Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0011	D-mannose Click for more detail	Bacteria	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Carbohydrate	Natural	elicit innate immune response	Mannose receptor	Mannose receptor (MR)	Human	NA	NA	P22897.fasta	P22897	1456	Induces pro-inflammatory cytokine response	NA	1906888	1991	Pubchem Assay
PRRID_0011	D-mannose Click for more detail	Bacteria	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Carbohydrate	Natural	elicit innate immune response	Mannose receptor	Mannose receptor (MR)	Human	NA	NA	P22897.fasta	P22897	1456	Induces pro-inflammatory cytokine response	NA	1906888	1991	Pubchem Assay
PRRID_0013	L-fucose Click for more detail	Bacteria	CC(C(C(C(C=O)O)O)O)O	NA	Carbohydrate	Natural	elicit innate immune response	Mannose receptor	Mannose receptor (MR)	Human	NA	NA	P22897.fasta	P22897	1456	Induces pro-inflammatory cytokine response	NA	1906888	1991	Pubchem Assay
PRRID_0013	L-fucose Click for more detail	Bacteria	CC(C(C(C(C=O)O)O)O)O	NA	Carbohydrate	Natural	elicit innate immune response	Mannose receptor	Mannose receptor (MR)	Human	NA	NA	P22897.fasta	P22897	1456	Induces pro-inflammatory cytokine response	NA	1906888	1991	Pubchem Assay
PRRID_0014	N-acetylmannosamine Click for more detail	Bacteria	CC(=O)NC1C(C(C(OC1O)CO)O)O	NA	Carbohydrate	Natural	elicit innate immune response	Mannose receptor	Mannose receptor (MR)	Human	NA	NA	P22897.fasta	P22897	1456	Induces pro-inflammatory cytokine response	NA	1906888	1991	Pubchem Assay
PRRID_0014	N-acetylmannosamine Click for more detail	Bacteria	CC(=O)NC1C(C(C(OC1O)CO)O)O	NA	Carbohydrate	Natural	elicit innate immune response	Mannose receptor	Mannose receptor (MR)	Human	NA	NA	P22897.fasta	P22897	1456	Induces pro-inflammatory cytokine response	NA	1906888	1991	Pubchem Assay
PRRID_0037	Escherichia coli Click for more detail	E. coli(Bacteria)	NA	NA	Whole cell	Natural	E.coli binds with MARCO with high affinity.	Macrophage receptor with collagenous structure (MARCO)	Scavenger receptor (SR)	Mice	Macrophages	NA	A2RT24.fasta	A2RT24	518	It plays a role in immunological reactions.	Immunoprecipitation	7867067	1995	Pubchem Assay
PRRID_0037	Escherichia coli Click for more detail	E. coli(Bacteria)	NA	NA	Whole cell	Natural	E.coli binds with MARCO with high affinity.	Macrophage receptor with collagenous structure (MARCO)	Scavenger receptor (SR)	Mice	Macrophages	NA	A2RT24.fasta	A2RT24	518	It plays a role in immunological reactions.	Immunoprecipitation	7867067	1995	Pubchem Assay
PRRID_0043	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole cell	Natural	S. aureus binds with MARCO with high affinity	Macrophage receptor with collagenous structure (MARCO)	Scavenger receptor (SR)	Mice	Macrophages	NA	A2RT24.fasta	A2RT24	518	It plays a role in immunological reactions.	Immunoprecipitation	7867067	1995	Pubchem Assay
PRRID_0043	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole cell	Natural	S. aureus binds with MARCO with high affinity	Macrophage receptor with collagenous structure (MARCO)	Scavenger receptor (SR)	Mice	Macrophages	NA	A2RT24.fasta	A2RT24	518	It plays a role in immunological reactions.	Immunoprecipitation	7867067	1995	Pubchem Assay
PRRID_0050	lipo-arabinomannan Click for more detail	mycobacteria (Mycobacterium tuberculosis; Erdman strain) (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	Immunostimulant	Mannose receptor	Mannose receptor (MR)	Human	Macrophages	NA	P22897.fasta	P22897	1456	NA	Chromatographic analyses	8906835	1996	Pubchem Assay
PRRID_0050	lipo-arabinomannan Click for more detail	mycobacteria (Mycobacterium tuberculosis; Erdman strain) (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	Immunostimulant	Mannose receptor	Mannose receptor (MR)	Human	Macrophages	NA	P22897.fasta	P22897	1456	NA	Chromatographic analyses	8906835	1996	Pubchem Assay
PRRID_0053	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8549669	1996	NA
PRRID_0053	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8549669	1996	NA
PRRID_0074	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycan recognition by TLR 2 leads to the activation of NF-KB, which leads to the secretion of proinflammatory cytokines.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Fibroblasts	LRR	O60603.fasta	O60603	784	TLR2 is responsible for recognzing the cell wall components of the gram-positive bacteria and induces the respective immune response.	EMSA	10384090	1999	Pubchem Assay
