ6Q899.fastaQ6Q899926NANA207395192010Pubchem Assay
PRRID_0473dsRNA

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VirusNANANucleic AcidNaturalNAMDA5Rig-like receptor (RLR)Mice (Murine)CytoplasmNAQ8R5F7.fastaQ8R5F71025NANA207395192010Pubchem Assay
PRRID_0473dsRNA

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VirusNANANucleic AcidNaturalNAMDA5Rig-like receptor (RLR)Mice (Murine)CytoplasmNAQ8R5F7.fastaQ8R5F71025NANA207395192010Pubchem Assay
PRRID_0476ds RNA with 5'-triphosphate end

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Sendai (virus)NANANucleic AcidNaturalIt's binding activate type I IFN responseRIG-1Rig-like receptor (RLR)NANANANANANAIt results into the anti-viral response by the immune system of hostNA206201292010NA
PRRID_0476ds RNA with 5'-triphosphate end

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Sendai (virus)NANANucleic AcidNaturalIt's binding activate type I IFN responseRIG-1Rig-like receptor (RLR)NANANANANANAIt results into the anti-viral response by the immune system of hostNA206201292010NA
PRRID_0477ds RNA with 5'-triphosphate end

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Influenza A (virus)NANANucleic AcidNaturalIt's binding activate type I IFN responseRIG-1Rig-like receptor (RLR)NANANANANANAIt results into the anti-viral response by the immune system of hostNA206201292010NA
PRRID_0477ds RNA with 5'-triphosphate end

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Influenza A (virus)NANANucleic AcidNaturalIt's binding activate type I IFN responseRIG-1Rig-like receptor (RLR)NANANANANANAIt results into the anti-viral response by the immune system of hostNA206201292010NA
PRRID_0597IVT-RNA

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NANANANucleic AcidSyntheticUpon recognition, these domains allow for CARD–CARD interaction with the mitochondrial adaptor proteins MAVS, which leads to the secretion of type-I interferonsRIG-1Rig-like receptor (RLR)NANANANANANAIFN triggers the expression of antiviral proteins, promote the destruction of infected cells by natural killer cells, and facilitate the production of neutralizing antibodies and cytotoxic T-cell responses.NA203547862010NA
PRRID_0597IVT-RNA

