TBLASTN 2.2.20 [Feb-08-2009]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment:
Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schäffer, and Yi-Kuo Yu (2005) "Protein database
searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= g6.t1
(481 letters)
Database: taget.fasta
3914 sequences; 7,230,561 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
lcl|NM_005163.2_cdsid_NP_005154.2 [gene=AKT1] [protein=RAC-alpha... 836 0.0
lcl|NM_181690.2_cdsid_NP_859029.1 [gene=AKT3] [protein=RAC-gamma... 758 0.0
lcl|NM_212535.2_cdsid_NP_997700.1 [gene=PRKCB] [protein=protein ... 337 2e-93
lcl|NM_001143677.1_cdsid_NP_001137149.1 [gene=SGK1] [protein=ser... 336 4e-93
lcl|NM_006255.3_cdsid_NP_006246.2 [gene=PRKCH] [protein=protein ... 331 1e-91
lcl|NM_002737.2_cdsid_NP_002728.1 [gene=PRKCA] [protein=protein ... 323 3e-89
lcl|NM_002744.4_cdsid_NP_002735.3 [gene=PRKCZ] [protein=protein ... 315 8e-87
lcl|NM_004586.2_cdsid_NP_004577.1 [gene=RPS6KA3] [protein=riboso... 291 2e-79
lcl|NM_003942.2_cdsid_NP_003933.1 [gene=RPS6KA4] [protein=riboso... 269 8e-73
lcl|NM_001261816.1_cdsid_NP_001248745.1 [gene=PDPK1] [protein=3-... 205 1e-53
lcl|NM_004409.3_cdsid_NP_004400.4 [gene=DMPK] [protein=myotonin-... 182 1e-46
lcl|NM_007271.2_cdsid_NP_009202.1 [gene=STK38] [protein=serine/t... 175 1e-44
lcl|NM_025164.3_cdsid_NP_079440.2 [gene=SIK3] [protein=serine/th... 155 1e-38
lcl|NM_033126.1_cdsid_NP_149117.1 [gene=PSKH2] [protein=serine/t... 155 2e-38
lcl|NM_032430.1_cdsid_NP_115806.1 [gene=BRSK1] [protein=serine/t... 152 1e-37
lcl|NM_004734.4_cdsid_NP_004725.1 [gene=DCLK1] [protein=serine/t... 152 1e-37
lcl|NM_003957.3_cdsid_NP_003948.2 [gene=BRSK2] [protein=serine/t... 148 2e-36
lcl|NM_014586.1_cdsid_NP_055401.1 [gene=HUNK] [protein=hormonall... 145 2e-35
lcl|NM_004073.2_cdsid_NP_004064.2 [gene=PLK3] [protein=serine/th... 144 4e-35
lcl|NM_172226.2_cdsid_NP_757380.1 [gene=CAMKK2] [protein=calcium... 135 2e-32
lcl|NM_172084.2_cdsid_NP_742081.1 [gene=CAMK2B] [protein=calcium... 133 5e-32
lcl|NM_002578.3_cdsid_NP_002569.1 [gene=PAK3] [protein=serine/th... 132 1e-31
lcl|NM_001128629.2_cdsid_NP_001122101.1 [gene=PAK6] [protein=ser... 129 8e-31
lcl|NM_016457.4_cdsid_NP_057541.2 [gene=PRKD2] [protein=serine/t... 126 8e-30
lcl|NM_053025.3_cdsid_NP_444253.3 [gene=MYLK] [protein=myosin li... 125 1e-29
lcl|NM_004759.4_cdsid_NP_004750.1 [gene=MAPKAPK2] [protein=MAP k... 123 5e-29
lcl|NM_004938.2_cdsid_NP_004929.2 [gene=DAPK1] [protein=death-as... 123 6e-29
lcl|NM_002401.3_cdsid_NP_002392.2 [gene=MAP3K3] [protein=mitogen... 114 4e-26
lcl|NM_005876.4_cdsid_NP_005867.3 [gene=SPEG] [protein=striated ... 112 1e-25
lcl|NM_004721.4_cdsid_NP_004712.1 [gene=MAP3K13] [protein=mitoge... 110 6e-25
lcl|NM_133494.2_cdsid_NP_598001.1 [gene=NEK7] [protein=serine/th... 109 1e-24
lcl|NM_001042600.1_cdsid_NP_001036065.1 [gene=MAP4K1] [protein=m... 107 5e-24
lcl|NM_133378.4_cdsid_NP_596869.4 [gene=TTN] [protein=titin isof... 103 7e-23
lcl|NM_006875.3_cdsid_NP_006866.2 [gene=PIM2] [protein=serine/th... 100 6e-22
lcl|NM_005109.2_cdsid_NP_005100.1 [gene=OXSR1] [protein=serine/t... 100 7e-22
lcl|NM_000455.4_cdsid_NP_000446.1 [gene=STK11] [protein=serine/t... 100 9e-22
lcl|NM_017433.4_cdsid_NP_059129.3 [gene=MYO3A] [protein=myosin-I... 96 9e-21
lcl|NM_004203.4_cdsid_NP_004194.3 [gene=PKMYT1] [protein=membran... 96 1e-20
lcl|NM_002446.3_cdsid_NP_002437.2 [gene=MAP3K10] [protein=mitoge... 94 3e-20
lcl|NM_032037.3_cdsid_NP_114426.1 [gene=TSSK6] [protein=testis-s... 93 9e-20
lcl|NM_021643.3_cdsid_NP_067675.1 [gene=TRIB2] [protein=tribbles... 92 1e-19
lcl|NM_002314.3_cdsid_NP_002305.1 [gene=LIMK1] [protein=LIM doma... 92 2e-19
lcl|NM_002596.3_cdsid_NP_002587.2 [gene=CDK18] [protein=cyclin-d... 89 1e-18
lcl|NM_000215.3_cdsid_NP_000206.2 [gene=JAK3] [protein=tyrosine-... 89 2e-18
lcl|NM_198465.2_cdsid_NP_940867.2 [gene=NRK] [protein=nik-relate... 86 1e-17
lcl|NM_012395.2_cdsid_NP_036527.1 [gene=CDK14] [protein=cyclin-d... 84 3e-17
lcl|NM_145331.2_cdsid_NP_663304.1 [gene=MAP3K7] [protein=mitogen... 84 5e-17
lcl|NM_001256196.1_cdsid_NP_001243125.1 [gene=ARAF] [protein=ser... 83 8e-17
lcl|NM_032387.4_cdsid_NP_115763.2 [gene=WNK4] [protein=serine/th... 82 2e-16
lcl|NM_006648.3_cdsid_NP_006639.3 [gene=WNK2] [protein=serine/th... 81 3e-16
lcl|NM_020975.4_cdsid_NP_066124.1 [gene=RET] [protein=proto-onco... 79 1e-15
lcl|NM_005546.3_cdsid_NP_005537.3 [gene=ITK] [protein=tyrosine-p... 79 1e-15
lcl|NM_004972.3_cdsid_NP_004963.1 [gene=JAK2] [protein=tyrosine-... 74 5e-14
lcl|NM_002031.2_cdsid_NP_002022.1 [gene=FRK] [protein=tyrosine-p... 73 8e-14
lcl|NM_024652.3_cdsid_NP_078928.3 [gene=LRRK1] [protein=leucine-... 72 2e-13
lcl|NM_139355.2_cdsid_NP_647612.1 [gene=MATK] [protein=megakaryo... 71 3e-13
lcl|NM_000142.4_cdsid_NP_000133.1 [gene=FGFR3] [protein=fibrobla... 70 8e-13
lcl|NM_000141.4_cdsid_NP_000132.3 [gene=FGFR2] [protein=fibrobla... 69 2e-12
lcl|NM_005781.4_cdsid_NP_005772.3 [gene=TNK2] [protein=activated... 68 3e-12
lcl|NM_002747.3_cdsid_NP_002738.2 [gene=MAPK4] [protein=mitogen-... 68 4e-12
lcl|NM_001174066.1_cdsid_NP_001167537.1 [gene=FGFR1] [protein=fi... 68 4e-12
lcl|NM_004444.4_cdsid_NP_004435.3 [gene=EPHB4] [protein=ephrin t... 67 5e-12
lcl|NM_001013703.2_cdsid_NP_001013725.2 [gene=EIF2AK4] [protein=... 67 5e-12
lcl|NM_001012338.2_cdsid_NP_001012338.1 [gene=NTRK3] [protein=NT... 67 6e-12
lcl|NM_004438.3_cdsid_NP_004429.1 [gene=EPHA4] [protein=ephrin t... 65 2e-11
lcl|NM_020526.3_cdsid_NP_065387.1 [gene=EPHA8] [protein=ephrin t... 64 4e-11
lcl|NM_173598.4_cdsid_NP_775869.3 [gene=KSR2] [protein=kinase su... 63 8e-11
lcl|NM_004071.3_cdsid_NP_004062.2 [gene=CLK1] [protein=dual spec... 63 9e-11
lcl|NM_022963.2_cdsid_NP_075252.2 [gene=FGFR4] [protein=fibrobla... 62 1e-10
lcl|NM_005204.3_cdsid_NP_005195.2 [gene=MAP3K8] [protein=mitogen... 62 2e-10
lcl|NM_005417.3_cdsid_NP_005408.1 [gene=SRC] [protein=proto-onco... 62 2e-10
lcl|NM_006871.3_cdsid_NP_006862.2 [gene=RIPK3] [protein=receptor... 62 2e-10
lcl|NM_002019.4_cdsid_NP_002010.2 [gene=FLT1] [protein=vascular ... 62 2e-10
lcl|NM_004431.3_cdsid_NP_004422.2 [gene=EPHA2] [protein=ephrin t... 62 3e-10
lcl|NM_001042599.1_cdsid_NP_001036064.1 [gene=ERBB4] [protein=re... 61 4e-10
lcl|NM_004439.5_cdsid_NP_004430.4 [gene=EPHA5] [protein=ephrin t... 61 4e-10
lcl|NM_002447.2_cdsid_NP_002438.2 [gene=MST1R] [protein=macropha... 60 7e-10
lcl|NM_001174168.1_cdsid_NP_001167639.1 [gene=SYK] [protein=tyro... 60 7e-10
lcl|NM_001160367.1_cdsid_NP_001153839.1 [gene=CDK10] [protein=cy... 60 8e-10
lcl|NM_014238.1_cdsid_NP_055053.1 [gene=KSR1] [protein=kinase su... 60 9e-10
lcl|NM_002020.4_cdsid_NP_002011.2 [gene=FLT4] [protein=vascular ... 59 1e-09
lcl|NM_000208.2_cdsid_NP_000199.2 [gene=INSR] [protein=insulin r... 59 1e-09
lcl|NM_002529.3_cdsid_NP_002520.2 [gene=NTRK1] [protein=high aff... 58 3e-09
lcl|NM_014215.2_cdsid_NP_055030.1 [gene=INSRR] [protein=insulin ... 58 3e-09
lcl|NM_002253.2_cdsid_NP_002244.1 [gene=KDR] [protein=vascular e... 58 3e-09
lcl|NM_012119.4_cdsid_NP_036251.2 [gene=CDK20] [protein=cyclin-d... 57 5e-09
lcl|NM_005372.1_cdsid_NP_005363.1 [gene=MOS] [protein=proto-onco... 57 5e-09
lcl|NM_020639.2_cdsid_NP_065690.2 [gene=RIPK4] [protein=receptor... 57 7e-09
lcl|NM_015076.3_cdsid_NP_055891.1 [gene=CDK19] [protein=cyclin-d... 57 9e-09
lcl|NM_000875.3_cdsid_NP_000866.1 [gene=IGF1R] [protein=insulin-... 57 9e-09
lcl|NM_013994.2_cdsid_NP_054700.2 [gene=DDR1] [protein=epithelia... 55 2e-08
lcl|NM_004560.3_cdsid_NP_004551.2 [gene=ROR2] [protein=tyrosine-... 52 2e-07
lcl|NM_001024847.2_cdsid_NP_001020018.1 [gene=TGFBR2] [protein=T... 52 2e-07
lcl|NM_005248.2_cdsid_NP_005239.1 [gene=FGR] [protein=tyrosine-p... 52 3e-07
lcl|NM_005211.3_cdsid_NP_005202.2 [gene=CSF1R] [protein=macropha... 50 7e-07
lcl|NM_145259.2_cdsid_NP_660302.2 [gene=ACVR1C] [protein=activin... 50 7e-07
lcl|NM_032538.1_cdsid_NP_115927.1 [gene=TTBK1] [protein=tau-tubu... 50 8e-07
lcl|NM_004119.2_cdsid_NP_004110.2 [gene=FLT3] [protein=receptor-... 49 1e-06
lcl|NM_005255.2_cdsid_NP_005246.2 [gene=GAK] [protein=cyclin-G-a... 49 2e-06
lcl|NM_001025243.1_cdsid_NP_001020414.1 [gene=IRAK1] [protein=in... 49 2e-06
>lcl|NM_005163.2_cdsid_NP_005154.2 [gene=AKT1] [protein=RAC-alpha
serine/threonine-protein kinase]
[protein_id=NP_005154.2] [location=555..1997]
Length = 1443
Score = 836 bits (2160), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 391/479 (81%), Positives = 443/479 (92%), Gaps = 1/479 (0%)
Frame = +1
Query: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC 60
M++V+++KEGWLHKRGEYIKTWRPRYFLLK+DG+FIGYKERP+ DQ PLNNFSVA+C
Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 180
Query: 61 QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM 120
QLMKTERPRPNTF+IRCLQWTTVIERTFHV++P+EREEW AIQ VA+ LK++ E+ M
Sbjct: 181 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQE--EEEM 354
Query: 121 DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM 180
D++ GSPSD+S EEMEV+++K + +VTMN+F+YLKLLGKGTFGKVILV+EKATGRYYAM
Sbjct: 355 DFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 534
Query: 181 KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH 240
KIL+KEVI+AKDEVAHT+TE+RVLQN+RHPFLTALKY+FQTHDRLCFVMEYANGGELFFH
Sbjct: 535 KILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 714
Query: 241 LSRERVFTEERARFYGAEIVSALEYLHS-RDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
LSRERVF+E+RARFYGAEIVSAL+YLHS ++VVYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 715 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 894
Query: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
GI DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 895 GIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 1074
Query: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
ELILMEEIRFPRTL PEAKSLL+GLLKKDPKQRLGGG DAKE+M+HRFF I WQ V +
Sbjct: 1075ELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 1254
Query: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSAS 478
KKL PPFKPQVTSE DTRYFD+EFTAQ ITITPPD+ DS+ ++ ++R HFPQFSYSAS
Sbjct: 1255KKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 1431
>lcl|NM_181690.2_cdsid_NP_859029.1 [gene=AKT3] [protein=RAC-gamma
serine/threonine-protein kinase isoform 2]
[protein_id=NP_859029.1] [location=113..1510]
Length = 1398
Score = 758 bits (1958), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 358/456 (78%), Positives = 409/456 (89%), Gaps = 1/456 (0%)
Frame = +1
Query: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLP-PLNNFSVAE 59
M++V+++KEGW+ KRGEYIK WRPRYFLLK+DGSFIGYKE+P+ D LP PLNNFSVA+
Sbjct: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQ--DVDLPYPLNNFSVAK 174
Query: 60 CQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDP 119
CQLMKTERP+PNTF+IRCLQWTTVIERTFHVD+P+EREEW AIQ VA+ L+++ E+
Sbjct: 175 CQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQE--EER 348
Query: 120 MDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYA 179
M+ S D+ EEM+ + + + K TMNDFDYLKLLGKGTFGKVILVREKA+G+YYA
Sbjct: 349 MNCSPTSQIDNIGEEEMDASTTHHKRK-TMNDFDYLKLLGKGTFGKVILVREKASGKYYA 525
Query: 180 MKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFF 239
MKIL+KEVIIAKDEVAHT+TESRVL+NTRHPFLT+LKY+FQT DRLCFVMEY NGGELFF
Sbjct: 526 MKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 705
Query: 240 HLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
HLSRERVF+E+R RFYGAEIVSAL+YLHS +VYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 706 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 885
Query: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
GI+D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 886 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 1065
Query: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
ELILME+I+FPRTLS +AKSLL+GLL KDP +RLGGGP DAKE+M H FF +NWQDV
Sbjct: 1066ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 1245
Query: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDR 455
KKL+PPFKPQVTSE DTRYFD+EFTAQ+ITITPP++
Sbjct: 1246KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEK 1353
>lcl|NM_212535.2_cdsid_NP_997700.1 [gene=PRKCB] [protein=protein
kinase C beta type isoform 1] [protein_id=NP_997700.1]
[location=198..2213]
Length = 2016
Score = 337 bits (864), Expect = 2e-93, Method: Compositional matrix adjust.
Identities = 160/351 (45%), Positives = 233/351 (66%), Gaps = 1/351 (0%)
Frame = +1
Query: 127 PSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKE 186
P + +T + + R ++ + DF++L +LGKG+FGKV+L K T YA+KIL+K+
Sbjct: 949 PEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD 1128
Query: 187 VIIAKDEVAHTVTESRVLQ-NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRER 245
V+I D+V T+ E RVL + PFLT L FQT DRL FVMEY NGG+L +H+ +
Sbjct: 1129 VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG 1308
Query: 246 VFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGA 305
F E A FY AEI L +L S+ ++YRD+KL+N+MLD +GHIKI DFG+CKE I DG
Sbjct: 1309 RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV 1488
Query: 306 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILME 365
T KTFCGTP+Y+APE++ YG++VDWW GV++YEM+ G+ PF +D + LF+ I+
Sbjct: 1489 TTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 1668
Query: 366 EIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPP 425
+ +P+++S EA ++ GL+ K P +RLG GP +++ EH FF I+W+ + +K++ PP
Sbjct: 1669 NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 1848
Query: 426 FKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYS 476
+KP+ + DT FD EFT Q + +TP D+ L ++ LDQ F FSY+
Sbjct: 1849 YKPKARDKRDTSNFDKEFTRQPVELTPTDK---LFIMNLDQ-NEFAGFSYT 1989
>lcl|NM_001143677.1_cdsid_NP_001137149.1 [gene=SGK1]
[protein=serine/threonine-protein kinase Sgk1 isoform 3]
[protein_id=NP_001137149.1] [location=51..1430]
Length = 1380
Score = 336 bits (862), Expect = 4e-93, Method: Compositional matrix adjust.
Identities = 157/300 (52%), Positives = 210/300 (70%), Gaps = 1/300 (0%)
Frame = +1
Query: 150 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTR 208
+DF +LK++GKG+FGKV+L R KA +YA+K+L+K+ I+ K E H ++E VL +N +
Sbjct: 370 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 549
Query: 209 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 268
HPFL L ++FQT D+L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS
Sbjct: 550 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 729
Query: 269 RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYG 328
++VYRD+K EN++LD GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y
Sbjct: 730 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 909
Query: 329 RAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKD 388
R VDWW LG V+YEM+ G PFY+++ +++ IL + ++ ++ A+ LL GLL+KD
Sbjct: 910 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKD 1089
Query: 389 PKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI 448
+RLG D E+ H FF INW D++ KK+ PPF P V+ D R+FD EFT + +
Sbjct: 1090RTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 1266
>lcl|NM_006255.3_cdsid_NP_006246.2 [gene=PRKCH] [protein=protein
kinase C eta type] [protein_id=NP_006246.2]
[location=306..2357]
Length = 2052
Score = 331 bits (849), Expect = 1e-91, Method: Compositional matrix adjust.
Identities = 156/349 (44%), Positives = 233/349 (66%), Gaps = 2/349 (0%)
Frame = +1
Query: 131 STTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIA 190
S+ E + V+ + ++ +++F+++++LGKG+FGKV+L R K TG YA+K+L+K+VI+
Sbjct: 1003 SSKEGNGIGVNSSN-RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQ 1179
Query: 191 KDEVAHTVTESRVLQNTR-HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTE 249
D+V T+TE R+L R HPFLT L FQT DRL FVME+ NGG+L FH+ + R F E
Sbjct: 1180 DDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDE 1359
Query: 250 ERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKT 309
RARFY AEI+SAL +LH + ++YRD+KL+N++LD +GH K+ DFG+CKEGI +G T T
Sbjct: 1360 ARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTAT 1539
Query: 310 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRF 369
FCGTP+Y+APE+L++ YG AVDWW +GV++YEM+CG PF ++ + LFE IL +E+ +
Sbjct: 1540 FCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVY 1719
Query: 370 PRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKE-VMEHRFFLSINWQDVVQKKLLPPFKP 428
P L +A +L + K+P RLG + ++ H FF I+W + +++ PPF+P
Sbjct: 1720 PTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 1899
Query: 429 QVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSA 477
++ S D FD +F + +TP D G L + + F FSY +
Sbjct: 1900 RIKSREDVSNFDPDFIKEEPVLTPIDE----GHLPMINQDEFRNFSYVS 2034
>lcl|NM_002737.2_cdsid_NP_002728.1 [gene=PRKCA] [protein=protein
kinase C alpha type] [protein_id=NP_002728.1]
[location=45..2063]
Length = 2019
Score = 323 bits (829), Expect = 3e-89, Method: Compositional matrix adjust.
Identities = 157/331 (47%), Positives = 222/331 (67%), Gaps = 1/331 (0%)
Frame = +1
Query: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 205
+V + DF++L +LGKG+FGKV+L K T YA+KIL+K+V+I D+V T+ E RVL
Sbjct: 997 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 1176
Query: 206 N-TRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 264
+ PFLT L FQT DRL FVMEY NGG+L +H+ + F E +A FY AEI L
Sbjct: 1177 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 1356
Query: 265 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 324
+LH R ++YRD+KL+N+MLD +GHIKI DFG+CKE + DG T +TFCGTP+Y+APE++
Sbjct: 1357 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAY 1536
Query: 325 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 384
YG++VDWW GV++YEM+ G+ PF +D + LF+ I+ + +P++LS EA S+ GL
Sbjct: 1537 QPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGL 1716
Query: 385 LKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT 444
+ K P +RLG GP ++V EH FF I+W+ + +++ PPFKP+V + FD FT
Sbjct: 1717 MTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFT 1893
Query: 445 AQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
+TPPD+ L + +DQ + F FSY
Sbjct: 1894 RGQPVLTPPDQ---LVIANIDQ-SDFEGFSY 1974
>lcl|NM_002744.4_cdsid_NP_002735.3 [gene=PRKCZ] [protein=protein
kinase C zeta type isoform 1] [protein_id=NP_002735.3]
[location=162..1940]
Length = 1779
Score = 315 bits (808), Expect = 8e-87, Method: Compositional matrix adjust.
Identities = 151/322 (46%), Positives = 214/322 (66%), Gaps = 9/322 (2%)
Frame = +1
Query: 142 KARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTES 201
K + + DFD ++++G+G++ KV+LVR K + YAMK+++KE++ +++ TE
Sbjct: 724 KISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEK 903
Query: 202 RVL-QNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIV 260
V Q + +PFL L FQT RL V+EY NGG+L FH+ R+R EE ARFY AEI
Sbjct: 904 HVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEIC 1083
Query: 261 SALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPE 320
AL +LH R ++YRD+KL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE
Sbjct: 1084 IALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPE 1263
Query: 321 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HERLFELILMEEIRFPRTL 373
+L +YG +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR L
Sbjct: 1264 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFL 1443
Query: 374 SPEAKSLLAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSINWQDVVQKKLLPPFKPQVTS 432
S +A +L G L KDPK+RLG P ++ H FF SI+W + +K+ LPPF+PQ+T
Sbjct: 1444 SVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITD 1623
Query: 433 EVDTRYFDDEFTAQSITITPPD 454
+ FD +FT++ + +TP D
Sbjct: 1624 DYGLDNFDTQFTSEPVQLTPDD 1689
>lcl|NM_004586.2_cdsid_NP_004577.1 [gene=RPS6KA3] [protein=ribosomal
protein S6 kinase alpha-3] [protein_id=NP_004577.1]
[location=1..2223]
Length = 2223
Score = 291 bits (744), Expect = 2e-79, Method: Compositional matrix adjust.
Identities = 147/348 (42%), Positives = 216/348 (62%), Gaps = 11/348 (3%)
Frame = +1
Query: 116 GEDPMDYKCGSPSDSSTTEEMEVA-------VSKARAKVTMNDFDYLKLLGKGTFGKVIL 168
G+ MD G + TEE+ + V + K + F+ LK+LG+G+FGKV L
Sbjct: 73 GQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFL 252
Query: 169 VREKATG----RYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDR 224
V+ K +G + YAMK+L+K + +D V T E +L HPF+ L YAFQT +
Sbjct: 253 VK-KISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGK 426
Query: 225 LCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD 284
L ++++ GG+LF LS+E +FTEE +FY AE+ AL++LHS ++YRD+K EN++LD
Sbjct: 427 LYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD 606
Query: 285 KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 344
++GHIK+TDFGL KE I +FCGT EY+APEV+ + ++ DWW GV+M+EM+
Sbjct: 607 EEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEML 786
Query: 345 CGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
G LPF +D + +IL ++ P+ LSPEA+SLL L K++P RLG GP +E+
Sbjct: 787 TGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIK 966
Query: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITP 452
H FF +I+W + ++++ PPFKP DT YFD EFTA++ +P
Sbjct: 967 RHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSP 1110
Score = 116 bits (291), Expect = 7e-27, Method: Compositional matrix adjust.
Identities = 83/276 (30%), Positives = 138/276 (50%), Gaps = 11/276 (3%)
Frame = +1
Query: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
+G G++ KAT +A+KI+ K +E+ +L+ +HP + LK
Sbjct: 1282 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI------EILLRYGQHPNIITLKD 1443
Query: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
+ + V E GGEL + R++ F+E A I +EYLH++ VV+RD+K
Sbjct: 1444 VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK 1623
Query: 278 LENLM-LDKDGH---IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 333
N++ +D+ G+ I+I DFG K+ ++ + T C T ++APEVL+ Y A D
Sbjct: 1624 PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI 1803
Query: 334 WGLGVVMYEMMCGRLPFYNQDHERLFELIL-MEEIRFP------RTLSPEAKSLLAGLLK 386
W LGV++Y M+ G PF N + E++ + +F ++S AK L++ +L
Sbjct: 1804 WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH 1983
Query: 387 KDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKL 422
DP QRL A V+ H + ++W + Q +L
Sbjct: 1984 VDPHQRL-----TAALVLRHPWI--VHWDQLPQYQL 2070
>lcl|NM_003942.2_cdsid_NP_003933.1 [gene=RPS6KA4] [protein=ribosomal
protein S6 kinase alpha-4 isoform a]
[protein_id=NP_003933.1] [location=84..2402]
Length = 2319
Score = 269 bits (687), Expect = 8e-73, Method: Compositional matrix adjust.
Identities = 141/330 (42%), Positives = 203/330 (61%), Gaps = 14/330 (4%)
Frame = +1
Query: 129 DSSTTEEM---EVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKA---TGRYYAMKI 182
D S E+ E ++ KV++ +F+ LK+LG G +GKV LVR+ G+ YAMK+
Sbjct: 19 DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 198
Query: 183 LRKEVIIAKDEVA-HTVTESRVLQNTRH-PFLTALKYAFQTHDRLCFVMEYANGGELFFH 240
LRK ++ + + HT TE VL+ R PFL L YAFQT +L +++Y +GGE+F H
Sbjct: 199 LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 378
Query: 241 LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG 300
L + + F E R YG EIV ALE+LH ++YRD+KLEN++LD +GHI +TDFGL KE
Sbjct: 379 LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 558
Query: 301 ISDGATMK-TFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFY----NQD 354
+++ +FCGT EY+APE++ +G+AVDWW LG++++E++ G PF
Sbjct: 559 LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 738
Query: 355 HERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINW 414
+ IL FP + P A+ LL LL KDPK+RLG GP A+EV H FF ++W
Sbjct: 739 QAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDW 918
Query: 415 QDVVQKKLLPPFKPQVTSEVDTRYFDDEFT 444
+ +K+ PF+PQ+ SE+D F +EFT
Sbjct: 919 VALAARKIPAPFRPQIRSELDVGNFAEEFT 1008
Score = 105 bits (262), Expect = 2e-23, Method: Compositional matrix adjust.
Identities = 82/252 (32%), Positives = 128/252 (50%), Gaps = 16/252 (6%)
Frame = +1
Query: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
LG+G+F R++ +G+ +A+KIL + + + V R+ Q+ HP + L
Sbjct: 1249 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL---EANTQREVAALRLCQS--HPNVVNLHE 1413
Query: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSR-DVVYRDI 276
V+E GGEL H+ ++R F+E A +VSA+ ++H VV+RD+
Sbjct: 1414 VHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDL 1593
Query: 277 KLENLMLDKD---GHIKITDFGLCK-EGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVD 332
K EN++ D +KI DFG + S G M+T C T +Y APE+L Y + D
Sbjct: 1594 KPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCD 1773
Query: 333 WWGLGVVMYEMMCGRLPFYNQD----HERLFELIL-MEEIRFP------RTLSPEAKSLL 381
W LGV++Y M+ G++PF + E++ + E RF + +S EAK L+
Sbjct: 1774 LWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELV 1953
Query: 382 AGLLKKDPKQRL 393
GLL DP +RL
Sbjct: 1954 RGLLTVDPAKRL 1989
>lcl|NM_001261816.1_cdsid_NP_001248745.1 [gene=PDPK1]
[protein=3-phosphoinositide-dependent protein kinase 1
isoform 3] [protein_id=NP_001248745.1]
[location=150..1514]
Length = 1365
Score = 205 bits (521), Expect = 1e-53, Method: Compositional matrix adjust.
Identities = 114/300 (38%), Positives = 172/300 (57%), Gaps = 8/300 (2%)
Frame = +1
Query: 151 DFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHP 210
DF + K+LG+G+F V+L RE AT R YA+KIL K II +++V + E V+ HP
Sbjct: 241 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHP 420
Query: 211 FLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRD 270
F L + FQ ++L F + YA GEL ++ + F E RFY AEIVSALEYLH +
Sbjct: 421 FFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKG 600
Query: 271 VVYRDIKLENLMLDKDGHIKITDFGLCK--EGISDGATMKTFCGTPEYLAPEVLEDNDYG 328
+++RD+K EN++L++D HI+ITDFG K S A +F GT +Y++PE+L +
Sbjct: 601 IIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSAC 780
Query: 329 RAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKD 388
++ D W LG ++Y+++ G PF + +F+ I+ E FP P+A+ L+ LL D
Sbjct: 781 KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLD 960
Query: 389 PKQRLGG------GPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDE 442
+RLG GP A H FF S+ W+++ Q+ P++T+ + DDE
Sbjct: 961 ATKRLGCEEMEGYGPLKA-----HPFFESVTWENLHQQT-----PPKLTAYLPAMSEDDE 1110
>lcl|NM_004409.3_cdsid_NP_004400.4 [gene=DMPK]
[protein=myotonin-protein kinase isoform 2]
[protein_id=NP_004400.4] [location=206..2095]
Length = 1890
Score = 182 bits (461), Expect = 1e-46, Method: Compositional matrix adjust.
Identities = 117/318 (36%), Positives = 171/318 (53%), Gaps = 15/318 (4%)
Frame = +1
Query: 138 VAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHT 197
+ V ++ +DF+ LK++G+G F +V +V+ K TG+ YAMKI+ K ++ + EV+
Sbjct: 169 IVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCF 348
Query: 198 VTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFY 255
E VL N ++T L +AFQ + L VMEY GG+L LS+ ER+ E ARFY
Sbjct: 349 REERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERI-PAEMARFY 525
Query: 256 GAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFC-GTP 314
AEIV A++ +H V+RDIK +N++LD+ GHI++ DFG C + +DG GTP
Sbjct: 526 LAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTP 705
Query: 315 EYLAPEVLEDNDYGRA-------VDWWGLGVVMYEMMCGRLPFYNQDHERLFELILM--E 365
+YL+PE+L+ G DWW LGV YEM G+ PFY + I+ E
Sbjct: 706 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 885
Query: 366 EIRFP---RTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKL 422
+ P + EA+ + LL P+ RLG G A + H FF ++W + +
Sbjct: 886 HLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRG--GAGDFRTHPFFFGLDWDGL--RDS 1050
Query: 423 LPPFKPQVTSEVDTRYFD 440
+PPF P DT FD
Sbjct: 1051VPPFTPDFEGATDTCNFD 1104
>lcl|NM_007271.2_cdsid_NP_009202.1 [gene=STK38]
[protein=serine/threonine-protein kinase 38]
[protein_id=NP_009202.1] [location=287..1684]
Length = 1398
Score = 175 bits (444), Expect = 1e-44, Method: Compositional matrix adjust.
Identities = 104/337 (30%), Positives = 176/337 (52%), Gaps = 39/337 (11%)
Frame = +1
Query: 144 RAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRV 203
R ++ + DF+ LK++G+G FG+V LV++K TG YAMKILRK ++ K++V H E +
Sbjct: 241 RTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDI 420
Query: 204 LQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 263
L ++ + Y+FQ L +ME+ GG++ L ++ TEE +FY AE V A+
Sbjct: 421 LVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAI 600
Query: 264 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK------------------------E 299
+ +H ++RDIK +NL+LD GH+K++DFGLC +
Sbjct: 601 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 780
Query: 300 GISDGATMKTF-----------CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 348
++ +T+ GTP+Y+APEV Y + DWW LGV+MYEM+ G
Sbjct: 781 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYP 960
Query: 349 PFYNQDHERLFELIL--MEEIRFPRT--LSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
PF ++ + ++ ++ E + FP +S +AK L+ + + R+G +E+
Sbjct: 961 PFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFC-CEWEHRIGA--PGVEEIK 1131
Query: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDD 441
+ FF ++W+ + ++ ++ S DT FD+
Sbjct: 1132SNSFFEGVDWEHIRERP--AAISIEIKSIDDTSNFDE 1236
>lcl|NM_025164.3_cdsid_NP_079440.2 [gene=SIK3]
[protein=serine/threonine-protein kinase SIK3]
[protein_id=NP_079440.2] [location=37..3828]
Length = 3792
Score = 155 bits (393), Expect = 1e-38, Method: Compositional matrix adjust.
Identities = 100/323 (30%), Positives = 163/323 (50%), Gaps = 12/323 (3%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 215
+ +GKG F V T A+KI+ K + ++ + E ++++ HP + L
Sbjct: 34 RTIGKGNFAVVKRATHLVTKAKVAIKIIDK-TQLDEENLKKIFREVQIMKMLCHPHIIRL 210
Query: 216 KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRD 275
+T + V EYA+GGE+F HL E+ AR +IV+A+ + H R++V+RD
Sbjct: 211 YQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRD 390
Query: 276 IKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWW 334
+K ENL+LD + +IKI DFG + G +KT+CG+P Y APE+ E +Y G VD W
Sbjct: 391 LKAENLLLDANLNIKIADFGFSNL-FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIW 567
Query: 335 GLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLG 394
LGVV+Y ++CG LPF + L +L + R P +S E + L+ +L DP +RL
Sbjct: 568 SLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLS 747
Query: 395 GGPSDAKEVMEHRFF-----------LSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEF 443
+++ +H++ L Q + +++ + P V ++ D E
Sbjct: 748 -----MEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 912
Query: 444 TAQSITITPPDRYDSLGLLELDQ 466
T QS+ D Y ++ L D+
Sbjct: 913 TLQSLRSDAYDHYSAIYSLLCDR 981
>lcl|NM_033126.1_cdsid_NP_149117.1 [gene=PSKH2]
[protein=serine/threonine-protein kinase H2]
[protein_id=NP_149117.1] [location=1..1158]
Length = 1158
Score = 155 bits (391), Expect = 2e-38, Method: Compositional matrix adjust.
Identities = 101/313 (32%), Positives = 158/313 (50%), Gaps = 18/313 (5%)
Frame = +1
Query: 138 VAVSKARAKV---TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEV 194
+ V++ RAK + +D L+G G+F +V+ V +K T + +A+K++ ++
Sbjct: 136 IQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETR---EREGR 306
Query: 195 AHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARF 254
V+E VL+ H ++ L F+T D++ VME A GGELF L + FTE A
Sbjct: 307 EACVSELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVR 486
Query: 255 YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGH---IKITDFGLCKEGISDGA-TMKTF 310
+ + YLH+ + +R++K ENL+ G I ITDFGL G G TMKT
Sbjct: 487 ILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTL 666
Query: 311 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP 370
CGTPEY+APEVL Y AVD W LGV+ Y ++ G LPF ++ RL+ IL + +
Sbjct: 667 CGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYT 846
Query: 371 R----TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSI-------NWQDVVQ 419
++S AK + LL + R+ G + ++H + +++ N Q +
Sbjct: 847 GEPWPSISHLAKDFIDKLLILEAGHRMSAG-----QALDHPWVITMAAGSSMKNLQRAIS 1011
Query: 420 KKLLPPFKPQVTS 432
+ L+ P S
Sbjct: 1012RNLMQRASPHSQS 1050
>lcl|NM_032430.1_cdsid_NP_115806.1 [gene=BRSK1]
[protein=serine/threonine-protein kinase BRSK1]
[protein_id=NP_115806.1] [location=278..2614]
Length = 2337
Score = 152 bits (384), Expect = 1e-37, Method: Compositional matrix adjust.
Identities = 84/257 (32%), Positives = 147/257 (57%), Gaps = 1/257 (0%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 215
K LGKG G V L TG+ A+KI+ +E + ++ + E +L+ HP + L
Sbjct: 112 KTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVLKL 288
Query: 216 KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRD 275
++ L V+E+ +GGELF +L ++ T + AR + +IVSAL++ HS + +RD
Sbjct: 289 HDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRD 468
Query: 276 IKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWW 334
+K ENL+LD+ +I+I DFG+ + D + ++T CG+P Y PEV++ Y GR D W
Sbjct: 469 LKPENLLLDEKNNIRIADFGMASLQVGD-SLLETSCGSPHYACPEVIKGEKYDGRRADMW 645
Query: 335 GLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLG 394
GV+++ ++ G LPF + + +L E + P + P+ +SLL G+++ +P++RL
Sbjct: 646 SCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRL- 822
Query: 395 GGPSDAKEVMEHRFFLS 411
+++ +H ++L
Sbjct: 823 ----SLEQIQKHPWYLG 861
>lcl|NM_004734.4_cdsid_NP_004725.1 [gene=DCLK1]
[protein=serine/threonine-protein kinase DCLK1 isoform 1]
[protein_id=NP_004725.1] [location=284..2473]
Length = 2190
Score = 152 bits (384), Expect = 1e-37, Method: Compositional matrix adjust.
Identities = 94/261 (36%), Positives = 137/261 (52%), Gaps = 10/261 (3%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 215
+ +G G F V E++T R YA+KI++K K+ + E +L+ +HP + L
Sbjct: 1180 RTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQN--EVSILRRVKHPNIVLL 1353
Query: 216 KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRD 275
L VME GG+LF ++ +TE A + SA++YLHS ++V+RD
Sbjct: 1354 IEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRD 1533
Query: 276 IKLENLML----DKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAV 331
IK ENL++ D +K+ DFGL I DG + T CGTP Y+APE++ + YG V
Sbjct: 1534 IKPENLLVYEHQDGSKSLKLGDFGLAT--IVDGP-LYTVCGTPTYVAPEIIAETGYGLKV 1704
Query: 332 DWWGLGVVMYEMMCGRLPF--YNQDHERLFELILMEEIRFPR----TLSPEAKSLLAGLL 385
D W GV+ Y ++CG PF D E LF+ ILM ++ FP +S AK L+ +L
Sbjct: 1705 DIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMML 1884
Query: 386 KKDPKQRLGGGPSDAKEVMEH 406
D QR A +V+EH
Sbjct: 1885 LVDVDQRF-----SAVQVLEH 1932
>lcl|NM_003957.3_cdsid_NP_003948.2 [gene=BRSK2]
[protein=serine/threonine-protein kinase BRSK2 isoform
2] [protein_id=NP_003948.2] [location=387..2393]
Length = 2007
Score = 148 bits (373), Expect = 2e-36, Method: Compositional matrix adjust.
Identities = 80/239 (33%), Positives = 135/239 (56%), Gaps = 1/239 (0%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 215
K LGKG G V L T + A+KI+ +E + ++ + E +L+ HP + L
Sbjct: 67 KTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVLKL 243
Query: 216 KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRD 275
++ L V+E+ +GGELF +L ++ T + AR + +I+SAL++ HS + +RD
Sbjct: 244 HDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRD 423
Query: 276 IKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWW 334
+K ENL+LD+ +I+I DFG+ + D + ++T CG+P Y PEV+ Y GR D W
Sbjct: 424 LKPENLLLDEKNNIRIADFGMASLQVGD-SLLETSCGSPHYACPEVIRGEKYDGRKADVW 600
Query: 335 GLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRL 393
GV+++ ++ G LPF + + +L E + P + P+ +SLL G+++ D +RL
Sbjct: 601 SCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRL 777
>lcl|NM_014586.1_cdsid_NP_055401.1 [gene=HUNK] [protein=hormonally
up-regulated neu tumor-associated kinase]
[protein_id=NP_055401.1] [location=361..2505]
Length = 2145
Score = 145 bits (365), Expect = 2e-35, Method: Compositional matrix adjust.
Identities = 88/241 (36%), Positives = 130/241 (53%), Gaps = 6/241 (2%)
Frame = +1
Query: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVT-ESRVLQNTRHPFLTALK 216
LG+G+F KV TG A+K++ K+ V + E ++ Q RHP +T L
Sbjct: 202 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 381
Query: 217 YAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDI 276
+T + VME GG L + ++ E AR Y +++SA+E+LH VV+RD+
Sbjct: 382 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 561
Query: 277 KLENLMLDKDGHIKITDFGL--CKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWW 334
K+ENL+LD+D +IK+ DFGL C + T CG+P Y APE+L YG +D W
Sbjct: 562 KIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVW 741
Query: 335 GLGVVMYEMMCGRLPFYNQ--DHERLFELILMEEIR-FPRTLSPEAKSLLAGLLKKDPKQ 391
+GV MY M+ G LPF + L++ ++ +E+ P LS A S L LL+ DP +
Sbjct: 742 SIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVK 921
Query: 392 R 392
R
Sbjct: 922 R 924
>lcl|NM_004073.2_cdsid_NP_004064.2 [gene=PLK3]
[protein=serine/threonine-protein kinase PLK3]
[protein_id=NP_004064.2] [location=101..2041]
Length = 1941
Score = 144 bits (362), Expect = 4e-35, Method: Compositional matrix adjust.
Identities = 81/258 (31%), Positives = 127/258 (49%), Gaps = 2/258 (0%)
Frame = +1
Query: 154 YLK--LLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 211
YLK LLGKG F + + TG YA+K++ + + + + E + ++ +H
Sbjct: 184 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 363
Query: 212 LTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDV 271
+ + F+ D + +E + L E R+Y +I+S L+YLH R +
Sbjct: 364 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 543
Query: 272 VYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAV 331
++RD+KL N + ++ +K+ DFGL KT CGTP Y+APEVL +G
Sbjct: 544 LHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEA 723
Query: 332 DWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQ 391
D W LG VMY ++CG PF D + + I P +LS A+ LLA +L+ P+
Sbjct: 724 DVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRD 903
Query: 392 RLGGGPSDAKEVMEHRFF 409
R PS +++ H FF
Sbjct: 904 R----PS-IDQILRHDFF 942
>lcl|NM_172226.2_cdsid_NP_757380.1 [gene=CAMKK2]
[protein=calcium/calmodulin-dependent protein kinase
kinase 2 isoform 2] [protein_id=NP_757380.1]
[location=176..1801]
Length = 1626
Score = 135 bits (339), Expect = 2e-32, Method: Compositional matrix adjust.