PRRID_0074	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycan recognition by TLR 2 leads to the activation of NF-KB, which leads to the secretion of proinflammatory cytokines.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Fibroblasts	LRR	O60603.fasta	O60603	784	TLR2 is responsible for recognzing the cell wall components of the gram-positive bacteria and induces the respective immune response.	EMSA	10384090	1999	Pubchem Assay
PRRID_0075	pneumolysin Click for more detail	S. pneumoniae (Bacteria)	MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND	471	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	ytokine induction is mediated through NF-kappaB activation	NA	10411278	1999	Pubchem Assay
PRRID_0075	pneumolysin Click for more detail	S. pneumoniae (Bacteria)	MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND	471	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	ytokine induction is mediated through NF-kappaB activation	NA	10411278	1999	Pubchem Assay
PRRID_0081	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	NA	Q9NR96.fasta	Q9NR96	1032	induce type I interferons (IFN) and other cytokines production.	NA	11130078	2000	Pubchem Assay
PRRID_0081	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	NA	Q9NR96.fasta	Q9NR96	1032	induce type I interferons (IFN) and other cytokines production.	NA	11130078	2000	Pubchem Assay
PRRID_0097	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0097	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0098	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0098	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0100	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	NA	NA	Q9JLF7.fasta	Q9JLF7	859	NA	tandem mass spectrometry	0	2001	Pubchem Assay
PRRID_0100	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	NA	NA	Q9JLF7.fasta	Q9JLF7	859	NA	tandem mass spectrometry	0	2001	Pubchem Assay
PRRID_0105	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0105	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0114	alpha-methylmannoside Click for more detail	Bacteria	COC1C(C(C(C(O1)CO)O)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0114	alpha-methylmannoside Click for more detail	Bacteria	COC1C(C(C(C(O1)CO)O)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0117	Fucose Click for more detail	Bacteria	CC(C(C(C(C=O)O)O)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0117	Fucose Click for more detail	Bacteria	CC(C(C(C(C=O)O)O)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0118	glucose Click for more detail	Bacteria	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0118	glucose Click for more detail	Bacteria	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0128	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Microvascular endothelial cells	LRR	O00206.fasta	O00206	839	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0128	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Microvascular endothelial cells	LRR	O00206.fasta	O00206	839	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0129	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	5MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	LRR	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0129	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	5MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	LRR	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0134	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0134	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0136	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0136	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0140	N-acetylmannosamine Click for more detail	Bacteria	CC(=O)NC1C(C(C(OC1O)CO)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0140	N-acetylmannosamine Click for more detail	Bacteria	CC(=O)NC1C(C(C(OC1O)CO)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0141	N-acetylmannosamine Click for more detail	Bacteria	CC(=O)NC1C(C(C(OC1O)CO)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0141	N-acetylmannosamine Click for more detail	Bacteria	CC(=O)NC1C(C(C(OC1O)CO)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0142	Neisserial porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	It leads to the induction of NF-kappaB nuclear translocation.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	It has the role in immunopotentiating activity, such as by stimulate B cells and up-regulate the surface expression of B7-2.	NF-kB luciferase reporter assay	11823477	2002	Pubchem Assay
