ProGlyProt ID BU163 Organism Information Organism Name Escherichia coli (ETEC) strain H10407 Domain Bacteria Classification Family: Enterobacteriaceae Order: "Enterobacteriales" Class: Gammaproteobacteria Division or phylum: "Proteobacteria" Taxonomic ID (NCBI) 316401 Genome Sequence (s) GeneBank FN649418 EMBL FN649418 Gene Information Gene Name etpA (ETEC_p948_0110) NCBI Gene ID Protein Information Protein Name EtpA Adhesin UniProtKB/SwissProt ID E3PP99 NCBI RefSeq EMBL-CDS CBJ04458.1 UniProtKB Sequence >tr|E3PP99|E3PP99_ECOH1 Two-partner secreted adhesin EtpA OS=Escherichia coli O78:H11 (strain H10407 / ETEC) GN=etpA PE=4 SV=1 MNRIYKLKFDKRRNELVVVSEITTGVGNAKATGSVEGEKSPRRGVRAMALSLLSGMMIMA HPAMSANLPTGGQIVAGSGSIQTPSGNQMNIHQNSQNMVANWNSFDIGKGNTVQFDQPSS SAVALNRVVGGGESQIMGNLKANGQVFLVNPNGVLFGEGASVSTSGFVASTRDIKNDDFM NRRYTFSGGQKAGAAIVNQGELTTNAGGYIVLAADRVSNSGTIRTPGGKTVLAASERITL QLDNGGLMSVQVTGDVVNALVENRGLVSARDGQVYLTALGRGMLMNTVLNVSGVVEASGM HRQDGNIVLDGGDSGVVHLSGTLQADNASGQGGKVVVQGKNILLDKGSNITATGGQGGGE VYVGGGWQGKDSNIRNADKVVMQGGARIDVSATQQGNGGTAVLWSDSYTNFHGQISAKGG ETGGNGGRVETSSHGNLQAFGTVSASAKKGKAGNWLLDSADITIVNGSNVSKTETTQSPP HTQFAPTAAGSAVSNTSINNRLNNGTSVTILTHRTRTGTAQGGNITVNAAINKSNGSDVN LTLQAGGNITVNNSITSTEGKLNVNLSGARTSNGSITISNNANITTNGGDITVGTTNTSN RVNISINNTTLNASNGNIQLTGTGTDSGILFAGNNRLTASNIALTGNSTSGNAINLTGTA TLNATNNITLTGSSTSGNAINLKGNNTLTASNITLTGESTSGNAINLTDTTGTTTLNATN NITMQGTRVQIKHSNITAGNFALNATVAGSEISNTTLTATNNINLAAKTNSASSGVYLKD ARITSTNGSITANGTATANGKATHLDGNVTLNASNGRIKLTGNGHGSASGILFAGNNRLT ASNIALTGNSTSGNAINLTGTATLNATNDITLTGSSTSGNAINLTGTATLNATNNITLTG SSTSGNAINLKGNNTLTASNITLTGESTSGNAINLTDTTGTTTLNATNNITMQGTRVQIK HSNITAGNFALNATVAGSEISNTTLTATNNINLAAKTNSASSGVYLKDARITSTNGSITA NGTATANGKATHLDGNVTLNASNGRIKLTGNGHGSASGILFAGNNRLTASNIALTGNSTS GNAINLTGTATLNATNDITLTGSSTSGNAINLTGTATLNATNNITLTGSSTSGNAINLKG NNTLTASNITLTGESTSGNAINLTDTTGTTTLNATNNITMQGTRVQIKHSNITAGNFALN ATVAGSEISNTTLTATNNINLAAKTNSASSGVYLKDARITSTNGSITANGTATANGKATH LDGNVTLNASNGRIKLTGNGHGSASGILFAGNNRLTASNIALTGNSTSGNAINLTGTATL NATNDITLTGSSTSGNAINLTGTATLNATNNITLTGSSTSGNAINLKGNNTLTASNITLT GESTSGNAINLTDTTGTTTLNATNNITMQGTRVQIKHSNITAGNFALNATVAGSEISNTT LTATNNINLAAKTNSASSGVYLKDARITSTNGSITANGTAPANDNATYLDGNVTLNASNG SIKLTGNGNGSTSGILFAGNNTLTASNITLTGNSEVYWQ Sequence length 1539 AA Subcellular Location Secreted Function EtpA adhesin has a role in bridging flagella and host cells. Colonization by ETEC H10407 is prevented by immunizing mice with recombinant, full length EtpA glycoprotein. Glycosylation Status Glycosylation Type Information currently not available with us. Technique(s) used for Glycosylation Detection DIG (digoxigenin) Glycan detection Literatures Reference(s) 1) Roy, K., Hamilton, D., Ostmann, M.M. and Fleckenstein, J.M. (2009) Vaccination with EtpA glycoprotein or flagellin protects against colonization with enterotoxigenic Escherichia coli in a murine model. Vaccine, 27, 4601-4608. [PubMed: 19523914] Year of Identification 2009