Identities = 83/292 (28%), Positives = 141/292 (48%), Gaps = 30/292 (10%)
Frame = +1
Query: 132 TTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVII-- 189
T E V+++ + V +N + +GKG++G V L + YYAMK+L K+ +I
Sbjct: 433 TVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQ 612
Query: 190 ---------------------AKDEVAHTVTESRVLQNTRHPFLTALKYAFQ--THDRLC 226
+ + E +L+ HP + L D L
Sbjct: 613 AGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLY 792
Query: 227 FVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKD 286
V E N G + + + +E++ARFY +++ +EYLH + +++RDIK NL++ +D
Sbjct: 793 MVFELVNQGPVM-EVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGED 969
Query: 287 GHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDND---YGRAVDWWGLGVVMYEM 343
GHIKI DFG+ E A + GTP ++APE L + G+A+D W +GV +Y
Sbjct: 970 GHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCF 1149
Query: 344 MCGRLPFYNQDHERLFELILMEEIRFPRT--LSPEAKSLLAGLLKKDPKQRL 393
+ G+ PF ++ L I + + FP ++ + K L+ +L K+P+ R+
Sbjct: 1150VFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRI 1305
>lcl|NM_172084.2_cdsid_NP_742081.1 [gene=CAMK2B]
[protein=calcium/calmodulin-dependent protein kinase
type II subunit beta isoform 8] [protein_id=NP_742081.1]
[location=211..1560]
Length = 1350
Score = 133 bits (335), Expect = 5e-32, Method: Compositional matrix adjust.
Identities = 83/256 (32%), Positives = 130/256 (50%), Gaps = 7/256 (2%)
Frame = +1
Query: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
+GKG F V + TG YA KI+ + + A+D E+R+ + +H + L
Sbjct: 58 IGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDH-QKLEREARICRLLKHSNIVRLHD 234
Query: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
+ V + GGELF + ++E A +I+ A+ + H VV+RD+K
Sbjct: 235 SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLK 414
Query: 278 LENLMLD---KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWW 334
ENL+L K +K+ DFGL E D F GTP YL+PEVL YG+ VD W
Sbjct: 415 PENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIW 594
Query: 335 GLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPR----TLSPEAKSLLAGLLKKDPK 390
GV++Y ++ G PF+++D +L++ I FP T++PEAK+L+ +L +P
Sbjct: 595 ACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPA 774
Query: 391 QRLGGGPSDAKEVMEH 406
+R+ A E ++H
Sbjct: 775 KRI-----TAHEALKH 807
>lcl|NM_002578.3_cdsid_NP_002569.1 [gene=PAK3]
[protein=serine/threonine-protein kinase PAK 3 isoform a]
[protein_id=NP_002569.1] [location=622..2256]
Length = 1635
Score = 132 bits (332), Expect = 1e-31, Method: Compositional matrix adjust.
Identities = 89/286 (31%), Positives = 142/286 (49%), Gaps = 13/286 (4%)
Frame = +1
Query: 137 EVAVSKARAKVTMND----FDYLKLLGKGTFGKVILVREKATGRYYAMKIL------RKE 186
E + K R+ V++ D + + +G+G G V + ATG+ A+K + +KE
Sbjct: 745 EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE 924
Query: 187 VIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERV 246
+II E V++ ++P + ++ D L VMEY GG L + E
Sbjct: 925 LII---------NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT-DVVTETC 1074
Query: 247 FTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGAT 306
E + E + AL++LHS V++RDIK +N++L DG +K+TDFG C + + +
Sbjct: 1075 MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 1254
Query: 307 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILME- 365
T GTP ++APEV+ YG VD W LG++ EM+ G P+ N++ R LI
Sbjct: 1255 RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG 1434
Query: 366 --EIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 409
E++ P LS + L L+ D +R AKE+++H F
Sbjct: 1435 TPELQNPERLSAVFRDFLNRCLEMDVDRR-----GSAKELLQHPFL 1557
>lcl|NM_001128629.2_cdsid_NP_001122101.1 [gene=PAK6]
[protein=serine/threonine-protein kinase PAK 6 isoform 1]
[protein_id=NP_001122101.1] [location=358..2403]
Length = 2046
Score = 129 bits (325), Expect = 8e-31, Method: Compositional matrix adjust.
Identities = 81/267 (30%), Positives = 150/267 (56%), Gaps = 10/267 (3%)
Frame = +1
Query: 154 YLKLLGKGTFGKVILVREKATGRYYAMKIL------RKEVIIAKDEVAHTVTESRVLQNT 207
Y+K+ G+G+ G V L REK +GR A+K++ R+E++ E ++++
Sbjct: 1228 YVKI-GEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLF---------NEVVIMRDY 1377
Query: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLH 267
+H + + ++ + L +ME+ GG L +S+ R+ E+ A A ++ AL YLH
Sbjct: 1378 QHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEA-VLQALAYLH 1554
Query: 268 SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY 327
++ V++RDIK ++++L DG +K++DFG C + D K+ GTP ++APEV+ + Y
Sbjct: 1555 AQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLY 1734
Query: 328 GRAVDWWGLGVVMYEMMCGRLPFYN----QDHERLFELILMEEIRFPRTLSPEAKSLLAG 383
VD W LG+++ EM+ G P+++ Q +RL + +++ +SP + L
Sbjct: 1735 ATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD-SPPPKLKNSHKVSPVLRDFLER 1911
Query: 384 LLKKDPKQRLGGGPSDAKEVMEHRFFL 410
+L +DP++R + A+E+++H F L
Sbjct: 1912 MLVRDPQER-----ATAQELLDHPFLL 1977
>lcl|NM_016457.4_cdsid_NP_057541.2 [gene=PRKD2]
[protein=serine/threonine-protein kinase D2 isoform A]
[protein_id=NP_057541.2] [location=758..3394]
Length = 2637
Score = 126 bits (316), Expect = 8e-30, Method: Compositional matrix adjust.
Identities = 93/287 (32%), Positives = 151/287 (52%), Gaps = 8/287 (2%)
Frame = +1
Query: 114 APGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKA 173
APG P ++ S S S + +++ V A D ++LG G FG V + +
Sbjct: 1555 APGHAP--HRQASLSISVSNSQIQENVDIATVYQIFPD----EVLGSGQFGVVYGGKHRK 1716
Query: 174 TGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYAN 233
TGR A+K++ K K E + E +LQ+ RHP + L+ F+T +++ VME +
Sbjct: 1717 TGRDVAVKVIDKLRFPTKQE-SQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLH 1893
Query: 234 GGELFFHLSRERVFTEER-ARFYGAEIVSALEYLHSRDVVYRDIKLENLML---DKDGHI 289
G L LS E+ ER +F +I+ AL +LH +++V+ D+K EN++L D +
Sbjct: 1894 GDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQV 2073
Query: 290 KITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP 349
K+ DFG + I + + ++ GTP YLAPEVL + Y R++D W +GV+MY + G P
Sbjct: 2074 KLCDFGFARI-IGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFP 2250
Query: 350 FYNQDHERLFELILMEEIRFPRT----LSPEAKSLLAGLLKKDPKQR 392
F N+D E + + I +P + +S A L+ LL+ ++R
Sbjct: 2251 F-NED-EDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKR 2385
>lcl|NM_053025.3_cdsid_NP_444253.3 [gene=MYLK] [protein=myosin light
chain kinase, smooth muscle isoform 1]
[protein_id=NP_444253.3] [location=283..6027]
Length = 5745
Score = 125 bits (315), Expect = 1e-29, Method: Compositional matrix adjust.
Identities = 83/267 (31%), Positives = 138/267 (51%), Gaps = 8/267 (2%)
Frame = +1
Query: 152 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 211
+D + LG G FG+V + EK T + +A K + K+ + ++ ++ HP
Sbjct: 4390 YDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEIS---IMNCLHHPK 4560
Query: 212 LTALKYAFQTHDRLCFVMEYANGGELFFHLSRERV-FTEERARFYGAEIVSALEYLHSRD 270
L AF+ + V+E +GGELF + E TE Y +I +EY+H +
Sbjct: 4561 LVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQG 4740
Query: 271 VVYRDIKLENLM-LDKDG-HIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYG 328
+V+ D+K EN+M ++K G IK+ DFGL + + + ++K GTPE++APEV+ G
Sbjct: 4741 IVHLDLKPENIMCVNKTGTRIKLIDFGLARR-LENAGSLKVLFGTPEFVAPEVINYEPIG 4917
Query: 329 RAVDWWGLGVVMYEMMCGRLPFY-NQDHERLFELIL----MEEIRFPRTLSPEAKSLLAG 383
A D W +GV+ Y ++ G PF + D+E L + ++ F +S +AK ++
Sbjct: 4918 YATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDE-ISDDAKDFISN 5094
Query: 384 LLKKDPKQRLGGGPSDAKEVMEHRFFL 410
LLKKD K RL D + ++H + +
Sbjct: 5095 LLKKDMKNRL-----DCTQCLQHPWLM 5160
>lcl|NM_004759.4_cdsid_NP_004750.1 [gene=MAPKAPK2] [protein=MAP
kinase-activated protein kinase 2 isoform 1]
[protein_id=NP_004750.1] [location=211..1323]
Length = 1113
Score = 123 bits (309), Expect = 5e-29, Method: Compositional matrix adjust.
Identities = 89/268 (33%), Positives = 134/268 (50%), Gaps = 13/268 (4%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 215
++LG G GKV+ + K T +A+K+L ++ A+ EV S+ R +
Sbjct: 202 QVLGLGINGKVLQIFNKRTQEKFALKML-QDCPKARREVELHWRASQCPHIVR--IVDVY 372
Query: 216 KYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVSALEYLHSRDVVY 273
+ + L VME +GGELF + ++ FTE A I A++YLHS ++ +
Sbjct: 373 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 552
Query: 274 RDIKLENLMLDK---DGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRA 330
RD+K ENL+ + +K+TDFG KE S + + T C TP Y+APEVL Y ++
Sbjct: 553 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVLGPEKYDKS 729
Query: 331 VDWWGLGVVMYEMMCGRLPFYNQD----HERLFELILMEEIRFPR----TLSPEAKSLLA 382
D W LGV+MY ++CG PFY+ + I M + FP +S E K L+
Sbjct: 730 CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 909
Query: 383 GLLKKDPKQRLGGGPSDAKEVMEHRFFL 410
LLK +P QR+ E M H + +
Sbjct: 910 NLLKTEPTQRM-----TITEFMNHPWIM 978
>lcl|NM_004938.2_cdsid_NP_004929.2 [gene=DAPK1]
[protein=death-associated protein kinase 1]
[protein_id=NP_004929.2] [location=376..4668]
Length = 4293
Score = 123 bits (309), Expect = 6e-29, Method: Compositional matrix adjust.
Identities = 80/256 (31%), Positives = 128/256 (50%), Gaps = 14/256 (5%)
Frame = +1
Query: 152 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVI------IAKDEVAHTVTESRVLQ 205
+D + LG G F V REK+TG YA K ++K ++++++ V+ +L+
Sbjct: 37 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVS---ILK 207
Query: 206 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 265
+HP + L ++ + ++E GGELF L+ + TEE A + +I++ + Y
Sbjct: 208 EIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYY 387
Query: 266 LHSRDVVYRDIKLENLM-LDKD---GHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV 321
LHS + + D+K EN+M LD++ IKI DFGL + I G K GTPE++APE+
Sbjct: 388 LHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK-IDFGNEFKNIFGTPEFVAPEI 564
Query: 322 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP----RTLSPEA 377
+ G D W +GV+ Y ++ G PF + + F S A
Sbjct: 565 VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALA 744
Query: 378 KSLLAGLLKKDPKQRL 393
K + LL KDPK+R+
Sbjct: 745 KDFIRRLLVKDPKKRM 792
>lcl|NM_002401.3_cdsid_NP_002392.2 [gene=MAP3K3]
[protein=mitogen-activated protein kinase kinase kinase 3
isoform 2] [protein_id=NP_002392.2] [location=320..2200]
Length = 1881
Score = 114 bits (285), Expect = 4e-26, Method: Compositional matrix adjust.
Identities = 70/204 (34%), Positives = 106/204 (51%), Gaps = 9/204 (4%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRYYAMKILR--KEVIIAKDEVAHTVTESRVLQNTRHPFLT 213
KLLG+G FG+V L + TGR A K ++ + EV+ E ++L+N +H +
Sbjct: 1096 KLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERI- 1272
Query: 214 ALKYAFQTHDR----LCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSR 269
++Y DR L MEY GG + L TE R Y +I+ + YLHS
Sbjct: 1273 -VQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSN 1449
Query: 270 DVVYRDIKLENLMLDKDGHIKITDFGLCKEGIS---DGATMKTFCGTPEYLAPEVLEDND 326
+V+RDIK N++ D G++K+ DFG K + G M++ GTP +++PEV+
Sbjct: 1450 MIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEG 1629
Query: 327 YGRAVDWWGLGVVMYEMMCGRLPF 350
YGR D W LG + EM+ + P+
Sbjct: 1630 YGRKADVWSLGCTVVEMLTEKPPW 1701
>lcl|NM_005876.4_cdsid_NP_005867.3 [gene=SPEG] [protein=striated
muscle preferentially expressed protein kinase isoform 1]
[protein_id=NP_005867.3] [location=1..9804]
Length = 9804
Score = 112 bits (281), Expect = 1e-25, Method: Compositional matrix adjust.
Identities = 68/204 (33%), Positives = 101/204 (49%), Gaps = 1/204 (0%)
Frame = +1
Query: 152 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 211
+ +L+ +G FG V RE ATGR + KI V A + + E VL+ H
Sbjct: 8896 YTFLEEKARGRFGVVRACRENATGRTFVAKI----VPYAAEGKRRVLQEYEVLRTLHHER 9063
Query: 212 LTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDV 271
+ +L A+ T L + E EL LS ++E+ Y +++ L+YLH V
Sbjct: 9064 IMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHV 9243
Query: 272 VYRDIKLENLMLDKDGHIKITDFGLCKEGISDGA-TMKTFCGTPEYLAPEVLEDNDYGRA 330
++ DIK +NL+L D +KI DFG + + GT E++APE+++ G A
Sbjct: 9244 LHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSA 9423
Query: 331 VDWWGLGVVMYEMMCGRLPFYNQD 354
D WG GV+ Y M+ GR PFY D
Sbjct: 9424 TDIWGAGVLTYIMLSGRSPFYEPD 9495
Score = 94.0 bits (232), Expect = 5e-20, Method: Compositional matrix adjust.
Identities = 77/271 (28%), Positives = 132/271 (48%), Gaps = 10/271 (3%)
Frame = +1
Query: 149 MNDF-DYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT 207
++DF D + +G+G F + + E+++G +A K + + AK + A E+R+L
Sbjct: 4789 LSDFYDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQ---AKPK-ASARREARLLARL 4956
Query: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLH 267
+H + AF+ L V E EL ++R+ E R Y +++ + YLH
Sbjct: 4957 QHDCVLYFHEAFERRRGLVIVTELCTE-ELLERIARKPTVCESEIRAYMRQVLEGIHYLH 5133
Query: 268 SRDVVYRDIKLENLML----DKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 323
V++ D+K ENL++ + ++I DFG +E ++ G GTPE++APE++
Sbjct: 5134 QSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQE-LTPGEPQYCQYGTPEFVAPEIVN 5310
Query: 324 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ-DHERLFEL----ILMEEIRFPRTLSPEAK 378
+ D W +GVV + + G PF + D L + + EE F +LS EA+
Sbjct: 5311 QSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTF-LSLSREAR 5487
Query: 379 SLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 409
L +L +D RL A+E +EH +F
Sbjct: 5488 GFLIKVLVQD---RLR---PTAEETLEHPWF 5562
>lcl|NM_004721.4_cdsid_NP_004712.1 [gene=MAP3K13]
[protein=mitogen-activated protein kinase kinase kinase
13 isoform 1] [protein_id=NP_004712.1]
[location=407..3307]
Length = 2901
Score = 110 bits (274), Expect = 6e-25, Method: Compositional matrix adjust.
Identities = 69/249 (27%), Positives = 119/249 (47%), Gaps = 2/249 (0%)
Frame = +1
Query: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 205
+V + L+ LG G G V L G++ A ++ K+V + T+ + L+
Sbjct: 484 EVPFEEISELQWLGSGAQGAVFL------GKFRAEEVAIKKVREQNE------TDIKHLR 627
Query: 206 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 265
+HP + A K C +MEY G+L+ L R T + I S + Y
Sbjct: 628 KLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNY 807
Query: 266 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDN 325
LH +++RD+K N+++ +KI+DFG KE +SD +T +F GT ++APEV+ +
Sbjct: 808 LHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGTVAWMAPEVIRNE 984
Query: 326 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP-RTLSPEA-KSLLAG 383
VD W GVV++E++ G +P+ + D + + + P + P+ K L+
Sbjct: 985 PVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQ 1164
Query: 384 LLKKDPKQR 392
+ P+ R
Sbjct: 1165TWQSKPRNR 1191
>lcl|NM_133494.2_cdsid_NP_598001.1 [gene=NEK7]
[protein=serine/threonine-protein kinase Nek7]
[protein_id=NP_598001.1] [location=328..1236]
Length = 909
Score = 109 bits (272), Expect = 1e-24, Method: Compositional matrix adjust.
Identities = 74/254 (29%), Positives = 125/254 (49%), Gaps = 9/254 (3%)
Frame = +1
Query: 148 TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT 207
T+ +F K +G+G F +V G A+K ++ ++ A + E +L+
Sbjct: 88 TLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL 267
Query: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGEL---FFHLSRERVFTEERARF-YGAEIVSAL 263
HP + +F + L V+E A+ G+L H +++ ER + Y ++ SAL
Sbjct: 268 NHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 447
Query: 264 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 323
E++HSR V++RDIK N+ + G +K+ D GL + S + GTP Y++PE +
Sbjct: 448 EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH 627
Query: 324 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELI-LMEEIRFPRT----LSPEAK 378
+N Y D W LG ++YEM + PFY D L+ L +E+ +P S E +
Sbjct: 628 ENGYNFKSDIWSLGCLLYEMAALQSPFYG-DKMNLYSLCKKIEQCDYPPLPSDHYSEELR 804
Query: 379 SLLAGLLKKDPKQR 392
L+ + DP++R
Sbjct: 805 QLVNMCINPDPEKR 846
>lcl|NM_001042600.1_cdsid_NP_001036065.1 [gene=MAP4K1]
[protein=mitogen-activated protein kinase kinase kinase
kinase 1 isoform 1] [protein_id=NP_001036065.1]
[location=109..2574]
Length = 2466
Score = 107 bits (266), Expect = 5e-24, Method: Compositional matrix adjust.
Identities = 72/268 (26%), Positives = 128/268 (47%), Gaps = 8/268 (2%)
Frame = +1
Query: 150 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRH 209
+ +D L+ LG GT+G+V R+K +G A+K+++ E D+V+ E +L+ RH
Sbjct: 43 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKME---PDDDVSTLQKEILILKTCRH 213
Query: 210 PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSR 269
+ A ++ +L ME+ G L +E + + E++ L YLHS+
Sbjct: 214 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQ 393
Query: 270 DVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE---DND 326
++RDIK N++++ G +++ DFG+ + + A +F GTP ++APEV
Sbjct: 394 KKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGG 573
Query: 327 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPR-----TLSPEAKSLL 381
Y D W LG+ E+ + P ++ R+ L+ + PR S + +
Sbjct: 574 YNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFI 753
Query: 382 AGLLKKDPKQRLGGGPSDAKEVMEHRFF 409
L K PK+R PS A +++ H+
Sbjct: 754 KVTLTKSPKKR----PS-ATKMLSHQLV 822
>lcl|NM_133378.4_cdsid_NP_596869.4 [gene=TTN] [protein=titin isoform
N2-A] [protein_id=NP_596869.4] [location=226..100497]
Length = 100272
Score = 103 bits (256), Expect = 7e-23, Method: Compositional matrix adjust.
Identities = 94/379 (24%), Positives = 168/379 (44%), Gaps = 24/379 (6%)
Frame = +1
Query: 52 LNNFSVAEC-----------QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWM 100
+ N+ V +C Q +T N F Q+ + E F + P E E
Sbjct: 93457 ITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSE-- 93630
Query: 101 RAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKL--- 157
+ K RA M+Y D E EV+++KA T ++ +
Sbjct: 93631 ---PTITKEDKTRA-----MNY------DEEVDETREVSMTKASHSSTKELYEKYMIAED 93768
Query: 158 LGKGTFGKVILVREKATGRYYAMKILR---KEVIIAKDEVAHTVTESRVLQNTRHPFLTA 214
LG+G FG V E ++ + Y K ++ + ++ K E++ +L RH +
Sbjct: 93769 LGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEIS-------ILNIARHRNILH 93927
Query: 215 LKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARF-YGAEIVSALEYLHSRDVVY 273
L +F++ + L + E+ +G ++F ++ ER Y ++ AL++LHS ++ +
Sbjct: 93928 LHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGH 94107
Query: 274 RDIKLENLMLD--KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAV 331
DI+ EN++ + IKI +FG ++ + G + PEY APEV + + A
Sbjct: 94108 FDIRPENIIYQTRRSSTIKIIEFGQARQ-LKPGDNFRLLFTAPEYYAPEVHQHDVVSTAT 94284
Query: 332 DWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP----RTLSPEAKSLLAGLLKK 387
D W LG ++Y ++ G PF + ++++ E I+ E F + +S EA + LL K
Sbjct: 94285 DMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVK 94464
Query: 388 DPKQRLGGGPSDAKEVMEH 406
+ K R+ A E ++H
Sbjct: 94465 ERKSRM-----TASEALQH 94506
>lcl|NM_006875.3_cdsid_NP_006866.2 [gene=PIM2]
[protein=serine/threonine-protein kinase pim-2]
[protein_id=NP_006866.2] [location=303..1238]
Length = 936
Score = 100 bits (248), Expect = 6e-22, Method: Compositional matrix adjust.
Identities = 72/246 (29%), Positives = 120/246 (48%), Gaps = 10/246 (4%)
Frame = +1
Query: 157 LLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTES-------RVLQNTRH 209
LLGKG FG V A+K++ + ++ ++ +VT +V H
Sbjct: 109 LLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGH 288
Query: 210 PFLTALKYAFQTHDRLCFVMEYA-NGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 268
P + L F+T + V+E +LF +++ + E +R + ++V+A+++ HS
Sbjct: 289 PGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHS 468
Query: 269 RDVVYRDIKLENLMLD-KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY 327
R VV+RDIK EN+++D + G K+ DFG + F GT Y PE + + Y
Sbjct: 469 RGVVHRDIKDENILIDLRRGCAKLIDFG--SGALLHDEPYTDFDGTRVYSPPEWISRHQY 642
Query: 328 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLK 386
W LG+++Y+M+CG +PF +D E IL E+ FP +SP+ +L+ L
Sbjct: 643 HALPATVWSLGILLYDMVCGDIPF-ERDQE-----ILEAELHFPAHVSPDCCALIRRCLA 804
Query: 387 KDPKQR 392
P R
Sbjct: 805 PKPSSR 822
>lcl|NM_005109.2_cdsid_NP_005100.1 [gene=OXSR1]
[protein=serine/threonine-protein kinase OSR1]
[protein_id=NP_005100.1] [location=343..1926]
Length = 1584
Score = 100 bits (248), Expect = 7e-22, Method: Compositional matrix adjust.
Identities = 78/302 (25%), Positives = 137/302 (45%), Gaps = 25/302 (8%)
Frame = +1
Query: 147 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVI-IAKDEVAHTVTESRVLQ 205
+ +D++ +++G G V A+K + E + DE+ + E + +
Sbjct: 34 INRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDEL---LKEIQAMS 204
Query: 206 NTRHPFLTALKYAFQTHDRLCFVMEYANGG---ELFFHL-----SRERVFTEERARFYGA 257
HP + + +F D L VM+ +GG ++ H+ + V E
Sbjct: 205 QCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILR 384
Query: 258 EIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFG----LCKEG-ISDGATMKTFCG 312
E++ LEYLH ++RD+K N++L +DG ++I DFG L G I+ KTF G
Sbjct: 385 EVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVG 564
Query: 313 TPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEE----- 366
TP ++APEV+E Y D W G+ E+ G P++ ++ L L +
Sbjct: 565 TPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLE 744
Query: 367 --IRFPRTLSPEAKS---LLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKK 421
++ L KS +++ L+KDP++R A E++ H+FF ++ +Q+K
Sbjct: 745 TGVQDKEMLKKYGKSFRKMISLCLQKDPEKR-----PTAAELLRHKFFQKAKNKEFLQEK 909
Query: 422 LL 423
L
Sbjct: 910 TL 915
>lcl|NM_000455.4_cdsid_NP_000446.1 [gene=STK11]
[protein=serine/threonine-protein kinase STK11]
[protein_id=NP_000446.1] [location=1116..2417]
Length = 1302
Score = 99.8 bits (247), Expect = 9e-22, Method: Compositional matrix adjust.
Identities = 79/277 (28%), Positives = 130/277 (46%), Gaps = 8/277 (2%)
Frame = +1
Query: 141 SKARAKVTMNDFDYLKLLGKGTFGKVILVREKAT-GRYYAMKILRKEVIIAKDEVAHTVT 199
+K K M D LLG+G++GKV V + T R + +K++ + A+
Sbjct: 127 AKLIGKYLMGD-----LLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKK 291
Query: 200 ESRVLQNTRHPFLTALKYAFQTHDR--LCFVMEYANGG-ELFFHLSRERVFTEERARFYG 256
E ++L+ RH + L ++ + VMEY G + E+ F +A Y
Sbjct: 292 EIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYF 471
Query: 257 AEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK--EGISDGATMKTFCGTP 314
+++ LEYLHS+ +V++DIK NL+L G +KI+D G+ + + T +T G+P
Sbjct: 472 CQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSP 651
Query: 315 EYLAPEVLE--DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRT 372
+ PE+ D G VD W GV +Y + G PF + +LFE I P
Sbjct: 652 AFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGD 831
Query: 373 LSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 409
P LL G+L+ +P +R +++ +H +F
Sbjct: 832 CGPPLSDLLKGMLEYEPAKRF-----SIRQIRQHSWF 927
>lcl|NM_017433.4_cdsid_NP_059129.3 [gene=MYO3A]
[protein=myosin-IIIa] [protein_id=NP_059129.3]
[location=361..5211]
Length = 4851
Score = 96.3 bits (238), Expect = 9e-21, Method: Compositional matrix adjust.
Identities = 84/287 (29%), Positives = 135/287 (47%), Gaps = 18/287 (6%)
Frame = +1
Query: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN-TRHP-----F 211
+GKGT+GKV V K G+ A+KIL + I DE E +L+ + HP +
Sbjct: 79 IGKGTYGKVFKVLNKKNGQKAAVKIL--DPIHDIDE--EIEAEYNILKALSDHPNVVRFY 246
Query: 212 LTALKYAFQTHDRLCFVMEYANGGELF----FHLSRERVFTEERARFYGAEIVSALEYLH 267
K D+L V+E +GG + L R +E + E + L++LH
Sbjct: 247 GIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLH 426
Query: 268 SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE---- 323
+ ++RD+K N++L +G +K+ DFG+ + S T GTP ++APEV+
Sbjct: 427 NNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQ 606
Query: 324 -DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHER-LFELILM--EEIRFPRTLSPEAKS 379
D Y D W LG+ E+ G P + R LF++ ++R P S E
Sbjct: 607 LDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFND 786
Query: 380 LLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPF 426
++ L KD ++R P+ E+++H+F I +DV+ +K L F
Sbjct: 787 FISKCLTKDYEKR----PT-VSELLQHKFITQIEGKDVMLQKQLTEF 912
>lcl|NM_004203.4_cdsid_NP_004194.3 [gene=PKMYT1]
[protein=membrane-associated tyrosine- and
threonine-specific cdc2-inhibitory kinase isoform 1]
[protein_id=NP_004194.3] [location=510..2009]
Length = 1500
Score = 95.5 bits (236), Expect = 1e-20, Method: Compositional matrix adjust.
Identities = 81/248 (32%), Positives = 120/248 (48%), Gaps = 5/248 (2%)
Frame = +1
Query: 150 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKD---EVAHTVTESRVLQN 206
F L LG G++G+V VR K GR YA+K KD ++A + +V Q
Sbjct: 322 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ- 498
Query: 207 TRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHL-SRERVFTEERARFYGAEIVSALEY 265
HP L+ A++ L E G L H + E + Y + + AL +
Sbjct: 499 --HPCCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAH 669
Query: 266 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDN 325
LHS+ +V+ D+K N+ L G K+ DFGL E + GA + G P Y+APE+L+
Sbjct: 670 LHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAG-EVQEGDPRYMAPELLQ-G 843
Query: 326 DYGRAVDWWGLGVVMYEMMCG-RLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 384
YG A D + LG+ + E+ C LP + ++L + L E F LS E +S+L +
Sbjct: 844 SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPE--FTAGLSSELRSVLVMM 1017
Query: 385 LKKDPKQR 392
L+ DPK R
Sbjct: 1018LEPDPKLR 1041
>lcl|NM_002446.3_cdsid_NP_002437.2 [gene=MAP3K10]
[protein=mitogen-activated protein kinase kinase kinase
10] [protein_id=NP_002437.2] [location=289..3153]
Length = 2865
Score = 94.4 bits (233), Expect = 3e-20, Method: Compositional matrix adjust.
Identities = 66/240 (27%), Positives = 118/240 (49%), Gaps = 15/240 (6%)
Frame = +1
Query: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILR----KEVIIAKDEVAHTVTES 201
++ ++ +++G G FGKV R G A+K R K+ + ++V E+
Sbjct: 274 EIPFHELQLEEIIGVGGFGKV--YRALWRGEEVAVKAARLDPEKDPAVTAEQVCQ---EA 438
Query: 202 RVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVS 261
R+ +HP + AL+ A LC VMEYA GG L L+ RV + ++
Sbjct: 439 RLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVN-WAVQVAR 615
Query: 262 ALEYLHSR---DVVYRDIKLENLMLDK--------DGHIKITDFGLCKEGISDGATMKTF 310
+ YLH+ +++RD+K N+++ + D +KITDFGL +E T +
Sbjct: 616 GMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREW--HKTTKMSA 789
Query: 311 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP 370
GT ++APEV+ + + ++ D W GV+++E++ G +P+ D + + M ++ P
Sbjct: 790 AGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLP 969
>lcl|NM_032037.3_cdsid_NP_114426.1 [gene=TSSK6]
[protein=testis-specific serine/threonine-protein kinase
6] [protein_id=NP_114426.1] [location=234..1055]
Length = 822
Score = 93.2 bits (230), Expect = 9e-20, Method: Compositional matrix adjust.
Identities = 72/246 (29%), Positives = 117/246 (47%), Gaps = 5/246 (2%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLT-A 214
+ +G+G++ KV + K A+K++ + E +L+ RHP +
Sbjct: 46 RTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHV 225
Query: 215 LKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYR 274
++ + +L VME A +L + R +AR A+I A+ YLH +V+R
Sbjct: 226 FEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHHLVHR 402
Query: 275 DIKLENLMLDKD-GHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYG-RAVD 332
D+K EN++L D +K+TDFG ++ T+CG+ Y +PEVL Y + D
Sbjct: 403 DLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYD 582
Query: 333 WWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRT--LSPEAKSLLAGLLKKDPK 390
W +GVV+Y M+ G +PF + D L + +P LS K+L+A LL+ P
Sbjct: 583 VWSMGVVLYVMVTGCMPFDDSDIAGLPRR-QKRGVLYPEGLELSERCKALIAELLQFSPS 759
Query: 391 QRLGGG 396
R G
Sbjct: 760 ARPSAG 777
>lcl|NM_021643.3_cdsid_NP_067675.1 [gene=TRIB2] [protein=tribbles
homolog 2] [protein_id=NP_067675.1]
[location=1437..2468]
Length = 1032
Score = 92.4 bits (228), Expect = 1e-19, Method: Compositional matrix adjust.
Identities = 53/165 (32%), Positives = 90/165 (54%), Gaps = 4/165 (2%)
Frame = +1
Query: 249 EERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGI--SDGAT 306
EE AR + +I SA+ + H +V RD+KL + + ++ L I D +
Sbjct: 448 EEAARLF-YQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDS 624
Query: 307 MKTFCGTPEYLAPEVLEDNDY--GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILM 364
+ G P Y++PE+L + G+A D W LGV++Y M+ GR PF++ + LF I
Sbjct: 625 LSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRR 804
Query: 365 EEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 409
+ P TLSP+AK L+ +L+++P +RL ++E+++H +F
Sbjct: 805 GQFNIPETLSPKAKCLIRSILRREPSERL-----TSQEILDHPWF 924
>lcl|NM_002314.3_cdsid_NP_002305.1 [gene=LIMK1] [protein=LIM domain
kinase 1 isoform 1] [protein_id=NP_002305.1]
[location=215..2158]
Length = 1944
Score = 91.7 bits (226), Expect = 2e-19, Method: Compositional matrix adjust.
Identities = 67/252 (26%), Positives = 116/252 (46%), Gaps = 16/252 (6%)
Frame = +1
Query: 113 RAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREK 172
R+PG + D +E + V R +D + ++LGKG FG+ I V +
Sbjct: 901 RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRI-FRPSDLIHGEVLGKGCFGQAIKVTHR 1077
Query: 173 ATGRYYAMKILRKEVIIAKDEVAHT-VTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEY 231
TG MK E+I +E T + E +V++ HP + RL F+ EY
Sbjct: 1078 ETGEVMVMK----ELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEY 1245
Query: 232 ANGGELFFHL-SRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIK 290
GG L + S + + + + +I S + YLHS ++++RD+ N ++ ++ ++
Sbjct: 1246 IKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVV 1425
Query: 291 ITDFGLCK---------EGI-----SDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 336
+ DFGL + EG+ D T G P ++APE++ Y VD +
Sbjct: 1426 VADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSF 1605
Query: 337 GVVMYEMMCGRL 348
G+V+ E++ GR+
Sbjct: 1606 GIVLCEII-GRV 1638
>lcl|NM_002596.3_cdsid_NP_002587.2 [gene=CDK18]
[protein=cyclin-dependent kinase 18 isoform b]
[protein_id=NP_002587.2] [location=345..1769]
Length = 1425
Score = 89.0 bits (219), Expect = 1e-18, Method: Compositional matrix adjust.
Identities = 57/217 (26%), Positives = 100/217 (46%), Gaps = 9/217 (4%)
Frame = +1
Query: 140 VSKARAKVTMNDFDYLKL--------LGKGTFGKVILVREKATGRYYAMKILRKEVIIAK 191
+S+ + +++D + KL LG+GT+ V R K T A+K +R E +
Sbjct: 370 LSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEH--EE 543
Query: 192 DEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEER 251
+ E +L+N +H + L T L V EY + + + +
Sbjct: 544 GAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHN 723
Query: 252 ARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFC 311
+ + +++ L Y H R +++RD+K +NL++++ G +K+ DFGL + T
Sbjct: 724 VKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEV 903
Query: 312 GTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGR 347
T Y P+V L +Y +D WG+G + YEM GR
Sbjct: 904 VTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGR 1014
>lcl|NM_000215.3_cdsid_NP_000206.2 [gene=JAK3]
[protein=tyrosine-protein kinase JAK3]
[protein_id=NP_000206.2] [location=101..3475]
Length = 3375
Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust.
Identities = 66/202 (32%), Positives = 93/202 (46%), Gaps = 10/202 (4%)
Frame = +1
Query: 152 FDYLKLLGKGTFGKVILVREKA----TGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT 207
Y+ LGKG FG V L R TG A+K L+ D+ E ++L+
Sbjct: 2464 LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS---GPDQQRDFQREIQILKAL 2634
Query: 208 RHPFLTALKYAFQTHDR--LCFVMEYANGGELFFHLSRERV-FTEERARFYGAEIVSALE 264
F+ + R L VMEY G L L R R R Y ++I +E
Sbjct: 2635 HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGME 2814
Query: 265 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK--EGISDGATMKTFCGTPEY-LAPEV 321
YL SR V+RD+ N++++ + H+KI DFGL K D ++ +P + APE
Sbjct: 2815 YLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPES 2994
Query: 322 LEDNDYGRAVDWWGLGVVMYEM 343
L DN + R D W GVV+YE+
Sbjct: 2995 LSDNIFSRQSDVWSFGVVLYEL 3060
>lcl|NM_198465.2_cdsid_NP_940867.2 [gene=NRK] [protein=nik-related
protein kinase] [protein_id=NP_940867.2]
[location=304..5052]
Length = 4749
Score = 85.9 bits (211), Expect = 1e-17, Method: Compositional matrix adjust.
Identities = 68/247 (27%), Positives = 115/247 (46%), Gaps = 36/247 (14%)
Frame = +1
Query: 152 FDYLKLLGKGTFGKVILVREKATGRYYAMKILR----------KEVIIAK---------- 191
F K +G GT+G++ L + TG + A+K++ + V + K
Sbjct: 73 FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSVGWRYS 252
Query: 192 DEVAHTVTESRVLQN-TRHPFLTALKYAF-------QTHDRLCFVMEYANGGEL--FFHL 241
DE TE +L+ + H + + AF Q H +L VME G + +
Sbjct: 253 DEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRH-QLWMVMELCAAGSVTDVVRM 429
Query: 242 SRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGI 301
+ + E+ + EI+ L +LH+ V++RDIK +N++L + +K+ DFG+ +
Sbjct: 430 TSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVS 609
Query: 302 SDGATMKTFCGTPEYLAPEVLE-DNDYGRAVDW----WGLGVVMYEMMCGRLPFYN-QDH 355
+F GTP ++APEV++ D D R+ D+ W +G+ EM G P N Q
Sbjct: 610 RTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPL 789
Query: 356 ERLFELI 362
E LF ++
Sbjct: 790 EALFVIL 810
>lcl|NM_012395.2_cdsid_NP_036527.1 [gene=CDK14]
[protein=cyclin-dependent kinase 14]
[protein_id=NP_036527.1] [location=145..1500]
Length = 1356
Score = 84.3 bits (207), Expect = 3e-17, Method: Compositional matrix adjust.
Identities = 50/202 (24%), Positives = 95/202 (47%), Gaps = 1/202 (0%)
Frame = +1
Query: 150 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRH 209
+ ++ L+ LG+G++ V + K G+ A+K++R + A + E+ +L+ +H
Sbjct: 343 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTA--IREASLLKGLKH 516
Query: 210 PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSR 269
+ L T + L V EY + + + + + +++ L Y+H R
Sbjct: 517 ANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQR 696
Query: 270 DVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV-LEDNDYG 328
+++RD+K +NL++ G +K+ DFGL + T T Y P+V L +Y
Sbjct: 697 YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYS 876
Query: 329 RAVDWWGLGVVMYEMMCGRLPF 350
+D WG+G + EM+ G F
Sbjct: 877 TCLDMWGVGCIFVEMIQGVAAF 942
>lcl|NM_145331.2_cdsid_NP_663304.1 [gene=MAP3K7]
[protein=mitogen-activated protein kinase kinase kinase
7 isoform B] [protein_id=NP_663304.1]
[location=419..2239]
Length = 1821
Score = 84.0 bits (206), Expect = 5e-17, Method: Compositional matrix adjust.
Identities = 71/254 (27%), Positives = 119/254 (46%), Gaps = 12/254 (4%)
Frame = +1
Query: 151 DFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHP 210
+ + +++G+G FG ++ + K + A+K + E E + E R L HP
Sbjct: 103 EIEVEEVVGRGAFG--VVCKAKWRAKDVAIKQIESE-----SERKAFIVELRQLSRVNHP 261
Query: 211 FLTALKYAFQTHDRLCFVMEYANGGELFFHLSRER---VFTEERARFYGAEIVSALEYLH 267
+ L A + +C VMEYA GG L+ L +T A + + + YLH
Sbjct: 262 NIVKLYGA--CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 435
Query: 268 S---RDVVYRDIKLENLMLDKDGHI-KITDFGLCKEGISDGAT-MKTFCGTPEYLAPEVL 322
S + +++RD+K NL+L G + KI DFG D T M G+ ++APEV
Sbjct: 436 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA----CDIQTHMTNNKGSAAWMAPEVF 603
Query: 323 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELI--LMEEIRFP--RTLSPEAK 378
E ++Y D + G++++E++ R PF ++ F ++ + R P + L +
Sbjct: 604 EGSNYSEKCDVFSWGIILWEVITRRKPF-DEIGGPAFRIMWAVHNGTRPPLIKNLPKPIE 780
Query: 379 SLLAGLLKKDPKQR 392
SL+ KDP QR
Sbjct: 781 SLMTRCWSKDPSQR 822
>lcl|NM_001256196.1_cdsid_NP_001243125.1 [gene=ARAF]
[protein=serine/threonine-protein kinase A-Raf isoform 2]
[protein_id=NP_001243125.1] [location=212..2041]
Length = 1830
Score = 83.2 bits (204), Expect = 8e-17, Method: Compositional matrix adjust.
Identities = 61/214 (28%), Positives = 105/214 (49%), Gaps = 9/214 (4%)
Frame = +1
Query: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYY---AMKILRKEVIIAKDEVAHTVTESR 202
+V ++ LK +G G+FG V GR++ A+K+L+ A+ A E +
Sbjct: 919 EVPPSEVQLLKRIGTGSFGTVF------RGRWHGDVAVKVLKVSQPTAEQAQAFK-NEMQ 1077
Query: 203 VLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLS-RERVFTEERARFYGAEIVS 261
VL+ TRH + L F T + ++ G L+ HL + F + +
Sbjct: 1078 VLRKTRHVNIL-LFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQ 1254
Query: 262 ALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLC--KEGISDGATMKTFCGTPEYLAP 319
++YLH++++++RD+K N+ L + +KI DFGL K S ++ G+ ++A
Sbjct: 1255 GMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAA 1434
Query: 320 EVL---EDNDYGRAVDWWGLGVVMYEMMCGRLPF 350
EV+ + N Y D + GVV+YE+M G LP+
Sbjct: 1435 EVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPY 1536
>lcl|NM_032387.4_cdsid_NP_115763.2 [gene=WNK4]
[protein=serine/threonine-protein kinase WNK4]
[protein_id=NP_115763.2] [location=69..3800]
Length = 3732
Score = 82.0 bits (201), Expect = 2e-16, Method: Compositional matrix adjust.
Identities = 72/281 (25%), Positives = 128/281 (45%), Gaps = 13/281 (4%)
Frame = +1
Query: 142 KARAKVTMNDFDYLKL---LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTV 198
+ +A T D YLK +G+G+F V + T A L+ + ++ E
Sbjct: 481 ETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKL-SRAERQRFS 657
Query: 199 TESRVLQNTRHP----FLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARF 254
E +L+ +HP F + K + + V E G L +L R R +
Sbjct: 658 EEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQR 837
Query: 255 YGAEIVSALEYLHSR--DVVYRDIKLENLML-DKDGHIKITDFGLCKEGISDGATMKTFC 311
+ +I+ L +LHSR +++RD+K +N+ + G +KI D GL + + K+
Sbjct: 838 WSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLAT--LKRASFAKSVI 1011
Query: 312 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN-QDHERLFELILM--EEIR 368
GTPE++APE+ E+ Y AVD + G+ M EM P+ Q+ +++ + +
Sbjct: 1012GTPEFMAPEMYEEK-YDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNS 1188
Query: 369 FPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 409
F + PE K ++ G ++ D +R ++++ H FF
Sbjct: 1189FHKVKIPEVKEIIEGCIRTDKNERF-----TIQDLLAHAFF 1296
>lcl|NM_006648.3_cdsid_NP_006639.3 [gene=WNK2]
[protein=serine/threonine-protein kinase WNK2]
[protein_id=NP_006639.3] [location=1..6654]
Length = 6654
Score = 81.3 bits (199), Expect = 3e-16, Method: Compositional matrix adjust.