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NANANANucleic AcidSyntheticUpon recognition, these domains allow for CARD–CARD interaction with the mitochondrial adaptor proteins MAVS, which leads to the secretion of type-I interferonsRIG-1Rig-like receptor (RLR)NANANANANANAIFN triggers the expression of antiviral proteins, promote the destruction of infected cells by natural killer cells, and facilitate the production of neutralizing antibodies and cytotoxic T-cell responses.NA203547862010NA
PRRID_0712NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Inhibit IFN production in mDCNA206720472010Pubchem Assay
PRRID_0712NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Inhibit IFN production in mDCNA206720472010Pubchem Assay
PRRID_0714NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0714NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0763polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticTheir binding leads to the enhanced production of type I IFNsRIG-1Rig-like receptor (RLR)HumanNk cell and mDCsNAO95786.fastaO95786925It resulted in direct activation NK cells leading to high IFN-γ production in synergy with mDC-released soluble mediators induced by dsRNANA206394882010Pubchem Assay
PRRID_0763polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticTheir binding leads to the enhanced production of type I IFNsRIG-1Rig-like receptor (RLR)HumanNk cell and mDCsNAO95786.fastaO95786925It resulted in direct activation NK cells leading to high IFN-γ production in synergy with mDC-released soluble mediators induced by dsRNANA206394882010Pubchem Assay
PRRID_0764polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticTheir binding leads to the enhanced production of type I IFNsRIG-1Rig-like receptor (RLR)HumanNk cell and mDCsNAO95786.fastaO95786925It resulted in direct activation NK cells leading to high IFN-γ production in synergy with mDC-released soluble mediators induced by dsRNANA206394882010Pubchem Assay
PRRID_0764polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticTheir binding leads to the enhanced production of type I IFNsRIG-1Rig-like receptor (RLR)HumanNk cell and mDCsNAO95786.fastaO95786925It resulted in direct activation NK cells leading to high IFN-γ production in synergy with mDC-released soluble mediators induced by dsRNANA206394882010Pubchem Assay
PRRID_0767polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticIt's binding activate type I IFN responseMDA5Rig-like receptor (RLR)NANANANANANAIt results into the anti-viral response by the immune system of hostNA206201292010NA
PRRID_0767polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticIt's binding activate type I IFN responseMDA5Rig-like receptor (RLR)NANANANANANAIt results into the anti-viral response by the immune system of hostNA206201292010NA
PRRID_0771polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticPoly[I:C] stimulate the activaion of natural killer cells which leads to the secretion of IL-6 ,TNF-‚ç∫ and IFN-MDA5Rig-like receptor (RLR)HumanNatural Killer cells from peripheral bloodNAQ53TB6.fastaQ53TB6435It has a immunostimulatory roleFlex-Set cytokine assay204270392010Pubchem Assay
PRRID_0771polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticPoly[I:C] stimulate the activaion of natural killer cells which leads to the secretion of IL-6 ,TNF-‚ç∫ and IFN-MDA5Rig-like receptor (RLR)HumanNatural Killer cells from peripheral bloodNAQ53TB6.fastaQ53TB6435It has a immunostimulatory roleFlex-Set cytokine assay204270392010Pubchem Assay
PRRID_0772polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticCells infected with viruses triggering MDA5-dependent IFN inductionRIG-1Rig-like receptor (RLR)NANANANANANAIFN triggers the expression of antiviral proteins, promote the destruction of infected cells by natural killer cells, and facilitate the production of neutralizing antibodies and cytotoxic T-cell responses.NA203547862010NA
PRRID_0772polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticCells infected with viruses triggering MDA5-dependent IFN inductionRIG-1Rig-like receptor (RLR)NANANANANANAIFN triggers the expression of antiviral proteins, promote the destruction of infected cells by natural killer cells, and facilitate the production of neutralizing antibodies and cytotoxic T-cell responses.NA203547862010NA
PRRID_0778profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY163ProteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD95MDA5Rig-like receptor (RLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainQ53TB6.fastaQ53TB6435It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0778profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY163ProteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD95MDA5Rig-like receptor (RLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainQ53TB6.fastaQ53TB6435It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0833Viral RNA

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Hepatitis C Virus (virus)NANANucleic AcidNaturalThe binding induces rapid interferon responsesRIG-1Rig-like receptor (RLR)NANANANANANANANA206779432010NA
PRRID_0833Viral RNA

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Hepatitis C Virus (virus)NANANucleic AcidNaturalThe binding induces rapid interferon responsesRIG-1Rig-like receptor (RLR)NANANANANANANANA206779432010NA
PRRID_0835Viral RNA

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Influenza A (virus)NANANucleic AcidNaturalUpon virus recognition, these domains allow for CARD–CARD interaction with the mitochondrial adaptor proteins MAVS, which leads to the secretion of type-I interferonsRIG-1Rig-like receptor (RLR)NANANANANANAIFN triggers the expression of antiviral proteins, promote the destruction of infected cells by natural killer cells, and facilitate the production of neutralizing antibodies and cytotoxic T-cell responses.NA203547862010NA
PRRID_0835Viral RNA

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Influenza A (virus)NANANucleic AcidNaturalUpon virus recognition, these domains allow for CARD–CARD interaction with the mitochondrial adaptor proteins MAVS, which leads to the secretion of type-I interferonsRIG-1Rig-like receptor (RLR)NANANANANANAIFN triggers the expression of antiviral proteins, promote the destruction of infected cells by natural killer cells, and facilitate the production of neutralizing antibodies and cytotoxic T-cell responses.NA203547862010NA
PRRID_0934LyoVec

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mimic of viral RNA (virus)NANANucleic AcidSyntheticelicit innate immune responseRIG-1Rig-like receptor (RLR)HumanEosinophilsNAO95786.fastaO95786925NAreal-time reverse transcription-PCR, FACS, ELISA219780012011Pubchem Assay
PRRID_0934LyoVec

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mimic of viral RNA (virus)NANANucleic AcidSyntheticelicit innate immune responseRIG-1Rig-like receptor (RLR)HumanEosinophilsNAO95786.fastaO95786925NAreal-time reverse transcription-PCR, FACS, ELISA219780012011Pubchem Assay
PRRID_0938Oligosaccharides of hyaluronic acid (HA)