PRRID_0142	Neisserial porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	It leads to the induction of NF-kappaB nuclear translocation.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	It has the role in immunopotentiating activity, such as by stimulate B cells and up-regulate the surface expression of B7-2.	NF-kB luciferase reporter assay	11823477	2002	Pubchem Assay
PRRID_0143	OspA Click for more detail	Borrelia burgdorferi(Bacteria)	MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALK	NA	Lipoprotein	Natural	immunostimulantt	Toll-like receptor 2 (TLR2)+unknown	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	human hyporesponsiveness to OspA vaccination	NA	12091878	2002	NA
PRRID_0143	OspA Click for more detail	Borrelia burgdorferi(Bacteria)	MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALK	NA	Lipoprotein	Natural	immunostimulantt	Toll-like receptor 2 (TLR2)+unknown	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	human hyporesponsiveness to OspA vaccination	NA	12091878	2002	NA
PRRID_0165	Escherichia coli Click for more detail	E. coli(Bacteria)	NA	NA	Whole cell	Natural	The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16.	Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16)	Scavenger receptor (SR)	Human	Macrophages and Dendritic cells	Chemokine domain	Q9H2A7.fasta	Q9H2A7	254	SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis.	ELISA	12902461	2003	Pubchem Assay
PRRID_0165	Escherichia coli Click for more detail	E. coli(Bacteria)	NA	NA	Whole cell	Natural	The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16.	Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16)	Scavenger receptor (SR)	Human	Macrophages and Dendritic cells	Chemokine domain	Q9H2A7.fasta	Q9H2A7	254	SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis.	ELISA	12902461	2003	Pubchem Assay
PRRID_0173	iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail	Bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Peptide	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Macrophages	NA	Q8BHB0.fasta	Q8BHB0	953	mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan.	ELISA	12796777	2003	Pubchem Assay
PRRID_0173	iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail	Bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Peptide	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Macrophages	NA	Q8BHB0.fasta	Q8BHB0	953	mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan.	ELISA	12796777	2003	Pubchem Assay
PRRID_0174	Lewis x Click for more detail	H. pylori (Bacteria)	CC1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)CO)O)O)O)CO)O)NC(=O)C)O)O)O	NA	Carbohydrate	Synthetic	It strongly binds to the DC-SIGN.	DC-SIGN	C type Lectin (CTL/CLR)	K562 cells	Dendritic cells	Lectin domain	NA	NA	NA	It induces the pathogen-driven inflammatory responses.	ELISA	12574325	2003	NA
PRRID_0174	Lewis x Click for more detail	H. pylori (Bacteria)	CC1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)CO)O)O)O)CO)O)NC(=O)C)O)O)O	NA	Carbohydrate	Synthetic	It strongly binds to the DC-SIGN.	DC-SIGN	C type Lectin (CTL/CLR)	K562 cells	Dendritic cells	Lectin domain	NA	NA	NA	It induces the pathogen-driven inflammatory responses.	ELISA	12574325	2003	NA
PRRID_0176	Lipopolysaccharide (LPS) Click for more detail	H. pylori (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Synthetic	It strongly binds to the DC-SIGN.	DC-SIGN	C type Lectin (CTL/CLR)	K562 cells	Dendritic cells	Lectin domain	NA	NA	NA	It induces the pathogen-driven inflammatory responses.	ELISA	12574325	2003	NA
PRRID_0176	Lipopolysaccharide (LPS) Click for more detail	H. pylori (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Synthetic	It strongly binds to the DC-SIGN.	DC-SIGN	C type Lectin (CTL/CLR)	K562 cells	Dendritic cells	Lectin domain	NA	NA	NA	It induces the pathogen-driven inflammatory responses.	ELISA	12574325	2003	NA