Identities = 73/280 (26%), Positives = 134/280 (47%), Gaps = 14/280 (5%)
Frame = +1
Query: 144 RAKVTMNDFDYLKL---LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTE 200
+A T D +LK LG+G+F V + T A L ++ + K E E
Sbjct: 550 KAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETWVEVAWCEL-QDRKLTKLERQRFKEE 726
Query: 201 SRVLQNTRHPFLTALKYAF---QTHDRLCFVM--EYANGGELFFHLSRERVFTEERARFY 255
+ +L+ +HP + Y F + C V+ E G L +L R +V + R +
Sbjct: 727 AEMLKGLQHPNIVRF-YDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSW 903
Query: 256 GAEIVSALEYLHSRD--VVYRDIKLENLML-DKDGHIKITDFGLCKEGISDGATMKTFCG 312
+I+ L +LH+R +++RD+K +N+ + G +KI D GL + + K+ G
Sbjct: 904 CRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT--LKRASFAKSVIG 1077
Query: 313 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN-QDHERLFELIL--MEEIRF 369
TPE++APE+ E++ Y +VD + G+ M EM P+ Q+ +++ + ++ F
Sbjct: 1078TPEFMAPEMYEEH-YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASF 1254
Query: 370 PRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 409
+ PE K ++ + K+ ++R + K+++ H FF
Sbjct: 1255EKVHDPEIKEIIGECICKNKEERY-----EIKDLLSHAFF 1359
>lcl|NM_020975.4_cdsid_NP_066124.1 [gene=RET] [protein=proto-oncogene
tyrosine-protein kinase receptor Ret isoform a precursor]
[protein_id=NP_066124.1] [location=191..3535]
Length = 3345
Score = 79.3 bits (194), Expect = 1e-15, Method: Compositional matrix adjust.
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 33/270 (12%)
Frame = +1
Query: 156 KLLGKGTFGKVIL-----VREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHP 210
K LG+G FGKV+ ++ +A A+K+L++ + E+ ++E VL+ HP
Sbjct: 2182 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLSEFNVLKQVNHP 2355
Query: 211 FLTALKYAFQTHDRLCFVMEYANGGEL--FFHLSR----------------------ERV 246
+ L A L ++EYA G L F SR ER
Sbjct: 2356 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 2535
Query: 247 FTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGAT 306
T + +I ++YL +V+RD+ N+++ + +KI+DFGL ++ + +
Sbjct: 2536 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 2715
Query: 307 MKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELI- 362
+K G +++A E L D+ Y D W GV+++E++ G P+ ERLF L+
Sbjct: 2716 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 2895
Query: 363 LMEEIRFPRTLSPEAKSLLAGLLKKDPKQR 392
+ P S E L+ K++P +R
Sbjct: 2896 TGHRMERPDNCSEEMYRLMLQCWKQEPDKR 2985
>lcl|NM_005546.3_cdsid_NP_005537.3 [gene=ITK]
[protein=tyrosine-protein kinase ITK/TSK]
[protein_id=NP_005537.3] [location=83..1945]
Length = 1863
Score = 79.3 bits (194), Expect = 1e-15, Method: Compositional matrix adjust.
Identities = 61/247 (24%), Positives = 114/247 (46%), Gaps = 4/247 (1%)
Frame = +1
Query: 150 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRH 209
++ +++ +G G FG V L + A+K +R+ + +D + E+ V+ H
Sbjct: 1081 SELTFVQEIGSGQFGLVHLGYWLNKDKV-AIKTIREGAMSEED----FIEEAEVMMKLSH 1245
Query: 210 PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRER-VFTEERARFYGAEIVSALEYLHS 268
P L L +C V E+ G L +L +R +F E ++ + YL
Sbjct: 1246 PKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 1425
Query: 269 RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTP-EYLAPEVLEDNDY 327
V++RD+ N ++ ++ IK++DFG+ + + D T T P ++ +PEV + Y
Sbjct: 1426 ACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRY 1605
Query: 328 GRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILME-EIRFPRTLSPEAKSLLAGLL 385
D W GV+M+E+ G++P+ N+ + + E I + PR S ++
Sbjct: 1606 SSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCW 1785
Query: 386 KKDPKQR 392
K+ P+ R
Sbjct: 1786 KERPEDR 1806
>lcl|NM_004972.3_cdsid_NP_004963.1 [gene=JAK2]
[protein=tyrosine-protein kinase JAK2]
[protein_id=NP_004963.1] [location=495..3893]
Length = 3399
Score = 73.9 bits (180), Expect = 5e-14, Method: Compositional matrix adjust.
Identities = 57/201 (28%), Positives = 99/201 (49%), Gaps = 11/201 (5%)
Frame = +1
Query: 154 YLKLLGKGTFGKVILVR----EKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRH 209
+L+ LGKG FG V + R + TG A+K L+ ++ + E +L++ +H
Sbjct: 2551 FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS---TEEHLRDFEREIEILKSLQH 2721
Query: 210 PFLTALKYAFQTHDR--LCFVMEYANGGEL--FFHLSRERVFTEERARFYGAEIVSALEY 265
+ K + R L +MEY G L + +ER+ + Y ++I +EY
Sbjct: 2722 DNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERI-DHIKLLQYTSQICKGMEY 2898
Query: 266 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGA--TMKTFCGTPEY-LAPEVL 322
L ++ ++RD+ N++++ + +KI DFGL K D +K +P + APE L
Sbjct: 2899 LGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESL 3078
Query: 323 EDNDYGRAVDWWGLGVVMYEM 343
++ + A D W GVV+YE+
Sbjct: 3079 TESKFSVASDVWSFGVVLYEL 3141
>lcl|NM_002031.2_cdsid_NP_002022.1 [gene=FRK]
[protein=tyrosine-protein kinase FRK]
[protein_id=NP_002022.1] [location=448..1965]
Length = 1518
Score = 73.2 bits (178), Expect = 8e-14, Method: Compositional matrix adjust.
Identities = 56/234 (23%), Positives = 109/234 (46%), Gaps = 8/234 (3%)
Frame = +1
Query: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 205
++ N LK LG G FG+V T A+K L+ + D + E+++++
Sbjct: 682 EIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPV-AVKTLKPGSMDPND----FLREAQIMK 846
Query: 206 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRE---RVFTEERARFYGAEIVSA 262
N RHP L L D + + E G L +L + ++ ++ A++ S
Sbjct: 847 NLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDM-AAQVASG 1023
Query: 263 LEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATM---KTFCGTP-EYLA 318
+ YL SR+ ++RD+ N+++ + K+ DFGL + D + + P ++ A
Sbjct: 1024MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 1203
Query: 319 PEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILMEEIRFPR 371
PE + N + D W G+++YE++ G++P+ ++ ++ L + R P+
Sbjct: 1204PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQM-LAQNYRLPQ 1362
>lcl|NM_024652.3_cdsid_NP_078928.3 [gene=LRRK1] [protein=leucine-rich
repeat serine/threonine-protein kinase 1]
[protein_id=NP_078928.3] [location=320..6367]
Length = 6048
Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust.
Identities = 51/161 (31%), Positives = 82/161 (50%), Gaps = 11/161 (6%)
Frame = +1
Query: 200 ESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLS---RERVFT---EERAR 253
E+ +L +HP + AL H LCF +E A L LS R+ F +
Sbjct: 3919 EASMLHALQHPCIVAL-IGISIHP-LCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQ 4092
Query: 254 FYGAEIVSALEYLHSRDVVYRDIKLENLM---LDKDGHI--KITDFGLCKEGISDGATMK 308
+I S L YLH +++++ D+K +N++ LD HI K++D+G+ ++ +GA
Sbjct: 4093 KIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGV 4272
Query: 309 TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP 349
GTP Y APE+ Y VD + G+V+YE++ G+ P
Sbjct: 4273 E--GTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRP 4389
>lcl|NM_139355.2_cdsid_NP_647612.1 [gene=MATK]
[protein=megakaryocyte-associated tyrosine-protein
kinase isoform a] [protein_id=NP_647612.1]
[location=401..1924]
Length = 1524
Score = 71.2 bits (173), Expect = 3e-13, Method: Compositional matrix adjust.
Identities = 62/232 (26%), Positives = 105/232 (45%), Gaps = 8/232 (3%)
Frame = +1
Query: 127 PSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKE 186
P T+ E +++A + + +G+G FG V+ G Y K+ K
Sbjct: 628 PKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVL------QGEYLGQKVAVKN 789
Query: 187 VIIAKDEVAHT-VTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHL---S 242
I D A + E+ V+ +H L L H L VME+ + G L L
Sbjct: 790 --IKCDVTAQAFLDETAVMTKMQHENLVRL-LGVILHQGLYIVMEHVSKGNLVNFLRTRG 960
Query: 243 RERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK---E 299
R V T + +F + +EYL S+ +V+RD+ N+++ +D K++DFGL K +
Sbjct: 961 RALVNTAQLLQF-SLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERK 1137
Query: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPF 350
G+ D + + ++ APE L+ + D W GV+++E+ GR P+
Sbjct: 1138GL-DSSRLPV-----KWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPY 1275
>lcl|NM_000142.4_cdsid_NP_000133.1 [gene=FGFR3] [protein=fibroblast
growth factor receptor 3 isoform 1 precursor]
[protein_id=NP_000133.1] [location=257..2677]
Length = 2421
Score = 70.1 bits (170), Expect = 8e-13, Method: Compositional matrix adjust.
Identities = 64/245 (26%), Positives = 112/245 (45%), Gaps = 25/245 (10%)
Frame = +1
Query: 143 ARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDE-----VAHT 197
+RA++T+ K LG+G FG+V++ + A K + V + KD+ ++
Sbjct: 1402 SRARLTLG-----KPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDL 1566
Query: 198 VTESRVLQNT-RHPFLTALKYAFQTHDRLCFVMEYANGGEL--FFHLSR----------- 243
V+E +++ +H + L A L ++EYA G L F R
Sbjct: 1567 VSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTC 1746
Query: 244 ---ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG 300
E T + ++ +EYL S+ ++RD+ N+++ +D +KI DFGL ++
Sbjct: 1747 KPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV 1926
Query: 301 ISDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHER 357
+ KT G +++APE L D Y D W GV+++E+ G P+ E
Sbjct: 1927 HNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEE 2106
Query: 358 LFELI 362
LF+L+
Sbjct: 2107 LFKLL 2121
>lcl|NM_000141.4_cdsid_NP_000132.3 [gene=FGFR2] [protein=fibroblast
growth factor receptor 2 isoform 1 precursor]
[protein_id=NP_000132.3] [location=648..3113]
Length = 2466
Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 60/232 (25%), Positives = 107/232 (46%), Gaps = 25/232 (10%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDE-----VAHTVTESRVLQNT-RH 209
K LG+G FG+V++ + + + V + KD+ ++ V+E +++ +H
Sbjct: 1453 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 1632
Query: 210 PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERV-----------FTEERARFYGA- 257
+ L A L ++EYA+ G L +L R EE+ F
Sbjct: 1633 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 1812
Query: 258 ----EIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCG- 312
++ +EYL S+ ++RD+ N+++ ++ +KI DFGL ++ + KT G
Sbjct: 1813 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 1992
Query: 313 -TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELI 362
+++APE L D Y D W GV+M+E+ G P+ E LF+L+
Sbjct: 1993 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 2148
>lcl|NM_005781.4_cdsid_NP_005772.3 [gene=TNK2] [protein=activated
CDC42 kinase 1 isoform 1] [protein_id=NP_005772.3]
[location=544..3660]
Length = 3117
Score = 68.2 bits (165), Expect = 3e-12, Method: Compositional matrix adjust.
Identities = 62/229 (27%), Positives = 99/229 (43%), Gaps = 8/229 (3%)
Frame = +1
Query: 151 DFDYLKLLGKGTFGKVILVREKA-TGR--YYAMKILRKEVIIAKDEVAHTVTESRVLQNT 207
D L+ LG G+FG V A +G+ A+K L+ +V+ + + + E + +
Sbjct: 373 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 552
Query: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERV-FTEERARFYGAEIVSALEYL 266
H L L Y + V E A G L L + + F Y ++ + YL
Sbjct: 553 DHRNLIRL-YGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYL 729
Query: 267 HSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE--GISDGATMKTFCGTP-EYLAPEVLE 323
S+ ++RD+ NL+L +KI DFGL + D M+ P + APE L+
Sbjct: 730 ESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK 909
Query: 324 DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILMEEIRFPR 371
+ A D W GV ++EM G+ P+ + ++ I E R PR
Sbjct: 910 TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPR 1056
>lcl|NM_002747.3_cdsid_NP_002738.2 [gene=MAPK4]
[protein=mitogen-activated protein kinase 4]
[protein_id=NP_002738.2] [location=1001..2764]
Length = 1764
Score = 67.8 bits (164), Expect = 4e-12, Method: Compositional matrix adjust.
Identities = 57/222 (25%), Positives = 97/222 (43%), Gaps = 16/222 (7%)
Frame = +1
Query: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRH-------- 209
LG G G V+ + R A+K K + + H + E ++++ H
Sbjct: 76 LGFGVNGLVLSAVDSRACRKVAVK---KIALSDARSMKHALREIKIIRRLDHDNIVKVYE 246
Query: 210 ---PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYL 266
P T L+ V EY L + EE A+ + +++ L+Y+
Sbjct: 247 VLGPKGTDLQGELFKFSVAYIVQEYMETD--LARLLEQGTLAEEHAKLFMYQLLRGLKYI 420
Query: 267 HSRDVVYRDIKLENLMLD-KDGHIKITDFGLCK---EGISDGATMKTFCGTPEYLAPEVL 322
HS +V++RD+K N+ + +D +KI DFGL + + S + T Y +P +L
Sbjct: 421 HSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLL 600
Query: 323 -EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 363
N+Y +A+D W G ++ EM+ GR+ F +LIL
Sbjct: 601 LSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLIL 726
>lcl|NM_001174066.1_cdsid_NP_001167537.1 [gene=FGFR1]
[protein=fibroblast growth factor receptor 1 isoform 3
precursor] [protein_id=NP_001167537.1]
[location=263..2464]
Length = 2202
Score = 67.8 bits (164), Expect = 4e-12, Method: Compositional matrix adjust.
Identities = 57/234 (24%), Positives = 106/234 (45%), Gaps = 27/234 (11%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGR-------YYAMKILRKEVIIAKDEVAHTVTESRVLQNT- 207
K LG+G FG+V+L + A+K+L+ + + +++ ++E +++
Sbjct: 1177 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA--TEKDLSDLISEMEMMKMIG 1350
Query: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRER----------------VFTEER 251
+H + L A L ++EYA+ G L +L R + +
Sbjct: 1351 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 1530
Query: 252 ARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFC 311
++ +EYL S+ ++RD+ N+++ +D +KI DFGL ++ KT
Sbjct: 1531 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 1710
Query: 312 G--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELI 362
G +++APE L D Y D W GV+++E+ G P+ E LF+L+
Sbjct: 1711 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 1872
>lcl|NM_004444.4_cdsid_NP_004435.3 [gene=EPHB4] [protein=ephrin type-B
receptor 4 precursor] [protein_id=NP_004435.3]
[location=492..3455]
Length = 2964
Score = 67.0 bits (162), Expect = 5e-12, Method: Compositional matrix adjust.
Identities = 59/234 (25%), Positives = 107/234 (45%), Gaps = 14/234 (5%)
Frame = +1
Query: 151 DFDYLKL---LGKGTFGKVILVREKATGRY---YAMKILRKEVIIAKDEVAHTVTESRVL 204
D Y+K+ +G G FG+V R KA G+ A+K L+ + + ++E+ ++
Sbjct: 1831 DVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGG--YTERQRREFLSEASIM 2004
Query: 205 QNTRHPFLTALKYAFQTHDRLCFVMEYANGGEL--FFHLSRERVFTEERARFYGAEIVSA 262
HP + L+ + + E+ G L F L+ + FT + I S
Sbjct: 2005 GQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQ-FTVIQLVGMLRGIASG 2181
Query: 263 LEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK---EGISDGATMKTFCGT--PEYL 317
+ YL V+RD+ N++++ + K++DFGL + E SD + G +
Sbjct: 2182 MRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWT 2361
Query: 318 APEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILMEEIRFP 370
APE + + A D W G+VM+E+M G P+++ ++ + I ++ R P
Sbjct: 2362 APEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLP 2520
>lcl|NM_001013703.2_cdsid_NP_001013725.2 [gene=EIF2AK4]
[protein=eukaryotic translation initiation factor 2-alpha
kinase 4] [protein_id=NP_001013725.2] [location=51..5000]
Length = 4950
Score = 67.0 bits (162), Expect = 5e-12, Method: Compositional matrix adjust.
Identities = 48/162 (29%), Positives = 77/162 (47%), Gaps = 27/162 (16%)
Frame = +1
Query: 258 EIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKT-------- 309
EI+ L Y+H + +++RD+K N+ LD D H+KI DFGL + ++ A K
Sbjct: 2491 EILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLI 2670
Query: 310 ----------FCGTPEYLAPEVL--EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHER 357
GT Y++PEV + Y + VD + LG++ +EM P ER
Sbjct: 2671 KSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEM--SYHPMVTAS-ER 2841
Query: 358 LFELILMEE---IRFPRTLS----PEAKSLLAGLLKKDPKQR 392
+F L + + +FP + KS+++ LL DP +R
Sbjct: 2842 IFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKR 2967
Score = 57.8 bits (138), Expect = 4e-09, Method: Compositional matrix adjust.
Identities = 35/119 (29%), Positives = 61/119 (51%), Gaps = 4/119 (3%)
Frame = +1
Query: 184 RKEVIIAKDEVAHTVTESRVLQNTRHPFLTA-LKYAFQTHDRLCFV---MEYANGGELFF 239
++++ K ++ T TE L HP + L + D V +E+ +G L
Sbjct: 988 KEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAA 1167
Query: 240 HLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK 298
HLS + R Y A+++S L+YLHS VV++ + N+++D +G +KITD+ + K
Sbjct: 1168 HLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISK 1344
>lcl|NM_001012338.2_cdsid_NP_001012338.1 [gene=NTRK3] [protein=NT-3
growth factor receptor isoform a precursor]
[protein_id=NP_001012338.1] [location=307..2826]
Length = 2520
Score = 67.0 bits (162), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 63/275 (22%), Positives = 112/275 (40%), Gaps = 39/275 (14%)
Frame = +1
Query: 158 LGKGTFGKVIL-----VREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFL 212
LG+G FGKV L + A+K L+ + A+ + E+ +L N +H +
Sbjct: 1630 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQR---EAELLTNLQHEHI 1800
Query: 213 TALKYAFQTHDRLCFVMEYANGGEL--FF--HLSRERVFTEERAR------------FYG 256
D L V EY G+L F H + + + R
Sbjct: 1801 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 1980
Query: 257 AEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD------GATMKTF 310
++I S + YL S+ V+RD+ N ++ + +KI DFG+ ++ S + F
Sbjct: 1981 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF 2160
Query: 311 CGTPE----------YLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLF 359
C E ++ PE + + D W GV+++E+ G+ P++ + +
Sbjct: 2161 CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 2340
Query: 360 ELILMEEI-RFPRTLSPEAKSLLAGLLKKDPKQRL 393
E I + PR E ++ G +++P+QRL
Sbjct: 2341 ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRL 2445
>lcl|NM_004438.3_cdsid_NP_004429.1 [gene=EPHA4] [protein=ephrin type-A
receptor 4 precursor] [protein_id=NP_004429.1]
[location=43..3003]
Length = 2961
Score = 65.1 bits (157), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 64/268 (23%), Positives = 116/268 (43%), Gaps = 8/268 (2%)
Frame = +1
Query: 111 KQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVR 170
KQ A E ++ + D T E+ AV + ++ + K++G G FG+V R
Sbjct: 1738 KQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGR 1917
Query: 171 EKATGR---YYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCF 227
K G+ A+K L+ + ++E+ ++ HP + L+ +
Sbjct: 1918 LKVPGKREICVAIKTLKAGY--TDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMI 2091
Query: 228 VMEYANGGEL-FFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKD 286
+ EY G L F + FT + I S ++YL V+RD+ N++++ +
Sbjct: 2092 ITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSN 2271
Query: 287 GHIKITDFGLCKEGISDGATMKTFCGTP---EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 343
K++DFG+ + D T G + APE + + A D W G+VM+E+
Sbjct: 2272 LVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEV 2451
Query: 344 MC-GRLPFYNQDHERLFELILMEEIRFP 370
M G P+++ ++ + + I E R P
Sbjct: 2452 MSYGERPYWDMSNQDVIKAI-EEGYRLP 2532
>lcl|NM_020526.3_cdsid_NP_065387.1 [gene=EPHA8] [protein=ephrin type-A
receptor 8 isoform 1 precursor] [protein_id=NP_065387.1]
[location=126..3143]
Length = 3018
Score = 64.3 bits (155), Expect = 4e-11, Method: Compositional matrix adjust.
Identities = 65/248 (26%), Positives = 111/248 (44%), Gaps = 11/248 (4%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRY---YAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFL 212
K++G G G+V R + G+ A+K L+ + + ++E+ ++ HP +
Sbjct: 1915 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY--TERQRRDFLSEASIMGQFDHPNI 2088
Query: 213 TALKYAFQTHDRLCFVM-EYANGGEL-FFHLSRERVFTEERARFYGAEIVSALEYLHSRD 270
L+ T RL ++ EY G L F + + FT + + + + YL
Sbjct: 2089 IRLE-GVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLG 2265
Query: 271 VVYRDIKLENLMLDKDGHIKITDFGLCK--EGISDGATMKTFCGTP-EYLAPEVLEDNDY 327
V+RD+ N+++D + K++DFGL + E D A T P + APE + +
Sbjct: 2266 YVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTF 2445
Query: 328 GRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILMEEIRFPRTLS-PEA-KSLLAGL 384
A D W GVVM+E++ G P++N + + + E R P + P A L+
Sbjct: 2446 SSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSV-EEGYRLPAPMGCPHALHQLMLDC 2622
Query: 385 LKKDPKQR 392
KD QR
Sbjct: 2623 WHKDRAQR 2646
>lcl|NM_173598.4_cdsid_NP_775869.3 [gene=KSR2] [protein=kinase
suppressor of Ras 2] [protein_id=NP_775869.3]
[location=56..2821]
Length = 2766
Score = 63.2 bits (152), Expect = 8e-11, Method: Compositional matrix adjust.
Identities = 54/219 (24%), Positives = 95/219 (43%), Gaps = 15/219 (6%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 215
+L+GKG FG+V R + I R +D++ E + TRH +
Sbjct: 1921 ELIGKGRFGQVYHGRWHGEVAIRLIDIERDN----EDQLKAFKREVMAYRQTRHENVVLF 2088
Query: 216 KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTE-ERARFYGAEIVSALEYLHSRDVVYR 274
A + L + G L+ + ++ + + R EIV + YLH++ ++++
Sbjct: 2089 MGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHK 2268
Query: 275 DIKLENLMLDKDGHIKITDFGLCK-EGISDGA----TMKTFCGTPEYLAPEVL------- 322
D+K +N+ D +G + ITDFGL G+ ++ G +LAPE++
Sbjct: 2269 DLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDT 2445
Query: 323 -EDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
ED + + D + LG + YE+ PF Q E +
Sbjct: 2446 EEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAII 2562
>lcl|NM_004071.3_cdsid_NP_004062.2 [gene=CLK1] [protein=dual
specificity protein kinase CLK1 isoform 1]
[protein_id=NP_004062.2] [location=182..1636]
Length = 1455
Score = 63.2 bits (152), Expect = 9e-11, Method: Compositional matrix adjust.
Identities = 69/265 (26%), Positives = 111/265 (41%), Gaps = 29/265 (10%)
Frame = +1
Query: 152 FDYLKLLGKGTFGKVI-LVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ--NTR 208
++ + LG+G FGKV+ + KA GR+ A+KI++ + E A +E +VL+ NT
Sbjct: 481 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN--VDRYCEAA--RSEIQVLEHLNTT 648
Query: 209 HPFLT----ALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEER---ARFYGAEIVS 261
P T + F+ H +C V E G + +E F R R +I
Sbjct: 649 DPNSTFRCVQMLEWFEHHGHICIVFELL--GLSTYDFIKENGFLPFRLDHIRKMAYQICK 822
Query: 262 ALEYLHSRDVVYRDIKLENLMLDKDGH-------------------IKITDFGLCKEGIS 302
++ +LHS + + D+K EN++ + + IK+ DFG
Sbjct: 823 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG---SATY 993
Query: 303 DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELI 362
D T T Y APEV+ + + D W +G ++ E G F D + L
Sbjct: 994 DDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKE--HLA 1167
Query: 363 LMEEIRFPRTLSPEAKSLLAGLLKK 387
+ME R L P K ++ K+
Sbjct: 1168MME-----RILGPLPKHMIQKTRKR 1227
>lcl|NM_022963.2_cdsid_NP_075252.2 [gene=FGFR4] [protein=fibroblast
growth factor receptor 4 isoform 2 precursor]
[protein_id=NP_075252.2] [location=54..2342]
Length = 2289
Score = 62.4 bits (150), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 73/268 (27%), Positives = 112/268 (41%), Gaps = 31/268 (11%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATG---------RYYAMKILRKEVIIAKDEVAHTVTESRVLQN 206
K LG+G FG+V VR +A G A+K+L+ + ++A V+E V++
Sbjct: 1291 KPLGEGCFGQV--VRAEAFGMDPARPDQASTVAVKMLKDNA--SDKDLADLVSEMEVMKL 1458
Query: 207 T-RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERV-----------FTEERARF 254
RH + L L ++E A G L L R +E F
Sbjct: 1459 IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF 1638
Query: 255 -----YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKT 309
++ ++YL SR ++RD+ N+++ +D +KI DFGL + KT
Sbjct: 1639 PVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT 1818
Query: 310 FCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILMEE 366
G +++APE L D Y D W G++++E+ G P+ E LF L L E
Sbjct: 1819 SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSL-LREG 1995
Query: 367 IRF--PRTLSPEAKSLLAGLLKKDPKQR 392
R P PE L+ P QR
Sbjct: 1996 HRMDRPPHCPPELYGLMRECWHAAPSQR 2079
>lcl|NM_005204.3_cdsid_NP_005195.2 [gene=MAP3K8]
[protein=mitogen-activated protein kinase kinase kinase
8] [protein_id=NP_005195.2] [location=613..2016]
Length = 1404
Score = 62.0 bits (149), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 58/242 (23%), Positives = 99/242 (40%), Gaps = 9/242 (3%)
Frame = +1
Query: 160 KGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAF 219
+G FGKV L ++ T + A K+ I D+ + E + RH + L A
Sbjct: 436 RGAFGKVYLAQDIKTKKRMACKL------IPVDQFKPSDVEIQAC--FRHENIAELYGAV 591
Query: 220 QTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLE 279
+ + ME GG + L E + ++ L++LHS+ V++ DIK
Sbjct: 592 LWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 771
Query: 280 NLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVV 339
N++ + + DFGL + D K GT Y++PEV+ + D + LG
Sbjct: 772 NIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 948
Query: 340 MYEMMCGRLPFYNQDHERLFELIL---------MEEIRFPRTLSPEAKSLLAGLLKKDPK 390
+ M G P+ + + L +E+I SP + L+ L+++P
Sbjct: 949 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDI--ADDCSPGMRELIEASLERNPN 1122
Query: 391 QR 392
R
Sbjct: 1123HR 1128
>lcl|NM_005417.3_cdsid_NP_005408.1 [gene=SRC] [protein=proto-oncogene
tyrosine-protein kinase Src] [protein_id=NP_005408.1]
[location=450..2060]
Length = 1611
Score = 62.0 bits (149), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 61/246 (24%), Positives = 113/246 (45%), Gaps = 11/246 (4%)
Frame = +1
Query: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
LG+G FG+V + T R A+K L+ + + + E++V++ RH L L Y
Sbjct: 826 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPE----AFLQEAQVMKKLRHEKLVQL-Y 987
Query: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARF-----YGAEIVSALEYLHSRDVV 272
A + + + V EY + G L L E T + R A+I S + Y+ + V
Sbjct: 988 AVVSEEPIYIVTEYMSKGSLLDFLKGE---TGKYLRLPQLVDMAAQIASGMAYVERMNYV 1158
Query: 273 YRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTP-EYLAPEVLEDNDYGRAV 331
+RD++ N+++ ++ K+ DFGL + + T + P ++ APE +
Sbjct: 1159 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 1338
Query: 332 DWWGLGVVMYEMMC-GRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLL----K 386
D W G+++ E+ GR+P+ + + + + E + PE L L+ +
Sbjct: 1339 DVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQCWR 1509
Query: 387 KDPKQR 392
K+P++R
Sbjct: 1510 KEPEER 1527
>lcl|NM_006871.3_cdsid_NP_006862.2 [gene=RIPK3]
[protein=receptor-interacting serine/threonine-protein
kinase 3] [protein_id=NP_006862.2] [location=211..1767]
Length = 1557
Score = 61.6 bits (148), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 54/209 (25%), Positives = 97/209 (46%), Gaps = 8/209 (3%)
Frame = +1
Query: 147 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 206
V++ + + +L+GKG FG V + + G A+KI+ + I + + ++ VL+
Sbjct: 46 VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLR- 222
Query: 207 TRHPFLTAL--KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 264
L + K + + V ++ G L L + E+V +
Sbjct: 223 -----LEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMF 387
Query: 265 YLHSRDVV--YRDIKLENLMLDKDGHIKITDFGLC--KEGISDGATMKTFCGTPEYLAPE 320
YLH ++ V +RD+K N++LD + H+K+ DFGL + G G GT YLAPE
Sbjct: 388 YLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPE 567
Query: 321 VLEDND--YGRAVDWWGLGVVMYEMMCGR 347
+ + + A D + G++M+ ++ GR
Sbjct: 568 LFVNVNRKASTASDVYSFGILMWAVLAGR 654
>lcl|NM_002019.4_cdsid_NP_002010.2 [gene=FLT1] [protein=vascular
endothelial growth factor receptor 1 isoform 1 precursor]
[protein_id=NP_002010.2] [location=286..4302]
Length = 4017
Score = 61.6 bits (148), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 40/147 (27%), Positives = 71/147 (48%), Gaps = 9/147 (6%)
Frame = +1
Query: 255 YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK------EGISDGATMK 308
Y ++ +E+L SR ++RD+ N++L ++ +KI DFGL + + + G T
Sbjct: 3004 YSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRL 3183
Query: 309 TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILMEEI 367
+++APE + D Y D W GV+++E+ G P+ + F L E +
Sbjct: 3184 PL----KWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGM 3351
Query: 368 RF--PRTLSPEAKSLLAGLLKKDPKQR 392
R P +PE ++ +DPK+R
Sbjct: 3352 RMRAPEYSTPEIYQIMLDCWHRDPKER 3432
>lcl|NM_004431.3_cdsid_NP_004422.2 [gene=EPHA2] [protein=ephrin type-A
receptor 2 precursor] [protein_id=NP_004422.2]
[location=156..3086]
Length = 2931
Score = 61.6 bits (148), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 51/247 (20%), Positives = 107/247 (43%), Gaps = 13/247 (5%)
Frame = +1
Query: 129 DSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVI--LVREKATGRYYAMKILRKE 186
D T E+ AV K ++ + K++G G FG+V +++ + + + I +
Sbjct: 1768 DPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLK 1947
Query: 187 VIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERV 246
+ + + E+ ++ H + L+ + + + EY G L ++
Sbjct: 1948 AGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGAL------DKF 2109
Query: 247 FTEERARFYGAEIV-------SALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
E+ F ++V + ++YL + + V+RD+ N++++ + K++DFGL +
Sbjct: 2110 LREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRV 2289
Query: 300 GISDGATMKTFCGTP---EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDH 355
D T G + APE + + A D W G+VM+E+M G P++ +
Sbjct: 2290 LEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN 2469
Query: 356 ERLFELI 362
+ + I
Sbjct: 2470 HEVMKAI 2490
>lcl|NM_001042599.1_cdsid_NP_001036064.1 [gene=ERBB4]
[protein=receptor tyrosine-protein kinase erbB-4 isoform
JM-a/CVT-2 precursor] [protein_id=NP_001036064.1]
[location=99..3977]
Length = 3879
Score = 61.2 bits (147), Expect = 4e-10, Method: Compositional matrix adjust.
Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 13/203 (6%)
Frame = +1
Query: 155 LKLLGKGTFGKV---ILVREKATGRY-YAMKILRKEVIIAKDEVAHTVTESRVLQNTRHP 210
+K+LG G FG V I V E T + A+KIL E K V + E+ ++ + HP
Sbjct: 2161 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEF-MDEALIMASMDHP 2334
Query: 211 FLTALKYAFQTHDRLCFVMEYANGGEL--FFHLSRERVFTEERARFYGAEIVSALEYLHS 268
L L + V + G L + H ++ + ++ + +I + YL
Sbjct: 2335 HLVRL-LGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN-WCVQIAKGMMYLEE 2508
Query: 269 RDVVYRDIKLENLMLDKDGHIKITDFGLC-------KEGISDGATMKTFCGTPEYLAPEV 321
R +V+RD+ N+++ H+KITDFGL KE +DG M +++A E
Sbjct: 2509 RRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPI-----KWMALEC 2673
Query: 322 LEDNDYGRAVDWWGLGVVMYEMM 344
+ + D W GV ++E+M
Sbjct: 2674 IHYRKFTHQSDVWSYGVTIWELM 2742
>lcl|NM_004439.5_cdsid_NP_004430.4 [gene=EPHA5] [protein=ephrin type-A
receptor 5 isoform a precursor] [protein_id=NP_004430.4]
[location=194..3307]
Length = 3114
Score = 60.8 bits (146), Expect = 4e-10, Method: Compositional matrix adjust.
Identities = 59/237 (24%), Positives = 105/237 (44%), Gaps = 11/237 (4%)
Frame = +1
Query: 129 DSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRY---YAMKILRK 185
D T E+ AV + ++ + +++G G FG+V R K G+ A+K L+
Sbjct: 1954 DPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLK- 2130
Query: 186 EVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR-E 244
V + + + E+ ++ HP + L+ + V EY G L L + +
Sbjct: 2131 -VGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKND 2307
Query: 245 RVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDG 304
FT + I + ++YL V+RD+ N++++ + K++DFGL + D
Sbjct: 2308 GQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDP 2487
Query: 305 ATMKTFCGTP---EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFY---NQD 354
T G + APE + + A D W G+VM+E++ G P++ NQD
Sbjct: 2488 EAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD 2658
>lcl|NM_002447.2_cdsid_NP_002438.2 [gene=MST1R]
[protein=macrophage-stimulating protein receptor isoform
1 preproprotein] [protein_id=NP_002438.2]
[location=265..4467]
Length = 4203
Score = 60.1 bits (144), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 58/232 (25%), Positives = 104/232 (44%), Gaps = 9/232 (3%)
Frame = +1
Query: 129 DSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVI---LVREKATGRYYAMKILRK 185
DS+ E++ + VT +D +++GKG FG V + + A+K L +
Sbjct: 3187 DSALLAEVKDVLIPHERVVTHSD----RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR 3354
Query: 186 EVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVM-EYANGGELF-FHLSR 243
I +V + E +++ HP + AL + L V+ Y G+L F S
Sbjct: 3355 --ITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSP 3528
Query: 244 ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD 303
+R T + +G ++ +EYL + V+RD+ N MLD+ +K+ DFGL ++ +
Sbjct: 3529 QRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDR 3708
Query: 304 ---GATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 351
P +++A E L+ + D W GV+++E++ P Y
Sbjct: 3709 EYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPY 3864
>lcl|NM_001174168.1_cdsid_NP_001167639.1 [gene=SYK]
[protein=tyrosine-protein kinase SYK isoform 2]
[protein_id=NP_001167639.1] [location=123..1961]
Length = 1839
Score = 60.1 bits (144), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 61/222 (27%), Positives = 97/222 (43%), Gaps = 15/222 (6%)
Frame = +1
Query: 144 RAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMK---------ILRKEVI--IAKD 192
R +T+ D K LG G FG V YY MK IL+ E KD
Sbjct: 1030 RKLLTLED----KELGSGNFGTV-------KKGYYQMKKVVKTVAVKILKNEANDPALKD 1176
Query: 193 EVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERA 252
E+ + E+ V+Q +P++ + + VME A G L +L + R ++
Sbjct: 1177 EL---LAEANVMQQLDNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNI 1344
Query: 253 RFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMK--TF 310
++ ++YL + V+RD+ N++L + KI+DFGL K +D K T
Sbjct: 1345 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTH 1524
Query: 311 CGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPF 350
P ++ APE + + D W GV+M+E G+ P+
Sbjct: 1525 GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 1650
>lcl|NM_001160367.1_cdsid_NP_001153839.1 [gene=CDK10]
[protein=cyclin-dependent kinase 10 isoform d]
[protein_id=NP_001153839.1] [location=219..1088]
Length = 870
Score = 60.1 bits (144), Expect = 8e-10, Method: Compositional matrix adjust.
Identities = 42/165 (25%), Positives = 77/165 (46%), Gaps = 5/165 (3%)
Frame = +1
Query: 197 TVTESRVLQNTRHPFLTALKYAFQTH--DRLCFVMEYANGGELFFHLSRERVFTEERARF 254
++ E +L RHP + LK + + + VM Y + F+E + +
Sbjct: 34 SLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKC 213
Query: 255 YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTP 314
+++ L+YLH +++RD+K+ NL++ G +K DFGL + M T
Sbjct: 214 IVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTL 393
Query: 315 EYLAPE-VLEDNDYGRAVDWWGLGVVMYEMMCGR--LPFYNQDHE 356
Y APE +L ++D W +G ++ E++ R LP ++ H+
Sbjct: 394 WYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQ 528
>lcl|NM_014238.1_cdsid_NP_055053.1 [gene=KSR1] [protein=kinase
suppressor of Ras 1] [protein_id=NP_055053.1]
[location=446..2734]
Length = 2289
Score = 59.7 bits (143), Expect = 9e-10, Method: Compositional matrix adjust.
Identities = 53/220 (24%), Positives = 96/220 (43%), Gaps = 21/220 (9%)
Frame = +1
Query: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL--QNTRHPFLTAL 215
+G+G +G+V GR++ +R + ++ + + V+ + TRH +
Sbjct: 1444 IGQGRWGRV------HRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLF 1605
Query: 216 KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTE-ERARFYGAEIVSALEYLHSRDVVYR 274
A L + + G L + + + + R EI+ + YLH++ +V++
Sbjct: 1606 MGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHK 1785
Query: 275 DIKLENLMLDKDGHIKITDFGL------CKEGISDGA---TMKTFCGTPEYLAPEVL--- 322
D+K +N+ D +G + ITDFGL +EG + + C YLAPE++
Sbjct: 1786 DLKSKNVFYD-NGKVVITDFGLFGISGVVREGRRENQLKLSHDWLC----YLAPEIVREM 1950
Query: 323 ---EDND---YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 356
+D D + +A D + G V YE+ P NQ E
Sbjct: 1951 TPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAE 2070
>lcl|NM_002020.4_cdsid_NP_002011.2 [gene=FLT4] [protein=vascular
endothelial growth factor receptor 3 isoform 2 precursor]
[protein_id=NP_002011.2] [location=80..3976]
Length = 3897
Score = 59.3 bits (142), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 39/143 (27%), Positives = 67/143 (46%), Gaps = 5/143 (3%)
Frame = +1
Query: 255 YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD-GATMKTFCGT 313
Y ++ +E+L SR ++RD+ N++L + +KI DFGL ++ D K
Sbjct: 3049 YSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARL 3228
Query: 314 P-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILME--EIRF 369
P +++APE + D Y D W GV+++E+ G P+ F L + +R
Sbjct: 3229 PLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRA 3408
Query: 370 PRTLSPEAKSLLAGLLKKDPKQR 392
P +P + ++ DPK R
Sbjct: 3409 PELATPAIRRIMLNCWSGDPKAR 3477
>lcl|NM_000208.2_cdsid_NP_000199.2 [gene=INSR] [protein=insulin
receptor isoform Long preproprotein]
[protein_id=NP_000199.2] [location=110..4258]
Length = 4149
Score = 59.3 bits (142), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 64/257 (24%), Positives = 114/257 (44%), Gaps = 20/257 (7%)
Frame = +1
Query: 127 PSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVI------LVREKATGRYYAM 180
P +E EV+ R K+T+ L+ LG+G+FG V +++ +A R A+
Sbjct: 3019 PCSVYVPDEWEVS----REKITL-----LRELGQGSFGMVYEGNARDIIKGEAETRV-AV 3168
Query: 181 KILRKEVIIAKDEVAHTVTESRVLQN-TRHPFLTALKYAFQTHDRLCFVMEYANGGELFF 239
K + + + E + E+ V++ T H + L + L VME G+L
Sbjct: 3169 KTVNESASLR--ERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLV-VMELMAHGDLKS 3339
Query: 240 HLSRERVFTE----------ERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHI 289
+L R E + AEI + YL+++ V+RD+ N M+ D +
Sbjct: 3340 YLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTV 3519
Query: 290 KITDFGLCKEGISDGATMKTFCGT--PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-G 346
KI DFG+ ++ K G ++APE L+D + + D W GVV++E+
Sbjct: 3520 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLA 3699
Query: 347 RLPFYNQDHERLFELIL 363
P+ +E++ + ++
Sbjct: 3700 EQPYQGLSNEQVLKFVM 3750
>lcl|NM_002529.3_cdsid_NP_002520.2 [gene=NTRK1] [protein=high affinity
nerve growth factor receptor isoform 2 precursor]
[protein_id=NP_002520.2] [location=57..2447]
Length = 2391
Score = 58.2 bits (139), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 63/267 (23%), Positives = 108/267 (40%), Gaps = 32/267 (11%)
Frame = +1
Query: 158 LGKGTFGKVILVR-----EKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFL 212
LG+G FGKV L + A+K L++ A+ + E+ +L +H +
Sbjct: 1546 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR---EAELLTMLQHQHI 1716
Query: 213 TALKYAFQTHDR-LCFVMEYANGGELFFHLSRERVFTEERARFYGAE------------- 258
+ T R L V EY G+L L R + G E
Sbjct: 1717 VRF-FGVCTEGRPLLMVFEYMRHGDLNRFL---RSHGPDAKLLAGGEDVAPGPLGLGQLL 1884
Query: 259 -----IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGIS------DGATM 307
+ + + YL V+RD+ N ++ + +KI DFG+ ++ S G TM
Sbjct: 1885 AVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTM 2064
Query: 308 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILM-E 365
++ PE + + D W GVV++E+ G+ P+Y + + I
Sbjct: 2065 LPI----RWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGR 2232
Query: 366 EIRFPRTLSPEAKSLLAGLLKKDPKQR 392
E+ PR PE +++ G +++P+QR
Sbjct: 2233 ELERPRACPPEVYAIMRGCWQREPQQR 2313
>lcl|NM_014215.2_cdsid_NP_055030.1 [gene=INSRR] [protein=insulin
receptor-related protein precursor]
[protein_id=NP_055030.1] [location=300..4193]
Length = 3894
Score = 58.2 bits (139), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 57/237 (24%), Positives = 100/237 (42%), Gaps = 19/237 (8%)
Frame = +1
Query: 146 KVTMNDFDYLKLLGKGTFGKVI--LVREKATGRY---YAMKILRKEVIIAKDEVAHTVTE 200
+V ++ LG+G+FG V L R G A+K + + + + E + E
Sbjct: 2917 EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNE--LASPRECIEFLKE 3090
Query: 201 SRVLQNTR-HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARF----- 254
+ V++ + H + L Q L +ME G+L HL R E
Sbjct: 3091 ASVMKAFKCHHVVRLLGVVSQGQPTL-VIMELMTRGDLKSHLRSLRPEAENNPGLPQPAL 3267
Query: 255 -----YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKT 309
EI + YL + V+RD+ N M+ +D +KI DFG+ ++ K
Sbjct: 3268 GEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKG 3447
Query: 310 FCGT--PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELIL 363
G ++APE L+D + D W GVV++E++ P+ +E++ + ++
Sbjct: 3448 GKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVM 3618
>lcl|NM_002253.2_cdsid_NP_002244.1 [gene=KDR] [protein=vascular
endothelial growth factor receptor 2 precursor]
[protein_id=NP_002244.1] [location=303..4373]
Length = 4071
Score = 58.2 bits (139), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 50/195 (25%), Positives = 85/195 (43%), Gaps = 5/195 (2%)
Frame = +1
Query: 247 FTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD-GA 305
T E Y ++ +E+L SR ++RD+ N++L + +KI DFGL ++ D
Sbjct: 2998 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY 3177
Query: 306 TMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPF--YNQDHERLFEL 361
K P +++APE + D Y D W GV+++E+ G P+ D E L
Sbjct: 3178 VRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRL 3357
Query: 362 ILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKK 421
+R P +PE + +P QR P+ ++ V L N Q +
Sbjct: 3358 KEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR----PTFSELVEHLGNLLQANAQQDGKDY 3525
Query: 422 LLPPFKPQVTSEVDT 436
++ P ++ E D+
Sbjct: 3526 IVLPISETLSMEEDS 3570
>lcl|NM_012119.4_cdsid_NP_036251.2 [gene=CDK20]
[protein=cyclin-dependent kinase 20 isoform 2]
[protein_id=NP_036251.2] [location=335..1312]
Length = 978
Score = 57.4 bits (137), Expect = 5e-09, Method: Compositional matrix adjust.
