Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
RID_0001	6-O-stearoyl-MDP (L18- MDP) Click for more detail	MDP (others)	CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Synthetic	It leads to the induction of interferon in the lung.	Nod-like receptor 2 (NOD2)	NOD-like receptor (NLR)		Lungs	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It augments host-resistance to viral infection.	Interferon assay	2417426	1985	Pubchem Assay
RID_0001	6-O-stearoyl-MDP (L18- MDP) Click for more detail	MDP (others)	CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Synthetic	It leads to the induction of interferon in the lung.	Nod-like receptor 2 (NOD2)	NOD-like receptor (NLR)		Lungs	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It augments host-resistance to viral infection.	Interferon assay	2417426	1985	Pubchem Assay
PRRID_0002	N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) Click for more detail	NA	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Synthetic	It leads to the induction of interferon in the lung.	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Sendai virus infected mice	Lungs	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It augments host-resistance to viral infection.	Interferon assay	2417426	1985	Pubchem Assay
PRRID_0002	N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) Click for more detail	NA	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Synthetic	It leads to the induction of interferon in the lung.	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Sendai virus infected mice	Lungs	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It augments host-resistance to viral infection.	Interferon assay	2417426	1985	Pubchem Assay
PRRID_0003	N(alpha)-acetylmuramyl-L-alanyl-D-isoglutaminyl-N(epsilon)-stearoyl'L'lysine (MDP-L ys-L18) Click for more detail	MDP (others)	CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Synthetic	It leads to the induction of interferon in the lung.	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Sendai virus infected mice	Lungs	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It augments host-resistance to viral infection.	Interferon assay	2417426	1985	Pubchem Assay
PRRID_0003	N(alpha)-acetylmuramyl-L-alanyl-D-isoglutaminyl-N(epsilon)-stearoyl'L'lysine (MDP-L ys-L18) Click for more detail	MDP (others)	CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Synthetic	It leads to the induction of interferon in the lung.	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Sendai virus infected mice	Lungs	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It augments host-resistance to viral infection.	Interferon assay	2417426	1985	Pubchem Assay
PRRID_0163	C12-iE-DAP Click for more detail	Chemical derivative of iE-DAP(others)	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Peptide	Synthetic	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Macrophages	NA	Q8BHB0.fasta	Q8BHB0	953	mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan.	ELISA	12796777	2003	Pubchem Assay
PRRID_0163	C12-iE-DAP Click for more detail	Chemical derivative of iE-DAP(others)	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Peptide	Synthetic	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Macrophages	NA	Q8BHB0.fasta	Q8BHB0	953	mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan.	ELISA	12796777	2003	Pubchem Assay
PRRID_0166	GlcNAc-MurNAc dipeptide (GM-Di) Click for more detail	Gram-negative bacteria	NA	NA	Carbohydrate	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9HC29.fasta	Q9HC29	1040	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0166	GlcNAc-MurNAc dipeptide (GM-Di) Click for more detail	Gram-negative bacteria	NA	NA	Carbohydrate	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9HC29.fasta	Q9HC29	1040	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0167	GlcNAc-MurNAc tripeptide muropeptide (GM-TriDAP) Click for more detail	Gram-negative bacteria	NA	NA	Carbohydrate	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0167	GlcNAc-MurNAc tripeptide muropeptide (GM-TriDAP) Click for more detail	Gram-negative bacteria	NA	NA	Carbohydrate	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0173	iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail	Bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Peptide	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Macrophages	NA	Q8BHB0.fasta	Q8BHB0	953	mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan.	ELISA	12796777	2003	Pubchem Assay