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Endogenous (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)Naturalthe activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction MDA5Rig-like receptor (RLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAQ53TB6.fastaQ53TB6435plays a fundamental role in pathogen recognition and activation of innate immunityNA219825582011Pubchem Assay
PRRID_0938Oligosaccharides of hyaluronic acid (HA)

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Endogenous (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)Naturalthe activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction MDA5Rig-like receptor (RLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAQ53TB6.fastaQ53TB6435plays a fundamental role in pathogen recognition and activation of innate immunityNA219825582011Pubchem Assay
PRRID_0950polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticelicit innate immune responseRIG-1Rig-like receptor (RLR)HumanEosinophilsNAO95786.fastaO95786925mediate the efficient induction of the type I IFN responsereal-time reverse transcription-PCR, FACS, ELISA219780012011Pubchem Assay
PRRID_0950polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticelicit innate immune responseRIG-1Rig-like receptor (RLR)HumanEosinophilsNAO95786.fastaO95786925mediate the efficient induction of the type I IFN responsereal-time reverse transcription-PCR, FACS, ELISA219780012011Pubchem Assay
PRRID_11765‚Ä- triphosphate ssRNA

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VirusNANANucleic AcidNaturaltriggers immune responsesRIG-1Rig-like receptor (RLR)Humanmost adult tissueshelicase domainO95786.fastaO95786925mediate the efficient induction of the type I IFN response.NA247628272014Pubchem_assay
PRRID_11765‚Ä- triphosphate ssRNA

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VirusNANANucleic AcidNaturaltriggers immune responsesRIG-1Rig-like receptor (RLR)Humanmost adult tissueshelicase domainO95786.fastaO95786925mediate the efficient induction of the type I IFN response.NA247628272014Pubchem_assay
PRRID_1613single-stranded RNA

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VirusNANANucleic AcidSyntheticinduce the production of proinflammatory cytokines in pDCRIG-1Rig-like receptor (RLR)Humanepithelial cells, myeloid cells, and CNS cellsCytosol of cellO95786.fastaO95786925Recognize distinct viruses and produce the antiviral immune changes that initiate an innate responseNA248291462014Pubchem_assay
PRRID_1613single-stranded RNA

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VirusNANANucleic AcidSyntheticinduce the production of proinflammatory cytokines in pDCRIG-1Rig-like receptor (RLR)Humanepithelial cells, myeloid cells, and CNS cellsCytosol of cellO95786.fastaO95786925Recognize distinct viruses and produce the antiviral immune changes that initiate an innate responseNA248291462014Pubchem_assay
PRRID_18945‚-dsRNA

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EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.NANANucleic AcidNaturalK63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerizationRIG-1Rig-like receptor (RLR)HumanCytoplasm, all mammalian cell typesNAO95786.fastaO95786925MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_18945‚-dsRNA

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EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.NANANucleic AcidNaturalK63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerizationRIG-1Rig-like receptor (RLR)HumanCytoplasm, all mammalian cell typesNAO95786.fastaO95786925MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2216KIN 100 (7-acetyl- 6-propyl-3-[2-pyridinyl]-iso avone)

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NANANAIsoflavones & benzothiazolesSyntheticactivity against hepatitis CRIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2216KIN 100 (7-acetyl- 6-propyl-3-[2-pyridinyl]-iso avone)

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NANANAIsoflavones & benzothiazolesSyntheticactivity against hepatitis CRIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2217KIN 101 (4′-bromo-7-[sulfoxymethyl]-iso avone)

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NANANAIsoflavones & benzothiazolesSyntheticactivity against influenza A virus.RIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2217KIN 101 (4′-bromo-7-[sulfoxymethyl]-iso avone)

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NANANAIsoflavones & benzothiazolesSyntheticactivity against influenza A virus.RIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2218KIN 1400

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NANANAhydroxyquinolineSyntheticable to inhibit replication of a broad spectrum of viruses (Flaviviridae, Filoviridae, Para- myxoviridae, Arenaviridae, and Orthomyxoviridae) to varying degrees by driving IRF3-dependent antiviral gene expression.RIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2218KIN 1400

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NANANAhydroxyquinolineSyntheticable to inhibit replication of a broad spectrum of viruses (Flaviviridae, Filoviridae, Para- myxoviridae, Arenaviridae, and Orthomyxoviridae) to varying degrees by driving IRF3-dependent antiviral gene expression.RIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2309Long ds RNA