Identities = 66/283 (23%), Positives = 118/283 (41%), Gaps = 20/283 (7%)
Frame = +1
Query: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMK--ILRKEVIIAKDEVAHTVTESRVLQN 206
M+ + L +G+G G V + TG A+K LR+ + + E + LQ
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRR---LEDGFPNQALREIKALQE 171
Query: 207 TR-HPFLTALKYAFQTHDRLCFVMEY--ANGGELFFHLSRERVFTEERARFYGAEIVSAL 263
+ ++ LK F E+ ++ E+ H +R + + + Y ++ +
Sbjct: 172 MEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRH--AQRPLAQAQVKSYLQMLLKGV 345
Query: 264 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDG--------ATMKTFC---- 311
+ H+ ++V+RD+K NL++ G +KI DFGL + DG AT C
Sbjct: 346 AFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSVGCIMGE 525
Query: 312 ---GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIR 368
G+P + +E Y + V E+ LP YN+ + + +EE+
Sbjct: 526 LLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELT--ELPDYNKISFKEQVPMPLEEVL 699
Query: 369 FPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLS 411
+SP+A LL L P QR+ A + + H++F +
Sbjct: 700 --PDVSPQALDLLGQFLLYPPHQRIA-----ASKALLHQYFFT 807
>lcl|NM_005372.1_cdsid_NP_005363.1 [gene=MOS]
[protein=proto-oncogene serine/threonine-protein kinase
mos] [protein_id=NP_005363.1] [location=1..1041]
Length = 1041
Score = 57.4 bits (137), Expect = 5e-09, Method: Compositional matrix adjust.
Identities = 39/145 (26%), Positives = 71/145 (48%), Gaps = 5/145 (3%)
Frame = +1
Query: 255 YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKT----F 310
Y ++V+ L +LHS+ +V+ D+K N+++ + KI+DFG C E + D +T
Sbjct: 541 YSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFG-CSEKLEDLLCFQTPSYPL 717
Query: 311 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP 370
GT + APE+L+ D + + +++M + P+ + L+ ++ +
Sbjct: 718 GGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGERQHILYAVVAYD----- 882
Query: 371 RTLSPEAKSLLAGLLKKD-PKQRLG 394
L P SL A + + P QRLG
Sbjct: 883 --LRP---SLSAAVFEDSLPGQRLG 942
>lcl|NM_020639.2_cdsid_NP_065690.2 [gene=RIPK4]
[protein=receptor-interacting serine/threonine-protein
kinase 4] [protein_id=NP_065690.2] [location=49..2403]
Length = 2355
Score = 57.0 bits (136), Expect = 7e-09, Method: Compositional matrix adjust.
Identities = 52/211 (24%), Positives = 99/211 (46%), Gaps = 7/211 (3%)
Frame = +1
Query: 150 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRH 209
+F + +G G FG+V VR + A+K + + E + E++ ++ +
Sbjct: 58 GEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKC-SPSLHVDDRERMELLEEAKKMEMAKF 234
Query: 210 PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLH-- 267
++ + Y + + VMEY G L L+ E + + R R E + +LH
Sbjct: 235 RYILPV-YGI-CREPVGLVMEYMETGSLEKLLASEPLPWDLRFRII-HETAVGMNFLHCM 405
Query: 268 SRDVVYRDIKLENLMLDKDGHIKITDFGLCK-EGISDG--ATMKTFCGTPEYLAPEVLED 324
+ +++ D+K N++LD H+KI+DFGL K G+S +M GT YL PE + +
Sbjct: 406 APPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIRE 585
Query: 325 ND--YGRAVDWWGLGVVMYEMMCGRLPFYNQ 353
+ D + +V++ ++ + PF ++
Sbjct: 586 KSRLFDTKHDVYSFAIVIWGVLTQKKPFADE 678
>lcl|NM_015076.3_cdsid_NP_055891.1 [gene=CDK19]
[protein=cyclin-dependent kinase 19]
[protein_id=NP_055891.1] [location=74..1582]
Length = 1509
Score = 56.6 bits (135), Expect = 9e-09, Method: Compositional matrix adjust.
Identities = 54/239 (22%), Positives = 103/239 (43%), Gaps = 34/239 (14%)
Frame = +1
Query: 158 LGKGTFGKVILVREK--ATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 215
+G+GT+G V R K + YA+K + I E +L+ +HP + AL
Sbjct: 79 VGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMS-----ACREIALLRELKHPNVIAL 243
Query: 216 KYAFQTHD--RLCFVMEYANGGELFFHLSRERVFTEER---------ARFYGAEIVSALE 264
+ F +H ++ + +YA +L+ + R + + +I+ +
Sbjct: 244 QKVFLSHSDRKVWLLFDYAEH-DLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIH 420
Query: 265 YLHSRDVVYRDIKLENLML----DKDGHIKITDFGLCK---EGISDGATMKTFCGTPEYL 317
YLH+ V++RD+K N+++ + G +KI D G + + A + T Y
Sbjct: 421 YLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYR 600
Query: 318 APE-VLEDNDYGRAVDWWGLGVVMYEMMCGRL-------------PFYNQDHERLFELI 362
APE +L Y +A+D W +G + E++ PF++ +R+F ++
Sbjct: 601 APELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVM 777
>lcl|NM_000875.3_cdsid_NP_000866.1 [gene=IGF1R] [protein=insulin-like
growth factor 1 receptor precursor]
[protein_id=NP_000866.1] [location=51..4154]
Length = 4104
Score = 56.6 bits (135), Expect = 9e-09, Method: Compositional matrix adjust.
Identities = 63/258 (24%), Positives = 111/258 (43%), Gaps = 20/258 (7%)
Frame = +1
Query: 126 SPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVI------LVREKATGRYYA 179
S +D +E EVA R K+TM+ + LG+G+FG V +V+++ R A
Sbjct: 2944 SAADVYVPDEWEVA----REKITMS-----RELGQGSFGMVYEGVAKGVVKDEPETRV-A 3093
Query: 180 MKILRKEVIIAKDEVAHTVTESRVLQNTR-HPFLTALKYAFQTHDRLCFVMEYANGGELF 238
+K + + + E + E+ V++ H + L Q L +ME G+L
Sbjct: 3094 IKTVNEAA--SMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV-IMELMTRGDLK 3264
Query: 239 FHLSRERVFTEERARF----------YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGH 288
+L R E EI + YL++ V+RD+ N M+ +D
Sbjct: 3265 SYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFT 3444
Query: 289 IKITDFGLCKEGISDGATMKTFCGT--PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC- 345
+KI DFG+ ++ K G +++PE L+D + D W GVV++E+
Sbjct: 3445 VKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATL 3624
Query: 346 GRLPFYNQDHERLFELIL 363
P+ +E++ ++
Sbjct: 3625 AEQPYQGLSNEQVLRFVM 3678
>lcl|NM_013994.2_cdsid_NP_054700.2 [gene=DDR1] [protein=epithelial
discoidin domain-containing receptor 1 isoform 3
precursor] [protein_id=NP_054700.2] [location=43..2802]
Length = 2760
Score = 55.1 bits (131), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 57/251 (22%), Positives = 103/251 (41%), Gaps = 48/251 (19%)
Frame = +1
Query: 158 LGKGTFGKVILVR----------------EKATGRYYAMKILRKEV-------IIAKDEV 194
LG+G FG+V L K A+KILR + + ++++
Sbjct: 1846 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRNDF 2025
Query: 195 AHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERAR- 253
+ E +++ + P + L D LC + +Y G+L LS ++ E++A
Sbjct: 2026 ---LKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQL--EDKAAE 2190
Query: 254 --------------------FYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITD 293
A+I S + YL + + V+RD+ N ++ ++ IKI D
Sbjct: 2191 GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIAD 2370
Query: 294 FGLCKEGIS-DGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYE--MMCGRLP 349
FG+ + + D ++ P ++A E + + A D W GV ++E M+C P
Sbjct: 2371 FGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQP 2550
Query: 350 FYNQDHERLFE 360
F E++ E
Sbjct: 2551 FGQLTDEQVIE 2583
>lcl|NM_004560.3_cdsid_NP_004551.2 [gene=ROR2]
[protein=tyrosine-protein kinase transmembrane receptor
ROR2 precursor] [protein_id=NP_004551.2]
[location=200..3031]
Length = 2832
Score = 52.4 bits (124), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 61/265 (23%), Positives = 118/265 (44%), Gaps = 32/265 (12%)
Frame = +1
Query: 130 SSTTEEMEVAV----SKARAK-VTMNDFDYLKLLGKGTFGKVIL--VREKATG---RYYA 179
+S +++ME+ + +A+ K ++++ +++ LG+ FGKV + A G + A
Sbjct: 1336 ASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVA 1515
Query: 180 MKILR-KEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELF 238
+K L+ K ++E H E+ + +HP + L L + Y + G+L
Sbjct: 1516 IKTLKDKAEGPLREEFRH---EAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLH 1686
Query: 239 FHLSRERVFTE--------------ERARFYG--AEIVSALEYLHSRDVVYRDIKLENLM 282
L ++ E F A+I + +EYL S VV++D+ N++
Sbjct: 1687 EFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVL 1866
Query: 283 LDKDGHIKITDFGLCKEGISDGATMKTFCGTP----EYLAPEVLEDNDYGRAVDWWGLGV 338
+ ++KI+D GL +E + A G ++APE + + D W GV
Sbjct: 1867 VYDKLNVKISDLGLFREVYA--ADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGV 2040
Query: 339 VMYEMMC-GRLPFYNQDHERLFELI 362
V++E+ G P+ ++ + E+I
Sbjct: 2041 VLWEVFSYGLQPYCGYSNQDVVEMI 2115
>lcl|NM_001024847.2_cdsid_NP_001020018.1 [gene=TGFBR2]
[protein=TGF-beta receptor type-2 isoform A precursor]
[protein_id=NP_001020018.1] [location=383..2161]
Length = 1779
Score = 52.0 bits (123), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 55/213 (25%), Positives = 91/213 (42%), Gaps = 26/213 (12%)
Frame = +1
Query: 157 LLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ--NTRH----P 210
L+GKG F +V + K + K I +E A TE + N +H
Sbjct: 820 LVGKGRFAEVYKAKLKQNTSEQFETVAVK--IFPYEEYASWKTEKDIFSDINLKHENILQ 993
Query: 211 FLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRD 270
FLTA + + + + + G L +L+R V + E R G+ + + +LHS
Sbjct: 994 FLTAEERKTELGKQYWLITAFHAKGNLQEYLTR-HVISWEDLRKLGSSLARGIAHLHSDH 1170
Query: 271 ---------VVYRDIKLENLMLDKDGHIKITDFGLCKE-----GISDGATMKTFCGTPEY 316
+V+RD+K N+++ D + DFGL + D A GT Y
Sbjct: 1171 TPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQV-GTARY 1347
Query: 317 LAPEV------LEDNDYGRAVDWWGLGVVMYEM 343
+APEV LE+ + + D + + +V++EM
Sbjct: 1348 MAPEVLESRMNLENVESFKQTDVYSMALVLWEM 1446
>lcl|NM_005248.2_cdsid_NP_005239.1 [gene=FGR]
[protein=tyrosine-protein kinase Fgr]
[protein_id=NP_005239.1] [location=229..1818]
Length = 1590
Score = 51.6 bits (122), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 49/229 (21%), Positives = 100/229 (43%), Gaps = 4/229 (1%)
Frame = +1
Query: 138 VAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHT 197
+ ++K +++ + + LG G FG V L + + A+K L+ + K
Sbjct: 745 LGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKV-AVKTLKPGTMSPK----AF 909
Query: 198 VTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGEL--FFHLSRERVFTEERARFY 255
+ E++V++ RH L L YA + + + V E+ G L F + +
Sbjct: 910 LEEAQVMKLLRHDKLVQL-YAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDM 1086
Query: 256 GAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTP- 314
A++ + Y+ + ++RD++ N+++ + KI DFGL + D P
Sbjct: 1087AAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPI 1266
Query: 315 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELI 362
++ APE + D W G+++ E++ GR+P+ + + E +
Sbjct: 1267KWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQV 1413
>lcl|NM_005211.3_cdsid_NP_005202.2 [gene=CSF1R] [protein=macrophage
colony-stimulating factor 1 receptor precursor]
[protein_id=NP_005202.2] [location=293..3211]
Length = 2919
Score = 50.1 bits (118), Expect = 7e-07, Method: Compositional matrix adjust.
Identities = 26/92 (28%), Positives = 55/92 (59%), Gaps = 3/92 (3%)
Frame = +1
Query: 255 YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHI-KITDFGLCKEGISDGA-TMKTFCG 312
+ +++ + +L S++ ++RD+ N++L +GH+ KI DFGL ++ ++D +K
Sbjct: 2272 FSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIVKGNAR 2448
Query: 313 TP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 343
P +++APE + D Y D W G++++E+
Sbjct: 2449 LPVKWMAPESIFDCVYTVQSDVWSYGILLWEI 2544
>lcl|NM_145259.2_cdsid_NP_660302.2 [gene=ACVR1C] [protein=activin
receptor type-1C isoform 1 precursor]
[protein_id=NP_660302.2] [location=244..1725]
Length = 1482
Score = 50.1 bits (118), Expect = 7e-07, Method: Compositional matrix adjust.
Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 28/216 (12%)
Frame = +1
Query: 156 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT--RHP--- 210
+++GKG FG+V + G A+KI ++DE + E+ + Q RH
Sbjct: 595 EIVGKGRFGEVW--HGRWCGEDVAVKIFS-----SRDERSW-FREAEIYQTVMLRHENIL 750
Query: 211 -FLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSR 269
F+ A T +L V EY G L+ +L+R V + I S L +LH
Sbjct: 751 GFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKL-ALSIASGLAHLHME 927
Query: 270 --------DVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTF-------CGTP 314
+ +RDIK +N+++ K I D GL + + + T GT
Sbjct: 928 IVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGL---AVKHDSILNTIDIPQNPKVGTK 1098
Query: 315 EYLAPEVLEDN-------DYGRAVDWWGLGVVMYEM 343
Y+APE+L+D + RA D + +G+V +E+
Sbjct: 1099RYMAPEMLDDTMNVNIFESFKRA-DIYSVGLVYWEI 1203
>lcl|NM_032538.1_cdsid_NP_115927.1 [gene=TTBK1] [protein=tau-tubulin
kinase 1] [protein_id=NP_115927.1] [location=280..4245]
Length = 3966
Score = 50.1 bits (118), Expect = 8e-07, Method: Compositional matrix adjust.
Identities = 54/231 (23%), Positives = 91/231 (39%), Gaps = 27/231 (11%)
Frame = +1
Query: 147 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 206
V + + LK +G G FG++ Y AM +L +E + K E A + ++
Sbjct: 85 VVKDRWKVLKKIGGGGFGEI----------YEAMDLLTRENVALKVESAQQPKQVLKME- 231
Query: 207 TRHPFLTALKYAFQTHDRLC-------------FVMEYANGGELFFHLSRER-VFTEERA 252
A+ Q D +C VM+ S+ R FT
Sbjct: 232 ------VAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTT 393
Query: 253 RFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKIT-------DFGLCKEGISDGA 305
G +I+ ++E +HS ++RDIK N + G + T DFGL ++ +
Sbjct: 394 LRLGKQILESIEAIHSVGFLHRDIKPSNFAM---GRLPSTYRKCYMLDFGLARQYTNTTG 564
Query: 306 TMK------TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 350
++ F GT Y + ++ + GR D W L ++ E G+LP+
Sbjct: 565 DVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPW 717
>lcl|NM_004119.2_cdsid_NP_004110.2 [gene=FLT3] [protein=receptor-type
tyrosine-protein kinase FLT3] [protein_id=NP_004110.2]
[location=83..3064]
Length = 2982
Score = 49.3 bits (116), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 27/102 (26%), Positives = 53/102 (51%), Gaps = 2/102 (1%)
Frame = +1
Query: 245 RVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDG 304
V T E + ++ +E+L + V+RD+ N+++ +KI DFGL ++ +SD
Sbjct: 2341 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS 2520
Query: 305 A-TMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 344
++ P +++APE L + Y D W G++++E+
Sbjct: 2521 NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 2646
>lcl|NM_005255.2_cdsid_NP_005246.2 [gene=GAK]
[protein=cyclin-G-associated kinase]
[protein_id=NP_005246.2] [location=200..4135]
Length = 3936
Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 42/160 (26%), Positives = 75/160 (46%), Gaps = 20/160 (12%)
Frame = +1
Query: 254 FYGAEIVSALEYLHSRD--VVYRDIKLENLMLDKDGHIKITDFGLC-------------- 297
FY + A++++H + +++RD+K+ENL+L G IK+ DFG
Sbjct: 454 FY--QTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQ 627
Query: 298 -KEGISDGATMKTFCGTPEYLAPEVLE---DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ 353
+ + + T T TP Y PE+++ + G D W LG ++Y + + PF +
Sbjct: 628 RRALVEEEITRNT---TPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF--E 792
Query: 354 DHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRL 393
D +L + I T SL+ +L+ +P++RL
Sbjct: 793 DGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERL 912
>lcl|NM_001025243.1_cdsid_NP_001020414.1 [gene=IRAK1]
[protein=interleukin-1 receptor-associated kinase 1
isoform 3] [protein_id=NP_001020414.1]
[location=80..1981]
Length = 1902
Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 57/219 (26%), Positives = 94/219 (42%), Gaps = 16/219 (7%)
Frame = +1
Query: 145 AKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHT-VTESRV 203
++ T N + LK+ G+G FG V + T YA+K L++ + V + +TE
Sbjct: 616 SRGTHNFSEELKI-GEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQ 786
Query: 204 LQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIV--- 260
L RHP + + C V + G L L + + +I+
Sbjct: 787 LSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGT 966
Query: 261 -SALEYLH--SRDVVYRDIKLENLMLDKDGHIKITDFGLCK----EGISDG-----ATMK 308
A+++LH S +++ DIK N++LD+ K+ DFGL + G S A +
Sbjct: 967 ARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQ 1146
Query: 309 TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 347
T GT YL E ++ D + GVV+ E + G+
Sbjct: 1147TVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 1263
BLAST Search Results
TBLASTN 2.2.20 [Feb-08-2009]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment:
Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schäffer, and Yi-Kuo Yu (2005) "Protein database
searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= g7.t1
(2005 letters)
Database: taget.fasta
3914 sequences; 7,230,561 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
lcl|NM_004304.4_cdsid_NP_004295.2 [gene=ALK] [protein=ALK tyrosi... 2615 0.0
lcl|NM_002344.5_cdsid_NP_002335.2 [gene=LTK] [protein=leukocyte ... 551 e-157
lcl|NM_000875.3_cdsid_NP_000866.1 [gene=IGF1R] [protein=insulin-... 165 6e-41
lcl|NM_002596.3_cdsid_NP_002587.2 [gene=CDK18] [protein=cyclin-d... 164 1e-40
lcl|NM_014215.2_cdsid_NP_055030.1 [gene=INSRR] [protein=insulin ... 159 3e-39
lcl|NM_012395.2_cdsid_NP_036527.1 [gene=CDK14] [protein=cyclin-d... 154 9e-38
lcl|NM_015076.3_cdsid_NP_055891.1 [gene=CDK19] [protein=cyclin-d... 149 4e-36
lcl|NM_000208.2_cdsid_NP_000199.2 [gene=INSR] [protein=insulin r... 149 5e-36
lcl|NM_001160367.1_cdsid_NP_001153839.1 [gene=CDK10] [protein=cy... 147 1e-35
lcl|NM_002747.3_cdsid_NP_002738.2 [gene=MAPK4] [protein=mitogen-... 135 9e-32
lcl|NM_002529.3_cdsid_NP_002520.2 [gene=NTRK1] [protein=high aff... 130 3e-30
lcl|NM_001012338.2_cdsid_NP_001012338.1 [gene=NTRK3] [protein=NT... 125 9e-29
lcl|NM_012119.4_cdsid_NP_036251.2 [gene=CDK20] [protein=cyclin-d... 123 3e-28
lcl|NM_000142.4_cdsid_NP_000133.1 [gene=FGFR3] [protein=fibrobla... 113 3e-25
lcl|NM_020975.4_cdsid_NP_066124.1 [gene=RET] [protein=proto-onco... 112 5e-25
lcl|NM_022963.2_cdsid_NP_075252.2 [gene=FGFR4] [protein=fibrobla... 112 7e-25
lcl|NM_001174066.1_cdsid_NP_001167537.1 [gene=FGFR1] [protein=fi... 107 1e-23
lcl|NM_004431.3_cdsid_NP_004422.2 [gene=EPHA2] [protein=ephrin t... 107 1e-23
lcl|NM_000141.4_cdsid_NP_000132.3 [gene=FGFR2] [protein=fibrobla... 107 1e-23
lcl|NM_004439.5_cdsid_NP_004430.4 [gene=EPHA5] [protein=ephrin t... 103 3e-22
lcl|NM_013994.2_cdsid_NP_054700.2 [gene=DDR1] [protein=epithelia... 103 4e-22
lcl|NM_004444.4_cdsid_NP_004435.3 [gene=EPHB4] [protein=ephrin t... 102 6e-22
lcl|NM_002447.2_cdsid_NP_002438.2 [gene=MST1R] [protein=macropha... 101 1e-21
lcl|NM_002031.2_cdsid_NP_002022.1 [gene=FRK] [protein=tyrosine-p... 99 7e-21
lcl|NM_004438.3_cdsid_NP_004429.1 [gene=EPHA4] [protein=ephrin t... 99 9e-21
lcl|NM_005211.3_cdsid_NP_005202.2 [gene=CSF1R] [protein=macropha... 94 2e-19
lcl|NM_004560.3_cdsid_NP_004551.2 [gene=ROR2] [protein=tyrosine-... 93 3e-19
lcl|NM_005546.3_cdsid_NP_005537.3 [gene=ITK] [protein=tyrosine-p... 92 6e-19
lcl|NM_020526.3_cdsid_NP_065387.1 [gene=EPHA8] [protein=ephrin t... 88 1e-17
lcl|NM_005417.3_cdsid_NP_005408.1 [gene=SRC] [protein=proto-onco... 88 1e-17
lcl|NM_001042599.1_cdsid_NP_001036064.1 [gene=ERBB4] [protein=re... 86 5e-17
lcl|NM_002401.3_cdsid_NP_002392.2 [gene=MAP3K3] [protein=mitogen... 85 1e-16
lcl|NM_139355.2_cdsid_NP_647612.1 [gene=MATK] [protein=megakaryo... 84 2e-16
lcl|NM_172084.2_cdsid_NP_742081.1 [gene=CAMK2B] [protein=calcium... 84 3e-16
lcl|NM_014916.3_cdsid_NP_055731.2 [gene=LMTK2] [protein=serine/t... 84 3e-16
lcl|NM_001128629.2_cdsid_NP_001122101.1 [gene=PAK6] [protein=ser... 83 4e-16
lcl|NM_016457.4_cdsid_NP_057541.2 [gene=PRKD2] [protein=serine/t... 82 6e-16
lcl|NM_002578.3_cdsid_NP_002569.1 [gene=PAK3] [protein=serine/th... 82 7e-16
lcl|NM_004071.3_cdsid_NP_004062.2 [gene=CLK1] [protein=dual spec... 82 9e-16
lcl|NM_005248.2_cdsid_NP_005239.1 [gene=FGR] [protein=tyrosine-p... 81 1e-15
lcl|NM_005781.4_cdsid_NP_005772.3 [gene=TNK2] [protein=activated... 79 8e-15
lcl|NM_002020.4_cdsid_NP_002011.2 [gene=FLT4] [protein=vascular ... 78 1e-14
lcl|NM_133494.2_cdsid_NP_598001.1 [gene=NEK7] [protein=serine/th... 75 7e-14
lcl|NM_004734.4_cdsid_NP_004725.1 [gene=DCLK1] [protein=serine/t... 75 9e-14
lcl|NM_001174168.1_cdsid_NP_001167639.1 [gene=SYK] [protein=tyro... 75 1e-13
lcl|NM_001261816.1_cdsid_NP_001248745.1 [gene=PDPK1] [protein=3-... 74 2e-13
lcl|NM_000455.4_cdsid_NP_000446.1 [gene=STK11] [protein=serine/t... 72 6e-13
lcl|NM_004073.2_cdsid_NP_004064.2 [gene=PLK3] [protein=serine/th... 72 9e-13
lcl|NM_032430.1_cdsid_NP_115806.1 [gene=BRSK1] [protein=serine/t... 72 1e-12
lcl|NM_053025.3_cdsid_NP_444253.3 [gene=MYLK] [protein=myosin li... 71 1e-12
lcl|NM_145331.2_cdsid_NP_663304.1 [gene=MAP3K7] [protein=mitogen... 71 2e-12
lcl|NM_004759.4_cdsid_NP_004750.1 [gene=MAPKAPK2] [protein=MAP k... 70 4e-12
lcl|NM_003942.2_cdsid_NP_003933.1 [gene=RPS6KA4] [protein=riboso... 69 6e-12
lcl|NM_001256196.1_cdsid_NP_001243125.1 [gene=ARAF] [protein=ser... 69 6e-12
lcl|NM_181690.2_cdsid_NP_859029.1 [gene=AKT3] [protein=RAC-gamma... 69 1e-11
lcl|NM_004938.2_cdsid_NP_004929.2 [gene=DAPK1] [protein=death-as... 68 2e-11
lcl|NM_004586.2_cdsid_NP_004577.1 [gene=RPS6KA3] [protein=riboso... 68 2e-11
lcl|NM_003957.3_cdsid_NP_003948.2 [gene=BRSK2] [protein=serine/t... 67 2e-11
lcl|NM_001143677.1_cdsid_NP_001137149.1 [gene=SGK1] [protein=ser... 67 2e-11
lcl|NM_002737.2_cdsid_NP_002728.1 [gene=PRKCA] [protein=protein ... 67 2e-11
lcl|NM_001013703.2_cdsid_NP_001013725.2 [gene=EIF2AK4] [protein=... 67 3e-11
lcl|NM_002019.4_cdsid_NP_002010.2 [gene=FLT1] [protein=vascular ... 66 4e-11
lcl|NM_004119.2_cdsid_NP_004110.2 [gene=FLT3] [protein=receptor-... 66 5e-11
lcl|NM_004972.3_cdsid_NP_004963.1 [gene=JAK2] [protein=tyrosine-... 66 6e-11
lcl|NM_005876.4_cdsid_NP_005867.3 [gene=SPEG] [protein=striated ... 66 6e-11
lcl|NM_004721.4_cdsid_NP_004712.1 [gene=MAP3K13] [protein=mitoge... 65 8e-11
lcl|NM_000215.3_cdsid_NP_000206.2 [gene=JAK3] [protein=tyrosine-... 65 1e-10
lcl|NM_198465.2_cdsid_NP_940867.2 [gene=NRK] [protein=nik-relate... 64 2e-10
lcl|NM_007271.2_cdsid_NP_009202.1 [gene=STK38] [protein=serine/t... 64 3e-10
lcl|NM_005109.2_cdsid_NP_005100.1 [gene=OXSR1] [protein=serine/t... 63 5e-10
lcl|NM_017433.4_cdsid_NP_059129.3 [gene=MYO3A] [protein=myosin-I... 62 6e-10
lcl|NM_002446.3_cdsid_NP_002437.2 [gene=MAP3K10] [protein=mitoge... 62 7e-10
lcl|NM_014586.1_cdsid_NP_055401.1 [gene=HUNK] [protein=hormonall... 62 7e-10
lcl|NM_000222.2_cdsid_NP_000213.1 [gene=KIT] [protein=mast/stem ... 62 7e-10
lcl|NM_005255.2_cdsid_NP_005246.2 [gene=GAK] [protein=cyclin-G-a... 62 8e-10
lcl|NM_001042600.1_cdsid_NP_001036065.1 [gene=MAP4K1] [protein=m... 62 1e-09
lcl|NM_212535.2_cdsid_NP_997700.1 [gene=PRKCB] [protein=protein ... 61 2e-09
lcl|NM_006648.3_cdsid_NP_006639.3 [gene=WNK2] [protein=serine/th... 61 2e-09
lcl|NM_014370.3_cdsid_NP_055185.2 [gene=SRPK3] [protein=SRSF pro... 61 2e-09
lcl|NM_005163.2_cdsid_NP_005154.2 [gene=AKT1] [protein=RAC-alpha... 61 2e-09
lcl|NM_032387.4_cdsid_NP_115763.2 [gene=WNK4] [protein=serine/th... 61 2e-09
lcl|NM_032037.3_cdsid_NP_114426.1 [gene=TSSK6] [protein=testis-s... 61 2e-09
lcl|NM_182691.2_cdsid_NP_872633.1 [gene=SRPK2] [protein=SRSF pro... 61 2e-09
lcl|NM_006255.3_cdsid_NP_006246.2 [gene=PRKCH] [protein=protein ... 60 3e-09
lcl|NM_033126.1_cdsid_NP_149117.1 [gene=PSKH2] [protein=serine/t... 60 3e-09
lcl|NM_002253.2_cdsid_NP_002244.1 [gene=KDR] [protein=vascular e... 60 4e-09
lcl|NM_005204.3_cdsid_NP_005195.2 [gene=MAP3K8] [protein=mitogen... 60 5e-09
lcl|NM_172226.2_cdsid_NP_757380.1 [gene=CAMKK2] [protein=calcium... 59 8e-09
lcl|NM_004409.3_cdsid_NP_004400.4 [gene=DMPK] [protein=myotonin-... 59 1e-08
lcl|NM_025164.3_cdsid_NP_079440.2 [gene=SIK3] [protein=serine/th... 58 1e-08
lcl|NM_002744.4_cdsid_NP_002735.3 [gene=PRKCZ] [protein=protein ... 58 2e-08
lcl|NM_002314.3_cdsid_NP_002305.1 [gene=LIMK1] [protein=LIM doma... 57 2e-08
lcl|NM_005372.1_cdsid_NP_005363.1 [gene=MOS] [protein=proto-onco... 56 5e-08
lcl|NM_004203.4_cdsid_NP_004194.3 [gene=PKMYT1] [protein=membran... 54 3e-07
lcl|NM_133378.4_cdsid_NP_596869.4 [gene=TTN] [protein=titin isof... 53 5e-07
lcl|NM_173598.4_cdsid_NP_775869.3 [gene=KSR2] [protein=kinase su... 52 9e-07
lcl|NM_018571.5_cdsid_NP_061041.2 [gene=STRADB] [protein=STE20-r... 52 1e-06
lcl|NM_024652.3_cdsid_NP_078928.3 [gene=LRRK1] [protein=leucine-... 51 2e-06
>lcl|NM_004304.4_cdsid_NP_004295.2 [gene=ALK] [protein=ALK tyrosine
kinase receptor precursor] [protein_id=NP_004295.2]
[location=953..5815]
Length = 4863
Score = 2615 bits (6778), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1266/1268 (99%), Positives = 1266/1268 (99%)
Frame = +1
Query: 721 VGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSS 780
VGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSS
Sbjct: 55 VGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSS 234
Query: 781 ELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRA 840
ELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRA
Sbjct: 235 ELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRA 414
Query: 841 KQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEV 900
KQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEV
Sbjct: 415 KQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEV 594
Query: 901 GREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSH 960
GREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSH
Sbjct: 595 GREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSH 774
Query: 961 RSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRG 1020
RSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRG
Sbjct: 775 RSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRG 954
Query: 1021 SFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLM 1080
SFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLM
Sbjct: 955 SFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLM 1134
Query: 1081 PTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQ 1140
PTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQ
Sbjct: 1135 PTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQ 1314
Query: 1141 SSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHT 1200
SSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHT
Sbjct: 1315 SSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHT 1494
Query: 1201 PQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRG 1260
PQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRG
Sbjct: 1495 PQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRG 1674
Query: 1261 VLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQG 1320
VLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQG
Sbjct: 1675 VLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQG 1854
Query: 1321 SRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFD 1380
SRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFD
Sbjct: 1855 SRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFD 2034
Query: 1381 PTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISG 1440
PTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISG
Sbjct: 2035 PTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISG 2214
Query: 1441 YGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGEN 1500
YGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGEN
Sbjct: 2215 YGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGEN 2394
Query: 1501 NVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHP 1560
NVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHP
Sbjct: 2395 NVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHP 2574
Query: 1561 ERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETR 1620
ERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETR
Sbjct: 2575 ERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETR 2754
Query: 1621 GGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGE 1680
GGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGE
Sbjct: 2755 GGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGE 2934
Query: 1681 VNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILS 1740
VNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILS
Sbjct: 2935 VNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILS 3114
Query: 1741 VVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCF 1800
VVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCF
Sbjct: 3115 VVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCF 3294
Query: 1801 AGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSE 1860
AGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSE
Sbjct: 3295 AGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSE 3474
Query: 1861 QDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQP 1920
QDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQP
Sbjct: 3475 QDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQP 3654
Query: 1921 SSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIY 1980
SSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIY
Sbjct: 3655 SSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIY 3834
Query: 1981 RASYYNGG 1988
RASYY G
Sbjct: 3835 RASYYRKG 3858
>lcl|NM_002344.5_cdsid_NP_002335.2 [gene=LTK] [protein=leukocyte
tyrosine kinase receptor isoform 1 precursor]
[protein_id=NP_002335.2] [location=179..2773]
Length = 2595
Score = 551 bits (1420), Expect = e-157, Method: Compositional matrix adjust.
Identities = 368/693 (53%), Positives = 456/693 (65%), Gaps = 14/693 (2%)
Frame = +1
Query: 1310 WLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPG 1369
W Q++ W+G + + S + +L S L +P R+ P L+P
Sbjct: 10 WGQLLVWFGAAGAILCSSPG---SQETFLRSSP----LPLASPSPRDPKVSAPPSILEPA 168
Query: 1370 ENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWK 1429
SP +P + + WLF+TCGASG HGPTQ QC+ AY +++ V VG+ G L+G+Q+W+
Sbjct: 169 --SPLNSPGTEGS--WLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWR 336
Query: 1430 VPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTN 1489
VP Y IS YGAAGGKG KN + R+HGV V IF+L + LYILVGQQGEDACP +
Sbjct: 337 VPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGS 516
Query: 1490 QLIQKVCIGENNVIEEEIRVNRS-----VHEWAGGGGGGGGATYVFKMKDGVPVPLIIAA 1544
Q VC+GE+ +EE ++ S WAGGGGGGGGATYVF+++ G PL++AA
Sbjct: 517 PESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAA 696
Query: 1545 GGGGRAYGAKTD----TFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQE 1600
GGGGRAY D PE+LEN S G G GAAGGGGGW AG+SLQE
Sbjct: 697 GGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQE 876
Query: 1601 GATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSF 1660
GA GG C +A GW GGFGGGGG C++GGGGGGY GG+A+ ++ DGEDGVSF
Sbjct: 877 GAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSF 1056
Query: 1661 ISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDG 1720
I P L+ L V E HGEV I+ +LNCSHC + +C E C C G LA D
Sbjct: 1057 IHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDN 1236
Query: 1721 VSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEY 1780
V+C+ +P PL L+++VV ++ ++ L++ +++V ++K Q LQ +M L SPE
Sbjct: 1237 VTCM--DLHKPPGPLVLMVAVVATSTLS-LLMVCGVLILVKQKKWQGLQ--EMRLPSPEL 1401
Query: 1781 KLSKLRTSTIMTDYNPNYCFAGKTSSIS-----DLKEVPRKNITLIRGLGHGAFGEVYEG 1835
+LSKLRTS I T NP YC G + S + EV N+TL+R LGHGAFGEVYEG
Sbjct: 1402 ELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEG 1581
Query: 1836 QVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF 1895
V G+P D SPLQVA+KTLPE+CS QDELDFLMEALIISKF HQNIVRC+G+SL++ PR
Sbjct: 1582 LVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRL 1761
Query: 1896 ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAAR 1955
ILLELM+GGD+KSFLR +RP QPS L M DLL +A+DIA GC YLEENHFIHRDIAAR
Sbjct: 1762 ILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAAR 1941
Query: 1956 NCLLTCPGPGRVAKIGDFGMARDIYRASYYNGG 1988
NCLL+C GP RVAKIGDFGMARDIYRASYY G
Sbjct: 1942 NCLLSCAGPSRVAKIGDFGMARDIYRASYYRRG 2040
>lcl|NM_000875.3_cdsid_NP_000866.1 [gene=IGF1R] [protein=insulin-like
growth factor 1 receptor precursor]
[protein_id=NP_000866.1] [location=51..4154]
Length = 4104
Score = 165 bits (418), Expect = 6e-41, Method: Compositional matrix adjust.
Identities = 97/265 (36%), Positives = 138/265 (52%), Gaps = 3/265 (1%)
Frame = +1
Query: 1730 EPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTST 1789
E + L + L V +V LV+ ++ V+ RK S+L
Sbjct: 2791 ENFIHLIIALPVAVLLIVGGLVI----MLYVFHRKRNN---------------SRLGNGV 2913
Query: 1790 IMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQV 1849
+ NP Y F+ + D EV R+ IT+ R LG G+FG VYEG G+ D +V
Sbjct: 2914 LYASVNPEY-FSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRV 3090
Query: 1850 AVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSF 1909
A+KT+ E S ++ ++FL EA ++ +FN ++VR +GV Q P +++ELM GDLKS+
Sbjct: 3091 AIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSY 3270
Query: 1910 LRETRPRPSQPSSLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGR 1966
LR RP LA + ++ +A +IA G YL N F+HRD+AARNC++
Sbjct: 3271 LRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AEDF 3441
Query: 1967 VAKIGDFGMARDIYRASYYNGGAGG 1991
KIGDFGM RDIY YY G G
Sbjct: 3442 TVKIGDFGMTRDIYETDYYRKGGKG 3516
Score = 56.2 bits (134), Expect = 6e-08, Method: Compositional matrix adjust.
Identities = 38/121 (31%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Frame = +1
Query: 25 DLRTYLDKAPP-----PGLPAETIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTS 76
DL++YL P P L ++ +++ + G+ +L+AN VHRDL N +V
Sbjct: 3256 DLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE 3435
Query: 77 GGTVKLADFGLAR-IYS---YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAE 132
TVK+ DFG+ R IY Y+ ++ W +PE L + T D+WS G + E
Sbjct: 3436 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWM-SPESLKDGVFTTYSDVWSFGVVLWE 3612
Query: 133 M 133
+
Sbjct: 3613 I 3615
>lcl|NM_002596.3_cdsid_NP_002587.2 [gene=CDK18]
[protein=cyclin-dependent kinase 18 isoform b]
[protein_id=NP_002587.2] [location=345..1769]
Length = 1425
Score = 164 bits (415), Expect = 1e-40, Method: Compositional matrix adjust.
Identities = 105/250 (42%), Positives = 147/250 (58%), Gaps = 14/250 (5%)
Frame = +1
Query: 9 TDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLK 68
TDR + TLVFE++D DL+ YLD + +K M Q LRGL + H I+HRDLK
Sbjct: 631 TDRSL--TLVFEYLDSDLKQYLDHCGN-LMSMHNVKIFMFQLLRGLAYCHHRKILHRDLK 801
Query: 69 PENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWYRAPEVLLQST-YATPVDMWSV 126
P+N+L+ G +KLADFGLAR S + VVTLWYR P+VLL ST Y+TP+DMW V
Sbjct: 802 PQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGV 981
Query: 127 GCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRG---AFPPRGPRPV 183
GCI EM +PLF G++ ++L IF L+G P E+ WP + +FP P+P+
Sbjct: 982 GCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL 1161
Query: 184 QSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY-------LHKDEAFQNLFQSVRE 236
+ P ++ G LL +L + R+SA AL HSY +H+ E ++F S++E
Sbjct: 1162INHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIF-SLKE 1338
Query: 237 V--IQNPGPR 244
+ ++PG R
Sbjct: 1339IQLQKDPGYR 1368
>lcl|NM_014215.2_cdsid_NP_055030.1 [gene=INSRR] [protein=insulin
receptor-related protein precursor]
[protein_id=NP_055030.1] [location=300..4193]
Length = 3894
Score = 159 bits (403), Expect = 3e-39, Method: Compositional matrix adjust.
Identities = 86/211 (40%), Positives = 121/211 (57%), Gaps = 3/211 (1%)
Frame = +1
Query: 1784 KLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPND 1843
K R T+ NP Y F+ + D EVPR+ I++IR LG G+FG VYEG G+
Sbjct: 2836 KKRNRTLYASVNPEY-FSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAG 3012
Query: 1844 PSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAG 1903
VA+KT+ E+ S ++ ++FL EA ++ F ++VR +GV Q P +++ELM
Sbjct: 3013 EESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTR 3192
Query: 1904 GDLKSFLRETRPRPSQPSSL---AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLT 1960
GDLKS LR RP L A+ +++ +A +IA G YL N F+HRD+AARNC+++
Sbjct: 3193 GDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVS 3372
Query: 1961 CPGPGRVAKIGDFGMARDIYRASYYNGGAGG 1991
KIGDFGM RD+Y YY G G
Sbjct: 3373 ---QDFTVKIGDFGMTRDVYETDYYRKGGKG 3456
Score = 60.1 bits (144), Expect = 4e-09, Method: Compositional matrix adjust.