PRRID_0173	iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail	Bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Peptide	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Macrophages	NA	Q8BHB0.fasta	Q8BHB0	953	mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan.	ELISA	12796777	2003	Pubchem Assay
PRRID_0178	M-Tri-DAP (MurNAc-L-Ala-D-g-Glu-mDAP) Click for more detail	Gram-negative bacteria	NA	NA	Peptide	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	production of pro-inflammatory cytokines	NA	12527755	2003	Pubchem Assay
PRRID_0178	M-Tri-DAP (MurNAc-L-Ala-D-g-Glu-mDAP) Click for more detail	Gram-negative bacteria	NA	NA	Peptide	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	production of pro-inflammatory cytokines	NA	12527755	2003	Pubchem Assay
PRRID_0180	muramyl tripeptide Click for more detail	muramyl dipeptide derivative (others)	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC	NA	Peptide	Synthetic	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	production of pro-inflammatory cytokines	NA	12527755	2003	Pubchem Assay
PRRID_0180	muramyl tripeptide Click for more detail	muramyl dipeptide derivative (others)	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC	NA	Peptide	Synthetic	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	production of pro-inflammatory cytokines	NA	12527755	2003	Pubchem Assay
PRRID_0181	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0181	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0188	Tri-DAP (L-Ala-D-g-Glu-mDAP) Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N	NA	Peptide	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation	NA	12527755	2003	Pubchem Assay
PRRID_0188	Tri-DAP (L-Ala-D-g-Glu-mDAP) Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N	NA	Peptide	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation	NA	12527755	2003	Pubchem Assay
PRRID_0220	FK156 Click for more detail	NA	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)NCC(=O)O)C(=O)O)NC(=O)C(C)O	NA	Peptide	Synthetic	It induces the secretion of the IL-8	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Monocytes	NA	Q9Y239.fasta	Q9Y239	953	It leads to the maturation and activation of the host cells.	ELISA	15617523	2005	Pubchem Assay
PRRID_0220	FK156 Click for more detail	NA	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)NCC(=O)O)C(=O)O)NC(=O)C(C)O	NA	Peptide	Synthetic	It induces the secretion of the IL-8	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Monocytes	NA	Q9Y239.fasta	Q9Y239	953	It leads to the maturation and activation of the host cells.	ELISA	15617523	2005	Pubchem Assay
PRRID_0221	FK565 Click for more detail	NA	CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OC(C)(C)C	NA	Peptide	Synthetic	It induces the secretion of the IL-8	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Monocytes	NA	Q9Y239.fasta	Q9Y239	953	It leads to the maturation and activation of the host cells.	ELISA	15617523	2005	Pubchem Assay
PRRID_0221	FK565 Click for more detail	NA	CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OC(C)(C)C	NA	Peptide	Synthetic	It induces the secretion of the IL-8	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Monocytes	NA	Q9Y239.fasta	Q9Y239	953	It leads to the maturation and activation of the host cells.	ELISA	15617523	2005	Pubchem Assay
PRRID_0225	muramyl tetrapeptide Click for more detail	muramyl dipeptide derivative (others)	NA	NA	Peptide	Synthetic	Immunostimulant	Nucleotide-binding oligomerization domain protein 1	NOD-like receptor (NLR)	Mice (Murine)	NA	NA	Q8BHB0.fasta	Q8BHB0	953	NA	ELISA	16211083	2005	Pubchem Assay
