Result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assayPdb
PRRID_0001Porins

Click for more detail

Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396ProteinNaturalelicit innate immune responseMannose-binding lectinsMannose receptorHumanNANAB1PN75.fastaB1PN7538MBL binding to N. meningitidis and increases complement activation and killing of organisms.ELISA150041832004NA PRR_0001.pdb
PRRID_0002polyinosinic-polycytidylic acid [poly(I:C)]

Click for more detail

NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticIt results into the induction of type I IFNsTLR3TLRChickenSpleenocytesLeucine-rich Repeat (LRR) DomainD6R3C9.fastaD6R3C966ImmunostimulationNA206922892010NA PRR_0002.pdb
PRRID_0003HMGB1

Click for more detail

NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalpromoting neuroinflammationCD24PRRHumanNANAP25063.fastaP2506380Activate NF-KBNA280491422017NA PRR_0003.pdb
PRRID_0004Heat shock protein

Click for more detail

NANANADAMPsNaturalnduce the maturation and activation of pDCs.CD91PRRHumanpDCsLeucine-rich Repeat (LRR) DomainQ71UW0.fastaQ71UW092NANA289610192017NA PRR_0004.pdb
PRRID_0005Peptidoglycan (PGN)

Click for more detail

Gram negative bacteria, Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantDjCTLCTLDugesia japonicaPharyngeal and epidermisDoamin of CLECTA0A1L2DBR5.fastaA0A1L2DBR5107foreign invaders and phagocytize or encapsulate the aggregates of killed bacteria which have been digested in intestinal cavity.Microbial binding assay275654082016NA PRR_0005.pdb
PRRID_0006NA

Click for more detail

E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396PAMPNaturalelicit innate immune responseCTL4CTLAnopheles gambiaeNANAB2FX81.fastaB2FX81150NANA290517622017NA PRR_0006.pdb
PRRID_0007mt-DNA

Click for more detail

All vertebrates(others)NANANucleic AcidNaturalCellular injury and necrosisTLR9TLRHumanGranulocytes and monocytesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NRN6154release of interferon type 1 and TNF-a through the activation of IL-1R-associated kinase 1, 2, and 4 and the phosphorylation of p38 MAPKNA280491422017NA PRR_0007.pdb
PRRID_0008NA

Click for more detail

E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396DAMPsNaturalelicit innate immune responseCTLMA2CTLAnopheles gambiaeNANAB2FX57.fastaB2FX57165NANA290517622017NA PRR_0008.pdb
PRRID_0009Mannose and fucose

Click for more detail

L. monocytogenes (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)ONAPAMPNaturalActivation of CLEC5ACLEC5ACTLHumanmonocytes, macrophages and neutrophils.NAQ14DL9.fastaQ14DL9165secretion of proinflammatory cytokines such as TNF, IL-6, CXCL-8, and IP-10.Binding assay288241662017NA PRR_0009.pdb
PRRID_0010Teneligliptin

Click for more detail

NACC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5NADPP4 inhibitorNaturalanti- inflammatory activitycav-1PRRMiceMacrophagesLeucine-rich Repeat (LRR) DomainP49817.fastaP49817178NANA291137972017NA PRR_0010.pdb
PRRID_0011TDM

Click for more detail

Mycobacterium spp.(Bacteria)NANAPAMPNaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017NA PRR_0011.pdb
PRRID_0012TDM

Click for more detail

Mycobacterium spp.(Bacteria)NANAPAMPNaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017NA PRR_0012.pdb
PRRID_0013b-1,3-glucans.

Click for more detail

Candida glabrata(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPAMPNaturalBinding and activation of Dectin -1Dectin-1CTLMiceMacrophagesNAQ9BXN2.fastaQ9BXN2247activation of the NF-κB and MAPK pathwaysBinding assay286585922017NA PRR_0013.pdb
PRRID_0014Staphylococcus aureus

Click for more detail

S. aureus (Bacteria)NANAWhole cellNaturalThe recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16.SR-PSOX/CXCL16Scavenger receptorHumanMacrophages and Dendritic cellsChemokine domainQ9H2A7.fastaQ9H2A7254SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis.ELISA129024612003NA PRR_0014.pdb
PRRID_0015NA

Click for more detail

S. pneumoniae (Bacteria)NANAPAMPNaturalImmunostimulantcollectin kidney 1 (CL-K1)CTLMiceNANAQ3SXB8.fastaQ3SXB8272binds to microbes and activates the lectin complement pathwayNA280686632017NA PRR_0015.pdb
PRRID_0016anti-citrullinated protein antibody-positive (ACPA+) RA.