Identities = 39/121 (32%), Positives = 62/121 (51%), Gaps = 12/121 (9%)
Frame = +1
Query: 25 DLRTYLDKAPP-----PGLPAETIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTS 76
DL+++L P PGLP + ++++ + G+ +L AN VHRDL N +V+
Sbjct: 3196 DLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ 3375
Query: 77 GGTVKLADFGLAR-IYS---YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAE 132
TVK+ DFG+ R +Y Y+ ++ W APE L + T D+WS G + E
Sbjct: 3376 DFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWM-APESLKDGIFTTHSDVWSFGVVLWE 3552
Query: 133 M 133
+
Sbjct: 3553 I 3555
>lcl|NM_012395.2_cdsid_NP_036527.1 [gene=CDK14]
[protein=cyclin-dependent kinase 14]
[protein_id=NP_036527.1] [location=145..1500]
Length = 1356
Score = 154 bits (390), Expect = 9e-38, Method: Compositional matrix adjust.
Identities = 101/234 (43%), Positives = 130/234 (55%), Gaps = 14/234 (5%)
Frame = +1
Query: 2 DVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC 61
D+ T T +TLVFE+V DL Y+DK P GL + +K + Q LRGL ++H
Sbjct: 538 DIIHTKET-----LTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRGLSYIHQRY 699
Query: 62 IVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWYRAPEVLLQST-YAT 119
I+HRDLKP+N+L++ G +KLADFGLAR S + VVTLWYR P+VLL ST Y+T
Sbjct: 700 ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYST 879
Query: 120 PVDMWSVGCIFAEMFRRKPLFCGNSEA-DQLGKIFDLIGLPPEDDWPRDVSLPRGAFPP- 177
+DMW VGCIF EM + F G + DQL +IF ++G P ED WP SLP F P
Sbjct: 880 CLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPH--FKPE 1053
Query: 178 ----------RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 221
R S V E+ ++L L +P R+SA AL H Y
Sbjct: 1054RFTLYSSKNLRQAWNKLSYVNHAEDLASKL----LQCSPKNRLSAQAALSHEYF 1203
>lcl|NM_015076.3_cdsid_NP_055891.1 [gene=CDK19]
[protein=cyclin-dependent kinase 19]
[protein_id=NP_055891.1] [location=74..1582]
Length = 1509
Score = 149 bits (377), Expect = 4e-36, Method: Compositional matrix adjust.
Identities = 93/254 (36%), Positives = 134/254 (52%), Gaps = 36/254 (14%)
Frame = +1
Query: 7 SRTDREIKVTLVFEHVDQDL-------RTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHA 59
S +DR KV L+F++ + DL R P LP +K L+ Q L G+ +LHA
Sbjct: 259 SHSDR--KVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHA 432
Query: 60 NCIVHRDLKPENILVT----SGGTVKLADFGLARIYSYQMA----LTPVVVTLWYRAPEV 111
N ++HRDLKP NILV G VK+AD G AR+++ + L PVVVT WYRAPE+
Sbjct: 433 NWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPEL 612
Query: 112 LL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSE---------ADQLGKIFDLIGLPPE 161
LL Y +D+W++GCIFAE+ +P+F E DQL +IF ++G P +
Sbjct: 613 LLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPAD 792
Query: 162 DDWPRDVSLPRGAFPPRGPRPV----QSVVPEMEESGAQ-------LLLEMLTFNPHKRI 210
DW +P + R S++ ME+ + LL ++LT +P KRI
Sbjct: 793 KDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRI 972
Query: 211 SAFRALQHSYLHKD 224
++ +ALQ Y +D
Sbjct: 973 TSEQALQDPYFQED 1014
>lcl|NM_000208.2_cdsid_NP_000199.2 [gene=INSR] [protein=insulin
receptor isoform Long preproprotein]
[protein_id=NP_000199.2] [location=110..4258]
Length = 4149
Score = 149 bits (376), Expect = 5e-36, Method: Compositional matrix adjust.
Identities = 83/205 (40%), Positives = 117/205 (57%), Gaps = 8/205 (3%)
Frame = +1
Query: 1795 NPNYCFAGK----TSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVA 1850
NP Y A + + D EV R+ ITL+R LG G+FG VYEG + + +VA
Sbjct: 2986 NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVA 3165
Query: 1851 VKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFL 1910
VKT+ E S ++ ++FL EA ++ F ++VR +GV + P +++ELMA GDLKS+L
Sbjct: 3166 VKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYL 3345
Query: 1911 RETRPR----PSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGR 1966
R RP P +P + +++ +A +IA G YL F+HRD+AARNC++
Sbjct: 3346 RSLRPEAENNPGRPPP-TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---AHDF 3513
Query: 1967 VAKIGDFGMARDIYRASYYNGGAGG 1991
KIGDFGM RDIY YY G G
Sbjct: 3514 TVKIGDFGMTRDIYETDYYRKGGKG 3588
Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust.
Identities = 41/121 (33%), Positives = 62/121 (51%), Gaps = 12/121 (9%)
Frame = +1
Query: 25 DLRTYLDKAPP-----PGLPAETIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTS 76
DL++YL P PG P T++++++ + G+ +L+A VHRDL N +V
Sbjct: 3328 DLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH 3507
Query: 77 GGTVKLADFGLAR-IYS---YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAE 132
TVK+ DFG+ R IY Y+ ++ W APE L + T DMWS G + E
Sbjct: 3508 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWM-APESLKDGVFTTSSDMWSFGVVLWE 3684
Query: 133 M 133
+
Sbjct: 3685 I 3687
>lcl|NM_001160367.1_cdsid_NP_001153839.1 [gene=CDK10]
[protein=cyclin-dependent kinase 10 isoform d]
[protein_id=NP_001153839.1] [location=219..1088]
Length = 870
Score = 147 bits (372), Expect = 1e-35, Method: Compositional matrix adjust.
Identities = 93/213 (43%), Positives = 129/213 (60%), Gaps = 6/213 (2%)
Frame = +1
Query: 15 VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILV 74
+ LV + +QDL + L+ P P A+ +K ++ Q LRGL +LH N I+HRDLK N+L+
Sbjct: 124 IFLVMGYCEQDLASLLENMPTPFSEAQ-VKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLM 300
Query: 75 TSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYRAPEVLLQSTYATP-VDMWSVGCIFAE 132
T G VK ADFGLAR Y + +TP VVTLWYRAPE+LL +T T +DMW+VGCI AE
Sbjct: 301 TDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAE 480
Query: 133 MFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR-GAFPPRGPRPVQSV---VP 188
+ +PL G SE Q+ I L+G P E+ WP LP G + R +P ++ P
Sbjct: 481 LLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRK-QPYNNLKHKFP 657
Query: 189 EMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 221
+ E+G +LL + ++P KR +A L+ SY
Sbjct: 658 WLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF 756
>lcl|NM_002747.3_cdsid_NP_002738.2 [gene=MAPK4]
[protein=mitogen-activated protein kinase 4]
[protein_id=NP_002738.2] [location=1001..2764]
Length = 1764
Score = 135 bits (339), Expect = 9e-32, Method: Compositional matrix adjust.
Identities = 78/213 (36%), Positives = 120/213 (56%), Gaps = 8/213 (3%)
Frame = +1
Query: 17 LVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS 76
+V E+++ DL L++ L E K M Q LRGL ++H+ ++HRDLKP NI +++
Sbjct: 307 IVQEYMETDLARLLEQG---TLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFIST 477
Query: 77 GGTV-KLADFGLARI----YSYQMALTPVVVTLWYRAPEVLLQ-STYATPVDMWSVGCIF 130
V K+ DFGLARI YS++ L+ +VT WYR+P +LL + Y +DMW+ GCI
Sbjct: 478 EDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIL 657
Query: 131 AEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPP--RGPRPVQSVVP 188
AEM + LF G E +Q+ I + I + E+D + + RP++ ++P
Sbjct: 658 AEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLP 837
Query: 189 EMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 221
E+ L ++LTFNP R++A LQH Y+
Sbjct: 838 EVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM 936
>lcl|NM_002529.3_cdsid_NP_002520.2 [gene=NTRK1] [protein=high affinity
nerve growth factor receptor isoform 2 precursor]
[protein_id=NP_002520.2] [location=57..2447]
Length = 2391
Score = 130 bits (326), Expect = 3e-30, Method: Compositional matrix adjust.
Identities = 76/187 (40%), Positives = 99/187 (52%), Gaps = 8/187 (4%)
Frame = +1
Query: 1810 LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLME 1869
+ + R++I L LG GAFG+V+ + + + + VAVK L E SE DF E
Sbjct: 1504 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQRE 1680
Query: 1870 ALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS--------QPS 1921
A +++ HQ+IVR GV + P ++ E M GDL FLR P P
Sbjct: 1681 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 1860
Query: 1922 SLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYR 1981
L + LL VA +A G YL HF+HRD+A RNCL+ G G V KIGDFGM+RDIY
Sbjct: 1861 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYS 2031
Query: 1982 ASYYNGG 1988
YY G
Sbjct: 2032 TDYYRVG 2052
Score = 55.8 bits (133), Expect = 7e-08, Method: Compositional matrix adjust.
Identities = 47/153 (30%), Positives = 72/153 (47%), Gaps = 21/153 (13%)
Frame = +1
Query: 15 VTLVFEHVDQ-DLRTYL--------------DKAPPPGLPAETIKDLMRQFLRGLDFLHA 59
+ +VFE++ DL +L D AP P L + + Q G+ +L
Sbjct: 1753 LLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP-LGLGQLLAVASQVAAGMVYLAG 1929
Query: 60 NCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS--YQMALTPVVVTLWYRAPEVLLQST 116
VHRDL N LV G VK+ DFG++R IYS Y ++ + + PE +L
Sbjct: 1930 LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRK 2109
Query: 117 YATPVDMWSVGCIFAEMFR--RKPLF-CGNSEA 146
+ T D+WS G + E+F ++P + N+EA
Sbjct: 2110 FTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 2208
>lcl|NM_001012338.2_cdsid_NP_001012338.1 [gene=NTRK3] [protein=NT-3
growth factor receptor isoform a precursor]
[protein_id=NP_001012338.1] [location=307..2826]
Length = 2520
Score = 125 bits (313), Expect = 9e-29, Method: Compositional matrix adjust.
Identities = 75/204 (36%), Positives = 106/204 (51%), Gaps = 13/204 (6%)
Frame = +1
Query: 1795 NPNYCFAGKTSSISD--LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVK 1852
NP Y G D ++ + R++I L R LG GAFG+V+ + + + VAVK
Sbjct: 1537 NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 1716
Query: 1853 TL--PEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFL 1910
L P + + +D F EA +++ H++IV+ GV P ++ E M GDL FL
Sbjct: 1717 ALKDPTLAARKD---FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 1887
Query: 1911 RETRP--------RPSQPS-SLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1961
R P +P Q L + +LH+A IA G YL HF+HRD+A RNCL+
Sbjct: 1888 RAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV-- 2061
Query: 1962 PGPGRVAKIGDFGMARDIYRASYY 1985
G + KIGDFGM+RD+Y YY
Sbjct: 2062 -GANLLVKIGDFGMSRDVYSTDYY 2130
>lcl|NM_012119.4_cdsid_NP_036251.2 [gene=CDK20]
[protein=cyclin-dependent kinase 20 isoform 2]
[protein_id=NP_036251.2] [location=335..1312]
Length = 978
Score = 123 bits (309), Expect = 3e-28, Method: Compositional matrix adjust.
Identities = 72/209 (34%), Positives = 108/209 (51%), Gaps = 3/209 (1%)
Frame = +1
Query: 16 TLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT 75
L FE + DL + A P L +K ++ L+G+ F HAN IVHRDLKP N+L++
Sbjct: 232 VLAFEFMLSDLAEVVRHAQRP-LAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLIS 408
Query: 76 SGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR 135
+ G +K+ADFGLAR++S + Y V SVGCI E+
Sbjct: 409 ASGQLKIADFGLARVFSPDGS------------------RLYTHQVATRSVGCIMGELLN 534
Query: 136 RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP---RGAFPPRGPRPVQSVVPEMEE 192
PLF G ++ +QL + ++G P WP LP + +F + P P++ V+P++
Sbjct: 535 GSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSP 714
Query: 193 SGAQLLLEMLTFNPHKRISAFRALQHSYL 221
LL + L + PH+RI+A +AL H Y
Sbjct: 715 QALDLLGQFLLYPPHQRIAASKALLHQYF 801
>lcl|NM_000142.4_cdsid_NP_000133.1 [gene=FGFR3] [protein=fibroblast
growth factor receptor 3 isoform 1 precursor]
[protein_id=NP_000133.1] [location=257..2677]
Length = 2421
Score = 113 bits (282), Expect = 3e-25, Method: Compositional matrix adjust.
Identities = 68/193 (35%), Positives = 100/193 (51%), Gaps = 13/193 (6%)
Frame = +1
Query: 1812 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPND--PSPLQVAVKTLPEVCSEQDELDFLME 1869
E+ R +TL + LG G FG+V + G+ D P+ VAVK L + +++D D + E
Sbjct: 1396 ELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSE 1575
Query: 1870 ALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP----------RPS 1918
++ H+NI+ +G Q P ++L+E A G+L+ FLR RP +P
Sbjct: 1576 MEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPP 1755
Query: 1919 QPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARD 1978
+ L DL+ A +A G +YL IHRD+AARN L+T V KI DFG+ARD
Sbjct: 1756 E-EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT---EDNVMKIADFGLARD 1923
Query: 1979 IYRASYYNGGAGG 1991
++ YY G
Sbjct: 1924 VHNLDYYKKTTNG 1962
Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 46/127 (36%), Positives = 63/127 (49%), Gaps = 17/127 (13%)
Frame = +1
Query: 25 DLRTYLDKAPPPGL---------PAE--TIKDLMR---QFLRGLDFLHANCIVHRDLKPE 70
+LR +L PPGL P E T KDL+ Q RG+++L + +HRDL
Sbjct: 1684 NLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAAR 1863
Query: 71 NILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVG 127
N+LVT +K+ADFGLAR Y T + + + APE L Y D+WS G
Sbjct: 1864 NVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 2043
Query: 128 CIFAEMF 134
+ E+F
Sbjct: 2044 VLLWEIF 2064
>lcl|NM_020975.4_cdsid_NP_066124.1 [gene=RET] [protein=proto-oncogene
tyrosine-protein kinase receptor Ret isoform a precursor]
[protein_id=NP_066124.1] [location=191..3535]
Length = 3345
Score = 112 bits (281), Expect = 5e-25, Method: Compositional matrix adjust.
Identities = 123/437 (28%), Positives = 182/437 (41%), Gaps = 35/437 (8%)
Frame = +1
Query: 1595 GKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEM-- 1652
G + E A SC + ++ E GG G G C G G I N ++ +
Sbjct: 1516 GSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTC 1695
Query: 1653 -DGEDGVSFISPLGILYTPALK--VMEGH--GEVN-IKHYLNCSHCEVDECHMDPESHKV 1706
DG V + I L+ ++ GH GE IK +C PE K
Sbjct: 1696 PDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCF-------PEEEK- 1851
Query: 1707 ICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQ 1766
CFC+ ED I P + + +V+ S +V+ L+ AF I ++ H+
Sbjct: 1852 -CFCE-----PED----IQDPLCDELCRTVIAAAVLFSFIVSVLLSAFC-IHCYHKFAHK 1998
Query: 1767 E-LQAMQMELQSP------EYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLK-EVPRKNI 1818
+ + +M + P Y S R ++ D N + D K E PRKN+
Sbjct: 1999 PPISSAEMTFRRPAQAFPVSYSSSGARRPSL--DSMENQVSVDAFKILEDPKWEFPRKNL 2172
Query: 1819 TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH 1878
L + LG G FG+V + + VAVK L E S + D L E ++ + NH
Sbjct: 2173 VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNH 2352
Query: 1879 QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP------------------RPSQP 1920
++++ G Q P +++E G L+ FLRE+R P +
Sbjct: 2353 PHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDE- 2529
Query: 1921 SSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIY 1980
+L M DL+ A I+ G QYL E +HRD+AARN L+ GR KI DFG++RD+Y
Sbjct: 2530 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV---AEGRKMKISDFGLSRDVY 2700
Query: 1981 RA-SYYNGGAGGTGGQW 1996
SY G +W
Sbjct: 2701 EEDSYVKRSQGRIPVKW 2751
Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 38/105 (36%), Positives = 53/105 (50%), Gaps = 7/105 (6%)
Frame = +1
Query: 36 PGLPAETIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IY 91
P A T+ DL+ Q +G+ +L +VHRDL NILV G +K++DFGL+R +Y
Sbjct: 2521 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 2700
Query: 92 ---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 133
SY + W A E L Y T D+WS G + E+
Sbjct: 2701 EEDSYVKRSQGRIPVKWM-AIESLFDHIYTTQSDVWSFGVLLWEI 2832
>lcl|NM_022963.2_cdsid_NP_075252.2 [gene=FGFR4] [protein=fibroblast
growth factor receptor 4 isoform 2 precursor]
[protein_id=NP_075252.2] [location=54..2342]
Length = 2289
Score = 112 bits (279), Expect = 7e-25, Method: Compositional matrix adjust.
Identities = 75/196 (38%), Positives = 104/196 (53%), Gaps = 14/196 (7%)
Frame = +1
Query: 1810 LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPS-PLQ---VAVKTLPEVCSEQDELD 1865
L E PR + L + LG G FG+V + GM DP+ P Q VAVK L + S++D D
Sbjct: 1255 LWEFPRDRLVLGKPLGEGCFGQVVRAEAFGM--DPARPDQASTVAVKMLKDNASDKDLAD 1428
Query: 1866 FLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-----RPSQ 1919
+ E ++ H+NI+ +GV Q P ++++E A G+L+ FLR RP P
Sbjct: 1429 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG 1608
Query: 1920 PSS----LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGM 1975
P S L+ L+ A +A G QYLE IHRD+AARN L+T V KI DFG+
Sbjct: 1609 PRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVT---EDNVMKIADFGL 1779
Query: 1976 ARDIYRASYYNGGAGG 1991
AR ++ YY + G
Sbjct: 1780 ARGVHHIDYYKKTSNG 1827
Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust.
Identities = 41/128 (32%), Positives = 56/128 (43%), Gaps = 18/128 (14%)
Frame = +1
Query: 25 DLRTYLDKAPPPG--------------LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPE 70
+LR +L PPG L + Q RG+ +L + +HRDL
Sbjct: 1549 NLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAAR 1728
Query: 71 NILVTSGGTVKLADFGLAR----IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSV 126
N+LVT +K+ADFGLAR I Y+ + W APE L Y D+WS
Sbjct: 1729 NVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWM-APEALFDRVYTHQSDVWSF 1905
Query: 127 GCIFAEMF 134
G + E+F
Sbjct: 1906 GILLWEIF 1929
>lcl|NM_001174066.1_cdsid_NP_001167537.1 [gene=FGFR1]
[protein=fibroblast growth factor receptor 1 isoform 3
precursor] [protein_id=NP_001167537.1]
[location=263..2464]
Length = 2202
Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust.
Identities = 67/192 (34%), Positives = 101/192 (52%), Gaps = 12/192 (6%)
Frame = +1
Query: 1812 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPND-PSPL-QVAVKTLPEVCSEQDELDFLME 1869
E+PR + L + LG G FG+V + G+ D P+ + +VAVK L +E+D D + E
Sbjct: 1147 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 1326
Query: 1870 ALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------RPSQ-- 1919
++ H+NI+ +G Q P ++++E + G+L+ +L+ RP PS
Sbjct: 1327 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 1506
Query: 1920 PSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI 1979
L+ DL+ A +A G +YL IHRD+AARN L+T V KI DFG+ARDI
Sbjct: 1507 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---EDNVMKIADFGLARDI 1677
Query: 1980 YRASYYNGGAGG 1991
+ YY G
Sbjct: 1678 HHIDYYKKTTNG 1713
Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 47/128 (36%), Positives = 63/128 (49%), Gaps = 18/128 (14%)
Frame = +1
Query: 25 DLRTYLDKAPPPGL---------PAETI--KDLMR---QFLRGLDFLHANCIVHRDLKPE 70
+LR YL PPGL P E + KDL+ Q RG+++L + +HRDL
Sbjct: 1435 NLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR 1614
Query: 71 NILVTSGGTVKLADFGLAR----IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSV 126
N+LVT +K+ADFGLAR I Y+ + W APE L Y D+WS
Sbjct: 1615 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWM-APEALFDRIYTHQSDVWSF 1791
Query: 127 GCIFAEMF 134
G + E+F
Sbjct: 1792 GVLLWEIF 1815
>lcl|NM_004431.3_cdsid_NP_004422.2 [gene=EPHA2] [protein=ephrin type-A
receptor 2 precursor] [protein_id=NP_004422.2]
[location=156..3086]
Length = 2931
Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust.
Identities = 80/240 (33%), Positives = 119/240 (49%), Gaps = 8/240 (3%)
Frame = +1
Query: 1757 IMIVYRRKHQELQAMQMELQSPE--YKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVP 1814
I RRK+Q + QSPE Y + + T +P+ + + E+
Sbjct: 1666 FFIHRRRKNQRAR------QSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIH 1827
Query: 1815 RKNITLIRGLGHGAFGEVYEGQV---SGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL 1871
+T + +G G FGEVY+G + SG P VA+KTL +E+ +DFL EA
Sbjct: 1828 PSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVP----VAIKTLKAGYTEKQRVDFLGEAG 1995
Query: 1872 IISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHV 1931
I+ +F+H NI+R GV + P I+ E M G L FLRE + ++L L+ +
Sbjct: 1996 IMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLRE------KDGEFSVLQLVGM 2157
Query: 1932 ARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR---DIYRASYYNGG 1988
R IA G +YL +++HRD+AARN L+ V K+ DFG++R D A+Y G
Sbjct: 2158 LRGIAAGMKYLANMNYVHRDLAARNILVNS---NLVCKVSDFGLSRVLEDDPEATYTTSG 2328
Score = 52.4 bits (124), Expect = 7e-07, Method: Compositional matrix adjust.
Identities = 28/93 (30%), Positives = 45/93 (48%), Gaps = 4/93 (4%)
Frame = +1
Query: 46 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVV---- 101
++R G+ +L VHRDL NILV S K++DFGL+R+ T
Sbjct: 2155 MLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGK 2334
Query: 102 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
+ + + APE + + + D+WS G + E+
Sbjct: 2335 IPIRWTAPEAISYRKFTSASDVWSFGIVMWEVM 2433
>lcl|NM_000141.4_cdsid_NP_000132.3 [gene=FGFR2] [protein=fibroblast
growth factor receptor 2 isoform 1 precursor]
[protein_id=NP_000132.3] [location=648..3113]
Length = 2466
Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust.
Identities = 65/192 (33%), Positives = 96/192 (50%), Gaps = 12/192 (6%)
Frame = +1
Query: 1812 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDP--SPLQVAVKTLPEVCSEQDELDFLME 1869
E PR +TL + LG G FG+V + G+ D + VAVK L + +E+D D + E
Sbjct: 1423 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 1602
Query: 1870 ALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPS------- 1921
++ H+NI+ +G Q P ++++E + G+L+ +LR RP + S
Sbjct: 1603 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP 1782
Query: 1922 --SLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI 1979
+ DL+ +A G +YL IHRD+AARN L+T V KI DFG+ARDI
Sbjct: 1783 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT---ENNVMKIADFGLARDI 1953
Query: 1980 YRASYYNGGAGG 1991
YY G
Sbjct: 1954 NNIDYYKKTTNG 1989
Score = 72.0 bits (175), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 46/127 (36%), Positives = 64/127 (50%), Gaps = 17/127 (13%)
Frame = +1
Query: 25 DLRTYLDKAPPPGL---------PAE--TIKDLMR---QFLRGLDFLHANCIVHRDLKPE 70
+LR YL PPG+ P E T KDL+ Q RG+++L + +HRDL
Sbjct: 1711 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 1890
Query: 71 NILVTSGGTVKLADFGLARIYS---YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVG 127
N+LVT +K+ADFGLAR + Y T + + + APE L Y D+WS G
Sbjct: 1891 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 2070
Query: 128 CIFAEMF 134
+ E+F
Sbjct: 2071 VLMWEIF 2091
>lcl|NM_004439.5_cdsid_NP_004430.4 [gene=EPHA5] [protein=ephrin type-A
receptor 5 isoform a precursor] [protein_id=NP_004430.4]
[location=194..3307]
Length = 3114
Score = 103 bits (256), Expect = 3e-22, Method: Compositional matrix adjust.
Identities = 69/218 (31%), Positives = 112/218 (51%), Gaps = 1/218 (0%)
Frame = +1
Query: 1761 YRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDL-KEVPRKNIT 1819
Y + Q+ + +M + KL +RT Y + + ++ + KE+ IT
Sbjct: 1867 YSKAKQDPEEEKMHFHNGHIKLPGVRT------YIDPHTYEDPNQAVHEFAKEIEASCIT 2028
Query: 1820 LIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ 1879
+ R +G G FGEV G++ +P L VA+KTL +E+ DFL EA I+ +F+H
Sbjct: 2029 IERVIGAGEFGEVCSGRLK-LPGK-RELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP 2202
Query: 1880 NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGC 1939
NI+ GV +S P I+ E M G L +FL++ ++ L+ + R I+ G
Sbjct: 2203 NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKK------NDGQFTVIQLVGMLRGISAGM 2364
Query: 1940 QYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 1977
+YL + ++HRD+AARN L+ V K+ DFG++R
Sbjct: 2365 KYLSDMGYVHRDLAARNILI---NSNLVCKVSDFGLSR 2469
>lcl|NM_013994.2_cdsid_NP_054700.2 [gene=DDR1] [protein=epithelial
discoidin domain-containing receptor 1 isoform 3
precursor] [protein_id=NP_054700.2] [location=43..2802]
Length = 2760
Score = 103 bits (256), Expect = 4e-22, Method: Compositional matrix adjust.
Identities = 71/204 (34%), Positives = 98/204 (48%), Gaps = 30/204 (14%)
Frame = +1
Query: 1812 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDP------------SPLQVAVKTLPEVCS 1859
+ PR + LG G FGEV+ +V P D PL VAVK L +
Sbjct: 1810 DFPRSRLRFKEKLGEGQFGEVHLCEVDS-PQDLVSLDFPLNVRKGHPLLVAVKILRPDAT 1986
Query: 1860 EQDEL------DFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLR-- 1911
+ DFL E I+S+ NI+R +GV +Q P ++ + M GDL FL
Sbjct: 1987 KNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAH 2166
Query: 1912 -------ETRP---RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1961
E P + +Q +++ LLHVA IA G +YL +F+HRD+A RNCL+
Sbjct: 2167 QLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV-- 2340
Query: 1962 PGPGRVAKIGDFGMARDIYRASYY 1985
G KI DFGM+R++Y YY
Sbjct: 2341 -GENFTIKIADFGMSRNLYAGDYY 2409
>lcl|NM_004444.4_cdsid_NP_004435.3 [gene=EPHB4] [protein=ephrin type-B
receptor 4 precursor] [protein_id=NP_004435.3]
[location=492..3455]
Length = 2964
Score = 102 bits (254), Expect = 6e-22, Method: Compositional matrix adjust.
Identities = 62/167 (37%), Positives = 88/167 (52%)
Frame = +1
Query: 1811 KEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEA 1870
KE+ + + +G G FGEV G++ S VA+KTL +E+ +FL EA
Sbjct: 1822 KEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESC--VAIKTLKGGYTERQRREFLSEA 1995
Query: 1871 LIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLH 1930
I+ +F H NI+R GV S+P IL E M G L SFLR ++ L+
Sbjct: 1996 SIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLR------LNDGQFTVIQLVG 2157
Query: 1931 VARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 1977
+ R IA G +YL E ++HRD+AARN L+ V K+ DFG++R
Sbjct: 2158 MLRGIASGMRYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSR 2289
Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 40/129 (31%), Positives = 58/129 (44%), Gaps = 9/129 (6%)
Frame = +1
Query: 46 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-------SYQMALT 98
++R G+ +L VHRDL NILV S K++DFGL+R +Y +L
Sbjct: 2158 MLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLG 2337
Query: 99 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM--FRRKPLFCGNSEADQLGKIFDLI 156
+ W APE + + + D WS G + E+ F +P + S D + I
Sbjct: 2338 GKIPIRW-TAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERP-YWDMSNQDVINAIEQDY 2511
Query: 157 GLPPEDDWP 165
LPP D P
Sbjct: 2512 RLPPPPDCP 2538
>lcl|NM_002447.2_cdsid_NP_002438.2 [gene=MST1R]
[protein=macrophage-stimulating protein receptor isoform
1 preproprotein] [protein_id=NP_002438.2]
[location=265..4467]
Length = 4203
Score = 101 bits (252), Expect = 1e-21, Method: Compositional matrix adjust.
Identities = 61/167 (36%), Positives = 88/167 (52%), Gaps = 2/167 (1%)
Frame = +1
Query: 1822 RGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNI 1881
R +G G FG VY G+ + +Q A+K+L + Q FL E L++ NH N+
Sbjct: 3256 RVIGKGHFGVVYHGEYIDQAQNR--IQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNV 3429
Query: 1882 VRCIGVSL--QSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGC 1939
+ IG+ L + LP +LL M GDL F+R + P+ + DL+ +A G
Sbjct: 3430 LALIGIMLPPEGLPH-VLLPYMCHGDLLQFIRSPQRNPT------VKDLISFGLQVARGM 3588
Query: 1940 QYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYN 1986
+YL E F+HRD+AARNC+L K+ DFG+ARDI YY+
Sbjct: 3589 EYLAEQKFVHRDLAARNCML---DESFTVKVADFGLARDILDREYYS 3720
Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 38/104 (36%), Positives = 51/104 (49%), Gaps = 9/104 (8%)
Frame = +1
Query: 42 TIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR------IYS 92
T+KDL+ Q RG+++L VHRDL N ++ TVK+ADFGLAR YS
Sbjct: 3541 TVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYS 3720
Query: 93 YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 136
Q + W A E L + T D+WS G + E+ R
Sbjct: 3721 VQQHRHARLPVKWM-ALESLQTYRFTTKSDVWSFGVLLWELLTR 3849
>lcl|NM_002031.2_cdsid_NP_002022.1 [gene=FRK]
[protein=tyrosine-protein kinase FRK]
[protein_id=NP_002022.1] [location=448..1965]
Length = 1518
Score = 99.0 bits (245), Expect = 7e-21, Method: Compositional matrix adjust.
Identities = 65/183 (35%), Positives = 96/183 (52%), Gaps = 7/183 (3%)
Frame = +1
Query: 1809 DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLM 1868
D E+ R +I L++ LG G FGEV+EG + N+ +P VAVKTL D DFL
Sbjct: 673 DQWEIDRNSIQLLKRLGSGQFGEVWEG----LWNNTTP--VAVKTLKP--GSMDPNDFLR 828
Query: 1869 EALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDL 1928
EA I+ H +++ V P +I+ ELM G L+ +L+ S + +
Sbjct: 829 EAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQN-----DTGSKIHLTQQ 993
Query: 1929 LHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR-------DIYR 1981
+ +A +A G YLE ++IHRD+AARN L+ G + K+ DFG+AR DIY
Sbjct: 994 VDMAAQVASGMAYLESRNYIHRDLAARNVLV---GEHNIYKVADFGLARVFKVDNEDIYE 1164
Query: 1982 ASY 1984
+ +
Sbjct: 1165 SRH 1173
Score = 55.5 bits (132), Expect = 8e-08, Method: Compositional matrix adjust.
Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 5/114 (4%)
Frame = +1
Query: 26 LRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF 85
L+ YL + D+ Q G+ +L + +HRDL N+LV K+ADF
Sbjct: 940 LQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADF 1119
Query: 86 GLARIYSYQM-----ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
GLAR++ + + + + + APE + + ++ D+WS G + E+
Sbjct: 1120 GLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEII 1281
>lcl|NM_004438.3_cdsid_NP_004429.1 [gene=EPHA4] [protein=ephrin type-A
receptor 4 precursor] [protein_id=NP_004429.1]
[location=43..3003]
Length = 2961
Score = 98.6 bits (244), Expect = 9e-21, Method: Compositional matrix adjust.
Identities = 59/167 (35%), Positives = 91/167 (54%)
Frame = +1
Query: 1811 KEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEA 1870
KE+ I + + +G G FGEV G++ +P + VA+KTL +++ DFL EA
Sbjct: 1840 KEIDASCIKIEKVIGVGEFGEVCSGRLK-VPG-KREICVAIKTLKAGYTDKQRRDFLSEA 2013
Query: 1871 LIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLH 1930
I+ +F+H NI+ GV + P I+ E M G L +FLR+ R ++ L+
Sbjct: 2014 SIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGR------FTVIQLVG 2175
Query: 1931 VARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 1977
+ R I G +YL + ++HRD+AARN L+ V K+ DFGM+R
Sbjct: 2176 MLRGIGSGMKYLSDMSYVHRDLAARNILV---NSNLVCKVSDFGMSR 2307
Score = 53.9 bits (128), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 38/130 (29%), Positives = 61/130 (46%), Gaps = 10/130 (7%)
Frame = +1
Query: 46 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI--------YSYQMAL 97
++R G+ +L VHRDL NILV S K++DFG++R+ Y+ +
Sbjct: 2176 MLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGK 2355
Query: 98 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM--FRRKPLFCGNSEADQLGKIFDL 155
P+ T APE + + + D+WS G + E+ + +P + S D + I +
Sbjct: 2356 IPIRWT----APEAIAYRKFTSASDVWSYGIVMWEVMSYGERP-YWDMSNQDVIKAIEEG 2520
Query: 156 IGLPPEDDWP 165
LPP D P
Sbjct: 2521 YRLPPPMDCP 2550
>lcl|NM_005211.3_cdsid_NP_005202.2 [gene=CSF1R] [protein=macrophage
colony-stimulating factor 1 receptor precursor]
[protein_id=NP_005202.2] [location=293..3211]
Length = 2919
Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust.
Identities = 81/274 (29%), Positives = 111/274 (40%), Gaps = 64/274 (23%)
Frame = +1
Query: 1776 QSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLK-EVPRKNITLIRGLGHGAFGEVYE 1834
Q P+Y++ R I + +Y F T + K E PR N+ + LG GAFG+V E
Sbjct: 1624 QKPKYQV---RWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVE 1794
Query: 1835 GQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLP 1893
G+ + + L+VAVK L ++ + E I+S H+NIV +G P
Sbjct: 1795 ATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGP 1974
Query: 1894 RFILLELMAGGDL----------------------------------KSFLRE------- 1912
++ E GDL K ++R
Sbjct: 1975 VLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQ 2154
Query: 1913 -----TRPRPSQPSS----------------LAMLDLLHVARDIACGCQYLEENHFIHRD 1951
RP SS L + DLLH + +A G +L + IHRD
Sbjct: 2155 GVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRD 2334
Query: 1952 IAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY 1985
+AARN LLT G VAKIGDFG+ARDI S Y
Sbjct: 2335 VAARNVLLT---NGHVAKIGDFGLARDIMNDSNY 2427
Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 37/111 (33%), Positives = 57/111 (51%), Gaps = 6/111 (5%)
Frame = +1
Query: 30 LDKAPPPGLPAETIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG 86
LDK G P E ++DL+ Q +G+ FL + +HRD+ N+L+T+G K+ DFG
Sbjct: 2224 LDKED--GRPLE-LRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFG 2394
Query: 87 LARIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
LAR S + + + + APE + Y D+WS G + E+F
Sbjct: 2395 LARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIF 2547
>lcl|NM_004560.3_cdsid_NP_004551.2 [gene=ROR2]
[protein=tyrosine-protein kinase transmembrane receptor
ROR2 precursor] [protein_id=NP_004551.2]
[location=200..3031]
Length = 2832
Score = 93.2 bits (230), Expect = 3e-19, Method: Compositional matrix adjust.
Identities = 56/188 (29%), Positives = 89/188 (47%), Gaps = 9/188 (4%)
Frame = +1
Query: 1808 SDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFL 1867
+ LKE+ + + LG FG+VY+G + G VA+KTL + +F
Sbjct: 1387 AKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFR 1566
Query: 1868 MEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRP---------S 1918
EA++ ++ H N+V +GV + P ++ + GDL FL P +
Sbjct: 1567 HEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRT 1746
Query: 1919 QPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARD 1978
S+L D +H+ IA G +YL +H +H+D+A RN L+ KI D G+ R+
Sbjct: 1747 VKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVY---DKLNVKISDLGLFRE 1917
Query: 1979 IYRASYYN 1986
+Y A YY
Sbjct: 1918 VYAADYYK 1941
Score = 68.9 bits (167), Expect = 7e-12, Method: Compositional matrix adjust.
Identities = 54/203 (26%), Positives = 91/203 (44%), Gaps = 24/203 (11%)
Frame = +1
Query: 3 VCATSRTDREIKVTLVFEHVDQ-DLRTYL--------------DKAPPPGLPAETIKDLM 47
VC ++ ++++F + DL +L D+ L L+
Sbjct: 1609 VCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLV 1788
Query: 48 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS--YQMALTPVVVTL 104
Q G+++L ++ +VH+DL N+LV VK++D GL R +Y+ Y L ++ +
Sbjct: 1789 AQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPI 1968
Query: 105 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR--KPLFCGNSEADQLGKIFDLIGLPPED 162
+ APE ++ ++ D+WS G + E+F +P +CG S D + I + LP D
Sbjct: 1969 RWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQP-YCGYSNQDVVEMIRNRQVLPCPD 2145
Query: 163 DWPRDVSLPR----GAFPPRGPR 181
D P V FP R PR
Sbjct: 2146 DCPAWVYALMIECWNEFPSRRPR 2214
>lcl|NM_005546.3_cdsid_NP_005537.3 [gene=ITK]
[protein=tyrosine-protein kinase ITK/TSK]
[protein_id=NP_005537.3] [location=83..1945]
Length = 1863
Score = 92.4 bits (228), Expect = 6e-19, Method: Compositional matrix adjust.
Identities = 62/180 (34%), Positives = 91/180 (50%)
Frame = +1
Query: 1818 ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN 1877
+T ++ +G G FG V+ G + D +VA+KT+ E E DF+ EA ++ K +
Sbjct: 1087 LTFVQEIGSGQFGLVHLGY--WLNKD----KVAIKTIRE--GAMSEEDFIEEAEVMMKLS 1242
Query: 1878 HQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIAC 1937
H +V+ GV L+ P ++ E M G L +LR +Q A LL + D+
Sbjct: 1243 HPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR------TQRGLFAAETLLGMCLDVCE 1404
Query: 1938 GCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYNGGAGGTGGQWA 1997
G YLEE IHRD+AARNCL+ G +V K+ DFGM R + Y + +WA
Sbjct: 1405 GMAYLEEACVIHRDLAARNCLV---GENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWA 1575
Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 34/122 (27%), Positives = 58/122 (47%), Gaps = 2/122 (1%)
Frame = +1
Query: 15 VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILV 74
+ LVFE ++ + + AET+ + G+ +L C++HRDL N LV
Sbjct: 1291 ICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLV 1470
Query: 75 TSGGTVKLADFGLARIY--SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAE 132
+K++DFG+ R + T + + +PEV S Y++ D+WS G + E
Sbjct: 1471 GENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWE 1650
Query: 133 MF 134
+F
Sbjct: 1651 VF 1656
>lcl|NM_020526.3_cdsid_NP_065387.1 [gene=EPHA8] [protein=ephrin type-A
receptor 8 isoform 1 precursor] [protein_id=NP_065387.1]
[location=126..3143]
Length = 3018
Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust.
Identities = 56/169 (33%), Positives = 88/169 (52%), Gaps = 2/169 (1%)
Frame = +1
Query: 1811 KEVPRKNITLIRGLGHGAFGEVYEGQ--VSGMPNDPSPLQVAVKTLPEVCSEQDELDFLM 1868
+E+ I + + +G G GEV G+ V G + P VA+K L +E+ DFL
Sbjct: 1882 REIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVP----VAIKALKAGYTERQRRDFLS 2049
Query: 1869 EALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDL 1928
EA I+ +F+H NI+R GV + I+ E M G L +FLR + ++ L
Sbjct: 2050 EASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLR------THDGQFTIMQL 2211
Query: 1929 LHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 1977
+ + R + G +YL + ++HRD+AARN L+ V K+ DFG++R
Sbjct: 2212 VGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS---NLVCKVSDFGLSR 2349
>lcl|NM_005417.3_cdsid_NP_005408.1 [gene=SRC] [protein=proto-oncogene
tyrosine-protein kinase Src] [protein_id=NP_005408.1]
[location=450..2060]
Length = 1611
Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust.
Identities = 66/199 (33%), Positives = 97/199 (48%), Gaps = 2/199 (1%)
Frame = +1
Query: 1808 SDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL-PEVCSEQDELDF 1866
D E+PR+++ L LG G FGEV+ G +G +VA+KTL P S + F
Sbjct: 778 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT------RVAIKTLKPGTMSPEA---F 930
Query: 1867 LMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLR-ETRPRPSQPSSLAM 1925
L EA ++ K H+ +V+ V + P +I+ E M+ G L FL+ ET L +
Sbjct: 931 LQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGET------GKYLRL 1089
Query: 1926 LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY 1985
L+ +A IA G Y+E +++HRD+ A N L+ G V K+ DFG+AR I Y
Sbjct: 1090 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYT 1260
Query: 1986 NGGAGGTGGQWAVAGPGLY 2004
+W LY
Sbjct: 1261 ARQGAKFPIKWTAPEAALY 1317
Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 33/95 (34%), Positives = 46/95 (48%), Gaps = 6/95 (6%)
Frame = +1
Query: 45 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY------SYQMALT 98
D+ Q G+ ++ VHRDL+ NILV K+ADFGLAR+ + Q A
Sbjct: 1102 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF 1281
Query: 99 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 133
P+ T APE L + D+WS G + E+
Sbjct: 1282 PIKWT----APEAALYGRFTIKSDVWSFGILLTEL 1374
>lcl|NM_001042599.1_cdsid_NP_001036064.1 [gene=ERBB4]
[protein=receptor tyrosine-protein kinase erbB-4 isoform
JM-a/CVT-2 precursor] [protein_id=NP_001036064.1]
[location=99..3977]
Length = 3879
Score = 86.3 bits (212), Expect = 5e-17, Method: Compositional matrix adjust.
Identities = 71/266 (26%), Positives = 125/266 (46%), Gaps = 1/266 (0%)
Frame = +1
Query: 1732 HLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIM 1791
H LI + V L +++ + + V R+ ++ +A++ L++ ++
Sbjct: 1939 HARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLET-----------ELV 2085
Query: 1792 TDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAV 1851
P +G + + L+ + + ++ LG GAFG VY+G + + + VA+
Sbjct: 2086 EPLTP----SGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKG-IWVPEGETVKIPVAI 2250
Query: 1852 KTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLR 1911
K L E + ++F+ EALI++ +H ++VR +GV L + + +LM G L ++
Sbjct: 2251 KILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVT-QLMPHGCLLEYVH 2427
Query: 1912 ETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIG 1971
E + ++ LL+ IA G YLEE +HRD+AARN L+ P KI
Sbjct: 2428 EHK------DNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH---VKIT 2580
Query: 1972 DFGMARDIY-RASYYNGGAGGTGGQW 1996
DFG+AR + YN G +W
Sbjct: 2581 DFGLARLLEGDEKEYNADGGKMPIKW 2658
>lcl|NM_002401.3_cdsid_NP_002392.2 [gene=MAP3K3]
[protein=mitogen-activated protein kinase kinase kinase 3
isoform 2] [protein_id=NP_002392.2] [location=320..2200]
Length = 1881
Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust.
