ProGlyProt ID BU245 Organism Information Organism Name Porphyromonas gingivalis Domain Bacteria Classification Family: "Porphyromonadaceae" Order: "Bacteroidales" Class: "Bacteroidia" Division or phylum: "Bacteroidetes" Taxonomic ID (NCBI) 837 Genome Sequence (s) GeneBank AP009380.1 EMBL AB016284 Gene Information Gene Name Mfa1 NCBI Gene ID 6330018 Protein Information Protein Name Mfa1 (67 kDa minor fimbrillin) UniProtKB/SwissProt ID O83017 NCBI RefSeq YP_001928403.1 EMBL-CDS BAA31954.1 UniProtKB Sequence >tr|O83017|O83017_PORGI 67kDa fimbrillin OS=Porphyromonas gingivalis GN=mfa1 PE=4 SV=1 MKLNKMFLVGALLSLGFASCSKEGNGPDPDNAAKSYMSMTLSMPMGSARAGDGQDQANPD YHYVGEWAGKDKIEKVSIYMVPQGGPGLVESAEDLDFGTYYENPTIDPATHNAILKPKKG IKVNSAVGKTVKVYVVLNDIAGKAKALLANVNAADFDAKFKEIIELSTQAQALGTVADGP NPATAAGKIAKKNGTTDETIMMTCLQPSDALTIEAAVSEANAIAGIKNQAKVTVERSVAR AMVSTKAQSYEIKATTQIGEIAAGSVLATITDIRWVVAQGERRQYLSKKRGTVPENTWVT PGSGFVPTSSTFHTNATEYYDYAGLWEDHNTNEAVISGTQVPTLADYQLQDVTGELANAL SGKFLLPNTHKSGANAASSDYKRGNTAYVLVRAKFTPKKEAFIDRGKTYSDNTAVPEYVA GEDFFVGENGQFYVSMKSVTDPKVGGVAGMKAHKYVKGKVLYYAWLNPSTTSPDSWWNSP VVRNNIYHIHIKSIKKLGFNWNPLVPDPDPSNPENPNNPDPNPDEPGTPVPTDPENPLPD QDTFMSVEVTVLPWKVHSYEVDL Sequence length 563 AA Subcellular Location Surface Function Minor fimbria of P. gingivalis intimately interacts with the SspB protein of Streptococcus gordonii.This interaction might aid in P. gingivalis colonization of plaque biofilm before it invades gingival tissue. The minor fimbria targets DC-SIGN on DCs for entry into DCs and that this targeting has the immunological consequence of dampening the immune response. Glycosylation Status Glycosylation Type Information currently not available with us. Technique(s) used for Glycosylation Detection ProQ staining Literatures Reference(s) 1) Zeituni, A.E., McCaig, W., Scisci, E., Thanassi, D.G. and Cutler, C.W. (2010) The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs. J Bacteriol, 192, 4103-4110. [PubMed: 20562309] Year of Identification 2010