ProGlyProt IDBU290
Organism Information
Organism NameTreponema pallidum subsp. pallidum Nichols
DomainBacteria
ClassificationFamily: Spirochaetaceae
Order: Spirochaetales
Class: Spirochaetes
Division or phylum: "Spirochaetes" or "Spirochaetae"
Taxonomic ID (NCBI)160
Genome Sequence (s)
GeneBankAE000520.1
EMBLAE000520
Gene Information
Gene NameflaB2 (TP_0792)
NCBI Gene ID2610779
Protein Information
Protein NameFlagellin FlaB2
UniProtKB/SwissProt IDP21991
NCBI RefSeqNP_219229.1
EMBL-CDSAAC65757.1
UniProtKB Sequence>sp|P21991|FLAB2_TREPA Flagellar filament 33 kDa core protein OS=Treponema pallidum GN=flaB2 PE=1 SV=2
MIINHNMSAMFSQRTLGHTNLSVQKNIEKLSSGLRINRSGDDASGLAVSEKMRSQIRGLN QASTNAQNGISFIQVAEAFLQETTDVIQRIRELSVQAANGIYSAEDRLYIQVEVSQLVAE VDRIASHAQFNGMNMLTGRFARQGGENTVTASMWFHIGANMDQRTRAYIGTMTAVAMGIR DAGDESVMNIDSPEKANRAIGTLDQAIKRINKQRADLGAYQNRLDHTVAGINVAAENLQA AESRIRDVDMAKEMVDYTKNQILVQSGTAMLAQANQATQSVLSLLR
Sequence length286 AA
Subcellular LocationPeriplasm
FunctionFlagellar 33 kDa core protein. It is the major component of the endoflagella which are required for motility of Treponemes.
Glycosylation Status
Glycosylation TypeInformation currently not available with us.
Technique(s) used for Glycosylation DetectionIntrinsic [14C]glucosamine-labeling, periodate oxidation-DIG (digoxigenin) hydrazide labeling
Literatures
Reference(s)1) Wyss, C. (1998) Flagellins, but not endoflagellar sheath proteins, of Treponema pallidum and of pathogen-related oral spirochetes are glycosylated. Infect Immun, 66, 5751-5754. [PubMed: 9826350]
2) Moskophidis, M. and Muller, F. (1985) Identification of glycosylated protein antigens of Treponema pallidum and Treponema phagedenis. Zentralbl Bakteriol Mikrobiol Hyg A, 259, 468-476. [PubMed: 3901616]
3) Moskophidis, M. and Muller, F. (1984) Molecular characterization of glycoprotein antigens on surface of Treponema pallidum: comparison with nonpathogenic Treponema phagedenis biotype Reiter. Infect Immun, 46, 867-869. [PubMed: 6389370]
Year of Identification1984