PRRID_0225	muramyl tetrapeptide Click for more detail	muramyl dipeptide derivative (others)	NA	NA	Peptide	Synthetic	Immunostimulant	Nucleotide-binding oligomerization domain protein 1	NOD-like receptor (NLR)	Mice (Murine)	NA	NA	Q8BHB0.fasta	Q8BHB0	953	NA	ELISA	16211083	2005	Pubchem Assay
PRRID_0275	Chlamydia trachomatis Click for more detail	Chlamydia trachomatis(Bacteria)	NA	NA	Whole organism	Natural	Chlamydia trachomatis infection leads to up-regulation of inflammatory IL-8.	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HeLa 229 epithelial cells	LRR	Q9Y239.fasta	Q9Y239	953	NOD1 and RIP2 activation is needed for the IL-8 response to C. trachomatis infection.	ELISA	18426885	2008	Pubchem Assay
PRRID_0275	Chlamydia trachomatis Click for more detail	Chlamydia trachomatis(Bacteria)	NA	NA	Whole organism	Natural	Chlamydia trachomatis infection leads to up-regulation of inflammatory IL-8.	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HeLa 229 epithelial cells	LRR	Q9Y239.fasta	Q9Y239	953	NOD1 and RIP2 activation is needed for the IL-8 response to C. trachomatis infection.	ELISA	18426885	2008	Pubchem Assay
PRRID_0368	Hyaluronan Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	Hyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation.	Nod-like receptor protein P3/Cryopyrin (NLRP3/Cryopyrin)	NOD-like receptor (NLR)	Mice	Macropahges	NA	Q8BHB0.fasta	Q8BHB0	953	It participates in the inflammatory response to injury or the cytokine response to hyaluronan.	ELISA	19258328	2009	Pubchem Assay
PRRID_0368	Hyaluronan Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	Hyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation.	Nod-like receptor protein P3/Cryopyrin (NLRP3/Cryopyrin)	NOD-like receptor (NLR)	Mice	Macropahges	NA	Q8BHB0.fasta	Q8BHB0	953	It participates in the inflammatory response to injury or the cytokine response to hyaluronan.	ELISA	19258328	2009	Pubchem Assay
PRRID_0410	Alpha toxin Click for more detail	S. aureus (Bacteria)	SDYYPRNSVDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWK	71	toxin	Natural	It‚Äôs binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1Œ≤	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	it activates the inflammasome via NLRP3	NA	20303873	2010	NA
PRRID_0410	Alpha toxin Click for more detail	S. aureus (Bacteria)	SDYYPRNSVDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWK	71	toxin	Natural	It‚Äôs binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1Œ≤	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	it activates the inflammasome via NLRP3	NA	20303873	2010	NA
PRRID_0425	Bacterial Antigen Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	It led to the activation of NF-Œ∫B and stimulate the production of cytokines IL-6 and TNF-‚ç∫	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Primary microglia and astrocytes	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It has the immunostimulatory role.	ELISA	20226841	2010	Pubchem Assay
PRRID_0425	Bacterial Antigen Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	It led to the activation of NF-Œ∫B and stimulate the production of cytokines IL-6 and TNF-‚ç∫	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Primary microglia and astrocytes	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It has the immunostimulatory role.	ELISA	20226841	2010	Pubchem Assay
PRRID_0428	BsaK Click for more detail	Burkholderia pseudomallei(Bacteria)	MVRLPDRHRPRVRRRREGSEQAVAGRPGEPHEKPERSDRARQLSDDHVRIQPVPERAEQRGQIDEGHRFVDRLELPLTLSTAPGRRGASRAAPGRTIMNITNPHAVPALPSLSEIESPERPATLDAILKQTLADANEKSNAAKTSIESRLADPVDFAQSEKLIALQTELSDYSIYVSLASTLARKAVSAVETLVKAQ	197	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0428	BsaK Click for more detail	Burkholderia pseudomallei(Bacteria)	MVRLPDRHRPRVRRRREGSEQAVAGRPGEPHEKPERSDRARQLSDDHVRIQPVPERAEQRGQIDEGHRFVDRLELPLTLSTAPGRRGASRAAPGRTIMNITNPHAVPALPSLSEIESPERPATLDAILKQTLADANEKSNAAKTSIESRLADPVDFAQSEKLIALQTELSDYSIYVSLASTLARKAVSAVETLVKAQ	197	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0459	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8BHB0.fasta	Q8BHB0	