Identities = 53/173 (30%), Positives = 82/173 (47%), Gaps = 7/173 (4%)
Frame = +1
Query: 4 CATSRTDREIKVTLVFE---HVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHAN 60
C R ++ + + + + V L+ Y L + RQ L G+ +LH+N
Sbjct: 1288 CLRDRAEKTLTIFMEYMPGGSVKDQLKAY------GALTESVTRKYTRQILEGMSYLHSN 1449
Query: 61 CIVHRDLKPENILVTSGGTVKLADFGLA-RIYSYQMA---LTPVVVTLWYRAPEVLLQST 116
IVHRD+K NIL S G VKL DFG + R+ + M+ + V T ++ +PEV+
Sbjct: 1450 MIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEG 1629
Query: 117 YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 169
Y D+WS+GC EM KP + +E + + IF + P P +S
Sbjct: 1630 YGRKADVWSLGCTVVEMLTEKPPW---AEYEAMAAIFKIATQPTNPQLPSHIS 1779
>lcl|NM_139355.2_cdsid_NP_647612.1 [gene=MATK]
[protein=megakaryocyte-associated tyrosine-protein kinase
isoform a] [protein_id=NP_647612.1] [location=401..1924]
Length = 1524
Score = 84.3 bits (207), Expect = 2e-16, Method: Compositional matrix adjust.
Identities = 60/163 (36%), Positives = 93/163 (57%), Gaps = 1/163 (0%)
Frame = +1
Query: 1816 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 1875
+++TL +G G FG V +G+ G +VAVK + + Q FL E +++K
Sbjct: 697 QHLTLGAQIGEGEFGAVLQGEYLGQ-------KVAVKNIKCDVTAQA---FLDETAVMTK 846
Query: 1876 FNHQNIVRCIGVSL-QSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARD 1934
H+N+VR +GV L Q L +I++E ++ G+L +FLR TR R ++ + LHVA
Sbjct: 847 MQHENLVRLLGVILHQGL--YIVMEHVSKGNLVNFLR-TRGRALVNTAQLLQFSLHVAE- 1014
Query: 1935 IACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 1977
G +YLE +HRD+AARN L++ VAK+ DFG+A+
Sbjct: 1015 ---GMEYLESKKLVHRDLAARNILVS---EDLVAKVSDFGLAK 1125
Score = 58.5 bits (140), Expect = 9e-09, Method: Compositional matrix adjust.
Identities = 34/121 (28%), Positives = 60/121 (49%), Gaps = 1/121 (0%)
Frame = +1
Query: 15 VTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENIL 73
+ +V EHV + +L +L + + G+++L + +VHRDL NIL
Sbjct: 898 LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNIL 1077
Query: 74 VTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 133
V+ K++DFGLA+ + + L + + + APE L + + D+WS G + E+
Sbjct: 1078 VSEDLVAKVSDFGLAK--AERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEV 1251
Query: 134 F 134
F
Sbjct: 1252 F 1254
>lcl|NM_172084.2_cdsid_NP_742081.1 [gene=CAMK2B]
[protein=calcium/calmodulin-dependent protein kinase
type II subunit beta isoform 8] [protein_id=NP_742081.1]
[location=211..1560]
Length = 1350
Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust.
Identities = 68/201 (33%), Positives = 91/201 (45%), Gaps = 17/201 (8%)
Frame = +1
Query: 47 MRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMALTPVVV 102
++Q L + H +VHRDLKPEN+L+ S G VKLADFGLA + Q A
Sbjct: 349 IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAG 528
Query: 103 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP-- 160
T Y +PEVL + Y PVD+W+ G I + L+G PP
Sbjct: 529 TPGYLSPEVLRKEAYGKPVDIWACGVILYIL---------------------LVGYPPFW 645
Query: 161 -EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH- 218
ED + GA+ P +V PE L+ +MLT NP KRI+A AL+H
Sbjct: 646 DEDQHKLYQQIKAGAYDFPSPE-WDTVTPE----AKNLINQMLTINPAKRITAHEALKHP 810
Query: 219 ---------SYLHKDEAFQNL 230
S +H+ E + L
Sbjct: 811 WVCQRSTVASMMHRQETVECL 873
>lcl|NM_014916.3_cdsid_NP_055731.2 [gene=LMTK2]
[protein=serine/threonine-protein kinase LMTK2 precursor]
[protein_id=NP_055731.2] [location=294..4805]
Length = 4512
Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust.
Identities = 53/180 (29%), Positives = 92/180 (51%), Gaps = 1/180 (0%)
Frame = +1
Query: 1806 SISDLK-EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDEL 1864
S+ LK +V R ++ I+ +G+G FG+V G++ S +V VK L + +++
Sbjct: 370 SVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIY---TGTSVARVIVKELKASANPKEQD 540
Query: 1865 DFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLA 1924
FL H NI++C+G ++++P ++ E GDLK++LR + S
Sbjct: 541 TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTM 720
Query: 1925 MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY 1984
+L +A ++A G + + HF+H D+A RNC LT K+GD+G+ Y+ Y
Sbjct: 721 LLQ--RMACEVAAGLAAMHKLHFLHSDLALRNCFLTS---DLNVKVGDYGIGFSRYKEDY 885
>lcl|NM_001128629.2_cdsid_NP_001122101.1 [gene=PAK6]
[protein=serine/threonine-protein kinase PAK 6 isoform 1]
[protein_id=NP_001122101.1] [location=358..2403]
Length = 2046
Score = 83.2 bits (204), Expect = 4e-16, Method: Compositional matrix adjust.
Identities = 57/185 (30%), Positives = 89/185 (48%), Gaps = 1/185 (0%)
Frame = +1
Query: 38 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMA 96
L E I + L+ L +LHA ++HRD+K ++IL+T G VKL+DFG A+I
Sbjct: 1492 LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPK 1671
Query: 97 LTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 156
+V T ++ APEV+ +S YAT VD+WS+G + EM +P + +S + ++ D
Sbjct: 1672 RKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD-- 1845
Query: 157 GLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 216
PP + V P + + L ML +P +R +A L
Sbjct: 1846 ------------------SPPPKLKNSHKVSPVLRD----FLERMLVRDPQERATAQELL 1959
Query: 217 QHSYL 221
H +L
Sbjct: 1960 DHPFL 1974
>lcl|NM_016457.4_cdsid_NP_057541.2 [gene=PRKD2]
[protein=serine/threonine-protein kinase D2 isoform A]
[protein_id=NP_057541.2] [location=758..3394]
Length = 2637
Score = 82.4 bits (202), Expect = 6e-16, Method: Compositional matrix adjust.
Identities = 52/120 (43%), Positives = 62/120 (51%), Gaps = 3/120 (2%)
Frame = +1
Query: 14 KVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENIL 73
KV +V E + D+ + + LP K L+ Q L L LH IVH DLKPEN+L
Sbjct: 1864 KVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVL 2043
Query: 74 VTSGG---TVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIF 130
+ S VKL DFG ARI + VV T Y APEVLL Y +DMWSVG I
Sbjct: 2044 LASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIM 2223
>lcl|NM_002578.3_cdsid_NP_002569.1 [gene=PAK3]
[protein=serine/threonine-protein kinase PAK 3 isoform a]
[protein_id=NP_002569.1] [location=622..2256]
Length = 1635
Score = 82.4 bits (202), Expect = 7e-16, Method: Compositional matrix adjust.
Identities = 41/103 (39%), Positives = 64/103 (62%), Gaps = 1/103 (0%)
Frame = +1
Query: 43 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVV 101
I + R+ L+ LDFLH+N ++HRD+K +NIL+ G+VKL DFG A+I Q + +V
Sbjct: 1090 IAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 1269
Query: 102 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS 144
T ++ APEV+ + Y VD+WS+G + EM +P + +
Sbjct: 1270 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 1398
Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 46/166 (27%), Positives = 71/166 (42%)
Frame = +1
Query: 1814 PRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALII 1873
P+K T +G GA G VY + + +VA+K + + EL + E L++
Sbjct: 790 PKKKYTRFEKIGQGASGTVYTAL-----DIATGQEVAIKQMNLQQQPKKEL-IINEILVM 951
Query: 1874 SKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVAR 1933
+ + NIV + L ++++E +AGG L + ET Q + V R
Sbjct: 952 RENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQ--------IAAVCR 1107
Query: 1934 DIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI 1979
+ +L N IHRDI + N LL G K+ DFG I
Sbjct: 1108 ECLQALDFLHSNQVIHRDIKSDNILLGMDGS---VKLTDFGFCAQI 1236
>lcl|NM_004071.3_cdsid_NP_004062.2 [gene=CLK1] [protein=dual
specificity protein kinase CLK1 isoform 1]
[protein_id=NP_004062.2] [location=182..1636]
Length = 1455
Score = 82.0 bits (201), Expect = 9e-16, Method: Composition-based stats.
Identities = 63/217 (29%), Positives = 100/217 (46%), Gaps = 38/217 (17%)
Frame = +1
Query: 43 IKDLMRQFLRGLDFLHANCIVHRDLKPENIL-VTSGGT------------------VKLA 83
I+ + Q + ++FLH+N + H DLKPENIL V S T +K+
Sbjct: 793 IRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVV 972
Query: 84 DFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGN 143
DFG A Y + T +V T YRAPEV+L ++ P D+WS+GCI E + +F +
Sbjct: 973 DFGSA-TYDDEHHST-LVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 1146
Query: 144 SEADQLGKIFDLIGLPPED----------------DWPRDVSLPRGAFPPRGPRPVQSVV 187
+ L + ++G P+ DW S G + R +P++ +
Sbjct: 1147 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSS--AGRYVSRRCKPLKEFM 1320
Query: 188 PEME---ESGAQLLLEMLTFNPHKRISAFRALQHSYL 221
+ E L+ +ML ++P KRI+ AL+H +
Sbjct: 1321 LSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 1431
>lcl|NM_005248.2_cdsid_NP_005239.1 [gene=FGR]
[protein=tyrosine-protein kinase Fgr]
[protein_id=NP_005239.1] [location=229..1818]
Length = 1590
Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust.
Identities = 62/178 (34%), Positives = 88/178 (49%), Gaps = 1/178 (0%)
Frame = +1
Query: 1808 SDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL-PEVCSEQDELDF 1866
D E+ R +ITL R LG G FG+V+ G +G +VAVKTL P S + F
Sbjct: 757 KDAWEISRSSITLERRLGTGCFGDVWLGTWNG------STKVAVKTLKPGTMSPKA---F 909
Query: 1867 LMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAML 1926
L EA ++ H +V+ V + P +I+ E M G L FL+ + L +
Sbjct: 910 LEEAQVMKLLRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKN-----PEGQDLRLP 1071
Query: 1927 DLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY 1984
L+ +A +A G Y+E ++IHRD+ A N L+ G KI DFG+AR I Y
Sbjct: 1072 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILV---GERLACKIADFGLARLIKDDEY 1236
Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 31/98 (31%), Positives = 46/98 (46%), Gaps = 6/98 (6%)
Frame = +1
Query: 45 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS------YQMALT 98
D+ Q G+ ++ +HRDL+ NILV K+ADFGLAR+ Q +
Sbjct: 1081 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 1260
Query: 99 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 136
P+ T APE L + D+WS G + E+ +
Sbjct: 1261 PIKWT----APEAALFGRFTIKSDVWSFGILLTELITK 1362
>lcl|NM_005781.4_cdsid_NP_005772.3 [gene=TNK2] [protein=activated
CDC42 kinase 1 isoform 1] [protein_id=NP_005772.3]
[location=544..3660]
Length = 3117
Score = 78.6 bits (192), Expect = 8e-15, Method: Compositional matrix adjust.
Identities = 59/164 (35%), Positives = 87/164 (53%), Gaps = 2/164 (1%)
Frame = +1
Query: 1816 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL-PEVCSEQDELD-FLMEALII 1873
K++ L+ LG G+FG V G+ P+ + + VAVK L P+V S+ + +D F+ E +
Sbjct: 370 KDLRLLEKLGDGSFGVVRRGEWDA-PSGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAM 543
Query: 1874 SKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVAR 1933
+H+N++R GV L + P ++ EL G L LR+ + + L A
Sbjct: 544 HSLDHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLRKHQ------GHFLLGTLSRYAV 702
Query: 1934 DIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 1977
+A G YLE FIHRD+AARN LL + KIGDFG+ R
Sbjct: 703 QVAEGMGYLESKRFIHRDLAARNLLLATRD---LVKIGDFGLMR 825
Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 43/129 (33%), Positives = 61/129 (47%), Gaps = 9/129 (6%)
Frame = +1
Query: 49 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALTPVVVT 103
Q G+ +L + +HRDL N+L+ + VK+ DFGL R Y M V
Sbjct: 703 QVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF 882
Query: 104 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR--RKPLFCGNSEADQLGKIFDLIG--LP 159
W APE L T++ D W G EMF ++P + G + + L KI D G LP
Sbjct: 883 AWC-APESLKTRTFSHASDTWMFGVTLWEMFTYGQEP-WIGLNGSQILHKI-DKEGERLP 1053
Query: 160 PEDDWPRDV 168
+D P+D+
Sbjct: 1054RPEDCPQDI 1080
>lcl|NM_002020.4_cdsid_NP_002011.2 [gene=FLT4] [protein=vascular
endothelial growth factor receptor 3 isoform 2 precursor]
[protein_id=NP_002011.2] [location=80..3976]
Length = 3897
Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust.
Identities = 70/245 (28%), Positives = 100/245 (40%), Gaps = 60/245 (24%)
Frame = +1
Query: 1812 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLME-A 1870
E PR+ + L R LG+GAFG+V E G+ S VAVK L E + + + E
Sbjct: 2515 EFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELK 2694
Query: 1871 LIISKFNHQNIVRCIGVSLQSL-PRFILLELMAGGDLKSFLRETR--------PRPSQPS 1921
++I NH N+V +G + P +++E G+L +FLR R P Q
Sbjct: 2695 ILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRG 2874
Query: 1922 SL-AMLDLLHVAR-----------------------------------------DIAC-- 1937
AM++L + R D+ C
Sbjct: 2875 RFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYS 3054
Query: 1938 -----GCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRA-SYYNGGAGG 1991
G ++L IHRD+AARN LL+ V KI DFG+ARDIY+ Y G+
Sbjct: 3055 FQVARGMEFLASRKCIHRDLAARNILLS---ESDVVKICDFGLARDIYKDPDYVRKGSAR 3225
Query: 1992 TGGQW 1996
+W
Sbjct: 3226 LPLKW 3240
Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 38/100 (38%), Positives = 54/100 (54%), Gaps = 7/100 (7%)
Frame = +1
Query: 42 TIKDLM---RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS---YQ 94
T++DL+ Q RG++FL + +HRDL NIL++ VK+ DFGLAR IY Y
Sbjct: 3028 TMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYV 3207
Query: 95 MALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
+ + W APE + Y T D+WS G + E+F
Sbjct: 3208 RKGSARLPLKWM-APESIFDKVYTTQSDVWSFGVLLWEIF 3324
>lcl|NM_133494.2_cdsid_NP_598001.1 [gene=NEK7]
[protein=serine/threonine-protein kinase Nek7]
[protein_id=NP_598001.1] [location=328..1236]
Length = 909
Score = 75.5 bits (184), Expect = 7e-14, Method: Compositional matrix adjust.
Identities = 37/108 (34%), Positives = 61/108 (56%), Gaps = 1/108 (0%)
Frame = +1
Query: 38 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ-MA 96
+P T+ Q L+ +H+ ++HRD+KP N+ +T+ G VKL D GL R +S + A
Sbjct: 397 IPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTA 576
Query: 97 LTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS 144
+V T +Y +PE + ++ Y D+WS+GC+ EM + F G+
Sbjct: 577 AHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDK 720
Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 44/170 (25%), Positives = 72/170 (42%), Gaps = 9/170 (5%)
Frame = +1
Query: 1817 NITLIRGLGHGAFGEVYEGQ--VSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIIS 1874
N + + +G G F EVY + G+P +Q+ ++ + D + E ++
Sbjct: 97 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIF-----DLMDAKARADCIKEIDLLK 261
Query: 1875 KFNHQNIVRCIGVSLQSLPRFILLELMAGGDL----KSFLRETRPRPSQPSSLAMLDLLH 1930
+ NH N+++ ++ I+LEL GDL K F ++ R P + + L
Sbjct: 262 QLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQL-- 435
Query: 1931 VARDIACGCQYLEENH---FIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 1977
C LE H +HRDI N +T G V K+GD G+ R
Sbjct: 436 --------CSALEHMHSRRVMHRDIKPANVFITATG---VVKLGDLGLGR 552
>lcl|NM_004734.4_cdsid_NP_004725.1 [gene=DCLK1]
[protein=serine/threonine-protein kinase DCLK1 isoform 1]
[protein_id=NP_004725.1] [location=284..2473]
Length = 2190
Score = 75.5 bits (184), Expect = 9e-14, Method: Compositional matrix adjust.
Identities = 67/229 (29%), Positives = 107/229 (46%), Gaps = 11/229 (4%)
Frame = +1
Query: 46 LMRQFLRGLDFLHANCIVHRDLKPENILVTS----GGTVKLADFGLARIYS---YQMALT 98
++ + +LH+ IVHRD+KPEN+LV ++KL DFGLA I Y + T
Sbjct: 1471 MLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGT 1650
Query: 99 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 158
P Y APE++ ++ Y VD+W+ G I + P F G+ + ++ +FD I +
Sbjct: 1651 PT-----YVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEV--LFDQILM 1809
Query: 159 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 218
D P P V +S +L+ ML + +R SA + L+H
Sbjct: 1810 GQVD----------------FPSPYWDNV---SDSAKELITMMLLVDVDQRFSAVQVLEH 1932
Query: 219 SYLHKDEAFQNLFQ-SVREVIQ---NPGPRHPEAASAAPPGASLLLLQQ 263
+++ D +N Q SV I+ N GP+ P + +A G S++ L
Sbjct: 1933 PWVNDDGLPENEHQLSVAGKIKKHFNTGPK-PNSTAA---GVSVIALDH 2067
>lcl|NM_001174168.1_cdsid_NP_001167639.1 [gene=SYK]
[protein=tyrosine-protein kinase SYK isoform 2]
[protein_id=NP_001167639.1] [location=123..1961]
Length = 1839
Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 57/189 (30%), Positives = 98/189 (51%), Gaps = 3/189 (1%)
Frame = +1
Query: 1813 VPRKNITL-IRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL 1871
+ RK +TL + LG G FG V +G + +K + +DEL L EA
Sbjct: 1024 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL--LAEAN 1197
Query: 1872 IISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHV 1931
++ + ++ IVR IG+ ++ +++E+ G L +L++ R + +++ +
Sbjct: 1198 VMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDK-------NIIEL 1353
Query: 1932 ARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRA--SYYNGGA 1989
++ G +YLEE++F+HRD+AARN LL AKI DFG+++ + RA +YY
Sbjct: 1354 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQ---HYAKISDFGLSKAL-RADENYYK--- 1512
Query: 1990 GGTGGQWAV 1998
T G+W V
Sbjct: 1513 AQTHGKWPV 1539
Score = 54.7 bits (130), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 8/102 (7%)
Frame = +1
Query: 41 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMA 96
+ I +L+ Q G+ +L + VHRDL N+L+ + K++DFGL++ +Y A
Sbjct: 1336 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 1515
Query: 97 LT----PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
T PV WY APE + +++ D+WS G + E F
Sbjct: 1516 QTHGKWPVK---WY-APECINYYKFSSKSDVWSFGVLMWEAF 1629
>lcl|NM_001261816.1_cdsid_NP_001248745.1 [gene=PDPK1]
[protein=3-phosphoinositide-dependent protein kinase 1
isoform 3] [protein_id=NP_001248745.1]
[location=150..1514]
Length = 1365
Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust.
Identities = 40/121 (33%), Positives = 63/121 (52%), Gaps = 3/121 (2%)
Frame = +1
Query: 49 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLW 105
+ + L++LH I+HRDLKPENIL+ +++ DFG A++ S Q V T
Sbjct: 562 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 741
Query: 106 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 165
Y +PE+L + + D+W++GCI ++ P F +E KI L PE +P
Sbjct: 742 YVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP 921
Query: 166 R 166
+
Sbjct: 922 K 924
>lcl|NM_000455.4_cdsid_NP_000446.1 [gene=STK11]
[protein=serine/threonine-protein kinase STK11]
[protein_id=NP_000446.1] [location=1116..2417]
Length = 1302
Score = 72.4 bits (176), Expect = 6e-13, Method: Compositional matrix adjust.
Identities = 61/221 (27%), Positives = 95/221 (42%), Gaps = 11/221 (4%)
Frame = +1
Query: 14 KVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENIL 73
K+ +V E+ ++ LD P P Q + GL++LH+ IVH+D+KP N+L
Sbjct: 370 KMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLL 549
Query: 74 VTSGGTVKLADFGLARIYSYQMALTPVVV---------TLWYRAPEVL--LQSTYATPVD 122
+T+GGT+K++D G+A AL P + ++ PE+ L + VD
Sbjct: 550 LTTGGTLKISDLGVAE------ALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVD 711
Query: 123 MWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRP 182
+WS G + F E D + K+F+ IG ++P PP
Sbjct: 712 IWSAGVTLYNITTGLYPF----EGDNIYKLFENIG-------KGSYAIPGDCGPPL---- 846
Query: 183 VQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 223
+ LL ML + P KR S + QHS+ K
Sbjct: 847 ------------SDLLKGMLEYEPAKRFSIRQIRQHSWFRK 933
>lcl|NM_004073.2_cdsid_NP_004064.2 [gene=PLK3]
[protein=serine/threonine-protein kinase PLK3]
[protein_id=NP_004064.2] [location=101..2041]
Length = 1941
Score = 72.0 bits (175), Expect = 9e-13, Method: Compositional matrix adjust.
Identities = 62/233 (26%), Positives = 98/233 (42%), Gaps = 1/233 (0%)
Frame = +1
Query: 43 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVV 101
++ +RQ L GL +LH I+HRDLK N +T +K+ DFGL AR+ + +
Sbjct: 484 VRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTIC 663
Query: 102 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 161
T Y APEVLL+ + D+WS+GC+ + P F E L + + I
Sbjct: 664 GTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPF----ETADLKETYRCIK-QVH 828
Query: 162 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 221
P +SLP QLL +L +P R S + L+H +
Sbjct: 829 YTLPASLSLP----------------------ARQLLAAILRASPRDRPSIDQILRHDFF 942
Query: 222 HKDEAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQ 274
K L S + + P +P + A SL +++ + Q++ +
Sbjct: 943 TKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNHAQERDE 1101
>lcl|NM_032430.1_cdsid_NP_115806.1 [gene=BRSK1]
[protein=serine/threonine-protein kinase BRSK1]
[protein_id=NP_115806.1] [location=278..2614]
Length = 2337
Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 65/211 (30%), Positives = 89/211 (42%), Gaps = 7/211 (3%)
Frame = +1
Query: 15 VTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENIL 73
+ LV EHV +L YL K L + + RQ + LDF H+ I HRDLKPEN+L
Sbjct: 316 LYLVLEHVSGGELFDYLVKKG--RLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLL 489
Query: 74 VTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTY-ATPVDMWSVGCIFAE 132
+ +++ADFG+A + L + Y PEV+ Y DMWS G I
Sbjct: 490 LDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFA 669
Query: 133 MFRRKPLFCGNSEADQLGKIFDLIG-LPPEDDWPRDV--SLPRGAF--PPRGPRPVQSVV 187
+ L+G LP +DD R + + RG F P P QS
Sbjct: 670 L---------------------LVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQS-- 780
Query: 188 PEMEESGAQLLLEMLTFNPHKRISAFRALQH 218
LL M+ P KR+S + +H
Sbjct: 781 ---------LLRGMIEVEPEKRLSLEQIQKH 846
>lcl|NM_053025.3_cdsid_NP_444253.3 [gene=MYLK] [protein=myosin light
chain kinase, smooth muscle isoform 1]
[protein_id=NP_444253.3] [location=283..6027]
Length = 5745
Score = 71.2 bits (173), Expect = 1e-12, Method: Composition-based stats.
Identities = 53/186 (28%), Positives = 79/186 (42%), Gaps = 2/186 (1%)
Frame = +1
Query: 41 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT--SGGTVKLADFGLARIYSYQMALT 98
E IK MRQ G++++H IVH DLKPENI+ +G +KL DFGLAR +L
Sbjct: 4681 ECIK-YMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLK 4857
Query: 99 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 158
+ T + APEV+ DMWS+G I + F G+++ + L +
Sbjct: 4858 VLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANV------ 5019
Query: 159 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 218
W D E+ + + +L + R+ + LQH
Sbjct: 5020 -TSATWDFD----------------DEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQH 5148
Query: 219 SYLHKD 224
+L KD
Sbjct: 5149 PWLMKD 5166
>lcl|NM_145331.2_cdsid_NP_663304.1 [gene=MAP3K7]
[protein=mitogen-activated protein kinase kinase kinase 7
isoform B] [protein_id=NP_663304.1] [location=419..2239]
Length = 1821
Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 56/187 (29%), Positives = 86/187 (45%)
Frame = +1
Query: 1805 SSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDEL 1864
S + + +E+ K I + +G GAFG V + + VA+K ++ SE +
Sbjct: 67 SQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAK-------DVAIK---QIESESERK 216
Query: 1865 DFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLA 1924
F++E +S+ NH NIV+ G L P +++E GG L + L P P ++ A
Sbjct: 217 AFIVELRQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHA 390
Query: 1925 MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY 1984
M L ++ +A ++ IHRD+ N LL G V KI DFG A DI
Sbjct: 391 MSWCLQCSQGVAY-LHSMQPKALIHRDLKPPNLLLV--AGGTVLKICDFGTACDIQTHMT 561
Query: 1985 YNGGAGG 1991
N G+
Sbjct: 562 NNKGSAA 582
Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust.
Identities = 73/239 (30%), Positives = 107/239 (44%), Gaps = 24/239 (10%)
Frame = +1
Query: 15 VTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMR---QFLRGLDFLHA---NCIVHRDL 67
V LV E+ + L L A P LP T M Q +G+ +LH+ ++HRDL
Sbjct: 298 VCLVMEYAEGGSLYNVLHGAEP--LPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDL 471
Query: 68 KPENILVTSGGTV-KLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSV 126
KP N+L+ +GGTV K+ DFG A Q +T + + APEV S Y+ D++S
Sbjct: 472 KPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSW 645
Query: 127 GCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPP-EDDWPRDVSLPRGAFPP---RGPR 181
G I E+ RRKP FD IG P W ++ G PP P+
Sbjct: 646 GIILWEVITRRKP--------------FDEIGGPAFRIMW----AVHNGTRPPLIKNLPK 771
Query: 182 PVQSVV-----------PEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEAFQN 229
P++S++ P MEE +++ ++ + P A LQ+ + DE N
Sbjct: 772 PIESLMTRCWSKDPSQRPSMEEI-VKIMTHLMRYFP----GADEPLQYPCQYSDEGQSN 933
>lcl|NM_004759.4_cdsid_NP_004750.1 [gene=MAPKAPK2] [protein=MAP
kinase-activated protein kinase 2 isoform 1]
[protein_id=NP_004750.1] [location=211..1323]
Length = 1113
Score = 70.1 bits (170), Expect = 4e-12, Method: Compositional matrix adjust.
Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 3/102 (2%)
Frame = +1
Query: 45 DLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVV 101
++M+ + +LH+ I HRD+KPEN+L TS +KL DFG A+ + +LT
Sbjct: 493 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC 672
Query: 102 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGN 143
T +Y APEVL Y DMWS+G I + P F N
Sbjct: 673 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN 798
>lcl|NM_003942.2_cdsid_NP_003933.1 [gene=RPS6KA4] [protein=ribosomal
protein S6 kinase alpha-4 isoform a]
[protein_id=NP_003933.1] [location=84..2402]
Length = 2319
Score = 69.3 bits (168), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 42/105 (40%), Positives = 56/105 (53%), Gaps = 6/105 (5%)
Frame = +1
Query: 46 LMRQFLRGLDFLHANC-IVHRDLKPENILV---TSGGTVKLADFGLARIY--SYQMALTP 99
++R + + F+H +VHRDLKPENIL T G VK+ DFG AR+ S + +
Sbjct: 1525 ILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQT 1704
Query: 100 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS 144
TL Y APE+L Q Y D+WS+G I M + F G S
Sbjct: 1705 PCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGAS 1839
Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust.
Identities = 30/89 (33%), Positives = 49/89 (55%), Gaps = 3/89 (3%)
Frame = +1
Query: 49 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV--TLWY 106
+ + L+ LH I++RDLK EN+L+ S G + L DFGL++ + + T+ Y
Sbjct: 430 EIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEY 609
Query: 107 RAPEVLLQST-YATPVDMWSVGCIFAEMF 134
APE++ T + VD WS+G + E+
Sbjct: 610 MAPEIIRSKTGHGKAVDWWSLGILLFELL 696
>lcl|NM_001256196.1_cdsid_NP_001243125.1 [gene=ARAF]
[protein=serine/threonine-protein kinase A-Raf isoform 2]
[protein_id=NP_001243125.1] [location=212..2041]
Length = 1830
Score = 69.3 bits (168), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 55/168 (32%), Positives = 78/168 (46%), Gaps = 3/168 (1%)
Frame = +1
Query: 1812 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP--EVCSEQDELDFLME 1869
EVP + L++ +G G+FG V+ G+ G VAVK L + +EQ + F E
Sbjct: 919 EVPPSEVQLLKRIGTGSFGTVFRGRWHG--------DVAVKVLKVSQPTAEQAQA-FKNE 1071
Query: 1870 ALIISKFNHQNIVRCIGVSLQSLPRF-ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDL 1928
++ K H NI+ +G + P F I+ + G L L R M+ L
Sbjct: 1072 MQVLRKTRHVNILLFMG--FMTRPGFAIITQWCEGSSLYHHLHVADTR------FDMVQL 1227
Query: 1929 LHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMA 1976
+ VAR A G YL + IHRD+ + N L G KIGDFG+A
Sbjct: 1228 IDVARQTAQGMDYLHAKNIIHRDLKSNNIFL---HEGLTVKIGDFGLA 1362
Score = 64.7 bits (156), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 6/96 (6%)
Frame = +1
Query: 45 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVV--- 101
D+ RQ +G+D+LHA I+HRDLK NI + G TVK+ DFGLA + + P+
Sbjct: 1231 DVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPS 1410
Query: 102 -VTLWYRAPEVLLQ--STYATPVDMWSVGCIFAEMF 134
LW A + +Q + Y+ D+++ G + E+
Sbjct: 1411 GSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 1518
>lcl|NM_181690.2_cdsid_NP_859029.1 [gene=AKT3] [protein=RAC-gamma
serine/threonine-protein kinase isoform 2]
[protein_id=NP_859029.1] [location=113..1510]
Length = 1398
Score = 68.6 bits (166), Expect = 1e-11, Method: Composition-based stats.
Identities = 52/180 (28%), Positives = 81/180 (45%), Gaps = 7/180 (3%)
Frame = +1
Query: 49 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYR 107
+ + LD+LH+ IV+RDLK EN+++ G +K+ DFGL + A + T Y
Sbjct: 760 EIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYL 939
Query: 108 APEVLLQSTYATPVDMWSVGCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 166
APEVL + Y VD W +G + EM R P + + E K+F+LI +
Sbjct: 940 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE-----KLFELILM-------E 1083
Query: 167 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYL 221
D+ PR + LL +L +P+KR+ A ++HS+
Sbjct: 1084DIKFPR----------------TLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF 1215
>lcl|NM_004938.2_cdsid_NP_004929.2 [gene=DAPK1]
[protein=death-associated protein kinase 1]
[protein_id=NP_004929.2] [location=376..4668]
Length = 4293
Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 50/202 (24%), Positives = 84/202 (41%), Gaps = 4/202 (1%)
Frame = +1
Query: 33 APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT----VKLADFGLA 88
A L E + ++Q L G+ +LH+ I H DLKPENI++ +K+ DFGLA
Sbjct: 316 AEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLA 495
Query: 89 RIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ 148
+ + T + APE++ DMWS+G I + F G+++ +
Sbjct: 496 HKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQET 675
Query: 149 LGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 208
L + + ED++ + S F R +L +P K
Sbjct: 676 LANV-SAVNYEFEDEYFSNTSALAKDFIRR----------------------LLVKDPKK 786
Query: 209 RISAFRALQHSYLHKDEAFQNL 230
R++ +LQH ++ + Q L
Sbjct: 787 RMTIQDSLQHPWIKPKDTQQAL 852
>lcl|NM_004586.2_cdsid_NP_004577.1 [gene=RPS6KA3] [protein=ribosomal
protein S6 kinase alpha-3] [protein_id=NP_004577.1]
[location=1..2223]
Length = 2223
Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 45/137 (32%), Positives = 66/137 (48%), Gaps = 2/137 (1%)
Frame = +1
Query: 25 DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLAD 84
DL T L K E +K + + LD LH+ I++RDLKPENIL+ G +KL D
Sbjct: 460 DLFTRLSKEV--MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTD 633
Query: 85 FGLAR-IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGN 143
FGL++ ++ T+ Y APEV+ + + D WS G + EM F G
Sbjct: 634 FGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGK 813
Query: 144 SEADQLGKIFDL-IGLP 159
+ + I +G+P
Sbjct: 814 DRKETMTMILKAKLGMP 864
Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust.
Identities = 49/178 (27%), Positives = 82/178 (46%), Gaps = 8/178 (4%)
Frame = +1
Query: 52 RGLDFLHANCIVHRDLKPENILVT--SGG--TVKLADFGLARIYSYQ--MALTPVVVTLW 105
+ +++LHA +VHRDLKP NIL SG ++++ DFG A+ + + +TP T
Sbjct: 1573 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP-CYTAN 1749
Query: 106 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 165
+ APEVL + Y D+WS+G + M F DD P
Sbjct: 1750 FVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGP-----------------DDTP 1878
Query: 166 RDV--SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 221
++ + G F G + ++ L+ +ML +PH+R++A L+H ++
Sbjct: 1879 EEILARIGSGKFSLSG-----GYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 2037
>lcl|NM_003957.3_cdsid_NP_003948.2 [gene=BRSK2]
[protein=serine/threonine-protein kinase BRSK2 isoform
2] [protein_id=NP_003948.2] [location=387..2393]
Length = 2007
Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 42/122 (34%), Positives = 60/122 (49%), Gaps = 2/122 (1%)
Frame = +1
Query: 15 VTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENIL 73
+ LV EHV +L YL K L + + RQ + LDF H++ I HRDLKPEN+L
Sbjct: 271 LYLVLEHVSGGELFDYLVKKG--RLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLL 444
Query: 74 VTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTY-ATPVDMWSVGCIFAE 132
+ +++ADFG+A + L + Y PEV+ Y D+WS G I
Sbjct: 445 LDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFA 624
Query: 133 MF 134
+
Sbjct: 625 LL 630
>lcl|NM_001143677.1_cdsid_NP_001137149.1 [gene=SGK1]
[protein=serine/threonine-protein kinase Sgk1 isoform 3]
[protein_id=NP_001137149.1] [location=51..1430]
Length = 1380
Score = 67.4 bits (163), Expect = 2e-11, Method: Composition-based stats.
Identities = 40/103 (38%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Frame = +1
Query: 53 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEV 111
L +LH+ IV+RDLKPENIL+ S G + L DFGL + + T T Y APEV
Sbjct: 709 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEV 888
Query: 112 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 154
L + Y VD W +G + EM P F + A+ I +
Sbjct: 889 LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN 1017
>lcl|NM_002737.2_cdsid_NP_002728.1 [gene=PRKCA] [protein=protein
kinase C alpha type] [protein_id=NP_002728.1]
[location=45..2063]
Length = 2019
Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 36/103 (34%), Positives = 54/103 (52%), Gaps = 1/103 (0%)
Frame = +1
Query: 53 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEV 111
GL FLH I++RDLK +N+++ S G +K+ADFG+ + + T T Y APE+
Sbjct: 1348 GLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEI 1527
Query: 112 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 154
+ Y VD W+ G + EM +P F G E + I +
Sbjct: 1528 IAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 1656
>lcl|NM_001013703.2_cdsid_NP_001013725.2 [gene=EIF2AK4]
[protein=eukaryotic translation initiation factor 2-alpha
kinase 4] [protein_id=NP_001013725.2] [location=51..5000]
Length = 4950
Score = 67.0 bits (162), Expect = 3e-11, Method: Compositional matrix adjust.
Identities = 47/131 (35%), Positives = 66/131 (50%), Gaps = 23/131 (17%)
Frame = +1
Query: 26 LRTYLDKAPPPGLPAETIK--DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLA 83
LR +D+ GL +T++ L R+ L GL ++H ++HRDLKP NI + S VK+
Sbjct: 2428 LRDTIDQ----GLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIG 2595
Query: 84 DFGLARIYSYQMA-------------------LTPVVVTLWYRAPEVL--LQSTYATPVD 122
DFGLA + A LT +V T Y +PEV +S Y VD
Sbjct: 2596 DFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVD 2775
Query: 123 MWSVGCIFAEM 133
++S+G IF EM
Sbjct: 2776 LFSLGIIFFEM 2808
Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 28/81 (34%), Positives = 47/81 (58%), Gaps = 1/81 (1%)
Frame = +1
Query: 10 DREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLK 68
D I V ++ EH+ L +L + P +P ++ Q L GLD+LH+N +VH+ L
Sbjct: 1108 DDSIVVDILVEHISGVSLAAHLSHSGP--IPVHQLRRYTAQLLSGLDYLHSNSVVHKVLS 1281
Query: 69 PENILVTSGGTVKLADFGLAR 89
N+LV + GTVK+ D+ +++
Sbjct: 1282 ASNVLVDAEGTVKITDYSISK 1344
>lcl|NM_002019.4_cdsid_NP_002010.2 [gene=FLT1] [protein=vascular
endothelial growth factor receptor 1 isoform 1 precursor]
[protein_id=NP_002010.2] [location=286..4302]
Length = 4017
Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust.
Identities = 37/99 (37%), Positives = 55/99 (55%), Gaps = 6/99 (6%)
Frame = +1
Query: 42 TIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSY--QM 95
T++DL+ Q RG++FL + +HRDL NIL++ VK+ DFGLAR IY +
Sbjct: 2983 TMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYV 3162
Query: 96 ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
+ L + APE + Y+T D+WS G + E+F
Sbjct: 3163 RKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIF 3279
Score = 56.6 bits (135), Expect = 4e-08, Method: Compositional matrix adjust.
Identities = 28/63 (44%), Positives = 38/63 (60%)
Frame = +1
Query: 1923 LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRA 1982
+ M DL+ + +A G ++L IHRD+AARN LL+ V KI DFG+ARDIY+
Sbjct: 2980 ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLS---ENNVVKICDFGLARDIYKN 3150
Query: 1983 SYY 1985
Y
Sbjct: 3151 PDY 3159
Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 31/105 (29%), Positives = 53/105 (50%), Gaps = 2/105 (1%)
Frame = +1
Query: 1812 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL 1871
E R+ + L + LG GAFG+V + G+ P+ VAVK L E + + + E
Sbjct: 2461 EFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELK 2640
Query: 1872 IISKFNHQ-NIVRCIGV-SLQSLPRFILLELMAGGDLKSFLRETR 1914
I++ H N+V +G + Q P +++E G+L ++L+ R
Sbjct: 2641 ILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKR 2775
>lcl|NM_004119.2_cdsid_NP_004110.2 [gene=FLT3] [protein=receptor-type
tyrosine-protein kinase FLT3] [protein_id=NP_004110.2]
[location=83..3064]
Length = 2982
Score = 66.2 bits (160), Expect = 5e-11, Method: Compositional matrix adjust.
Identities = 40/106 (37%), Positives = 55/106 (51%), Gaps = 9/106 (8%)
Frame = +1
Query: 38 LPAETIKDLM---RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ 94
L T +DL+ Q +G++FL VHRDL N+LVT G VK+ DFGLAR
Sbjct: 2338 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI--- 2508
Query: 95 MALTPVVVT------LWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
M+ + VV + + APE L + Y D+WS G + E+F
Sbjct: 2509 MSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 2646
Score = 65.5 bits (158), Expect = 8e-11, Method: Compositional matrix adjust.
Identities = 53/201 (26%), Positives = 90/201 (44%), Gaps = 4/201 (1%)
Frame = +1
Query: 1720 GVSC--IVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQS 1777
G SC I+ +P P + +S + V L + ++I ++ K Q + E
Sbjct: 1561 GTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQ----FRYE--- 1719
Query: 1778 PEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLK-EVPRKNITLIRGLGHGAFGEVYEGQ 1836
S+L+ + + Y + DLK E PR+N+ + LG GAFG+V
Sbjct: 1720 -----SQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNAT 1884
Query: 1837 VSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRF 1895
G+ +QVAVK L E + + E ++++ +H+NIV +G S P +
Sbjct: 1885 AYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIY 2064
Query: 1896 ILLELMAGGDLKSFLRETRPR 1916
++ E GDL ++LR R +
Sbjct: 2065 LIFEYCCYGDLLNYLRSKREK 2127
Score = 58.5 bits (140), Expect = 9e-09, Method: Compositional matrix adjust.
Identities = 34/77 (44%), Positives = 45/77 (58%), Gaps = 3/77 (3%)
Frame = +1
Query: 1912 ETRPRPSQPSSLAML---DLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA 1968
E + R + L +L DLL A +A G ++LE +HRD+AARN L+T G+V
Sbjct: 2305 ENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVT---HGKVV 2475
Query: 1969 KIGDFGMARDIYRASYY 1985
KI DFG+ARDI S Y
Sbjct: 2476 KICDFGLARDIMSDSNY 2526
>lcl|NM_004972.3_cdsid_NP_004963.1 [gene=JAK2]
[protein=tyrosine-protein kinase JAK2]
[protein_id=NP_004963.1] [location=495..3893]
Length = 3399
Score = 65.9 bits (159), Expect = 6e-11, Method: Composition-based stats.
Identities = 51/171 (29%), Positives = 85/171 (49%), Gaps = 2/171 (1%)
Frame = +1
Query: 1809 DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLM 1868
D + +++ ++ LG G FG V + + ++ + VAVK L + +E+ DF
Sbjct: 2518 DPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEV-VAVKKL-QHSTEEHLRDFER 2691
Query: 1869 EALIISKFNHQNIVRCIGVSLQSLPRFI--LLELMAGGDLKSFLRETRPRPSQPSSLAML 1926
E I+ H NIV+ GV + R + ++E + G L+ +L++ + R + +
Sbjct: 2692 EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER------IDHI 2853
Query: 1927 DLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 1977
LL I G +YL +IHRD+A RN L+ RV KIGDFG+ +
Sbjct: 2854 KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE--NENRV-KIGDFGLTK 2997
Score = 62.0 bits (149), Expect = 1e-09, Method: Composition-based stats.
Identities = 30/90 (33%), Positives = 48/90 (53%), Gaps = 4/90 (4%)
Frame = +1
Query: 49 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTL 104
Q +G+++L +HRDL NILV + VK+ DFGL ++ Y P +
Sbjct: 2875 QICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPI 3054
Query: 105 WYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
++ APE L +S ++ D+WS G + E+F
Sbjct: 3055 FWYAPESLTESKFSVASDVWSFGVVLYELF 3144
>lcl|NM_005876.4_cdsid_NP_005867.3 [gene=SPEG] [protein=striated
muscle preferentially expressed protein kinase isoform 1]
[protein_id=NP_005867.3] [location=1..9804]
Length = 9804
Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust.