PRRID_0179	Mannose capped lipoarabinomannan Click for more detail	Mycobacterium tuberculosis (Bacteria)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Carbohydrate	Synthetic	It strongly binds to the DC-SIGN.	DC-SIGN	C type Lectin (CTL/CLR)	K562 cells	Dendritic cells	Lectin domain	NA	NA	NA	It induces the pathogen-driven inflammatory responses.	ELISA	12574325	2003	NA
PRRID_0179	Mannose capped lipoarabinomannan Click for more detail	Mycobacterium tuberculosis (Bacteria)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Carbohydrate	Synthetic	It strongly binds to the DC-SIGN.	DC-SIGN	C type Lectin (CTL/CLR)	K562 cells	Dendritic cells	Lectin domain	NA	NA	NA	It induces the pathogen-driven inflammatory responses.	ELISA	12574325	2003	NA
PRRID_0182	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0182	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0183	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0183	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0184	PIM6 Click for more detail	Mycobacterium bovis Bacillus Calmette Guerin (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0184	PIM6 Click for more detail	Mycobacterium bovis Bacillus Calmette Guerin (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0185	PIM6 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0185	PIM6 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0187	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole cell	Natural	The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16.	Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16)	Scavenger receptor (SR)	Human	Macrophages and Dendritic cells	Chemokine domain	Q9H2A7.fasta	Q9H2A7	254	SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis.	ELISA	12902461	2003	Pubchem Assay
PRRID_0187	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole cell	Natural	The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16.	Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16)	Scavenger receptor (SR)	Human	Macrophages and Dendritic cells	Chemokine domain	Q9H2A7.fasta	Q9H2A7	254	SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis.	ELISA	12902461	2003	Pubchem Assay
PRRID_0188	Tri-DAP (L-Ala-D-g-Glu-mDAP) Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N	NA	Peptide	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation	NA	12527755	2003	Pubchem Assay
PRRID_0188	Tri-DAP (L-Ala-D-g-Glu-mDAP) Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N	NA	Peptide	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation	NA	12527755	2003	Pubchem Assay
PRRID_0189	(man)3-ara Click for more detail	Mycobacteria (Bacteria)	NA	NA	Carbohydrate	Natural	elicit innate immune response	DC-SIGN	C type Lectin (CTL/CLR)	THP-1 and K562	NA	NA	NA	NA	NA	It inhibits the immuno-stimulatory function of dendritic cells.	ELISA	15481146	2004	NA
PRRID_0189	(man)3-ara Click for more detail	Mycobacteria (Bacteria)	NA	NA	Carbohydrate	Natural	elicit innate immune response	DC-SIGN	C type Lectin (CTL/CLR)	THP-1 and K562	NA	NA	NA	NA	NA	It inhibits the immuno-stimulatory function of dendritic cells.	ELISA	15481146	2004	NA
PRRID_0190	(man)3-ara Click for more detail	Mycobacteria (Bacteria)	NA	NA	Carbohydrate	Natural	elicit innate immune response	DC-SIGNR	C type Lectin (CTL/CLR)	THP-1 and K562	NA	NA	NA	NA	NA	It inhibits the immuno-stimulatory function of dendritic cells.	ELISA	15481146	2004	NA
PRRID_0190	(man)3-ara Click for more detail	Mycobacteria (Bacteria)	NA	NA	Carbohydrate	Natural	elicit innate immune response	DC-SIGNR	C type Lectin (CTL/CLR)	THP-1 and K562	NA	NA	NA	NA	NA	It inhibits the immuno-stimulatory function of dendritic cells.	ELISA	15481146	2004	NA
PRRID_0191	(man)3-ara Click for more detail	Mycobacteria (Bacteria)	NA	NA	Carbohydrate	Natural	elicit innate immune response	mSIGN-R1	C type Lectin (CTL/CLR)	THP-1 and K562	NA	NA	NA	NA	NA	It inhibits the immuno-stimulatory function of dendritic cells.	ELISA	15481146	2004	NA
PRRID_0191	(man)3-ara Click for more detail	Mycobacteria (Bacteria)	NA	NA	Carbohydrate	Natural	elicit innate immune response	mSIGN-R1	C type Lectin (CTL/CLR)	THP-1 and K562	NA	NA	NA	NA	NA	It inhibits the immuno-stimulatory function of dendritic cells.	ELISA	15481146	2004	NA