953	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0459	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8BHB0.fasta	Q8BHB0	953	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0460	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0460	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0464	diaminopimelic acid (C12-iEDAP) Click for more detail	Gram-negative and Gram-positive bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Muropeptide	Natural	It's binding to NOD1 induce NFŒ∫B activation, activation of MAP kinases and expression of chemokines CCL5 (RANTES) and CXCL1 (KC) and of nitric oxide	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	C57BL/6 Mice	liver and Hepatocytes	NA	Q8BHB0.fasta	Q8BHB0	953	It helps in attracting leukocytes to the liver during infection and for hepatic NLRs to augment innate immune responses to pathogens.	Immunoblotting and EMSA	20615568	2010	Pubchem Assay
PRRID_0464	diaminopimelic acid (C12-iEDAP) Click for more detail	Gram-negative and Gram-positive bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Muropeptide	Natural	It's binding to NOD1 induce NFŒ∫B activation, activation of MAP kinases and expression of chemokines CCL5 (RANTES) and CXCL1 (KC) and of nitric oxide	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	C57BL/6 Mice	liver and Hepatocytes	NA	Q8BHB0.fasta	Q8BHB0	953	It helps in attracting leukocytes to the liver during infection and for hepatic NLRs to augment innate immune responses to pathogens.	Immunoblotting and EMSA	20615568	2010	Pubchem Assay
PRRID_0497	EprJ and EscI Click for more detail	E. coli(Bacteria)	MSVSNMPPIDRAEQSTAHEIQQAKVIDLNDRVLNLDNPDDKMISAFANYAVQTENWQQNALQALRSDKEGLTPEKLLVLQDHVLNYNVEVSLVEH, MIYFLTDLIKFYCLMKLYEYKNIKIDLVLTEDIIPEDKLLEIIQSDDIVKLARKKTCEHLLRARRKSKKLKTESRKKIARKIMAMRERIRKNNKIKLEKEVNKSIKWVKDIQDIELVLMQDIMNKVHSSLTNALHSLDTSSRINWDDLLNEVVRETLSHNNIVGAIKITKNPDIKLDPGEANNIQLINDADAPLNKIIIENEYMRITLDPLEQINILLNSFKENYLSIIQE	95,231	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0497	EprJ and EscI Click for more detail	E. coli(Bacteria)	MSVSNMPPIDRAEQSTAHEIQQAKVIDLNDRVLNLDNPDDKMISAFANYAVQTENWQQNALQALRSDKEGLTPEKLLVLQDHVLNYNVEVSLVEH, MIYFLTDLIKFYCLMKLYEYKNIKIDLVLTEDIIPEDKLLEIIQSDDIVKLARKKTCEHLLRARRKSKKLKTESRKKIARKIMAMRERIRKNNKIKLEKEVNKSIKWVKDIQDIELVLMQDIMNKVHSSLTNALHSLDTSSRINWDDLLNEVVRETLSHNNIVGAIKITKNPDIKLDPGEANNIQLINDADAPLNKIIIENEYMRITLDPLEQINILLNSFKENYLSIIQE	95,231	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0498	extracellular ATP Click for more detail	Injured cell (others)	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Endogenous	Natural	It‚Äôs binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1Œ≤	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It activates the inflammasome via NLRP3	NA	20303873	2010	NA
PRRID_0498	extracellular ATP Click for more detail	Injured cell (others)	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Endogenous	Natural	It‚Äôs binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1Œ≤	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It activates the inflammasome via NLRP3	NA	20303873	2010	NA
PRRID_0502	Fibrillar amyloid-b peptide Click for more detail	Alzheimer‚Äôs disease brain plaques(others)	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Endogenous	Natural	It‚Äôs binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1Œ≤	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It activates the inflammasome via NLRP3	NA	20303873	2010	NA
PRRID_0502	Fibrillar amyloid-b peptide Click for more detail	Alzheimer‚Äôs disease brain plaques(others)	MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN	770	Endogenous	Natural	It‚Äôs binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1Œ≤	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It activates the inflammasome via NLRP3	NA	20303873	2010	NA