Identities = 42/127 (33%), Positives = 68/127 (53%), Gaps = 7/127 (5%)
Frame = +1
Query: 41 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPV 100
+ + M Q L+GLD+LH + ++H D+KP+N+L+ +K+ DFG A+ Y+ Q AL P+
Sbjct: 9178 DDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQ-ALRPL 9354
Query: 101 ---VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGN---SEADQLGKIF 153
TL + APE++ + D+W G + M R P + + +EA +G F
Sbjct: 9355 GHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRF 9534
Query: 154 DLIGLPP 160
D L P
Sbjct: 9535 DAFQLYP 9555
Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 37/106 (34%), Positives = 55/106 (51%), Gaps = 9/106 (8%)
Frame = +1
Query: 33 APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT----VKLADFGLA 88
A P + I+ MRQ L G+ +LH + ++H D+KPEN+LV G V++ DFG A
Sbjct: 5056 ARKPTVCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNA 5235
Query: 89 RIYS-----YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCI 129
+ + Y TP V APE++ QS + D+W VG +
Sbjct: 5236 QELTPGEPQYCQYGTPEFV-----APEIVNQSPVSGVTDIWPVGVV 5358
>lcl|NM_004721.4_cdsid_NP_004712.1 [gene=MAP3K13]
[protein=mitogen-activated protein kinase kinase kinase
13 isoform 1] [protein_id=NP_004712.1]
[location=407..3307]
Length = 2901
Score = 65.5 bits (158), Expect = 8e-11, Method: Compositional matrix adjust.
Identities = 30/82 (36%), Positives = 48/82 (58%)
Frame = +1
Query: 53 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 112
G+++LH + I+HRDLK N+LVT VK++DFG ++ S + T+ + APEV+
Sbjct: 796 GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI 975
Query: 113 LQSTYATPVDMWSVGCIFAEMF 134
+ VD+WS G + E+
Sbjct: 976 RNEPVSEKVDIWSFGVVLWELL 1041
>lcl|NM_000215.3_cdsid_NP_000206.2 [gene=JAK3]
[protein=tyrosine-protein kinase JAK3]
[protein_id=NP_000206.2] [location=101..3475]
Length = 3375
Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 33/90 (36%), Positives = 51/90 (56%), Gaps = 4/90 (4%)
Frame = +1
Query: 49 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTL 104
Q +G+++L + VHRDL NILV S VK+ADFGLA++ Y + P +
Sbjct: 2794 QICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPI 2973
Query: 105 WYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
++ APE L + ++ D+WS G + E+F
Sbjct: 2974 FWYAPESLSDNIFSRQSDVWSFGVVLYELF 3063
Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 54/166 (32%), Positives = 78/166 (46%), Gaps = 4/166 (2%)
Frame = +1
Query: 1816 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 1875
+++ I LG G FG V + + ++ L VAVK L +Q DF E I+
Sbjct: 2458 RHLKYISQLGKGNFGSVELCRYDPLGDNTGAL-VAVKQLQHSGPDQQR-DFQREIQILKA 2631
Query: 1876 FNHQNIVRCIGVSL----QSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHV 1931
+ IV+ GVS QSL +++E + G L+ FL+ R R L LL
Sbjct: 2632 LHSDFIVKYRGVSYGPGRQSLR--LVMEYLPSGCLRDFLQRHRAR------LDASRLLLY 2787
Query: 1932 ARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 1977
+ I G +YL +HRD+AARN L+ KI DFG+A+
Sbjct: 2788 SSQICKGMEYLGSRRCVHRDLAARNILVESEAH---VKIADFGLAK 2916
>lcl|NM_198465.2_cdsid_NP_940867.2 [gene=NRK] [protein=nik-related
protein kinase] [protein_id=NP_940867.2]
[location=304..5052]
Length = 4749
Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 6/111 (5%)
Frame = +1
Query: 38 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMA 96
L + I + R+ L+GL LHA+ ++HRD+K +N+L+T VKL DFG+ A++
Sbjct: 445 LKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGR 624
Query: 97 LTPVVVTLWYRAPEVLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFCG 142
+ T ++ APEV+ + +Y D+WSVG EM P C
Sbjct: 625 RNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCN 777
>lcl|NM_007271.2_cdsid_NP_009202.1 [gene=STK38]
[protein=serine/threonine-protein kinase 38]
[protein_id=NP_009202.1] [location=287..1684]
Length = 1398
Score = 63.5 bits (153), Expect = 3e-10, Method: Composition-based stats.
Identities = 43/163 (26%), Positives = 67/163 (41%), Gaps = 39/163 (23%)
Frame = +1
Query: 38 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA--------- 88
L E + + + + +D +H +HRD+KP+N+L+ S G VKL+DFGL
Sbjct: 550 LTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRT 729
Query: 89 -----------RIYSYQMALTPVVVTLWYR----------------APEVLLQSTYATPV 121
+++Q + W R APEV +Q+ Y
Sbjct: 730 EFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLC 909
Query: 122 DMWSVGCIFAEMFRRKPLFCGNSEADQLGKIF---DLIGLPPE 161
D WS+G I EM P FC + + K+ + + PPE
Sbjct: 910 DWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPE 1038
>lcl|NM_005109.2_cdsid_NP_005100.1 [gene=OXSR1]
[protein=serine/threonine-protein kinase OSR1]
[protein_id=NP_005100.1] [location=343..1926]
Length = 1584
Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust.
Identities = 38/104 (36%), Positives = 56/104 (53%), Gaps = 8/104 (7%)
Frame = +1
Query: 38 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-------RI 90
L TI ++R+ L GL++LH N +HRD+K NIL+ G+V++ADFG++ I
Sbjct: 352 LDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDI 531
Query: 91 YSYQMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEM 133
++ T V W APEV+ Q Y D+WS G E+
Sbjct: 532 TRNKVRKTFVGTPCWM-APEVMEQVRGYDFKADIWSFGITAIEL 660
>lcl|NM_017433.4_cdsid_NP_059129.3 [gene=MYO3A]
[protein=myosin-IIIa] [protein_id=NP_059129.3]
[location=361..5211]
Length = 4851
Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust.
Identities = 38/97 (39%), Positives = 55/97 (56%), Gaps = 6/97 (6%)
Frame = +1
Query: 43 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVV 101
I ++ + L GL LH N +HRD+K NIL+T+ G VKL DFG+ A++ S + V
Sbjct: 379 IAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSV 558
Query: 102 VTLWYRAPEVL-----LQSTYATPVDMWSVGCIFAEM 133
T ++ APEV+ L +TY D WS+G E+
Sbjct: 559 GTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIEL 669
Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 50/201 (24%), Positives = 89/201 (44%), Gaps = 6/201 (2%)
Frame = +1
Query: 1798 YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEV 1857
+ GKT + + P + +G G +G+V++ + N + + AVK L +
Sbjct: 4 FPLIGKTIIFDNFPD-PSDTWEITETIGKGTYGKVFK-----VLNKKNGQKAAVKILDPI 165
Query: 1858 CSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLP-----RFILLELMAGGDLKSFLR 1911
+E++ E I+ +H N+VR G+ + +++LEL +GG + ++
Sbjct: 166 HDIDEEIE--AEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVK 339
Query: 1912 ETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIG 1971
R + S + +LH A G Q+L N IHRD+ N LLT G K+
Sbjct: 340 GFLKRGERMSEPLIAYILHEA---LMGLQHLHNNKTIHRDVKGNNILLTTEGG---VKLV 501
Query: 1972 DFGMARDIYRASYYNGGAGGT 1992
DFG++ + + + GT
Sbjct: 502 DFGVSAQLTSTRHRRNTSVGT 564
>lcl|NM_002446.3_cdsid_NP_002437.2 [gene=MAP3K10]
[protein=mitogen-activated protein kinase kinase kinase
10] [protein_id=NP_002437.2] [location=289..3153]
Length = 2865
Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 63/268 (23%), Positives = 115/268 (42%), Gaps = 15/268 (5%)
Frame = +1
Query: 38 LPAETIKDLMRQFLRGLDFLHANC---IVHRDLKPENILVTSG--------GTVKLADFG 86
+P + + Q RG+++LH + I+HRDLK NIL+ +K+ DFG
Sbjct: 571 VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFG 750
Query: 87 LARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSE 145
LAR + ++ W APEV+ S ++ D+WS G + E+ P ++
Sbjct: 751 LAREWHKTTKMSAAGTYAWM-APEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDAL 927
Query: 146 ADQLGKIFDLIGLPPEDDWPRDVS--LPRGAFP-PRGPRPVQSVVPEMEESGAQLLLEML 202
A G + + LP P + L P P G S++ +E L +M
Sbjct: 928 AVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQM- 1104
Query: 203 TFNPHKRISAFRALQHSYLHKDEAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQ 262
+ +F +LQ + + Q++F +R + R E AA
Sbjct: 1105------PLESFHSLQEDWKLE---IQHMFDDLRTKEKELRSREEELLRAA---------- 1227
Query: 263 QQQQQQQQQQQQQQQQQQQQQQETSPRQ 290
Q+Q+ Q++Q ++++Q+ +++ + R+
Sbjct: 1228QEQRFQEEQLRRREQELAEREMDIVERE 1311
Score = 52.0 bits (123), Expect = 9e-07, Method: Compositional matrix adjust.
Identities = 51/190 (26%), Positives = 78/190 (41%), Gaps = 8/190 (4%)
Frame = +1
Query: 1811 KEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEA 1870
+E+P + L +G G FG+VY G ++ + P V +EQ EA
Sbjct: 271 QEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQ----VCQEA 438
Query: 1871 LIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLH 1930
+ H NI+ G L +++E GG L L R P L++
Sbjct: 439 RLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHV--------LVN 594
Query: 1931 VARDIACGCQYLEENH---FIHRDIAARNCLLTCPGPGR-----VAKIGDFGMARDIYRA 1982
A +A G YL + IHRD+ + N L+ V KI DFG+AR+ ++
Sbjct: 595 WAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT 774
Query: 1983 SYYNGGAGGT 1992
+ + A GT
Sbjct: 775 TKMS--AAGT 798
>lcl|NM_014586.1_cdsid_NP_055401.1 [gene=HUNK] [protein=hormonally
up-regulated neu tumor-associated kinase]
[protein_id=NP_055401.1] [location=361..2505]
Length = 2145
Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 32/91 (35%), Positives = 48/91 (52%), Gaps = 3/91 (3%)
Frame = +1
Query: 47 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR---IYSYQMALTPVVVT 103
+RQ + ++ LH +VHRDLK EN+L+ +KL DFGL+ I Y + +
Sbjct: 499 IRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGS 678
Query: 104 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
Y APE+L + Y +D+WS+G M
Sbjct: 679 PAYAAPELLARKKYGPKIDVWSIGVNMYAML 771
>lcl|NM_000222.2_cdsid_NP_000213.1 [gene=KIT] [protein=mast/stem cell
growth factor receptor Kit isoform 1 precursor]
[protein_id=NP_000213.1] [location=88..3018]
Length = 2931
Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 79/319 (24%), Positives = 120/319 (37%), Gaps = 73/319 (22%)
Frame = +1
Query: 1740 SVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYN-PNY 1798
++ T L+ +++A +IV ++ LQ E+Q ++ + N NY
Sbjct: 1558 TLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWK-----------VVEEINGNNY 1704
Query: 1799 CFAGKTSSISDLK-EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEV 1857
+ T D K E PR ++ + LG GAFG+V E G+ + + VAVK L +
Sbjct: 1705 VYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KP 1881
Query: 1858 CSEQDELDFLMEALIISKF--NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETR- 1914
+ E + LM L + + NH NIV +G P ++ E GDL +FLR R
Sbjct: 1882 SAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRD 2061
Query: 1915 -----PRPSQPSSLAMLDLLHVAR-----------DIACGCQYLEENH-----------F 1947
+ + +LLH D+ G Y+ +
Sbjct: 2062 SFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSY 2241
Query: 1948 IHRDI-------------------------------AARNC----------LLTCPGPGR 1966
I RD+ A++NC LLT GR
Sbjct: 2242 IERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLT---HGR 2412
Query: 1967 VAKIGDFGMARDIYRASYY 1985
+ KI DFG+ARDI S Y
Sbjct: 2413 ITKICDFGLARDIKNDSNY 2469
Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust.
Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 4/90 (4%)
Frame = +1
Query: 49 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTL 104
Q +G+ FL + +HRDL NIL+T G K+ DFGLAR +Y + +
Sbjct: 2323 QVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVK 2502
Query: 105 WYRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
W APE + Y D+WS G E+F
Sbjct: 2503 W-MAPESIFNCVYTFESDVWSYGIFLWELF 2589
>lcl|NM_005255.2_cdsid_NP_005246.2 [gene=GAK]
[protein=cyclin-G-associated kinase]
[protein_id=NP_005246.2] [location=200..4135]
Length = 3936
Score = 62.4 bits (150), Expect = 8e-10, Method: Compositional matrix adjust.
Identities = 58/202 (28%), Positives = 91/202 (45%), Gaps = 23/202 (11%)
Frame = +1
Query: 17 LVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQFLRGLDFLHANC--IVHRDLKPENIL 73
L+ E L +L K G L +T+ + Q R + +H I+HRDLK EN+L
Sbjct: 361 LLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL 540
Query: 74 VTSGGTVKLADFGLARIYSY---------QMALTPVVVTL----WYRAPEVL-LQSTY-- 117
+++ GT+KL DFG A S+ + AL +T YR PE++ L S +
Sbjct: 541 LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPI 720
Query: 118 ATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPED-DWPRDVSLPRGAF 175
D+W++GCI + FR+ P + +L + +PP D + SL R
Sbjct: 721 GEKQDIWALGCILYLLCFRQHPF----EDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAML 888
Query: 176 P--PRGPRPVQSVVPEMEESGA 195
P + VV +++E A
Sbjct: 889 QVNPEERLSIAEVVHQLQEIAA 954
>lcl|NM_001042600.1_cdsid_NP_001036065.1 [gene=MAP4K1]
[protein=mitogen-activated protein kinase kinase kinase
kinase 1 isoform 1] [protein_id=NP_001036065.1]
[location=109..2574]
Length = 2466
Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 36/100 (36%), Positives = 56/100 (56%), Gaps = 4/100 (4%)
Frame = +1
Query: 43 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVV 101
I + R+ L+GL +LH+ +HRD+K NIL+ G V+LADFG+ A+I + +
Sbjct: 340 ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFI 519
Query: 102 VTLWYRAPE---VLLQSTYATPVDMWSVGCIFAEMFRRKP 138
T ++ APE V L+ Y D+WS+G E+ +P
Sbjct: 520 GTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQP 639
>lcl|NM_212535.2_cdsid_NP_997700.1 [gene=PRKCB] [protein=protein
kinase C beta type isoform 1] [protein_id=NP_997700.1]
[location=198..2213]
Length = 2016
Score = 61.2 bits (147), Expect = 2e-09, Method: Composition-based stats.
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Frame = +1
Query: 53 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEV 111
GL FL + I++RDLK +N+++ S G +K+ADFG+ + + T T Y APE+
Sbjct: 1357 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 1536
Query: 112 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 154
+ Y VD W+ G + EM + F G E + I +
Sbjct: 1537 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 1665
>lcl|NM_006648.3_cdsid_NP_006639.3 [gene=WNK2]
[protein=serine/threonine-protein kinase WNK2]
[protein_id=NP_006639.3] [location=1..6654]
Length = 6654
Score = 61.2 bits (147), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 40/111 (36%), Positives = 61/111 (54%), Gaps = 3/111 (2%)
Frame = +1
Query: 26 LRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC--IVHRDLKPENILVTS-GGTVKL 82
L+TYL + + + ++ RQ L+GL FLH I+HRDLK +NI +T G+VK+
Sbjct: 847 LKTYLKRFK--VMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKI 1020
Query: 83 ADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 133
D GLA + A + V+ T + APE + + Y VD+++ G EM
Sbjct: 1021GDLGLATLKRASFAKS-VIGTPEFMAPE-MYEEHYDESVDVYAFGMCMLEM 1167
>lcl|NM_014370.3_cdsid_NP_055185.2 [gene=SRPK3] [protein=SRSF
protein kinase 3 isoform 1] [protein_id=NP_055185.2]
[location=87..1790]
Length = 1704
Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 28/66 (42%), Positives = 41/66 (62%), Gaps = 1/66 (1%)
Frame = +1
Query: 13 IKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC-IVHRDLKPEN 71
+ V +V E + L ++ K+ GLP +K ++RQ L GLD+LH C I+H D+KPEN
Sbjct: 472 VHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPEN 651
Query: 72 ILVTSG 77
IL+ G
Sbjct: 652 ILLCVG 669
>lcl|NM_005163.2_cdsid_NP_005154.2 [gene=AKT1] [protein=RAC-alpha
serine/threonine-protein kinase]
[protein_id=NP_005154.2] [location=555..1997]
Length = 1443
Score = 60.8 bits (146), Expect = 2e-09, Method: Composition-based stats.
Identities = 43/121 (35%), Positives = 64/121 (52%), Gaps = 3/121 (2%)
Frame = +1
Query: 49 QFLRGLDFLHA-NCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWY 106
+ + LD+LH+ +V+RDLK EN+++ G +K+ DFGL + A + T Y
Sbjct: 766 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEY 945
Query: 107 RAPEVLLQSTYATPVDMWSVGCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 165
APEVL + Y VD W +G + EM R P + + E K+F+LI L E +P
Sbjct: 946 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE-----KLFELI-LMEEIRFP 1107
Query: 166 R 166
R
Sbjct: 1108R 1110
>lcl|NM_032387.4_cdsid_NP_115763.2 [gene=WNK4]
[protein=serine/threonine-protein kinase WNK4]
[protein_id=NP_115763.2] [location=69..3800]
Length = 3732
Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 40/111 (36%), Positives = 61/111 (54%), Gaps = 3/111 (2%)
Frame = +1
Query: 26 LRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC--IVHRDLKPENILVTS-GGTVKL 82
L+TYL + + ++ RQ LRGL FLH+ I+HRDLK +N+ +T G+VK+
Sbjct: 784 LKTYLRRFRE--MKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKI 957
Query: 83 ADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 133
D GLA + A + V+ T + APE + + Y VD+++ G EM
Sbjct: 958 GDLGLATLKRASFAKS-VIGTPEFMAPE-MYEEKYDEAVDVYAFGMCMLEM 1104
>lcl|NM_032037.3_cdsid_NP_114426.1 [gene=TSSK6]
[protein=testis-specific serine/threonine-protein kinase
6] [protein_id=NP_114426.1] [location=234..1055]
Length = 822
Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 64/212 (30%), Positives = 92/212 (43%), Gaps = 4/212 (1%)
Frame = +1
Query: 14 KVTLVFEHVDQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENI 72
K+ +V E DL + + PG+ A +DL Q + +LH + +VHRDLK EN+
Sbjct: 253 KLYIVMEAAATDLLQAVQRNGRIPGVQA---RDLFAQIAGAVRYLHDHHLVHRDLKCENV 423
Query: 73 LVT-SGGTVKLADFGLAR-IYSYQMALTPVVVTLWYRAPEVLLQSTYA-TPVDMWSVGCI 129
L++ VKL DFG R + Y T + Y +PEVLL Y D+WS+G +
Sbjct: 424 LLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVV 603
Query: 130 FAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPE 189
M G D D+ GLP RG P G E
Sbjct: 604 LYVM------VTGCMPFDD----SDIAGLPRRQK--------RGVLYPEG--------LE 705
Query: 190 MEESGAQLLLEMLTFNPHKRISAFRALQHSYL 221
+ E L+ E+L F+P R SA + ++ +L
Sbjct: 706 LSERCKALIAELLQFSPSARPSAGQVARNCWL 801
>lcl|NM_182691.2_cdsid_NP_872633.1 [gene=SRPK2] [protein=SRSF
protein kinase 2 isoform b precursor]
[protein_id=NP_872633.1] [location=235..2301]
Length = 2067
Score = 60.8 bits (146), Expect = 2e-09, Method: Composition-based stats.
Identities = 29/63 (46%), Positives = 43/63 (68%), Gaps = 1/63 (1%)
Frame = +1
Query: 13 IKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC-IVHRDLKPEN 71
I V +VFE + L ++ K+ GLP +K ++RQ L+GLD+LH+ C I+H D+KPEN
Sbjct: 478 IHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPEN 657
Query: 72 ILV 74
IL+
Sbjct: 658 ILM 666
>lcl|NM_006255.3_cdsid_NP_006246.2 [gene=PRKCH] [protein=protein
kinase C eta type] [protein_id=NP_006246.2]
[location=306..2357]
Length = 2052
Score = 60.5 bits (145), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 46/139 (33%), Positives = 66/139 (47%), Gaps = 3/139 (2%)
Frame = +1
Query: 21 HVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV 80
H+ + R D+A AE I LM FLH I++RDLK +N+L+ G
Sbjct: 1330 HIQKSRR--FDEARARFYAAEIISALM--------FLHDKGIIYRDLKLDNVLLDHEGHC 1479
Query: 81 KLADFGLARIYSYQMALTPVVV-TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPL 139
KLADFG+ + T T Y APE+L + Y VD W++G + EM
Sbjct: 1480 KLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEM------ 1641
Query: 140 FCGNS--EADQLGKIFDLI 156
CG++ EA+ +F+ I
Sbjct: 1642 LCGHAPFEAENEDDLFEAI 1698
>lcl|NM_033126.1_cdsid_NP_149117.1 [gene=PSKH2]
[protein=serine/threonine-protein kinase H2]
[protein_id=NP_149117.1] [location=1..1158]
Length = 1158
Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 37/84 (44%), Positives = 50/84 (59%), Gaps = 7/84 (8%)
Frame = +1
Query: 53 GLDFLHANCIVHRDLKPENILVTSGG---TVKLADFGLARIYSYQMALTPVVVTLW---- 105
G+ +LHA I HR+LKPEN+L G + + DFGLA YS + + + TL
Sbjct: 508 GIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLA--YSGKKSGDWTMKTLCGTPE 681
Query: 106 YRAPEVLLQSTYATPVDMWSVGCI 129
Y APEVLL+ Y + VDMW++G I
Sbjct: 682 YIAPEVLLRKPYTSAVDMWALGVI 753
>lcl|NM_002253.2_cdsid_NP_002244.1 [gene=KDR] [protein=vascular
endothelial growth factor receptor 2 precursor]
[protein_id=NP_002244.1] [location=303..4373]
Length = 4071
Score = 60.1 bits (144), Expect = 4e-09, Method: Compositional matrix adjust.
Identities = 32/89 (35%), Positives = 47/89 (52%), Gaps = 3/89 (3%)
Frame = +1
Query: 49 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS--YQMALTPVVVTLW 105
Q +G++FL + +HRDL NIL++ VK+ DFGLAR IY + + L
Sbjct: 3031 QVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLK 3210
Query: 106 YRAPEVLLQSTYATPVDMWSVGCIFAEMF 134
+ APE + Y D+WS G + E+F
Sbjct: 3211 WMAPETIFDRVYTIQSDVWSFGVLLWEIF 3297
Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 32/105 (30%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Frame = +1
Query: 1812 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL 1871
E PR + L + LG GAFG+V E G+ + VAVK L E + + + E
Sbjct: 2482 EFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELK 2661
Query: 1872 IISKFNHQ-NIVRCIGVSLQ-SLPRFILLELMAGGDLKSFLRETR 1914
I+ H N+V +G + P +++E G+L ++LR R
Sbjct: 2662 ILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKR 2796
>lcl|NM_005204.3_cdsid_NP_005195.2 [gene=MAP3K8]
[protein=mitogen-activated protein kinase kinase kinase
8] [protein_id=NP_005195.2] [location=613..2016]
Length = 1404
Score = 59.7 bits (143), Expect = 5e-09, Method: Compositional matrix adjust.
Identities = 49/184 (26%), Positives = 80/184 (43%), Gaps = 7/184 (3%)
Frame = +1
Query: 46 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TL 104
+ + L+GLDFLH+ ++H D+KP NI+ S V L DFGL+ + + + T
Sbjct: 697 VTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTE 873
Query: 105 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 164
Y +PEV+L ++T D++S+G M G PP W
Sbjct: 874 IYMSPEVILCRGHSTKADIYSLGATLIHM---------------------QTGTPP---W 981
Query: 165 PRDVSLPRGAFPP------RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 218
+ PR A+P + P++ + + +L+ L NP+ R A L+H
Sbjct: 982 VK--RYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKH 1155
Query: 219 SYLH 222
L+
Sbjct: 1156EALN 1167
>lcl|NM_172226.2_cdsid_NP_757380.1 [gene=CAMKK2]
[protein=calcium/calmodulin-dependent protein kinase
kinase 2 isoform 2] [protein_id=NP_757380.1]
[location=176..1801]
Length = 1626
Score = 58.9 bits (141), Expect = 8e-09, Method: Compositional matrix adjust.
Identities = 37/123 (30%), Positives = 64/123 (52%), Gaps = 4/123 (3%)
Frame = +1
Query: 12 EIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPEN 71
E + +VFE V+Q + P L + + + ++G+++LH I+HRD+KP N
Sbjct: 778 EDHLYMVFELVNQGPVMEVPTLKP--LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSN 951
Query: 72 ILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEVLLQSTYA---TPVDMWSVG 127
+LV G +K+ADFG++ + AL V T + APE L ++ +D+W++G
Sbjct: 952 LLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMG 1131
Query: 128 CIF 130
Sbjct: 1132VTL 1140
>lcl|NM_004409.3_cdsid_NP_004400.4 [gene=DMPK]
[protein=myotonin-protein kinase isoform 2]
[protein_id=NP_004400.4] [location=206..2095]
Length = 1890
Score = 58.5 bits (140), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 49/151 (32%), Positives = 73/151 (48%), Gaps = 10/151 (6%)
Frame = +1
Query: 12 EIKVTLVFEH-VDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPE 70
E + LV E+ V DL T L K +PAE + + + + +D +H VHRD+KP+
Sbjct: 421 ENYLYLVMEYYVGGDLLTLLSKFGE-RIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPD 597
Query: 71 NILVTSGGTVKLADFGLARIYSYQMALTPVVV--TLWYRAPEVL-------LQSTYATPV 121
NIL+ G ++LADFG + +V T Y +PE+L +Y
Sbjct: 598 NILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPEC 777
Query: 122 DMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 152
D W++G EMF + F +S A+ GKI
Sbjct: 778 DWWALGVFAYEMFYGQTPFYADSTAETYGKI 870
>lcl|NM_025164.3_cdsid_NP_079440.2 [gene=SIK3]
[protein=serine/threonine-protein kinase SIK3]
[protein_id=NP_079440.2] [location=37..3828]
Length = 3792
Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 60/229 (26%), Positives = 96/229 (41%), Gaps = 1/229 (0%)
Frame = +1
Query: 47 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 106
+Q + + F H IVHRDLK EN+L+ + +K+ADFG + +++ L + Y
Sbjct: 331 FKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPY 510
Query: 107 RAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 165
APE+ Y P VD+WS+G + L CG D G ++
Sbjct: 511 AAPELFEGKEYDGPKVDIWSLGVVLY------VLVCGALPFD---------GSTLQNLRA 645
Query: 166 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 225
R +S G F R P M L+ ML +P+KR+S + +H ++ +
Sbjct: 646 RVLS---GKF--RIPFF-------MSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGD 789
Query: 226 AFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQ 274
A N + + E Q R + P +LL + ++Q Q
Sbjct: 790 ADPNFDRLIAECQQLKEERQVD-----PLNEDVLLAMEDMGLDKEQTLQ 921
>lcl|NM_002744.4_cdsid_NP_002735.3 [gene=PRKCZ] [protein=protein
kinase C zeta type isoform 1] [protein_id=NP_002735.3]
[location=162..1940]
Length = 1779
Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 40/127 (31%), Positives = 64/127 (50%), Gaps = 7/127 (5%)
Frame = +1
Query: 14 KVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENI 72
++ LV E+V+ DL ++ + LP E + + L+FLH I++RDLK +N+
Sbjct: 973 RLFLVIEYVNGGDLMFHMQRQRK--LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNV 1146
Query: 73 LVTSGGTVKLADFGLARIYSYQMALTPVVVTLW------YRAPEVLLQSTYATPVDMWSV 126
L+ + G +KL D+G+ + L P T Y APE+L Y VD W++
Sbjct: 1147 LLDADGHIKLTDYGMCK-----EGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWAL 1311
Query: 127 GCIFAEM 133
G + EM
Sbjct: 1312 GVLMFEM 1332
>lcl|NM_002314.3_cdsid_NP_002305.1 [gene=LIMK1] [protein=LIM domain
kinase 1 isoform 1] [protein_id=NP_002305.1]
[location=215..2158]
Length = 1944
Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 34/119 (28%), Positives = 56/119 (47%)
Frame = +1
Query: 1859 SEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS 1918
E+ + FL E ++ H N+++ IGV + + E + GG L+ ++ S
Sbjct: 1120 DEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIK------S 1281
Query: 1919 QPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 1977
S + A+DIA G YL + IHRD+ + NCL+ + + DFG+AR
Sbjct: 1282 MDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVR---ENKNVVVADFGLAR 1449
Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 35/118 (29%), Positives = 54/118 (45%), Gaps = 15/118 (12%)
Frame = +1
Query: 53 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA---------------L 97
G+ +LH+ I+HRDL N LV V +ADFGLAR+ +
Sbjct: 1339 GMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKR 1518
Query: 98 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL 155
VV ++ APE++ +Y VD++S G + E+ R N++ D L + D
Sbjct: 1519 YTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRV-----NADPDYLPRTMDF 1677
>lcl|NM_005372.1_cdsid_NP_005363.1 [gene=MOS]
[protein=proto-oncogene serine/threonine-protein kinase
mos] [protein_id=NP_005363.1] [location=1..1041]
Length = 1041
Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust.
Identities = 32/99 (32%), Positives = 50/99 (50%), Gaps = 4/99 (4%)
Frame = +1
Query: 51 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG----LARIYSYQMALTPVVVTLWY 106
+ GL FLH+ IVH DLKP NIL++ K++DFG L + +Q P+ T +
Sbjct: 556 VNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLEDLLCFQTPSYPLGGTYTH 735
Query: 107 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSE 145
RAPE+L D++S +M ++ + G +
Sbjct: 736 RAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGERQ 852
>lcl|NM_004203.4_cdsid_NP_004194.3 [gene=PKMYT1]
[protein=membrane-associated tyrosine- and
threonine-specific cdc2-inhibitory kinase isoform 1]
[protein_id=NP_004194.3] [location=510..2009]
Length = 1500
Score = 53.9 bits (128), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 43/124 (34%), Positives = 56/124 (45%)
Frame = +1
Query: 38 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL 97
LP + +R L L LH+ +VH D+KP NI + G KL DFGL A
Sbjct: 613 LPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAG 792
Query: 98 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 157
Y APE LLQ +Y T D++S+G E+ L G QL + +
Sbjct: 793 EVQEGDPRYMAPE-LLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGY---- 957
Query: 158 LPPE 161
LPPE
Sbjct: 958 LPPE 969
>lcl|NM_133378.4_cdsid_NP_596869.4 [gene=TTN] [protein=titin isoform
N2-A] [protein_id=NP_596869.4] [location=226..100497]
Length = 100272
Score = 53.1 bits (126), Expect = 5e-07, Method: Composition-based stats.
Identities = 30/89 (33%), Positives = 44/89 (49%), Gaps = 2/89 (2%)
Frame = +1
Query: 43 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPV 100
I + Q L FLH++ I H D++PENI+ + T+K+ +FG AR +
Sbjct: 94042 IVSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLL 94221
Query: 101 VVTLWYRAPEVLLQSTYATPVDMWSVGCI 129
Y APEV +T DMWS+G +
Sbjct: 94222 FTAPEYYAPEVHQHDVVSTATDMWSLGTL 94308
>lcl|NM_173598.4_cdsid_NP_775869.3 [gene=KSR2] [protein=kinase
suppressor of Ras 2] [protein_id=NP_775869.3]
[location=56..2821]
Length = 2766
Score = 52.0 bits (123), Expect = 9e-07, Method: Compositional matrix adjust.
Identities = 43/176 (24%), Positives = 79/176 (44%), Gaps = 1/176 (0%)
Frame = +1
Query: 1801 AGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSE 1860
A +TS ++P + + + +G G FG+VY G+ G +VA++ +
Sbjct: 1858 ASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG--------EVAIRLIDIERDN 2013
Query: 1861 QDELD-FLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQ 1919
+D+L F E + + H+N+V +G + I+ L G L S +R+ +
Sbjct: 2014 EDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAK----- 2178
Query: 1920 PSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGM 1975
L + +A++I G YL +H+D+ ++N G+V I DFG+
Sbjct: 2179 -IVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFY---DNGKVV-ITDFGL 2331
>lcl|NM_018571.5_cdsid_NP_061041.2 [gene=STRADB]
[protein=STE20-related kinase adapter protein beta
isoform 1] [protein_id=NP_061041.2] [location=366..1622]
Length = 1257
Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 38/123 (30%), Positives = 60/123 (48%), Gaps = 13/123 (10%)
Frame = +1
Query: 24 QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLA 83
Q LRTY P G+ I++++ +RGL++LH N +HR +K +IL++ G V L+
Sbjct: 436 QLLRTYF----PEGMSETLIRNILFGAVRGLNYLHQNGCIHRSIKASHILISGDGLVTLS 603
Query: 84 DFGLARIYS-----------YQMALTPVVVTLWYRAPEVLLQST--YATPVDMWSVGCIF 130
GL+ ++S Y V W +PE+L Q Y D++SVG
Sbjct: 604 --GLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWL-SPELLRQDLHGYNVKSDIYSVGITA 774
Query: 131 AEM 133
E+
Sbjct: 775 CEL 783
>lcl|NM_024652.3_cdsid_NP_078928.3 [gene=LRRK1] [protein=leucine-rich
repeat serine/threonine-protein kinase 1]
[protein_id=NP_078928.3] [location=320..6367]
Length = 6048
Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 52/165 (31%), Positives = 85/165 (51%), Gaps = 12/165 (7%)
Frame = +1
Query: 49 QFLRGLDFLHANCIVHRDLKPENILVTSGGT-----VKLADFGLARIYSYQMALTPVVVT 103
Q GL +LH I+ DLK +NILV S +KL+D+G++R ++ AL V T
Sbjct: 4105 QIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALG-VEGT 4281
Query: 104 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSE---ADQLGK-IFDLIGLP 159
Y+APE+ + Y VDM+S G + E+ + G+ + A +L K I ++G P
Sbjct: 4282 PGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQP 4461
Query: 160 PEDDWPRDVSLPRGAFPPR-GPRPVQ-SVVPEMEE-SGAQLLLEM 201
E + R +L + + RP+ SVV +M++ + A + E+
Sbjct: 4462 EEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYEL 4596
BLAST Search Results
TBLASTN 2.2.20 [Feb-08-2009]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment:
Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schäffer, and Yi-Kuo Yu (2005) "Protein database
searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= g8.t1
(522 letters)
Database: taget.fasta
3914 sequences; 7,230,561 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
lcl|NM_004964.2_cdsid_NP_004955.2 [gene=HDAC1] [protein=histone ... 318 1e-87
lcl|NM_002596.3_cdsid_NP_002587.2 [gene=CDK18] [protein=cyclin-d... 186 6e-48
lcl|NM_012395.2_cdsid_NP_036527.1 [gene=CDK14] [protein=cyclin-d... 164 4e-41
lcl|NM_001160367.1_cdsid_NP_001153839.1 [gene=CDK10] [protein=cy... 137 6e-33
lcl|NM_015076.3_cdsid_NP_055891.1 [gene=CDK19] [protein=cyclin-d... 131 2e-31
lcl|NM_012119.4_cdsid_NP_036251.2 [gene=CDK20] [protein=cyclin-d... 124 4e-29
lcl|NM_006037.3_cdsid_NP_006028.2 [gene=HDAC4] [protein=histone ... 104 3e-23
lcl|NM_002747.3_cdsid_NP_002738.2 [gene=MAPK4] [protein=mitogen-... 99 2e-21
lcl|NM_172084.2_cdsid_NP_742081.1 [gene=CAMK2B] [protein=calcium... 73 1e-13
lcl|NM_004071.3_cdsid_NP_004062.2 [gene=CLK1] [protein=dual spec... 69 1e-12
lcl|NM_001128629.2_cdsid_NP_001122101.1 [gene=PAK6] [protein=ser... 69 2e-12
lcl|NM_133494.2_cdsid_NP_598001.1 [gene=NEK7] [protein=serine/th... 67 6e-12
lcl|NM_003942.2_cdsid_NP_003933.1 [gene=RPS6KA4] [protein=riboso... 65 2e-11
lcl|NM_002401.3_cdsid_NP_002392.2 [gene=MAP3K3] [protein=mitogen... 62 2e-10
lcl|NM_004734.4_cdsid_NP_004725.1 [gene=DCLK1] [protein=serine/t... 62 3e-10
lcl|NM_004586.2_cdsid_NP_004577.1 [gene=RPS6KA3] [protein=riboso... 60 9e-10
lcl|NM_002578.3_cdsid_NP_002569.1 [gene=PAK3] [protein=serine/th... 60 1e-09
lcl|NM_181690.2_cdsid_NP_859029.1 [gene=AKT3] [protein=RAC-gamma... 59 2e-09
lcl|NM_032430.1_cdsid_NP_115806.1 [gene=BRSK1] [protein=serine/t... 59 2e-09
lcl|NM_003957.3_cdsid_NP_003948.2 [gene=BRSK2] [protein=serine/t... 58 3e-09
lcl|NM_002737.2_cdsid_NP_002728.1 [gene=PRKCA] [protein=protein ... 58 3e-09
lcl|NM_000455.4_cdsid_NP_000446.1 [gene=STK11] [protein=serine/t... 58 3e-09
lcl|NM_016457.4_cdsid_NP_057541.2 [gene=PRKD2] [protein=serine/t... 58 4e-09
lcl|NM_006255.3_cdsid_NP_006246.2 [gene=PRKCH] [protein=protein ... 57 1e-08
lcl|NM_033126.1_cdsid_NP_149117.1 [gene=PSKH2] [protein=serine/t... 56 1e-08
lcl|NM_001042600.1_cdsid_NP_001036065.1 [gene=MAP4K1] [protein=m... 56 2e-08
lcl|NM_014370.3_cdsid_NP_055185.2 [gene=SRPK3] [protein=SRSF pro... 55 2e-08
lcl|NM_014586.1_cdsid_NP_055401.1 [gene=HUNK] [protein=hormonall... 55 2e-08
lcl|NM_004759.4_cdsid_NP_004750.1 [gene=MAPKAPK2] [protein=MAP k... 54 5e-08
lcl|NM_005417.3_cdsid_NP_005408.1 [gene=SRC] [protein=proto-onco... 54 6e-08
lcl|NM_000215.3_cdsid_NP_000206.2 [gene=JAK3] [protein=tyrosine-... 54 7e-08
lcl|NM_025164.3_cdsid_NP_079440.2 [gene=SIK3] [protein=serine/th... 54 7e-08
lcl|NM_005109.2_cdsid_NP_005100.1 [gene=OXSR1] [protein=serine/t... 53 9e-08
lcl|NM_001012338.2_cdsid_NP_001012338.1 [gene=NTRK3] [protein=NT... 53 9e-08
lcl|NM_004972.3_cdsid_NP_004963.1 [gene=JAK2] [protein=tyrosine-... 53 1e-07
lcl|NM_001261816.1_cdsid_NP_001248745.1 [gene=PDPK1] [protein=3-... 53 1e-07
lcl|NM_002031.2_cdsid_NP_002022.1 [gene=FRK] [protein=tyrosine-p... 52 2e-07
lcl|NM_172226.2_cdsid_NP_757380.1 [gene=CAMKK2] [protein=calcium... 52 2e-07
lcl|NM_005248.2_cdsid_NP_005239.1 [gene=FGR] [protein=tyrosine-p... 51 3e-07
lcl|NM_005876.4_cdsid_NP_005867.3 [gene=SPEG] [protein=striated ... 51 3e-07
lcl|NM_182691.2_cdsid_NP_872633.1 [gene=SRPK2] [protein=SRSF pro... 51 3e-07
lcl|NM_053025.3_cdsid_NP_444253.3 [gene=MYLK] [protein=myosin li... 51 4e-07
lcl|NM_004073.2_cdsid_NP_004064.2 [gene=PLK3] [protein=serine/th... 51 4e-07
lcl|NM_212535.2_cdsid_NP_997700.1 [gene=PRKCB] [protein=protein ... 51 4e-07
lcl|NM_002253.2_cdsid_NP_002244.1 [gene=KDR] [protein=vascular e... 51 5e-07
lcl|NM_032037.3_cdsid_NP_114426.1 [gene=TSSK6] [protein=testis-s... 50 6e-07
lcl|NM_002447.2_cdsid_NP_002438.2 [gene=MST1R] [protein=macropha... 50 7e-07
lcl|NM_005255.2_cdsid_NP_005246.2 [gene=GAK] [protein=cyclin-G-a... 50 8e-07
lcl|NM_017433.4_cdsid_NP_059129.3 [gene=MYO3A] [protein=myosin-I... 50 8e-07
lcl|NM_000141.4_cdsid_NP_000132.3 [gene=FGFR2] [protein=fibrobla... 50 9e-07
lcl|NM_005163.2_cdsid_NP_005154.2 [gene=AKT1] [protein=RAC-alpha... 50 9e-07
lcl|NM_004203.4_cdsid_NP_004194.3 [gene=PKMYT1] [protein=membran... 50 1e-06
lcl|NM_001013703.2_cdsid_NP_001013725.2 [gene=EIF2AK4] [protein=... 49 1e-06
lcl|NM_001143677.1_cdsid_NP_001137149.1 [gene=SGK1] [protein=ser... 49 2e-06
lcl|NM_145331.2_cdsid_NP_663304.1 [gene=MAP3K7] [protein=mitogen... 49 2e-06
lcl|NM_002019.4_cdsid_NP_002010.2 [gene=FLT1] [protein=vascular ... 49 2e-06
lcl|NM_198465.2_cdsid_NP_940867.2 [gene=NRK] [protein=nik-relate... 49 2e-06
lcl|NM_001174066.1_cdsid_NP_001167537.1 [gene=FGFR1] [protein=fi... 49 2e-06
lcl|NM_002744.4_cdsid_NP_002735.3 [gene=PRKCZ] [protein=protein ... 48 4e-06
lcl|NM_022963.2_cdsid_NP_075252.2 [gene=FGFR4] [protein=fibrobla... 47 6e-06
lcl|NM_005372.1_cdsid_NP_005363.1 [gene=MOS] [protein=proto-onco... 47 6e-06
lcl|NM_004721.4_cdsid_NP_004712.1 [gene=MAP3K13] [protein=mitoge... 47 6e-06
>lcl|NM_004964.2_cdsid_NP_004955.2 [gene=HDAC1] [protein=histone
deacetylase 1] [protein_id=NP_004955.2]
[location=64..1512]
Length = 1449
Score = 318 bits (816), Expect = 1e-87, Method: Compositional matrix adjust.
Identities = 145/335 (43%), Positives = 224/335 (66%), Gaps = 1/335 (0%)
Frame = +1
Query: 1 MVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGL 59
M H+L+ Y L+++M I +P A+ EEM +H+D Y++ L+ + + ++ ++ + +
Sbjct: 109 MTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNV 288
Query: 60 GYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDA 119
G DCP +G+F++ G ++ +A L +A+NW+GG HHAKK EASGFCY+ND
Sbjct: 289 GEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDI 468
Query: 120 VLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVG 179
VL IL L + +R+LY+D+D+HHGDGVE+AF T +VMTVS HK+ +FPGTGD+ D+G
Sbjct: 469 VLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIG 645
Query: 180 LGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFN 239
GKG+YY+VN P++DGI DE Y I + V+ +V + F P AVVLQ G+D+++GD + FN
Sbjct: 646 AGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFN 825
Query: 240 MTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFT 299
+T G KC++++ + L L+LGGGGY + N ARCWTY T V L + +E+P +++F
Sbjct: 826 LTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFE 1005
Query: 300 AYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNL 334
+GPD+ L I+PS ++N +++I + NL
Sbjct: 1006YFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENL 1110
>lcl|NM_002596.3_cdsid_NP_002587.2 [gene=CDK18]
[protein=cyclin-dependent kinase 18 isoform b]
[protein_id=NP_002587.2] [location=345..1769]
Length = 1425
Score = 186 bits (473), Expect = 6e-48, Method: Compositional matrix adjust.