Click for more detail

Present in the majority of patients with Rheumatoid arthritis (others)NANANANaturalNACaspase-1NLRHumanmast cellsNAB4DVD8.fastaB4DVD8301contribute to the protective functions of the immune cellsFlow cytometry248186342014NA PRR_0016.pdb
PRRID_0017ssDNA

Click for more detail

NANANANANaturalImmunostimulantTREX1/exonucleasePRRHumanVirion CytosolNAQ9NSU2.fastaQ9NSU2314dNMPsNA229829432012NA PRR_0017.pdb
PRRID_0018oxidized LDL (OxLDL)

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalOxLDL pretreatment increased expression of macrosialin.MicrosialinScavenger receptorMicePeritoneal macrophagesNAA0A0R4J1C8.fastaA0A0R4J1C8335It leads to the binding and uptake of oxidised form of LDL by resident mouse peritoneal macrophages.Endocytic degradation assays95988391998NA PRR_0018.pdb
PRRID_0019fMLF

Click for more detail

NANANAPeptideSyntheticIt activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinasesFormyl peptide receptor-1PRRHumanNeutrophilsNAP21462.fastaP21462350It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli.Chemotaxis assay202036102010NA PRR_0019.pdb
PRRID_0020P2Y2PalIC3

Click for more detail

NANANAPAMPNaturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)PRRHumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017NA PRR_0020.pdb
PRRID_0021Hypochlorite modified HDL

Click for more detail

Host (Endogenous) (others)CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)CNALipoproteinNaturalIt has a high affinity for the Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1).Lectin-like oxidized LDLreceptor-1CTLMice (Murine)CHO Cells—ldlA cellsNAQ9EQ09.fastaQ9EQ09363It impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport.NA120701412002NA PRR_0021.pdb
PRRID_0022Lipopolysaccharide (LPS)

Click for more detail

Escherichia coli serotype 0127:B8 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALPSNaturalBinding of LPS trigger the NFKB pathway.CD14PRRWistar RatPineal gland (pinealocytes)NAQ63691.fastaQ63691372The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF and inhibiting melatonin synthesisNA205868882010NA PRR_0022.pdb
PRRID_0023NA

Click for more detail

NANANANANaturalNAPTX3PRRHumanNANAP26022.fastaP26022381NANA290662552017NA PRR_0023.pdb
PRRID_0024dsDNA

Click for more detail

Vesicular stomatitis (virus) NANANucleic AcidNaturalLRRFIP1 bound β-catenin and promoted the activation of β-catenin, which subsequently bound IRF3 which leads to the production of IFN-βLRRFIP2Cytosolic receptorRAW264.7 cellscytoplasmNAQ91WK0.fastaQ91WK0415It induce the production of type I interferon is important for pathogen elimination.ELISA204538442010NA PRR_0024.pdb
PRRID_0025β-galactosides

Click for more detail

Leishmania major (others)C(C1C(C(C(C(O1)O)O)O)O)ONAPAMPNaturalcutaneous and visceral leishmaniasisGal-3PRRMicelymph nodes and higher parasite load in the footpadscarbohydrate recognition domainQ9JHE4 .fastaQ9JHE4423via modulation of the Notch signaling pathwayNA289862482018NA PRR_0025.pdb
PRRID_0026Long ds RNA

Click for more detail

EMCV, poliovirus and coxasackie virus; Rotavirus, dengue virus, WNV, murine hepatitis virus(virus)NANAPAMPNaturalfilament formation mediated receptor tetramerizationMDA5RLRHumanCytoplasm, all mammalian cell typesNAQ53TB6.fastaQ53TB6435MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017NA PRR_0026.pdb
PRRID_0027LPS and β-1,3-glucan

