ProGlyProt ID BU227 Organism Information Organism Name Mycobacterium tuberculosis H37Rv Domain Bacteria Classification Family: Mycobacteriaceae Suborder: Corynebacterineae Order: Actinomycetales Subclass: Actinobacteridae Class: Actinobacteria Division or phylum: "Actinobacteria" Taxonomic ID (NCBI) Genome Sequence (s) GeneBank EMBL Gene Information Gene Name NCBI Gene ID Protein Information Protein Name 38 kDa antigen UniProtKB/SwissProt ID NCBI RefSeq EMBL-CDS UniProtKB Sequence Sequence length Subcellular Location Function It is a disease associated species-specific antigen that displays high immunogenicity at B- and T-cell levels. Two epitopes namely a carbohydrate-dependent and a carbohydrate-independent, have been identified on this antigen using TB71 and TB72 monoclonal antibodies. Owing to its highly specific recognition of patients with lung tuberculosis and its nonreactivity with normal sera, it has a great potential for the serological diagnosis of tuberculosis. Glycosylation Status Glycosylation Type Information currently not available with us. Technique(s) used for Glycosylation Detection Schiff's reagent staining, peroxidase-conjugated concanavalin A (ConA)-binding Literatures Reference(s) 1) Rosales-Borjas, D.M., Zambrano-Villa, S., Elinos, M., Kasem, H., Osuna, A., Mancilla, R. and Ortiz-Ortiz, L. (1998) Rapid screening test for tuberculosis using a 38-kDa antigen from Mycobacterium tuberculosis. J Clin Lab Anal, 12, 126-129. [PubMed: 9524298] 2) Espitia, C. and Mancilla, R. (1989) Identification, isolation and partial characterization of Mycobacterium tuberculosis glycoprotein antigens. Clin Exp Immunol, 77, 378-383. [PubMed: 2478323] Year of Identification 1989