ProGlyProt IDBU291
Organism Information
Organism NameTreponema pallidum subsp. pallidum Nichols
DomainBacteria
ClassificationFamily: Spirochaetaceae
Order: Spirochaetales
Class: Spirochaetes
Division or phylum: "Spirochaetes" or "Spirochaetae"
Taxonomic ID (NCBI)160
Genome Sequence (s)
GeneBankAE000520.1
EMBLAE000520
Gene Information
Gene NameflaB3 (TP_0870)
NCBI Gene ID2611107
Protein Information
Protein NameFlagellin FlaB3
UniProtKB/SwissProt IDP21992
NCBI RefSeqNP_219305.1
EMBL-CDSAAC65835.1
UniProtKB Sequence>sp|P21992|FLAB3_TREPA Flagellar filament 31 kDa core protein OS=Treponema pallidum GN=flaB3 PE=1 SV=3
MIINHNMSAMFAQRQGGINGLAIAKNIEKLSSGYRINRAGDDASGLAVSEKMRSQIRGLN QAGQNIQNGISFIQATEGYLAETTEIVQRLRELAIQAANGIYSAEDRMQIQVEVSQLVDE VDRIASQAQFNGMNLLTGRFSRESALGPMQLHVGANMDQNEKIFINTMTASALGFFSDEG TDGSRSISIATVDGANKVIGTLDSALKEINKQRADLGAYQNRFETAYQGIAIAAENLQAA ESRIRDADLAQQMVDYTKNQILEQSTMAMLAQANTQPQAVLRLMQ
Sequence length285 AA
Subcellular LocationPeriplasm
FunctionFlagellar 31 kDa core protein. It is the major component of the endoflagella which are required for motility of Treponemes.
Glycosylation Status
Glycosylation TypeInformation currently not available with us.
Technique(s) used for Glycosylation DetectionIntrinsic [14C]glucosamine-labeling, periodate oxidation-DIG (digoxigenin) hydrazide labeling
Literatures
Reference(s)1) Wyss, C. (1998) Flagellins, but not endoflagellar sheath proteins, of Treponema pallidum and of pathogen-related oral spirochetes are glycosylated. Infect Immun, 66, 5751-5754. [PubMed: 9826350]
2) Moskophidis, M. and Muller, F. (1985) Identification of glycosylated protein antigens of Treponema pallidum and Treponema phagedenis. Zentralbl Bakteriol Mikrobiol Hyg A, 259, 468-476. [PubMed: 3901616]
3) Moskophidis, M. and Muller, F. (1984) Molecular characterization of glycoprotein antigens on surface of Treponema pallidum: comparison with nonpathogenic Treponema phagedenis biotype Reiter. Infect Immun, 46, 867-869. [PubMed: 6389370]
Year of Identification1984