PRRID_0206	Not Determined Click for more detail	Uropathogenic E.coli (Bacteria)	NA	NA	Others	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	macrophages and liver, kidney, and bladder epithelial cells	NA	NA	NA	NA	NA	NA	15001781	2004	NA
PRRID_0206	Not Determined Click for more detail	Uropathogenic E.coli (Bacteria)	NA	NA	Others	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	macrophages and liver, kidney, and bladder epithelial cells	NA	NA	NA	NA	NA	NA	15001781	2004	NA
PRRID_0207	Opacity protein Click for more detail	Neisseria meningitidis (Bacteria)	MNPAPKNLLFSSLLFSSLLFSSLLFSSAAQAASEDSSRSPYYVQADLAYAAERITHDYPKATGANNTSTVSDYFRNIRAHSIHPRVSVGYDFGDWRIAADYASYRKWNNNKYSVNTKEVSRNNSNGNDTWQELKTENQENGSFHAVSSLGLSAIYDFKLNDKFDKFKPYIGARVAYGHVKHQVHSVRKETTTVFSKPSGSATKPGQIPSLVTKPAYHESHSISSLGLGVIAGVGFDITPKLTLDTGYRYHNWGRLENTRFKTHEVSLGVRYRF	273	Protein	Natural	elicit innate immune response	Mannose-binding lectins	Mannose receptor (MR)	Human	NA	NA	B1PN75.fasta	B1PN75	38	MBL binding to N. meningitidis and increases complement activation and killing of organisms.	ELISA	15004183	2004	Pubchem Assay
PRRID_0207	Opacity protein Click for more detail	Neisseria meningitidis (Bacteria)	MNPAPKNLLFSSLLFSSLLFSSLLFSSAAQAASEDSSRSPYYVQADLAYAAERITHDYPKATGANNTSTVSDYFRNIRAHSIHPRVSVGYDFGDWRIAADYASYRKWNNNKYSVNTKEVSRNNSNGNDTWQELKTENQENGSFHAVSSLGLSAIYDFKLNDKFDKFKPYIGARVAYGHVKHQVHSVRKETTTVFSKPSGSATKPGQIPSLVTKPAYHESHSISSLGLGVIAGVGFDITPKLTLDTGYRYHNWGRLENTRFKTHEVSLGVRYRF	273	Protein	Natural	elicit innate immune response	Mannose-binding lectins	Mannose receptor (MR)	Human	NA	NA	B1PN75.fasta	B1PN75	38	MBL binding to N. meningitidis and increases complement activation and killing of organisms.	ELISA	15004183	2004	Pubchem Assay
PRRID_0208	Porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	elicit innate immune response	Mannose-binding lectins	Mannose receptor (MR)	Human	NA	NA	B1PN75.fasta	B1PN75	38	MBL binding to N. meningitidis and increases complement activation and killing of organisms.	ELISA	15004183	2004	Pubchem Assay
PRRID_0208	Porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	elicit innate immune response	Mannose-binding lectins	Mannose receptor (MR)	Human	NA	NA	B1PN75.fasta	B1PN75	38	MBL binding to N. meningitidis and increases complement activation and killing of organisms.	ELISA	15004183	2004	Pubchem Assay
PRRID_0219	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0219	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0228	Seeligeriolysin O ((rLSO483) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0228	Seeligeriolysin O ((rLSO483) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0229	Seeligeriolysin O ((rLSO483) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0229	Seeligeriolysin O ((rLSO483) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0230	Seeligeriolysin O (rLSO530) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0230	Seeligeriolysin O (rLSO530) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0231	Seeligeriolysin O (rLSO530) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0231	Seeligeriolysin O (rLSO530) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0240	CpG-ODNs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0240	CpG-ODNs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0254	Lipopolysaccharide (LPS) Click for more detail	enterobacterial bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal¬†immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	17353199	2007	Pubchem Assay
PRRID_0254	Lipopolysaccharide (LPS) Click for more detail	enterobacterial bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal¬†immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	17353199	2007	Pubchem Assay
PRRID_0255	Lipopolysaccharide (LPS) Click for more detail	E.coli strain O111:B4(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal¬†immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	17353199	2007	Pubchem Assay
PRRID_0255	Lipopolysaccharide (LPS) Click for more detail	E.coli strain O111:B4(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal¬†immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	17353199	2007	Pubchem Assay

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