Click for more detail

BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAGlycoproteinNaturalNATmGNBP1GNBPsTenebrio molitormembrane localisedNAB1B5K2.fastaB1B5K2442NAAntibacterial activity assay181950052008NA PRR_0027.pdb
PRRID_0028Mannan

Click for more detail

Fungi(Yeast)N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=ONAPolysaccharidesNaturalcell wall polysaccharide found in yeasts.Mannose receptorMannose receptorEuropean and African ChildrenDC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin)NAA5D8T8.fastaA5D8T8446Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammationELISA247435422014NA PRR_0028.pdb
PRRID_0029Advanced Glycation End Products (AGE)

Click for more detail

Host (Endogenous) (others)NANAProteinNaturalAGE is a potent activator of MSR.Macrophage Scavenger Receptor (MSR)Scavenger receptorHumanMacrophagesNAP21757.fastaP21757451The MSR mediates the endocytic uptake and degradation of AGE proteins.NA76072091995NA PRR_0029.pdb
PRRID_0030rBanLec

Click for more detail

E. coli(Bacteria)NANANASyntheticImmunostimulantCD4PRRMicePeritoneal macrophagesNAP06332.fastaP06332457production of TNFα and NO in BALB/c macrophages.ELISA282350502017NA PRR_0030.pdb
PRRID_0031NA

Click for more detail

Acanthocheilonema viteae(others)NANAPAMPNaturalNAScavenger receptor class AScavenger receptorMicelamina propria macrophageNAQ08857.fastaQ08857472It protect against microbial induced pregnancy lossNA207118462010NA PRR_0031.pdb
PRRID_0032Cryptococcus neoformans

Click for more detail

Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.SCARF1Scavenger receptorMiceMacropahgesNAQ68EF1.fastaQ68EF1474Macrophages phagocytose and kill C. neoformans and binding of these fungi to endothelial cells initiates tissue invasion.NA192376022009NA PRR_0032.pdb
PRRID_0033NA

Click for more detail

NANANANANANAPTX4PRRHumanNANAQ96A99.fastaQ96A99478NANA290662552017NA PRR_0033.pdb
PRRID_0034Lipopolysaccharide (LPS)

Click for more detail

Pseudomonas aeruginosa (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALPSNaturalstimulation of THP-1 macrophagesMUC1 mucinPRRHumansurface of epithelial cells and some hematopoietic cellsNAA0A087X2A4.fastaA0A087X2A4484phagocytic activity and cytokine productionELISA288227662017NA PRR_0034.pdb
PRRID_0035GW4064

Click for more detail

NANANAPAMPNaturalGW4064 attenuated LPS-induced ileum injury and mitochondria dysfunction by sup- pressed TLR4/MyD88 signaling-mediated inflammation and apoptosis.Farnesoid X receptor (FXR)PRRMiceMacrophagesNAQ60641.fastaQ60641488role in enteroprotection and mucosal injury by regulating inflammatory responses and barrier function in the intestinal tract.RT-qPCR286473622017NA PRR_0035.pdb
PRRID_0036Hypochlorite modified HDL

Click for more detail

Host (Endogenous) (others)CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)CNALipoproteinNaturalIt has a high affinity for the Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1).Scavenger receptor class B, type I (SR-BI)Scavenger receptorMice (Murine)CHO Cells—ldlA cellsNAQ06BI8.fastaQ06BI8494It impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport.NA120701412002NA PRR_0036.pdb
PRRID_0037b-1,3-glucan and lipopolysaccharide

Click for more detail

Gram positive bacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPeptidoglycanNaturalNADmGNBP1GNBPsDrosophila melanogastermembrane localisedNAQ9NHB0.fastaQ9NHB0494NANA292294432017NA PRR_0037.pdb
PRRID_0038Bacterial Antigen

Click for more detail

L. monocytogenes (Bacteria)NANANANaturalIt's binding leads to the bacterial uptake via phagocytosisclass B scavenger receptor type I (SR-BI)Scavenger receptorMiceTrophoblast giant cells and J774 cellsNAQ61009.fastaQ61009509It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.NA204716812010NA PRR_0038.pdb
PRRID_0039Uric acid