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EMCV, poliovirus and coxasackie virus; Rotavirus, dengue virus, WNV, murine hepatitis virus(virus)NANAPattern-associated molecular patterns (PAMPs)Naturalfilament formation mediated receptor tetramerizationMDA5Rig-like receptor (RLR)HumanCytoplasm, all mammalian cell typesNAQ53TB6.fastaQ53TB6435MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2309Long ds RNA

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EMCV, poliovirus and coxasackie virus; Rotavirus, dengue virus, WNV, murine hepatitis virus(virus)NANAPattern-associated molecular patterns (PAMPs)Naturalfilament formation mediated receptor tetramerizationMDA5Rig-like receptor (RLR)HumanCytoplasm, all mammalian cell typesNAQ53TB6.fastaQ53TB6435MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2558polydeoxyadenylic:polydeoxyt hymidylic acid (poly[dA:dT])

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BacteriaCC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O.C1C(C(OC1N2C=NC3=C2N=CN=C3N)COP(=O)(O)O)ONANucleic AcidSyntheticThe classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.RIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2558polydeoxyadenylic:polydeoxyt hymidylic acid (poly[dA:dT])

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BacteriaCC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O.C1C(C(OC1N2C=NC3=C2N=CN=C3N)COP(=O)(O)O)ONANucleic AcidSyntheticThe classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.RIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2561polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticNAMDA5Rig-like receptor (RLR)bat cell lineCytosolNANANANANART-qPCR291226342017NA
PRRID_2561polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticNAMDA5Rig-like receptor (RLR)bat cell lineCytosolNANANANANART-qPCR291226342017NA
PRRID_2565polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticThe classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.RIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2565polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticThe classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.RIG-1Rig-like receptor (RLR)HumanCytoplasmCarbohydrate recognition domain (CRD)O95786.fastaO95786925NF-κB-mediated in ammatory cytokine pro- duction.NA287764162017Pubchem_assay
PRRID_2584rb-dsRNA

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Rice- bran (plant)NANAPattern-associated molecular patterns (PAMPs)Naturalactivate caspase 1 via TRIF, resulting in the release of IL-1b and LDHMDA5Rig-like receptor (RLR)MiceNANAQ8R5F7.fastaQ8R5F71025Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD.RT-qPCR288480652017Pubchem_assay
PRRID_2584rb-dsRNA

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Rice- bran (plant)NANAPattern-associated molecular patterns (PAMPs)Naturalactivate caspase 1 via TRIF, resulting in the release of IL-1b and LDHMDA5Rig-like receptor (RLR)MiceNANAQ8R5F7.fastaQ8R5F71025Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD.RT-qPCR288480652017Pubchem_assay
PRRID_2614short dsRNA

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EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.NANAPattern-associated molecular patterns (PAMPs)NaturalK63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerizationRIG-1Rig-like receptor (RLR)HumanCytoplasm, all mammalian cell typesNAO95786.fastaO95786925MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2614short dsRNA

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EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.NANAPattern-associated molecular patterns (PAMPs)NaturalK63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerizationRIG-1Rig-like receptor (RLR)HumanCytoplasm, all mammalian cell typesNAO95786.fastaO95786925MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2686viral double stranded RNA

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VirusNANANucleic AcidNaturalNARIG-1Rig-like receptor (RLR)NANANANANANANANA288015212017NA
PRRID_2686viral double stranded RNA

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VirusNANANucleic AcidNaturalNARIG-1Rig-like receptor (RLR)NANANANANANANANA288015212017NA
PRRID_2687viral double stranded RNA

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VirusNANANucleic AcidNaturalNAMDA5Rig-like receptor (RLR)NANANANANANANANA288015212017NA
PRRID_2687viral double stranded RNA

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VirusNANANucleic AcidNaturalNAMDA5Rig-like receptor (RLR)NANANANANANANANA288015212017NA
PRRID_2692Viral sensor

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VirusNANANANaturalNARIG-1 (DDX58)Rig-like receptor (RLR)HumanNARIG-1-like receptor familyO95786.fastaO95786925NANA290662552017Pubchem_assay
PRRID_2692Viral sensor

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VirusNANANANaturalNARIG-1 (DDX58)Rig-like receptor (RLR)HumanNARIG-1-like receptor familyO95786.fastaO95786925NANA290662552017Pubchem_assay