| ProGlyProt ID | BU227 | | Organism Information | | Organism Name | Mycobacterium tuberculosis H37Rv | | Domain | Bacteria | | Classification | Family: Mycobacteriaceae
Suborder: Corynebacterineae
Order: Actinomycetales
Subclass: Actinobacteridae
Class: Actinobacteria
Division or phylum: "Actinobacteria" | | Taxonomic ID (NCBI) | | | Genome Sequence (s) | | GeneBank | | | EMBL | | | Gene Information | | Gene Name | | | NCBI Gene ID | | | Protein Information | | Protein Name | 38 kDa antigen | | UniProtKB/SwissProt ID | | | NCBI RefSeq | | | EMBL-CDS | | | UniProtKB Sequence | | | Sequence length | | | Subcellular Location | | | Function | It is a disease associated species-specific antigen that displays high immunogenicity at B- and T-cell levels. Two epitopes namely a carbohydrate-dependent and a carbohydrate-independent, have been identified on this antigen using TB71 and TB72 monoclonal antibodies. Owing to its highly specific recognition of patients with lung tuberculosis and its nonreactivity with normal sera, it has a great potential for the serological diagnosis of tuberculosis. | | Glycosylation Status | | Glycosylation Type | Information currently not available with us. | | Technique(s) used for Glycosylation Detection | Schiff's reagent staining, peroxidase-conjugated concanavalin A (ConA)-binding | | Literatures | | Reference(s) | 1) Rosales-Borjas, D.M., Zambrano-Villa, S., Elinos, M., Kasem, H., Osuna, A., Mancilla, R. and Ortiz-Ortiz, L. (1998) Rapid screening test for tuberculosis using a 38-kDa antigen from Mycobacterium tuberculosis. J Clin Lab Anal, 12, 126-129. [PubMed: 9524298]
2) Espitia, C. and Mancilla, R. (1989) Identification, isolation and partial characterization of Mycobacterium tuberculosis glycoprotein antigens. Clin Exp Immunol, 77, 378-383. [PubMed: 2478323] | | Year of Identification | 1989 |
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