ProGlyProt ID BU289 Organism Information Organism Name Treponema pallidum subsp. pallidum Nichols Domain Bacteria Classification Family: Spirochaetaceae Order: Spirochaetales Class: Spirochaetes Division or phylum: "Spirochaetes" or "Spirochaetae" Taxonomic ID (NCBI) 160 Genome Sequence (s) GeneBank AE000520.1 EMBL AE000520 Gene Information Gene Name flaB1 (TP_0868) NCBI Gene ID 2611100 Protein Information Protein Name Flagellin FlaB1 UniProtKB/SwissProt ID P21990 NCBI RefSeq NP_219303.1 EMBL-CDS AAC65834.1 UniProtKB Sequence >sp|P21990|FLAB1_TREPA Flagellar filament 34.5 kDa core protein OS=Treponema pallidum GN=flaB1 PE=1 SV=2 MIINHNMSAMFAQRTLGHTNVQVGKGIEKLSSGYRINRAGDDASGLAVSEKMRSQIRGLN QASTNASNGVNFIQVTEAYLQETTDIMQRIRELAIQAANGIYSAEDRMQIQVEVSQLVAE VDRIASSAQFNGMNLLTGRFSRTEGENVIGGSMWFHIGANMDQRMRVYIGTMTAVALGVR NGVDESIMSIETADSANKSIGTIDAALKRINKQRADLGGYQNRMEYTVVGLDIAAENLQA AESRIRDANIAKQMVEYTKNQVLTQSGTAMLAQANTSAQSILSILR Sequence length 286 AA Subcellular Location Periplasm Function Flagellar 35 kDa core protein. It is the major component of the endoflagella which are required for motility of Treponemes. Glycosylation Status Glycosylation Type Information currently not available with us. Technique(s) used for Glycosylation Detection Intrinsic [14C]glucosamine-labeling, periodate oxidation-DIG (digoxigenin) hydrazide labeling Literatures Reference(s) 1) Wyss, C. (1998) Flagellins, but not endoflagellar sheath proteins, of Treponema pallidum and of pathogen-related oral spirochetes are glycosylated. Infect Immun, 66, 5751-5754. [PubMed: 9826350] 2) Moskophidis, M. and Muller, F. (1985) Identification of glycosylated protein antigens of Treponema pallidum and Treponema phagedenis. Zentralbl Bakteriol Mikrobiol Hyg A, 259, 468-476. [PubMed: 3901616] 3) Moskophidis, M. and Muller, F. (1984) Molecular characterization of glycoprotein antigens on surface of Treponema pallidum: comparison with nonpathogenic Treponema phagedenis biotype Reiter. Infect Immun, 46, 867-869. [PubMed: 6389370] Year of Identification 1984