ProGlyProt IDBU266
Organism Information
Organism NameStreptococcus pyogenes strain Su
DomainBacteria
ClassificationFamily: Streptococcaceae
Order: Lactobacillales
Class: Bacilli (or Firmibacteria)
Division or phylum: "Firmicutes"
Taxonomic ID (NCBI)1314
Genome Sequence (s)
GeneBank
EMBLX55659
Gene Information
Gene NamearcA or sagP
NCBI Gene ID
Protein Information
Protein NameStreptococcal acid glycoprotein SAGP
UniProtKB/SwissProt IDP0C0B3
NCBI RefSeq
EMBL-CDSCAA39192.1
UniProtKB Sequence>sp|P0C0B3|ARCA_STRPY Arginine deiminase OS=Streptococcus pyogenes GN=arcA PE=1 SV=2
MTAQTPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDIPFLEDAQKEHDAFAQA LRDEGIEVLYLETLAAESLVTPEIREAFIDEYLSEANIRGRATKKAIRELLMAIEDNQEL IEKTMAGVQKSELPEIPASEKGLTDLVESNYPFAIDPMPNLYFTRDPFATIGTGVSLNHM FSETRNRETLYGKYIFTHHPIYGGGKVPMVYDRNETTRIEGGDELVLSKDVLAVGISQRT DAASIEKLLVNIFKQNLGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLRV YSVTYDNEELHIVEEKGDLAELLAANLGVEKVDLIRCGGDNLVAAGREQWNDGSNTLTIA PGVVVVYNRNTITNAILESKGLKLIKIHGSELVRGRGGPRCMSMPFEREDI
Sequence length411 AA
Subcellular LocationIntracellular
FunctionAntitumour protein.
Glycosylation Status
Glycosylation Type
Technique(s) used for Glycosylation Detection
Literatures
Reference(s)1) Degnan, B.A., Fontaine, M.C., Doebereiner, A.H., Lee, J.J., Mastroeni, P., Dougan, G., Goodacre, J.A. and Kehoe, M.A. (2000) Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein. Infect Immun, 68, 2441-2448. [PubMed: 10768929]
2) Degnan, B.A., Palmer, J.M., Robson, T., Jones, C.E., Fischer, M., Glanville, M., Mellor, G.D., Diamond, A.G., Kehoe, M.A. and Goodacre, J.A. (1998) Inhibition of human peripheral blood mononuclear cell proliferation by Streptococcus pyogenes cell extract is associated with arginine deiminase activity. Infect Immun, 66, 3050-3058. [PubMed: 9632565]
3) Kanaoka, M., Negoro, T., Kawanaka, C., Agui, H. and Nabeshima, S. (1991) Streptococcal antitumor protein: expression in Escherichia coli cells and properties of the recombinant protein. Agric Biol Chem, 55, 743-750. [PubMed: 1368629]
4) Kanaoka, M., Fukita, Y., Taya, K., Kawanaka, C., Negoro, T. and Agui, H. (1987) A
Year of Identification1985