| ProGlyProt ID | BU228 | | Organism Information | | Organism Name | Mycobacterium vaccae | | Domain | Bacteria | | Classification | Family: Mycobacteriaceae
Suborder: Corynebacterineae
Order: Actinomycetales
Subclass: Actinobacteridae
Class: Actinobacteria
Division or phylum: "Actinobacteria" | | Taxonomic ID (NCBI) | | | Genome Sequence (s) | | GeneBank | | | EMBL | | | Gene Information | | Gene Name | | | NCBI Gene ID | | | Protein Information | | Protein Name | PS4A (water soluble protein- polysaccharide) | | UniProtKB/SwissProt ID | | | NCBI RefSeq | | | EMBL-CDS | | | UniProtKB Sequence | | | Sequence length | | | Subcellular Location | Intracellular | | Function | PS4A significantly decreased tumor incidence in vivo, produced activation of murine peritoneal macrophages. However, the antineoplastic activity was only attributable to the high molecular weight fraction of the protein-polysaccharia complex. The low molecular weight fraction had no antineoplastic activity in viva despite stimulation of TNF-a production in vitro. In vitro experiments also demonstrated that although all PS4A components significantly increased TNF-α production by macrophages, the | | Glycosylation Status | | Glycosylation Type | | | Technique(s) used for Glycosylation Detection | | | Literatures | | Reference(s) | 1) Tian, X.X., Li, A., Farrugia, I.V., Mo, X., Crich, D. and Groves, M.J. (2000) Isolation and identification of poly-alpha-(1-->4)-linked 3-O-methyl-D-mannopyranose from a hot-water extract of Mycobacterium vaccae. Carbohydr Res, 324, 38-44. [PubMed: 10723610]
2) Tian, X.X., Li, A., Zhou, W., Farrugia, I.V. and Groves, M.J. (1999) Isolation and biological activities of an antineoplastic protein-polysaccharide complex (PS4A) obtained from Mycobacterium vaccae. Anticancer Res, 19, 237-243. [PubMed: 10226548] | | Year of Identification | 2000 |
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