PRRID_0509	Flagellin Click for more detail	Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤ and IL-18, leads to pathogen clearance and sepsis resistance.	IPAF	NOD-like receptor (NLR)	Human	NA	NA	Q15399.fasta	Q15399	786	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0509	Flagellin Click for more detail	Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤ and IL-18, leads to pathogen clearance and sepsis resistance.	IPAF	NOD-like receptor (NLR)	Human	NA	NA	Q15399.fasta	Q15399	786	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0518	Flagellin Click for more detail	Legionella pneumophila (Bacteria)	MIINHNLAAINSHRVLKFQNEEVSKNMEKLSSGMRINRAGDDASGLAVSEKMRTQVNGLRQAERNTEDGMSLIQTTEGFLQESNDIIQRIRTLAIQSSNGIYTDEDRQMIQVEVSQLIDEVDRIASQAEFNKMNLLQGDFARGSRATSMWFHLGPNMHQRERVFIATMTARALNLKGQSGDLLSLSTADKSNDAIGTLDAALTRISKQRANLGAYFNRLEHAAKGLMNAYENTQASESRIRDADMAEETVAFTKNQILVQSGTAMLAQANVRPQGVLSLLR	281	Protein	Natural	Their bining activate the caspase-1 platform	Naip5	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	implicated in the restriction of Legionella growth in macrophages,	NA	20605429	2010	NA
PRRID_0518	Flagellin Click for more detail	Legionella pneumophila (Bacteria)	MIINHNLAAINSHRVLKFQNEEVSKNMEKLSSGMRINRAGDDASGLAVSEKMRTQVNGLRQAERNTEDGMSLIQTTEGFLQESNDIIQRIRTLAIQSSNGIYTDEDRQMIQVEVSQLIDEVDRIASQAEFNKMNLLQGDFARGSRATSMWFHLGPNMHQRERVFIATMTARALNLKGQSGDLLSLSTADKSNDAIGTLDAALTRISKQRANLGAYFNRLEHAAKGLMNAYENTQASESRIRDADMAEETVAFTKNQILVQSGTAMLAQANVRPQGVLSLLR	281	Protein	Natural	Their bining activate the caspase-1 platform	Naip5	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	implicated in the restriction of Legionella growth in macrophages,	NA	20605429	2010	NA
PRRID_0521	flagellin and functional type III or Type IV secretion systems Click for more detail	Salmonella (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Their bining activate the caspase-1 platform	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It helps in restriction of salmonella growth in macrophages,	NA	20605429	2010	NA
PRRID_0521	flagellin and functional type III or Type IV secretion systems Click for more detail	Salmonella (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Their bining activate the caspase-1 platform	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It helps in restriction of salmonella growth in macrophages,	NA	20605429	2010	NA
PRRID_0522	flagellin and functional type III or Type IV secretion systems Click for more detail	Legionella pneumophila (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Their bining activate the caspase-1 platform	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	implicated in the restriction of Legionella growth in macrophages,	NA	20605429	2010	NA
PRRID_0522	flagellin and functional type III or Type IV secretion systems Click for more detail	Legionella pneumophila (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Their bining activate the caspase-1 platform	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	implicated in the restriction of Legionella growth in macrophages,	NA	20605429	2010	NA
PRRID_0554	hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail	Vibrio vulnificus (Bacteria)	MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY	4595	Protein	Natural	It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Macropahes	NA	Q8R4B8.fasta	Q8R4B8	1033	It leads to the pathogen clearance	ELISA	20348425	2010	Pubchem Assay
PRRID_0554	hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail	Vibrio vulnificus (Bacteria)	MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY	4595	Protein	Natural	It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Macropahes	NA	Q8R4B8.fasta	Q8R4B8	1033	It leads to the pathogen clearance	ELISA	20348425	2010	Pubchem Assay
PRRID_0555	hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail	Vibrio cholerae (Bacteria)	MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL	4558	Protein	Natural	It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Macrophages	NA	Q8R4B8.fasta	Q8R4B8	1033	It leads to the pathogen clearance	ELISA	20348425	2010	Pubchem Assay
PRRID_0555	hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail	Vibrio cholerae (Bacteria)	MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL	4558	Protein	Natural	It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Macrophages	NA	Q8R4B8.fasta	Q8R4B8	1033	It leads to the pathogen clearance	ELISA	20348425	2010	Pubchem Assay