Click for more detail

NAC12=C(NC(=O)N1)NC(=O)NC2=ONADAMPsNaturalInduce the synthesis of IL-1β, TNF-α and TGF-β by murine macrophages.TLR2TLRMice (Murine)MacrophagesLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9QUK7511NANA289610192017NA PRR_0039.pdb
PRRID_0040Staphylococcus aureus

Click for more detail

S. aureus (Bacteria)NANAWhole cellNaturalS. aureus binds with MARCO with high affinityMARCOScavenger receptorMiceMacrophagesNAA2RT24.fastaA2RT24518It plays a role in immunological reactions.Immunoprecipitation78670671995NA PRR_0040.pdb
PRRID_0041NA

Click for more detail

NANANANANANAMARCOScavenger receptorHumanNANAQ9UEW3.fastaQ9UEW3520NANA290662552017NA PRR_0041.pdb
PRRID_0042dsDNA

Click for more detail

HSV-1 (virus)NANANucleic AcidNaturalIt mediate IFNs and cytokine productionRNA Pol-IIIDNA receptorMice (Murine)CytoplasmNAQ9D483.fastaQ9D483533It has the role in the inflammation.NA207395192010NA PRR_0042.pdb
PRRID_0043Fungal chitin

Click for more detail

Candida albicans(fungi)NANANANaturalNACARD9NLRHumanmyeloid cells,Caspase Recruitment DomainQ9H257.fastaQ9H257536NAInvasive CNS candidiasis293077702018NA PRR_0043.pdb
PRRID_0044muramyl tripeptide

Click for more detail

Mycobacteria (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCCNAPeptideNaturalin vitro activates NodPGLYRP-2PGRPHumanintraepithelial T lymphocytesintracellular receptorsQ96PD5.fastaQ96PD5576recognises peptidoglycan of bacterial cell wallNA247793902014NA PRR_0044.pdb
PRRID_0045Lipopolysaccharide (LPS)

Click for more detail

Pseudomonas aeruginosa (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALPSNaturalstimulation of THP-1 macrophagesMUC1 mucinPRRMicesurface of epithelial cells and some hematopoietic cellsNAQ02496.fastaQ02496630phagocytic activity and cytokine productionELISA288227662017NA PRR_0045.pdb
PRRID_0046Sindbis virus (SINV) RNA

Click for more detail

VirusNANAPAMPNaturalImmunostimulantTetrachlorodibenzo-p-dioxin (TCDD)- inducible poly(ADP ribose) polymerase (TIPARP)PRRMiceCytoplasmzinc finger domainQ8C1B2.fastaQ8C1B2657recruits an exosome to induce viral RNA degradation.RNA immunoprecipitation Assay282134972017NA PRR_0046.pdb
PRRID_0047Lipopolysaccharide (LPS)

Click for more detail

Gram negative bacteria, Gram-positive bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALPSNaturalBacterial infectionMjSRCScavenger receptorMarsupenaeus japonicushemocytesCCP and MAM domainsA0A1L2DC21.fastaA0A1L2DC21692phagocytosisNA286026822017NA PRR_0047.pdb
PRRID_0048dsDNA

Click for more detail

Listeria monocytogenes (Bacteria)NANANucleic AcidNaturalLRRFIP1 bound β-catenin and promoted the activation of β-catenin, which subsequently bound IRF3 which leads to the production of IFN-βLRRFIP1Cytosolic receptorRAW264.7 cellscytoplasmNAQ3UZ39.fastaQ3UZ39729It induce the production of type I interferon is important for pathogen elimination.ELISA204538442010NA PRR_0048.pdb
PRRID_0049Lipoprotein

Click for more detail

BacteriaNANAPAMPNaturalNATLR2TLRRatbrain (vasculature)Leucine-rich Repeat (LRR) DomainQ6YGU2.fastaQ6YGU2784protein ‚Üë, activation in ischemic strokeNA288015212017NA PRR_0049.pdb
PRRID_0050Peptidoglycan (PGN)

Click for more detail

BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseTLR2TLRChickensplenocytescell surfaceQ9DD78.fastaQ9DD78793TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-cELISA247977222014NA PRR_0050.pdb