ProGlyProt ID BU180 Organism Information Organism Name Mycobacterium bovis BCG strain 1173P2 Domain Bacteria Classification Family: Mycobacteriaceae Suborder: Corynebacterineae Order: Actinomycetales Subclass: Actinobacteridae Class: Actinobacteria Division or phylum: "Actinobacteria" Taxonomic ID (NCBI) 410289 Genome Sequence (s) GeneBank AM408590.1 EMBL AM408590 Gene Information Gene Name hbhA (BCG_0516) NCBI Gene ID 4696475 Protein Information Protein Name HBHA (heparin-binding hemagglutinin) UniProtKB/SwissProt ID A1KFU9 NCBI RefSeq YP_976614.1 EMBL-CDS CAL70501.1 UniProtKB Sequence >sp|A1KFU9|HBHA_MYCBP Heparin-binding hemagglutinin OS=Mycobacterium bovis (strain BCG / Pasteur 1173P2) GN=hbhA PE=1 SV=1 MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKL QEDLPEQLTELREKFTAEELRKAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSA RAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPKKAAPAKKAAPAKKAAPAKK AAAKKAPAKKAAAKKVTQK Sequence length 199 AA Subcellular Location Surface Function Mycobacterial heparin-binding hemagglutinin (HBHA) functions as an adhesin for epithelial cells and induces bacterial auto-aggregation.Glycosylation of HBHA may protect the protein from proteolytic degradation (crucial for its stabilty), important for HBHA-mediated hemagglutination and for certain immunologic properties of the protein. Glycosylation Status Glycosylation Type Information currently not available with us. Technique(s) used for Glycosylation Detection Mass shift detected on SDS-polyacrylamide gel and carbohydrate content determination by GC/ mass spectrophotometry analysis Literatures Reference(s) 1) Menozzi, F.D., Bischoff, R., Fort, E., Brennan, M.J. and Locht, C. (1998) Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin. Proc Natl Acad Sci U S A, 95, 12625-12630. [PubMed: 9770536] Year of Identification 1998