PRRID_0568	Hyaluronan Click for more detail	Injured cell (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Endogenous	Natural	It‚Äôs binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1Œ≤	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It activates the inflammasome via NLRP3	NA	20303873	2010	NA
PRRID_0568	Hyaluronan Click for more detail	Injured cell (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Endogenous	Natural	It‚Äôs binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1Œ≤	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It activates the inflammasome via NLRP3	NA	20303873	2010	NA
PRRID_0598	KF1B Click for more detail	NA	NA	NA	NA	Synthetic	induction of chemokines and other proinflammatory molecules	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	NA	epithial cells	NA	NA	NA	NA	NA	NA	20685341	2010	NA
PRRID_0598	KF1B Click for more detail	NA	NA	NA	NA	Synthetic	induction of chemokines and other proinflammatory molecules	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	NA	epithial cells	NA	NA	NA	NA	NA	NA	20685341	2010	NA
PRRID_0603	lethal toxin (LeTx) Click for more detail	Bacillus anthracis(Bacteria)	NA	NA	toxin	Natural	It‚Äôs binding to the IPAF leads to the activation of caspase-1 via ASC adaptor protein	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Mice	Macropahges	NA	Q2LKU9.fasta	Q2LKU9	1182	It activates the inflammasome via NLRP1	NA	20303873	2010	Pubchem Assay
PRRID_0603	lethal toxin (LeTx) Click for more detail	Bacillus anthracis(Bacteria)	NA	NA	toxin	Natural	It‚Äôs binding to the IPAF leads to the activation of caspase-1 via ASC adaptor protein	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Mice	Macropahges	NA	Q2LKU9.fasta	Q2LKU9	1182	It activates the inflammasome via NLRP1	NA	20303873	2010	Pubchem Assay
PRRID_0677	MAVS Click for more detail	NA	NA	NA	Protein	Natural	Their bining activate the caspase-1 platform	Nod-like receptor X1 (NLRX1)	NOD-like receptor (NLR)	NA	Mitochondria	NA	NA	NA	NA	It suppresses MAVS-dependent antiviral pathways or promoting the generation of reactive oxygen species (ROS)	NA	20605429	2010	NA
PRRID_0677	MAVS Click for more detail	NA	NA	NA	Protein	Natural	Their bining activate the caspase-1 platform	Nod-like receptor X1 (NLRX1)	NOD-like receptor (NLR)	NA	Mitochondria	NA	NA	NA	NA	It suppresses MAVS-dependent antiviral pathways or promoting the generation of reactive oxygen species (ROS)	NA	20605429	2010	NA
PRRID_0679	mesodiaminopimelic acid Click for more detail	Bacteria	C(CC(C(=O)O)N)CC(C(=O)O)N	NA	Peptide	Natural	upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation	NA	20303873	2010	NA
PRRID_0679	mesodiaminopimelic acid Click for more detail	Bacteria	C(CC(C(=O)O)N)CC(C(=O)O)N	NA	Peptide	Natural	upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation	NA	20303873	2010	NA
PRRID_0693	muramyl dipeptide (MDP) Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation	NA	20303873	2010	NA
PRRID_0693	muramyl dipeptide (MDP) Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation	NA	20303873	2010	NA
PRRID_0694	muramyl dipeptide (MDP) + LPS + Poly(I:C) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Peptide	Natural	It help in NF	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	C57BL/6 Mice	liver and Hepatocytes	NA	Q3UP24.fasta	Q3UP24	1024	It plays an important regulatory role in many inflammatory processes involving the liver.	Immunoblotting and EMSA	20615568	2010	Pubchem Assay
PRRID_0694	muramyl dipeptide (MDP) + LPS + Poly(I:C) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Peptide	Natural	It help in NF	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	C57BL/6 Mice	liver and Hepatocytes	NA	Q3UP24.fasta	Q3UP24	1024	It plays an important regulatory role in many inflammatory processes involving the liver.	Immunoblotting and EMSA	20615568	2010	Pubchem Assay
