ProGlyProt IDBU267
Organism Information
Organism NameStreptococcus pyogenes type M5 (Manfredo strain)
DomainBacteria
ClassificationFamily: Streptococcaceae
Order: Lactobacillales
Class: Bacilli (or Firmibacteria)
Division or phylum: "Firmicutes"
Taxonomic ID (NCBI)160491
Genome Sequence (s)
GeneBankAM295007.1
EMBLAM295007
Gene Information
Gene NamesagP or arcA (SpyM50577)
NCBI Gene ID4964002
Protein Information
Protein NameStreptococcal acid glycoprotein SAGP
UniProtKB/SwissProt IDP58827
NCBI RefSeqYP_001128150.1
EMBL-CDSCAM29914.1
UniProtKB Sequence>sp|P58827|ARCA_STRPG Arginine deiminase OS=Streptococcus pyogenes serotype M5 (strain Manfredo) GN=arcA PE=1 SV=3
MTAQTPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDIPFLEDAQKEHDAFAQA LRDEGIEVLYLETLAAESLVTPEIREAFIDEYLSEANIRGRATKKAIRELLMAIEDNQEL IEKTMAGVQKSELPEIPASEKGLTDLVESNYPFAIDPMPNLYFTRDPFATIGTGVSLNHM FSETRNRETLYGKYIFTHHPIYGGGKVPMVYDRNETTRIEGGDELVLSKDVLAVGISQRT DAASIEKLLVNIFKQNLGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLRV YSVTYDNEELHIIEEKGDLAELLAANLGVEKVDLIRCGGDNLVAAGREQWNDGSNTLTIA PGVVVVYNRNTITNAILESKGLKLIKIHGSELVRGRGGPRCMSMPFEREDI
Sequence length411 AA
Subcellular LocationIntracellular
FunctionSAGP,or its homolog,possesses AD (L-arginine deiminase) activity. The potent inhibition of proliferation of human T-cells by streptococcal CE is due to activity of this enzyme.
Glycosylation Status
Glycosylation Type
Technique(s) used for Glycosylation Detection
Literatures
Reference(s)1) Degnan, B.A., Fontaine, M.C., Doebereiner, A.H., Lee, J.J., Mastroeni, P., Dougan, G., Goodacre, J.A. and Kehoe, M.A. (2000) Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein. Infect Immun, 68, 2441-2448. [PubMed: 10768929]
2) Degnan, B.A., Palmer, J.M., Robson, T., Jones, C.E., Fischer, M., Glanville, M., Mellor, G.D., Diamond, A.G., Kehoe, M.A. and Goodacre, J.A. (1998) Inhibition of human peripheral blood mononuclear cell proliferation by Streptococcus pyogenes cell extract is associated with arginine deiminase activity. Infect Immun, 66, 3050-3058. [PubMed: 9632565]
Year of Identification2000