Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0018Advanced Glycation End Products (AGE)

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Endogenous (others)NANAOthersNaturalelicit innate immune responseReceptor for Advanced Glycation End-productsReceptor for advanced glycation endproducts (RAGE)HumanNANANANANAinduces pro-inflammatory cytokine responseNA13788431992NA
PRRID_0018Advanced Glycation End Products (AGE)

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Endogenous (others)NANAOthersNaturalelicit innate immune responseReceptor for Advanced Glycation End-productsReceptor for advanced glycation endproducts (RAGE)HumanNANANANANAinduces pro-inflammatory cytokine responseNA13788431992NA
PRRID_0561HMGB1

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Mouse model of endotoxemiaMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActs as a mediator of inflammation and organ damageRAGEReceptor for advanced glycation endproducts (RAGE)MiceNALeucine-rich Repeat (LRR) DomainQ62151.fastaQ62151402Acts as a mediator of inflammation and organ damageNA207403412010Pubchem Assay
PRRID_0561HMGB1

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Mouse model of endotoxemiaMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActs as a mediator of inflammation and organ damageRAGEReceptor for advanced glycation endproducts (RAGE)MiceNALeucine-rich Repeat (LRR) DomainQ62151.fastaQ62151402Acts as a mediator of inflammation and organ damageNA207403412010Pubchem Assay
PRRID_1009NFPs in combination with mitochondrial transcription factor

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NANANANANaturalImmunostimulantRAGE Receptor for advanced glycation endproducts (RAGE)NANANANANANATLR9 antagonistsNA229829432012NA
PRRID_1009NFPs in combination with mitochondrial transcription factor

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NANANANANaturalImmunostimulantRAGE Receptor for advanced glycation endproducts (RAGE)NANANANANANATLR9 antagonistsNA229829432012NA
PRRID_1013S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantRAGEReceptor for advanced glycation endproducts (RAGE)NANANANANANABlocking antibodiesNA229829432012NA
PRRID_1013S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantRAGEReceptor for advanced glycation endproducts (RAGE)NANANANANANABlocking antibodiesNA229829432012NA
PRRID_1136S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalNARAGEReceptor for advanced glycation endproducts (RAGE)Humangraft-versus-host disease (GVHD)NANANANAS100 proteins were significantly more detected in saliva of GVHD patientsNA239853022013NA
PRRID_1136S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalNARAGEReceptor for advanced glycation endproducts (RAGE)Humangraft-versus-host disease (GVHD)NANANANAS100 proteins were significantly more detected in saliva of GVHD patientsNA239853022013NA
PRRID_1610S100A12

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BacteriaMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92ProteinNaturalNASoluble RAGE (sRAGE)Receptor for advanced glycation endproducts (RAGE)NANANANANANANANA251830172014NA
PRRID_1610S100A12

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BacteriaMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92ProteinNaturalNASoluble RAGE (sRAGE)Receptor for advanced glycation endproducts (RAGE)NANANANANANANANA251830172014NA
PRRID_1904Ab

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)NaturalCellular injury and necrosisRAGEReceptor for advanced glycation endproducts (RAGE)HumanNANAQ15109.fastaQ15109404Activate NF-KBNA280491422017Pubchem_assay
PRRID_1904Ab

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)NaturalCellular injury and necrosisRAGEReceptor for advanced glycation endproducts (RAGE)HumanNANAQ15109.fastaQ15109404Activate NF-KBNA280491422017Pubchem_assay
PRRID_1982Chromogranin A

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)Naturalactivate microglial cellsRAGEReceptor for advanced glycation endproducts (RAGE)HumanNANAQ15109.fastaQ15109404Activate NF-KBNA280491422017Pubchem_assay
PRRID_1982Chromogranin A

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)Naturalactivate microglial cellsRAGEReceptor for advanced glycation endproducts (RAGE)HumanNANAQ15109.fastaQ15109404Activate NF-KBNA280491422017Pubchem_assay
PRRID_2154Heparan sulfate

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Glycosaminoglycan (others)COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)ONADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityRAGEReceptor for advanced glycation endproducts (RAGE)NANANANANANANANA292901392017NA
PRRID_2154Heparan sulfate

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Glycosaminoglycan (others)COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)ONADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityRAGEReceptor for advanced glycation endproducts (RAGE)NANANANANANANANA292901392017NA
PRRID_2165HMGB1