PRRID_0697	MxiI Click for more detail	Shigella flexneri (Bacteria)	MNYIYPVNQVDIIKASDFQSQEISSLEDVVSAKYSDIKMDTDIQVSQIMEMVSNPESLNPESLAKLQTTLSNYSIGVSLAGTLARKTVSAVETLLKS	97	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0697	MxiI Click for more detail	Shigella flexneri (Bacteria)	MNYIYPVNQVDIIKASDFQSQEISSLEDVVSAKYSDIKMDTDIQVSQIMEMVSNPESLNPESLAKLQTTLSNYSIGVSLAGTLARKTVSAVETLLKS	97	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0699	N1L Click for more detail	Vaccinia(virus)	MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK	117	Protein	Natural	Suppress IRF3 activation (Bind to TBK1)	The class II transactivator (CIITA)	NOD-like receptor (NLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	P33076.fasta	P33076	1130	Suppress IFN production	NA	20672047	2010	Pubchem Assay
PRRID_0699	N1L Click for more detail	Vaccinia(virus)	MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK	117	Protein	Natural	Suppress IRF3 activation (Bind to TBK1)	The class II transactivator (CIITA)	NOD-like receptor (NLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	P33076.fasta	P33076	1130	Suppress IFN production	NA	20672047	2010	Pubchem Assay
PRRID_0703	NA Click for more detail	NA	NA	NA	NA	Natural	NA	The class II transactivator (CIITA)	NOD-like receptor (NLR)	Human	NA	NA	P33076.fasta	P33076	1130	It is a key regulator of class II MHC genes, such as it exert transcriptional regulator activity or other nuclear functions.	NA	20303873	2010	Pubchem Assay
PRRID_0703	NA Click for more detail	NA	NA	NA	NA	Natural	NA	The class II transactivator (CIITA)	NOD-like receptor (NLR)	Human	NA	NA	P33076.fasta	P33076	1130	It is a key regulator of class II MHC genes, such as it exert transcriptional regulator activity or other nuclear functions.	NA	20303873	2010	Pubchem Assay
PRRID_0729	Peptidoglycan (PGN) Click for more detail	Escherichia coli, Chlamydia pneumoniae, Campylobacter jejuni, Salmonella typhimurium, Pseudomonas ae	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Activates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤, which results into pathogen clearance and sepsis resistance	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	NA	NA	Q9Y239.fasta	Q9Y239	953	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0729	Peptidoglycan (PGN) Click for more detail	Escherichia coli, Chlamydia pneumoniae, Campylobacter jejuni, Salmonella typhimurium, Pseudomonas ae	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Activates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤, which results into pathogen clearance and sepsis resistance	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	NA	NA	Q9Y239.fasta	Q9Y239	953	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0733	Peptidoglycan (PGN) Click for more detail	E. coli K12(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Macropahges	NA	Q8K3Z0.fasta	Q8K3Z0	1020	NA	NA	20696824	2010	Pubchem Assay
PRRID_0733	Peptidoglycan (PGN) Click for more detail	E. coli K12(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Macropahges	NA	Q8K3Z0.fasta	Q8K3Z0	1020	NA	NA	20696824	2010	Pubchem Assay
PRRID_0738	Peptidoglycan (PGN) Click for more detail	Borrelia burgdorferi(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	PBMCs	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It aids in the induction of inflammtory reaction against Borrelia burgdorferi	ELISA	20441518	2010	Pubchem Assay
PRRID_0738	Peptidoglycan (PGN) Click for more detail	Borrelia burgdorferi(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	PBMCs	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It aids in the induction of inflammtory reaction against Borrelia burgdorferi	ELISA	20441518	2010	Pubchem Assay
PRRID_0739	Peptidoglycan (PGN) Click for more detail	Borrelia burgdorferi(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	PBMCs	NA	Q9HC29.fasta	Q9HC29	1040	It aids in the induction of inflammtory reaction against Borrelia burgdorferi	ELISA	20441518	2010	Pubchem Assay
PRRID_0739	Peptidoglycan (PGN) Click for more detail	Borrelia burgdorferi(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	PBMCs	NA	Q9HC29.fasta	Q9HC29	1040	It aids in the induction of inflammtory reaction against Borrelia burgdorferi	ELISA	20441518	2010	Pubchem Assay