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nucleus, autophagosome (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityRAGEReceptor for advanced glycation endproducts (RAGE)NANAextracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.NANANANANA292901392017NA
PRRID_2165HMGB1

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nucleus, autophagosome (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityRAGEReceptor for advanced glycation endproducts (RAGE)NANAextracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.NANANANANA292901392017NA
PRRID_2172HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalpromoting neuroinflammationRAGEReceptor for advanced glycation endproducts (RAGE)HumanNAaQ15109.fastaQ15109404Activate NF-KBNA280491422017Pubchem_assay
PRRID_2172HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalpromoting neuroinflammationRAGEReceptor for advanced glycation endproducts (RAGE)HumanNAaQ15109.fastaQ15109404Activate NF-KBNA280491422017Pubchem_assay
PRRID_2179HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalInduce the expression of the cytokines TNF-α, IL-6 and IL-8 by human macrophages.RAGEReceptor for advanced glycation endproducts (RAGE)HumanMacrophagesNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2179HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalInduce the expression of the cytokines TNF-α, IL-6 and IL-8 by human macrophages.RAGEReceptor for advanced glycation endproducts (RAGE)HumanMacrophagesNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2180HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalPromote human monocyte recruitmentRAGEReceptor for advanced glycation endproducts (RAGE)HumanMonocyteNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2180HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalPromote human monocyte recruitmentRAGEReceptor for advanced glycation endproducts (RAGE)HumanMonocyteNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2360Myosin

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Cytosol, endosome(others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityRAGEReceptor for advanced glycation endproducts (RAGE)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2360Myosin

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Cytosol, endosome(others)NANADamage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityRAGEReceptor for advanced glycation endproducts (RAGE)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_2602S100 proteins

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Cytosol(others)MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityRAGEReceptor for advanced glycation endproducts (RAGE)NANAextracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.NANANANANA292901392017NA
PRRID_2602S100 proteins

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Cytosol(others)MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)Naturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityRAGEReceptor for advanced glycation endproducts (RAGE)NANAextracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.NANANANANA292901392017NA
PRRID_2605S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)Naturalacts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,RAGEReceptor for advanced glycation endproducts (RAGE)HumanNANAQ15109.fastaQ15109404Activate NF-KBNA280491422017Pubchem_assay
PRRID_2605S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)Naturalacts as stimulator of cell pro- liferation and migration and inhibitor of apoptosis and differ- entiation,RAGEReceptor for advanced glycation endproducts (RAGE)HumanNANAQ15109.fastaQ15109404Activate NF-KBNA280491422017Pubchem_assay
PRRID_2606S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalPromote human neutrophil migrationRAGEReceptor for advanced glycation endproducts (RAGE)HumanNeutrophilsNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2606S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalPromote human neutrophil migrationRAGEReceptor for advanced glycation endproducts (RAGE)HumanNeutrophilsNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2607S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalPromote human neutrophil migrationRAGEReceptor for advanced glycation endproducts (RAGE)HumanNeutrophilsNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2607S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalPromote human neutrophil migrationRAGEReceptor for advanced glycation endproducts (RAGE)HumanNeutrophilsNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2608S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-12 by human monocytesRAGEReceptor for advanced glycation endproducts (RAGE)HumanMonocyteNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2608S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-12 by human monocytesRAGEReceptor for advanced glycation endproducts (RAGE)HumanMonocyteNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2609S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-12 by human monocytesRAGEReceptor for advanced glycation endproducts (RAGE)HumanMonocyteNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2609S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β, and IL-12 by human monocytesRAGEReceptor for advanced glycation endproducts (RAGE)HumanMonocyteNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2610S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalInduce the expression levels of the adhesionRAGEReceptor for advanced glycation endproducts (RAGE)HumanNeutrophils and HUVECsNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2610S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalInduce the expression levels of the adhesionRAGEReceptor for advanced glycation endproducts (RAGE)HumanNeutrophils and HUVECsNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2611S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalInduce the expression levels of the adhesionRAGEReceptor for advanced glycation endproducts (RAGE)HumanNeutrophils and HUVECsNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay
PRRID_2611S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalInduce the expression levels of the adhesionRAGEReceptor for advanced glycation endproducts (RAGE)HumanNeutrophils and HUVECsNAQ15109.fastaQ15109404NANA289610192017Pubchem_assay