PRRID_0746	PGNmonomer Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It initiates the activation of NF-	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	NA	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It act as potent costimulator of the innate immune system in the presence of TLR signals	Luciferase assay	20522786	2010	Pubchem Assay
PRRID_0746	PGNmonomer Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It initiates the activation of NF-	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	NA	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It act as potent costimulator of the innate immune system in the presence of TLR signals	Luciferase assay	20522786	2010	Pubchem Assay
PRRID_0775	Pore-forming toxins Click for more detail	Listeria monocytogenes, Staphylococcus aureus, Aeromonas hydrophila, microbial toxins (Bacteria)	NA	NA	Protein	Natural	Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤ and IL-18, leads to pathogen clearance and sepsis resistance.	Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containin (NALP)	NOD-like receptor (NLR)		NA	NA	Q9C000.fasta	Q9C000	1473	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0775	Pore-forming toxins Click for more detail	Listeria monocytogenes, Staphylococcus aureus, Aeromonas hydrophila, microbial toxins (Bacteria)	NA	NA	Protein	Natural	Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤ and IL-18, leads to pathogen clearance and sepsis resistance.	Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containin (NALP)	NOD-like receptor (NLR)		NA	NA	Q9C000.fasta	Q9C000	1473	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0777	PrgJ Click for more detail	S. typhimurium (Bacteria)	MSIATIVPENAVIGQAVNIRSMETDIVSLDDRLLQAFSGSAIATAVDKQTITNRIEDPNLVTDPKELAISQEMISDYNLYVSMVSTLTRKGVGAVETLLRS	101	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0777	PrgJ Click for more detail	S. typhimurium (Bacteria)	MSIATIVPENAVIGQAVNIRSMETDIVSLDDRLLQAFSGSAIATAVDKQTITNRIEDPNLVTDPKELAISQEMISDYNLYVSMVSTLTRKGVGAVETLLRS	101	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0780	PscI Click for more detail	Pseudomonas aeruginosa (Bacteria)	MDISRMGAQAQITSLEELSGGPAGAAHVAEFERAMGGAGSLGGDLLSELGQIRERFSQAKQELQMELSTPGDDPNSLMQMQWSLMRITMQEELIAKTVGRMSQNVETLMKTQ	112	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0780	PscI Click for more detail	Pseudomonas aeruginosa (Bacteria)	MDISRMGAQAQITSLEELSGGPAGAAHVAEFERAMGGAGSLGGDLLSELGQIRERFSQAKQELQMELSTPGDDPNSLMQMQWSLMRITMQEELIAKTVGRMSQNVETLMKTQ	112	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0814	T3SS Click for more detail	Gram-negative bacteria	MKIPSLQSNFNFSAPAGYSAPIAPNRAENAYADYVLDIGKRIPLSAADLSNVYESVIRAVHDSRSRLIDQHTVDMIGNTVLDALSRSQTFRDAVSYGIHNEKVHIGCIKYRNEYELNEESSVKIDDIQSLTCNELYEYDVGQEPIFPICEAGENDNEEPYVSFSVAPDTDSYEMPSWQEGLIHEIIHHVTGSSDPSGDSNIELGPTEILARRVAQELGWSVPDFKGYAEPEREAHLRLRNLNALRQAAMRHEENERAFFERLGTISDRYEASPDFTEYSAVSNIGYGFIQQHDFPGLAINDNLQDANQIQLYHGAPYIFTFGDVDKHNQR	330	Protein	Natural	It activates caspase 1 dependent IL-1Œ≤ and IL-18 secretion in response.	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It act as VAMPs, which results into the clearance of the pathogen due to the activation of the immune systems	NA	20349122	2010	NA
PRRID_0814	T3SS Click for more detail	Gram-negative bacteria	MKIPSLQSNFNFSAPAGYSAPIAPNRAENAYADYVLDIGKRIPLSAADLSNVYESVIRAVHDSRSRLIDQHTVDMIGNTVLDALSRSQTFRDAVSYGIHNEKVHIGCIKYRNEYELNEESSVKIDDIQSLTCNELYEYDVGQEPIFPICEAGENDNEEPYVSFSVAPDTDSYEMPSWQEGLIHEIIHHVTGSSDPSGDSNIELGPTEILARRVAQELGWSVPDFKGYAEPEREAHLRLRNLNALRQAAMRHEENERAFFERLGTISDRYEASPDFTEYSAVSNIGYGFIQQHDFPGLAINDNLQDANQIQLYHGAPYIFTFGDVDKHNQR	330	Protein	Natural	It activates caspase 1 dependent IL-1Œ≤ and IL-18 secretion in response.	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It act as VAMPs, which results into the clearance of the pathogen due to the activation of the immune systems	NA	20349122	2010	NA

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