Identities = 88/177 (49%), Positives = 126/177 (71%), Gaps = 1/177 (0%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 406
R++LHRDLKPQNLLI+++G +KLADFGLARA +P + Y++EVVTLWYR P+VLLGS Y
Sbjct: 775 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 954
Query: 407 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN-T 465
STP+D+W +G I E+AT +PLF G + ++L IFR LGTP E WP V + +++ +
Sbjct: 955 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 1134
Query: 466 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 522
FP + P L +H LD +G+ LLS +L+Y+ R+S + AL+H YF L ++ ++
Sbjct: 1135FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 1305
>lcl|NM_012395.2_cdsid_NP_036527.1 [gene=CDK14]
[protein=cyclin-dependent kinase 14]
[protein_id=NP_036527.1] [location=145..1500]
Length = 1356
Score = 164 bits (414), Expect = 4e-41, Method: Compositional matrix adjust.
Identities = 89/181 (49%), Positives = 110/181 (60%), Gaps = 11/181 (6%)
Frame = +1
Query: 346 RRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 405
+R +LHRDLKPQNLLI D G +KLADFGLARA +P Y++EVVTLWYR P+VLLGS
Sbjct: 691 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTE 870
Query: 406 YSTPVDIWSIGTIFAELATKKPLFHGDSEI-DQLFRIFRALGTPNNEVWPEVESLQDY-- 462
YST +D+W +G IF E+ F G +I DQL RIF LGTPN + WP V SL +
Sbjct: 871 YSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP 1050
Query: 463 --------KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 514
KN W S +H + DL SK+L P R+S + AL+H YF+D
Sbjct: 1051ERFTLYSSKNLRQAWNKLSYVNHAE-------DLASKLLQCSPKNRLSAQAALSHEYFSD 1209
Query: 515 L 515
L
Sbjct: 1210L 1212
>lcl|NM_001160367.1_cdsid_NP_001153839.1 [gene=CDK10]
[protein=cyclin-dependent kinase 10 isoform d]
[protein_id=NP_001153839.1] [location=219..1088]
Length = 870
Score = 137 bits (344), Expect = 6e-33, Method: Compositional matrix adjust.
Identities = 75/170 (44%), Positives = 104/170 (61%), Gaps = 1/170 (0%)
Frame = +1
Query: 346 RRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 405
R ++HRDLK NLL+ DKG +K ADFGLARA+G+P++ T +VVTLWYR+PE+LLG+
Sbjct: 253 RNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTT 432
Query: 406 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 465
+T +D+W++G I AEL +PL G SEI Q+ I + LGTP+ +WP L
Sbjct: 433 QTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQY 612
Query: 466 FPKWKP-GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 514
+ +P +L L E GL LL + +YDP KR + L YF +
Sbjct: 613 SLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKE 762
>lcl|NM_015076.3_cdsid_NP_055891.1 [gene=CDK19]
[protein=cyclin-dependent kinase 19]
[protein_id=NP_055891.1] [location=74..1582]
Length = 1509
Score = 131 bits (330), Expect = 2e-31, Method: Compositional matrix adjust.
Identities = 75/196 (38%), Positives = 106/196 (54%), Gaps = 25/196 (12%)
Frame = +1
Query: 344 NWRRRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTH---EVVTLWYRS 396
NW VLHRDLKP N+L+ ++G +K+AD G AR F P++ VVT WYR+
Sbjct: 433 NW---VLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 603
Query: 397 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI---------DQLFRIFRALGT 447
PE+LLG+ Y+ +DIW+IG IFAEL T +P+FH E DQL RIF +G
Sbjct: 604 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGF 783
Query: 448 PNNEVWPEVESLQDYKNTFPKWKPGSLAS---------HVKNLDENGLDLLSKMLIYDPA 498
P ++ W ++ + +Y ++ + A+ H D LL K+L DP
Sbjct: 784 PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPT 963
Query: 499 KRISGKMALNHPYFND 514
KRI+ + AL PYF +
Sbjct: 964 KRITSEQALQDPYFQE 1011
>lcl|NM_012119.4_cdsid_NP_036251.2 [gene=CDK20]
[protein=cyclin-dependent kinase 20 isoform 2]
[protein_id=NP_036251.2] [location=335..1312]
Length = 978
Score = 124 bits (310), Expect = 4e-29, Method: Compositional matrix adjust.
Identities = 74/190 (38%), Positives = 102/190 (53%), Gaps = 2/190 (1%)
Frame = +1
Query: 325 QILNYIKGNLNGRLYQNRENWRRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-IR 383
Q+ +Y++ L G + + N ++HRDLKP NLLI G +K+ADFGLAR F R
Sbjct: 307 QVKSYLQMLLKGVAFCHANN----IVHRDLKPANLLISASGQLKIADFGLARVFSPDGSR 474
Query: 384 VYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 443
+YTH+V T S+G I EL PLF G ++I+QL + R
Sbjct: 475 LYTHQVAT---------------------RSVGCIMGELLNGSPLFPGKNDIEQLCYVLR 591
Query: 444 ALGTPNNEVWPEVESLQDY-KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 502
LGTPN +VWPE+ L DY K +F + P L + ++ LDLL + L+Y P +RI+
Sbjct: 592 ILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIA 771
Query: 503 GKMALNHPYF 512
AL H YF
Sbjct: 772 ASKALLHQYF 801
>lcl|NM_006037.3_cdsid_NP_006028.2 [gene=HDAC4] [protein=histone
deacetylase 4] [protein_id=NP_006028.2]
[location=793..4047]
Length = 3255
Score = 104 bits (259), Expect = 3e-23, Method: Compositional matrix adjust.
Identities = 85/309 (27%), Positives = 144/309 (46%), Gaps = 27/309 (8%)
Frame = +1
Query: 4 SLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQ-------HLQKVSQEGDDDHPDSIE 56
S ++ L + ++ + A++EE+ T H++A+ + QK+ + S+
Sbjct: 2059 SRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVF 2238
Query: 57 Y-----GLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAI-NWSGGW-------H 103
G+G D ++ I++ + G A + A C+++ + KVA G+ H
Sbjct: 2239 VRLPCGGVGVD---SDTIWNEVHSAGAARL-AVGCVVELVFKVATGELKNGFAVVRPPGH 2406
Query: 104 HAKKDEASGFCYLNDAVLG--ILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSL 161
HA++ GFCY N + +L+ R +IL VD D+HHG+G + AF V+ +SL
Sbjct: 2407 HAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSL 2586
Query: 162 HKFSPG-FFPGTGDVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAF 216
H++ G FFPG+G +VG G G ++VN+ G+ D +Y +V+ + F
Sbjct: 2587 HRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEF 2766
Query: 217 NPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCW 276
P V++ G D + G P TP+ GGYNL +ARC+
Sbjct: 2767 APDVVLVSSGFDAVEGHP------TPL---------------------GGYNL--SARCF 2859
Query: 277 TYLTGVILG 285
YLT ++G
Sbjct: 2860 GYLTKQLMG 2886
>lcl|NM_002747.3_cdsid_NP_002738.2 [gene=MAPK4]
[protein=mitogen-activated protein kinase 4]
[protein_id=NP_002738.2] [location=1001..2764]
Length = 1764
Score = 98.6 bits (244), Expect = 2e-21, Method: Compositional matrix adjust.
Identities = 62/180 (34%), Positives = 92/180 (51%), Gaps = 15/180 (8%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKG-TIKLADFGLARAFGIPIRVYTHE------VVTLWYRSPEVLL 401
VLHRDLKP N+ I + +K+ DFGLAR I + Y+H+ +VT WYRSP +LL
Sbjct: 433 VLHRDLKPANIFISTEDLVLKIGDFGLAR---IVDQHYSHKGYLSEGLVTKWYRSPRLLL 603
Query: 402 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE-------VWP 454
Y+ +D+W+ G I AE+ T + LF G E++Q+ I + E V P
Sbjct: 604 SPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMP 783
Query: 455 E-VESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 513
V S + K K P ++ +D L K+L ++P R++ +M L HPY +
Sbjct: 784 SFVSSTWEVKRPLRKLLP--------EVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMS 939
>lcl|NM_172084.2_cdsid_NP_742081.1 [gene=CAMK2B]
[protein=calcium/calmodulin-dependent protein kinase
type II subunit beta isoform 8] [protein_id=NP_742081.1]
[location=211..1560]
Length = 1350
Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 58/166 (34%), Positives = 79/166 (47%), Gaps = 3/166 (1%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 405
V+HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL A
Sbjct: 394 VVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA- 570
Query: 406 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 465
Y PVDIW+ G I L P F D + +L++ +A Y
Sbjct: 571 YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKAGA---------------YDFP 702
Query: 466 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 511
P+W ++ KNL +++ML +PAKRI+ AL HP+
Sbjct: 703 SPEWD--TVTPEAKNL-------INQMLTINPAKRITAHEALKHPW 813
>lcl|NM_004071.3_cdsid_NP_004062.2 [gene=CLK1] [protein=dual
specificity protein kinase CLK1 isoform 1]
[protein_id=NP_004062.2] [location=182..1636]
Length = 1455
Score = 69.3 bits (168), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 62/206 (30%), Positives = 89/206 (43%), Gaps = 34/206 (16%)
Frame = +1
Query: 348 RVLHRDLKPQNLLI--------------DDKGT-----IKLADFGLARAFGIPIRVYTHE 388
++ H DLKP+N+L D+ T IK+ DFG A ++
Sbjct: 847 KLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA---TYDDEHHSTL 1017
Query: 389 VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP 448
V T YR+PEV+L +S P D+WSIG I E +F + L + R LG
Sbjct: 1018 VSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPL 1194
Query: 449 NNEVWPEVESLQDYKNTFPKWKPGS-----LASHVKNLDENGL----------DLLSKML 493
+ + + + + W S ++ K L E L DL+ KML
Sbjct: 1195 PKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKML 1374
Query: 494 IYDPAKRISGKMALNHPYFNDLDNQI 519
YDPAKRI+ + AL HP+F+ L I
Sbjct: 1375 EYDPAKRITLREALKHPFFDLLKKSI 1452
>lcl|NM_001128629.2_cdsid_NP_001122101.1 [gene=PAK6]
[protein=serine/threonine-protein kinase PAK 6 isoform 1]
[protein_id=NP_001122101.1] [location=358..2403]
Length = 2046
Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 47/164 (28%), Positives = 77/164 (46%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 408
V+HRD+K ++L+ G +KL+DFG + V T ++ +PEV + + Y+T
Sbjct: 1564 VIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEV-ISRSLYAT 1740
Query: 409 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 468
VDIWS+G + E+ +P + DS + + R L+D + PK
Sbjct: 1741 EVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKR------------------LRD--SPPPK 1860
Query: 469 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 512
K S V D L +ML+ DP +R + + L+HP+
Sbjct: 1861 LKNSHKVSPVLR------DFLERMLVRDPQERATAQELLDHPFL 1974
>lcl|NM_133494.2_cdsid_NP_598001.1 [gene=NEK7]
[protein=serine/threonine-protein kinase Nek7]
[protein_id=NP_598001.1] [location=328..1236]
Length = 909
Score = 67.0 bits (162), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 35/86 (40%), Positives = 48/86 (55%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 406
RRV+HRD+KP N+ I G +KL D GL R F V T +Y SPE + + Y
Sbjct: 463 RRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG-Y 639
Query: 407 STPVDIWSIGTIFAELATKKPLFHGD 432
+ DIWS+G + E+A + F+GD
Sbjct: 640 NFKSDIWSLGCLLYEMAALQSPFYGD 717
>lcl|NM_003942.2_cdsid_NP_003933.1 [gene=RPS6KA4] [protein=ribosomal
protein S6 kinase alpha-4 isoform a]
[protein_id=NP_003933.1] [location=84..2402]
Length = 2319
Score = 65.5 bits (158), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 48/174 (27%), Positives = 77/174 (44%), Gaps = 6/174 (3%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSARYS 407
+++RDLK +N+L+D +G I L DFGL++ F + T T+ Y +PE++ +
Sbjct: 469 IIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHG 648
Query: 408 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 467
VD WS+G + EL T F + E + + R + + P +
Sbjct: 649 KAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRI----------- 795
Query: 468 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLD 516
G +A DLL ++L DP KR+ + NHP+F LD
Sbjct: 796 ----GPVAQ----------DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 915
Score = 54.7 bits (130), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 14/167 (8%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDK---GTIKLADFGLAR----AFGIPIRVYTHEVVTLWYRSPEVLL 401
V+HRDLKP+N+L D +K+ DFG AR + G+P++ TL Y +PE LL
Sbjct: 1576 VVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQT---PCFTLQYAAPE-LL 1743
Query: 402 GSARYSTPVDIWSIGTIFAELATKKPLFHGDS-------EIDQLFRIFRALGTPNNEVWP 454
Y D+WS+G I + + + F G S + + +I + + E W
Sbjct: 1744 AQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAW- 1920
Query: 455 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI 501
+ + E +L+ +L DPAKR+
Sbjct: 1921 ------------------------QGVSEEAKELVRGLLTVDPAKRL 1989
>lcl|NM_002401.3_cdsid_NP_002392.2 [gene=MAP3K3]
[protein=mitogen-activated protein kinase kinase kinase 3
isoform 2] [protein_id=NP_002392.2] [location=320..2200]
Length = 1881
Score = 62.0 bits (149), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 47/169 (27%), Positives = 76/169 (44%), Gaps = 6/169 (3%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAF------GIPIRVYTHEVVTLWYRSPEVLLG 402
++HRD+K N+L D G +KL DFG ++ G +R T T ++ SPEV+ G
Sbjct: 1453 IVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTG---TPYWMSPEVISG 1623
Query: 403 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 462
Y D+WS+G E+ T+KP + +E + + IF+ P N P
Sbjct: 1624 EG-YGRKADVWSLGCTVVEMLTEKPPW---AEYEAMAAIFKIATQPTNPQLP-------- 1767
Query: 463 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 511
SH+ E+G D L ++ + + +R S + L H +
Sbjct: 1768 -------------SHI---SEHGRDFLRRIFV-EARQRPSAEELLTHHF 1863
>lcl|NM_004734.4_cdsid_NP_004725.1 [gene=DCLK1]
[protein=serine/threonine-protein kinase DCLK1 isoform 1]
[protein_id=NP_004725.1] [location=284..2473]
Length = 2190
Score = 61.6 bits (148), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 48/170 (28%), Positives = 76/170 (44%), Gaps = 4/170 (2%)
Frame = +1
Query: 349 VLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 404
++HRD+KP+NLL+ D ++KL DFGLA P+ T Y +PE++ +
Sbjct: 1519 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCG---TPTYVAPEIIAETG 1689
Query: 405 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 464
Y VDIW+ G I L P F G + ++ +G + +P
Sbjct: 1690 -YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVD---FPS--------- 1830
Query: 465 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 514
P W N+ ++ +L++ ML+ D +R S L HP+ ND
Sbjct: 1831 --PYW---------DNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 1947
>lcl|NM_004586.2_cdsid_NP_004577.1 [gene=RPS6KA3] [protein=ribosomal
protein S6 kinase alpha-3] [protein_id=NP_004577.1]
[location=1..2223]
Length = 2223
Score = 60.1 bits (144), Expect = 9e-10, Method: Compositional matrix adjust.
Identities = 39/113 (34%), Positives = 64/113 (56%), Gaps = 2/113 (1%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 407
+++RDLKP+N+L+D++G IKL DFGL++ + + Y+ T+ Y +PEV + ++
Sbjct: 565 IIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSF-CGTVEYMAPEV-VNRRGHT 738
Query: 408 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA-LGTPNNEVWPEVESL 459
D WS G + E+ T F G + + I +A LG P + PE +SL
Sbjct: 739 QSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF-LSPEAQSL 894
Score = 57.4 bits (137), Expect = 5e-09, Method: Compositional matrix adjust.
Identities = 47/170 (27%), Positives = 75/170 (44%), Gaps = 7/170 (4%)
Frame = +1
Query: 349 VLHRDLKPQNLL-IDDKG---TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 404
V+HRDLKP N+L +D+ G +I++ DFG A+ + T + +PEVL
Sbjct: 1603 VVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQG 1782
Query: 405 RYSTPVDIWSIGTIFAELATK-KPLFHG--DSEIDQLFRIFRALGTPNNEVWPEVESLQD 461
Y DIWS+G + + T P +G D+ + L RI + + W
Sbjct: 1783 -YDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYW-------- 1935
Query: 462 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 511
++ + DL+SKML DP +R++ + L HP+
Sbjct: 1936 -----------------NSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPW 2034
>lcl|NM_002578.3_cdsid_NP_002569.1 [gene=PAK3]
[protein=serine/threonine-protein kinase PAK 3 isoform a]
[protein_id=NP_002569.1] [location=622..2256]
Length = 1635
Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 47/165 (28%), Positives = 76/165 (46%)
Frame = +1
Query: 348 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 407
+V+HRD+K N+L+ G++KL DFG + V T ++ +PEV+ A Y
Sbjct: 1144 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YG 1320
Query: 408 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 467
VDIWS+G + E+ +P + ++ + L+ I GTP LQ+
Sbjct: 1321 PKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTP---------ELQN------ 1452
Query: 468 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 512
P L++ + D L++ L D +R S K L HP+
Sbjct: 1453 ---PERLSAVFR-------DFLNRCLEMDVDRRGSAKELLQHPFL 1557
>lcl|NM_181690.2_cdsid_NP_859029.1 [gene=AKT3] [protein=RAC-gamma
serine/threonine-protein kinase isoform 2]
[protein_id=NP_859029.1] [location=113..1510]
Length = 1398
Score = 58.9 bits (141), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 53/177 (29%), Positives = 85/177 (48%), Gaps = 6/177 (3%)
Frame = +1
Query: 348 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 407
++++RDLK +NL++D G IK+ DFGL + T Y +PEVL + Y
Sbjct: 796 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDND-YG 972
Query: 408 TPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 466
VD W +G + E+ + P ++ D E +LF E+ ++D K F
Sbjct: 973 RAVDWWGLGVVMYEMMCGRLPFYNQDHE--KLF---------------ELILMEDIK--F 1095
Query: 467 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFNDLDNQ 518
P+ +L+S K+ LLS +LI DP KR+ G K + H +F+ ++ Q
Sbjct: 1096PR----TLSSDAKS-------LLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQ 1233
>lcl|NM_032430.1_cdsid_NP_115806.1 [gene=BRSK1]
[protein=serine/threonine-protein kinase BRSK1]
[protein_id=NP_115806.1] [location=278..2614]
Length = 2337
Score = 58.5 bits (140), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 43/164 (26%), Positives = 70/164 (42%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 408
+ HRDLKP+NLL+D+K I++ADFG+A + + + + Y PEV+ G
Sbjct: 454 ICHRDLKPENLLLDEKNNIRIADFGMA-SLQVGDSLLETSCGSPHYACPEVIKGEKYDGR 630
Query: 409 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 468
D+WS G I L F D+ L ++ R + + + P+ +S
Sbjct: 631 RADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQS---------- 780
Query: 469 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 512
LL M+ +P KR+S + HP++
Sbjct: 781 -------------------LLRGMIEVEPEKRLSLEQIQKHPWY 855
>lcl|NM_003957.3_cdsid_NP_003948.2 [gene=BRSK2]
[protein=serine/threonine-protein kinase BRSK2 isoform
2] [protein_id=NP_003948.2] [location=387..2393]
Length = 2007
Score = 58.2 bits (139), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 35/111 (31%), Positives = 56/111 (50%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 408
+ HRDLKP+NLL+D+K I++ADFG+A + + + + Y PEV+ G
Sbjct: 409 ICHRDLKPENLLLDEKNNIRIADFGMA-SLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 585
Query: 409 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 459
D+WS G I L F D+ L ++ R + + + P+ +SL
Sbjct: 586 KADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSL 738
>lcl|NM_002737.2_cdsid_NP_002728.1 [gene=PRKCA] [protein=protein
kinase C alpha type] [protein_id=NP_002728.1]
[location=45..2063]
Length = 2019
Score = 58.2 bits (139), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 44/179 (24%), Positives = 82/179 (45%), Gaps = 8/179 (4%)
Frame = +1
Query: 346 RRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPEVLLG 402
+R +++RDLK N+++D +G IK+ADFG+ + G+ R + T Y +PE+ +
Sbjct: 1366 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCG---TPDYIAPEI-IA 1533
Query: 403 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 462
Y VD W+ G + E+ +P F G+ E D+LF +S+ ++
Sbjct: 1534 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE-DELF-----------------QSIMEH 1659
Query: 463 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLD 516
++P K+L + + + ++ PAKR+ + H +F +D
Sbjct: 1660 NVSYP-----------KSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRID 1803
>lcl|NM_000455.4_cdsid_NP_000446.1 [gene=STK11]
[protein=serine/threonine-protein kinase STK11]
[protein_id=NP_000446.1] [location=1116..2417]
Length = 1302
Score = 58.2 bits (139), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 47/168 (27%), Positives = 75/168 (44%), Gaps = 4/168 (2%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARA---FGIPIRVYTHEVVTLWYRSPEVLLGSAR 405
++H+D+KP NLL+ GT+K++D G+A A F T + + ++ PE+ G
Sbjct: 514 IVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQ-GSPAFQPPEIANGLDT 690
Query: 406 YST-PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 464
+S VDIWS G + T F GD+ ++++F +G + +
Sbjct: 691 FSGFKVDIWSAGVTLYNITTGLYPFEGDN----IYKLFENIGKGSYAI------------ 822
Query: 465 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 512
PG + DLL ML Y+PAKR S + H +F
Sbjct: 823 ------PGDCGPPLS-------DLLKGMLEYEPAKRFSIRQIRQHSWF 927
>lcl|NM_016457.4_cdsid_NP_057541.2 [gene=PRKD2]
[protein=serine/threonine-protein kinase D2 isoform A]
[protein_id=NP_057541.2] [location=758..3394]
Length = 2637
Score = 57.8 bits (138), Expect = 4e-09, Method: Compositional matrix adjust.
Identities = 57/206 (27%), Positives = 94/206 (45%), Gaps = 14/206 (6%)
Frame = +1
Query: 323 IQQILNYIKGNLNGRLYQN---------RENWRRRVLHRDLKPQNLLI---DDKGTIKLA 370
++ IL+ KG L RL + R + ++H DLKP+N+L+ D +KL
Sbjct: 1903 LEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLC 2082
Query: 371 DFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSARYSTPVDIWSIGTI-FAELATKKPL 428
DFG AR G + + VV T Y +PEVLL Y+ +D+WS+G I + L+ P
Sbjct: 2083 DFGFARIIG--EKSFRRSVVGTPAYLAPEVLLNQG-YNRSLDMWSVGVIMYVSLSGTFP- 2250
Query: 429 FHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDL 488
F+ D +I+ + +Q+ +P AS ++ +DL
Sbjct: 2251 FNEDEDIN--------------------DQIQNAAFMYP-------ASPWSHISAGAIDL 2349
Query: 489 LSKMLIYDPAKRISGKMALNHPYFND 514
++ +L KR S +L+HP+ +
Sbjct: 2350 INNLLQVKMRKRYSVDKSLSHPWLQE 2427
>lcl|NM_006255.3_cdsid_NP_006246.2 [gene=PRKCH] [protein=protein
kinase C eta type] [protein_id=NP_006246.2]
[location=306..2357]
Length = 2052
Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 51/175 (29%), Positives = 80/175 (45%), Gaps = 7/175 (4%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSARYS 407
+++RDLK N+L+D +G KLADFG+ + GI V T T Y +PE+ L Y
Sbjct: 1423 IIYRDLKLDNVLLDHEGHCKLADFGMCKE-GICNGVTTATFCGTPDYIAPEI-LQEMLYG 1596
Query: 408 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 467
VD W++G + E+ F ++E D +F A+ N+EV +P
Sbjct: 1597 PAVDWWAMGVLLYEMLCGHAPFEAENEDD----LFEAI--LNDEV------------VYP 1722
Query: 468 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMA-LNHPYFNDLD 516
W L E+ +L + +P R+ G+ A L HP+F ++D
Sbjct: 1723 TW-----------LHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEID 1854
>lcl|NM_033126.1_cdsid_NP_149117.1 [gene=PSKH2]
[protein=serine/threonine-protein kinase H2]
[protein_id=NP_149117.1] [location=1..1158]
Length = 1158
Score = 55.8 bits (133), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 48/169 (28%), Positives = 78/169 (46%), Gaps = 5/169 (2%)
Frame = +1
Query: 348 RVLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVV--TLWYRSPEVLLG 402
++ HR+LKP+NLL ++ I + DFGLA + G +T + + T Y +PEVLL
Sbjct: 532 QITHRNLKPENLLYYHPGEESKILITDFGLAYS-GKKSGDWTMKTLCGTPEYIAPEVLLR 708
Query: 403 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 462
Y++ VD+W++G I L + F +S+ +I + E WP +
Sbjct: 709 KP-YTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSI------ 867
Query: 463 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 511
SH+ D + K+LI + R+S AL+HP+
Sbjct: 868 -------------SHLAK------DFIDKLLILEAGHRMSAGQALDHPW 957
>lcl|NM_001042600.1_cdsid_NP_001036065.1 [gene=MAP4K1]
[protein=mitogen-activated protein kinase kinase kinase
kinase 1 isoform 1] [protein_id=NP_001036065.1]
[location=109..2574]
Length = 2466
Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 31/86 (36%), Positives = 51/86 (59%), Gaps = 3/86 (3%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR- 405
++ +HRD+K N+LI+D G ++LADFG++ G + + T ++ +PEV + +
Sbjct: 391 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 570
Query: 406 -YSTPVDIWSIGTIFAELAT-KKPLF 429
Y+ DIWS+G ELA + PLF
Sbjct: 571 GYNELCDIWSLGITAIELAELQPPLF 648
>lcl|NM_014370.3_cdsid_NP_055185.2 [gene=SRPK3] [protein=SRSF protein
kinase 3 isoform 1] [protein_id=NP_055185.2]
[location=87..1790]
Length = 1704
Score = 55.5 bits (132), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 59/185 (31%), Positives = 76/185 (41%), Gaps = 25/185 (13%)
Frame = +1
Query: 354 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 413
L+PQN DK IK+AD G A + +T ++ T YR+ EVL+G A Y P DIW
Sbjct: 1183 LEPQNA---DKIKIKIADLGNACWVH---KHFTEDIQTRQYRAVEVLIG-AEYGPPADIW 1341
Query: 414 SIGTIFAELATKKPLFHGDS------EIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 467
S + ELAT LF S + D + I LG ++ P Y F
Sbjct: 1342 STACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLG----DIPPAFALSGRYSREFF 1509
Query: 468 KWKPGSLASHVKNLDENGL-------------------DLLSKMLIYDPAKRISGKMALN 508
+ G L H+ NL GL L M+ Y P KR S L
Sbjct: 1510 N-RRGEL-RHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQ 1683
Query: 509 HPYFN 513
HP+ N
Sbjct: 1684 HPWLN 1698
>lcl|NM_014586.1_cdsid_NP_055401.1 [gene=HUNK] [protein=hormonally
up-regulated neu tumor-associated kinase]
[protein_id=NP_055401.1] [location=361..2505]
Length = 2145
Score = 55.5 bits (132), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Frame = +1
Query: 346 RRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-----PIRVYTHEVVTLWYRSPEVL 400
R V+HRDLK +NLL+D+ IKL DFGL+ GI P ++ + + Y +PE L
Sbjct: 535 RAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDP---FSTQCGSPAYAAPE-L 702
Query: 401 LGSARYSTPVDIWSIGT-IFAELATKKPL 428
L +Y +D+WSIG ++A L P
Sbjct: 703 LARKKYGPKIDVWSIGVNMYAMLTGTLPF 789
>lcl|NM_004759.4_cdsid_NP_004750.1 [gene=MAPKAPK2] [protein=MAP
kinase-activated protein kinase 2 isoform 1]
[protein_id=NP_004750.1] [location=211..1323]
Length = 1113
Score = 53.9 bits (128), Expect = 5e-08, Method: Compositional matrix adjust.
Identities = 46/170 (27%), Positives = 75/170 (44%), Gaps = 6/170 (3%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 405
+ HRD+KP+NLL K +KL DFG A+ T T +Y +PEV LG +
Sbjct: 544 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEV-LGPEK 717
Query: 406 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES---LQDY 462
Y D+WS+G I L P F+ + + + P +++ + Y
Sbjct: 718 YDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPGMKTRIRMGQY 852
Query: 463 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 512
+ P+W ++ VK L N +L +P +R++ +NHP+
Sbjct: 853 EFPNPEW--SEVSEEVKMLIRN-------LLKTEPTQRMTITEFMNHPWI 975
>lcl|NM_005417.3_cdsid_NP_005408.1 [gene=SRC] [protein=proto-oncogene
tyrosine-protein kinase Src] [protein_id=NP_005408.1]
[location=450..2060]
Length = 1611
Score = 53.9 bits (128), Expect = 6e-08, Method: Compositional matrix adjust.
Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 28/179 (15%)
Frame = +1
Query: 322 RIQQILNYIKGNLNGRLYQNRENWRRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP 381
R+ Q+++ +G Y R N+ +HRDL+ N+L+ + K+ADFGLAR I
Sbjct: 1084 RLPQLVDMAAQIASGMAYVERMNY----VHRDLRAANILVGENLVCKVADFGLARL--IE 1245
Query: 382 IRVYTHEV---VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKK----PLFHGDSE 434
YT + + +PE L R++ D+WS G + EL TK P
Sbjct: 1246 DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV 1422
Query: 435 IDQLFRIFRALGTPN---------NEVW-------PEVESLQD-----YKNTFPKWKPG 472
+DQ+ R +R P + W P E LQ + +T P+++PG
Sbjct: 1423 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPG 1599
>lcl|NM_000215.3_cdsid_NP_000206.2 [gene=JAK3]
[protein=tyrosine-protein kinase JAK3]
[protein_id=NP_000206.2] [location=101..3475]
Length = 3375
Score = 53.5 bits (127), Expect = 7e-08, Method: Compositional matrix adjust.
Identities = 44/140 (31%), Positives = 66/140 (47%), Gaps = 14/140 (10%)
Frame = +1
Query: 299 TAYGP-----DYVLEITPS-CRPDRNEPHRIQ----QILNYIKGNLNGRLYQNRENWRRR 348
+YGP V+E PS C D + HR + ++L Y G Y RR
Sbjct: 2665 VSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGS----RR 2832
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT----HEVVTLWYRSPEVLLGSA 404
+HRDL +N+L++ + +K+ADFGLA+ + Y + WY +PE L +
Sbjct: 2833 CVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY-APESLSDNI 3009
Query: 405 RYSTPVDIWSIGTIFAELAT 424
+S D+WS G + EL T
Sbjct: 3010 -FSRQSDVWSFGVVLYELFT 3066
>lcl|NM_025164.3_cdsid_NP_079440.2 [gene=SIK3]
[protein=serine/threonine-protein kinase SIK3]
[protein_id=NP_079440.2] [location=37..3828]
Length = 3792
Score = 53.5 bits (127), Expect = 7e-08, Method: Compositional matrix adjust.
Identities = 31/87 (35%), Positives = 45/87 (51%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 406
R ++HRDLK +NLL+D IK+ADFG + F P ++ + Y +PE+ G
Sbjct: 370 RNIVHRDLKAENLLLDANLNIKIADFGFSNLF-TPGQLLKTWCGSPPYAAPELFEGKEYD 546
Query: 407 STPVDIWSIGTIFAELATKKPLFHGDS 433
VDIWS+G + L F G +
Sbjct: 547 GPKVDIWSLGVVLYVLVCGALPFDGST 627
>lcl|NM_005109.2_cdsid_NP_005100.1 [gene=OXSR1]
[protein=serine/threonine-protein kinase OSR1]
[protein_id=NP_005100.1] [location=343..1926]
Length = 1584
Score = 53.1 bits (126), Expect = 9e-08, Method: Compositional matrix adjust.
Identities = 49/175 (28%), Positives = 76/175 (43%), Gaps = 6/175 (3%)
Frame = +1
Query: 350 LHRDLKPQNLLIDDKGTIKLADFGLAR--AFGIPI---RVYTHEVVTLWYRSPEVLLGSA 404
+HRD+K N+L+ + G++++ADFG++ A G I +V V T + +PEV+
Sbjct: 427 IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVR 606
Query: 405 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW-PEVESLQDYK 463
Y DIWS G ELAT +H + L + P+ E + E L+ Y
Sbjct: 607 GYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQN-DPPSLETGVQDKEMLKKYG 783
Query: 464 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 518
+F K ++S L DP KR + L H +F N+
Sbjct: 784 KSFRK-------------------MISLCLQKDPEKRPTAAELLRHKFFQKAKNK 891
>lcl|NM_001012338.2_cdsid_NP_001012338.1 [gene=NTRK3] [protein=NT-3
growth factor receptor isoform a precursor]
[protein_id=NP_001012338.1] [location=307..2826]
Length = 2520
Score = 53.1 bits (126), Expect = 9e-08, Method: Compositional matrix adjust.
Identities = 43/173 (24%), Positives = 81/173 (46%), Gaps = 19/173 (10%)
Frame = +1
Query: 295 HEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLNGRLYQNRENWRRRVLHRDL 354
++F A+GPD ++ + R + E + Q+L+ +G +Y +++ +HRDL
Sbjct: 1876 NKFLRAHGPDAMILVDGQPRQAKGELG-LSQMLHIASQIASGMVYLASQHF----VHRDL 2040
Query: 355 KPQNLLIDDKGTIKLADFGLAR----------------AFGIPIRVYTHEVVTLWYRSPE 398
+N L+ +K+ DFG++R F I V H ++ + + PE
Sbjct: 2041 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPE 2220
Query: 399 VLLGSARYSTPVDIWSIGTIFAELAT--KKPLFH-GDSEIDQLFRIFRALGTP 448
++ +++T D+WS G I E+ T K+P F ++E+ + R L P
Sbjct: 2221 SIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERP 2376
>lcl|NM_004972.3_cdsid_NP_004963.1 [gene=JAK2]
[protein=tyrosine-protein kinase JAK2]
[protein_id=NP_004963.1] [location=495..3893]
Length = 3399
Score = 52.8 bits (125), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 28/82 (34%), Positives = 44/82 (53%), Gaps = 4/82 (4%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT----HEVVTLWYRSPEVLLG 402
+R +HRDL +N+L++++ +K+ DFGL + Y E WY +PE L
Sbjct: 2908 KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APESLTE 3084
Query: 403 SARYSTPVDIWSIGTIFAELAT 424
S ++S D+WS G + EL T
Sbjct: 3085 S-KFSVASDVWSFGVVLYELFT 3147
>lcl|NM_001261816.1_cdsid_NP_001248745.1 [gene=PDPK1]
[protein=3-phosphoinositide-dependent protein kinase 1
isoform 3] [protein_id=NP_001248745.1]
[location=150..1514]
Length = 1365
Score = 52.8 bits (125), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 47/175 (26%), Positives = 78/175 (44%), Gaps = 8/175 (4%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE--VVTLWYRSPEVLLGSARY 406
++HRDLKP+N+L+++ I++ DFG A+ + V T Y SPE+L +
Sbjct: 601 IIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSAC 780
Query: 407 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 466
+ D+W++G I +L P F +E + IF+ + + +PE F
Sbjct: 781 KS-SDLWALGCIIYQLVAGLPPFRAGNE----YLIFQKIIKLEYD-FPE--------KFF 918
Query: 467 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALN-HPYFNDL 515
PK + DL+ K+L+ D KR+ G L HP+F +
Sbjct: 919 PKAR----------------DLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 1035
>lcl|NM_002031.2_cdsid_NP_002022.1 [gene=FRK]
[protein=tyrosine-protein kinase FRK]
[protein_id=NP_002022.1] [location=448..1965]
Length = 1518
Score = 52.0 bits (123), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 29/82 (35%), Positives = 47/82 (57%), Gaps = 4/82 (4%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI---PIRVYTHEV-VTLWYRSPEVLLG 402
R +HRDL +N+L+ + K+ADFGLAR F + I HE+ + + + +PE +
Sbjct: 1042 RNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEA-IR 1218
Query: 403 SARYSTPVDIWSIGTIFAELAT 424
S ++S D+WS G + E+ T
Sbjct: 1219 SNKFSIKSDVWSFGILLYEIIT 1284
>lcl|NM_172226.2_cdsid_NP_757380.1 [gene=CAMKK2]
[protein=calcium/calmodulin-dependent protein kinase
kinase 2 isoform 2] [protein_id=NP_757380.1]
[location=176..1801]
Length = 1626
Score = 52.0 bits (123), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 24/75 (32%), Positives = 46/75 (61%), Gaps = 2/75 (2%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 406
++++HRD+KP NLL+ + G IK+ADFG++ F + ++ V T + +PE L + +
Sbjct: 916 QKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKI 1095
Query: 407 ST--PVDIWSIGTIF 419
+ +D+W++G
Sbjct: 1096FSGKALDVWAMGVTL 1140
>lcl|NM_005248.2_cdsid_NP_005239.1 [gene=FGR]
[protein=tyrosine-protein kinase Fgr]
[protein_id=NP_005239.1] [location=229..1818]
Length = 1590
Score = 51.2 bits (121), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 11/115 (9%)
Frame = +1
Query: 322 RIQQILNYIKGNLNGRLYQNRENWRRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--- 378
R+ Q+++ G Y R N+ +HRDL+ N+L+ ++ K+ADFGLAR
Sbjct: 1063 RLPQLVDMAAQVAEGMAYMERMNY----IHRDLRAANILVGERLACKIADFGLARLIKDD 1230
Query: 379 --------GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATK 425
PI+ + +PE L R++ D+WS G + EL TK
Sbjct: 1231 EYNPCQGSKFPIK----------WTAPEAAL-FGRFTIKSDVWSFGILLTELITK 1362
>lcl|NM_005876.4_cdsid_NP_005867.3 [gene=SPEG] [protein=striated
muscle preferentially expressed protein kinase isoform 1]
[protein_id=NP_005867.3] [location=1..9804]
Length = 9804
Score = 51.2 bits (121), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 44/168 (26%), Positives = 69/168 (41%), Gaps = 2/168 (1%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-PIRVYTHEVVTLWYRSPEVLLGSARYS 407
VLH D+KP NLL+ +K+ DFG A+ + +R H TL + +PE++ G
Sbjct: 9241 VLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEP-IG 9417
Query: 408 TPVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 466
+ DIW G + + L+ + P + D + T V ++ Q Y NT
Sbjct: 9418 SATDIWGAGVLTYIMLSGRSPFYEPDPQ-----------ETEARIVGGRFDAFQLYPNT- 9561
Query: 467 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 514
++ L K+L P R S + L HP+ D
Sbjct: 9562 ---------------SQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQD 9660
>lcl|NM_182691.2_cdsid_NP_872633.1 [gene=SRPK2] [protein=SRSF protein
kinase 2 isoform b precursor] [protein_id=NP_872633.1]
[location=235..2301]
Length = 2067
Score = 51.2 bits (121), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 58/181 (32%), Positives = 79/181 (43%), Gaps = 21/181 (11%)
Frame = +1
Query: 354 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 413
L P+N DK +K+AD G A + +T ++ T YRS EVL+G A YSTP DIW
Sbjct: 1546 LDPRNA---DKIRVKIADLGNACWVH---KHFTEDIQTRQYRSIEVLIG-AGYSTPADIW 1704
Query: 414 SIGTIFAELATKKPLFHGDS------EIDQLFRIFRALGTPNNEVWPEVESLQDYKNT-- 465
S + ELAT LF S + D + I LG+ + +++ N
Sbjct: 1705 STACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRG 1884
Query: 466 ----FPKWKPGSLASHVKNLDENG---------LDLLSKMLIYDPAKRISGKMALNHPYF 512
K KP SL + +++ G D L ML P KR S L HP+
Sbjct: 1885 ELRHITKLKPWSLFDVL--VEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 2058
Query: 513 N 513
N
Sbjct: 2059 N 2061
>lcl|NM_053025.3_cdsid_NP_444253.3 [gene=MYLK] [protein=myosin light
chain kinase, smooth muscle isoform 1]
[protein_id=NP_444253.3] [location=283..6027]
Length = 5745
Score = 51.2 bits (121), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 46/195 (23%), Positives = 84/195 (43%), Gaps = 6/195 (3%)
Frame = +1
Query: 324 QQILNYIKGNLNGRLYQNRENWRRRVLHRDLKPQNLL-IDDKGT-IKLADFGLARAFGIP 381
++ + Y++ G Y +++ ++H DLKP+N++ ++ GT IKL DFGLAR
Sbjct: 4678 RECIKYMRQISEGVEYIHKQG----IVHLDLKPENIMCVNKTGTRIKLIDFGLAR----- 4830
Query: 382 IRVYTHEVVTLWYRSPEVLLGSARYSTPV----DIWSIGTIFAELATKKPLFHGDSEIDQ 437
R+ + + + +PE + P+ D+WSIG I L + F GD++ +
Sbjct: 4831 -RLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNET 5007
Query: 438 LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDP 497
L + A ++E + E+ ++ D +S +L D
Sbjct: 5008 LANVTSATWDFDDEAFDEI-------------------------SDDAKDFISNLLKKDM 5112
Query: 498 AKRISGKMALNHPYF 512
R+ L HP+
Sbjct: 5113 KNRLDCTQCLQHPWL 5157
>lcl|NM_004073.2_cdsid_NP_004064.2 [gene=PLK3]
[protein=serine/threonine-protein kinase PLK3]
[protein_id=NP_004064.2] [location=101..2041]
Length = 1941
Score = 51.2 bits (121), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 35/119 (29%), Positives = 58/119 (48%)
Frame = +1
Query: 325 QILNYIKGNLNGRLYQNRENWRRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV 384
++ Y++ L+G Y ++ R +LHRDLK N I + +K+ DFGLA P +
Sbjct: 481 EVRYYLRQILSGLKYLHQ----RGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQR 648
Query: 385 YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 443
T Y +PEVLL + D+WS+G + L P F +++ + +R +
Sbjct: 649 KKTICGTPNYVAPEVLLRQG-HGPEADVWSLGCVMYTLLCGSPPFE-TADLKETYRCIK 819
>lcl|NM_212535.2_cdsid_NP_997700.1 [gene=PRKCB] [protein=protein
kinase C beta type isoform 1] [protein_id=NP_997700.1]
[location=198..2213]
Length = 2016
Score = 51.2 bits (121), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 30/95 (31%), Positives = 53/95 (55%), Gaps = 3/95 (3%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPEVLLGSAR 405
+++RDLK N+++D +G IK+ADFG+ + G+ + + T Y +PE+ +
Sbjct: 1384 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEI-IAYQP 1551
Query: 406 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR 440
Y VD W+ G + E+ + F G+ E D+LF+
Sbjct: 1552 YGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ 1653
>lcl|NM_002253.2_cdsid_NP_002244.1 [gene=KDR] [protein=vascular
endothelial growth factor receptor 2 precursor]
[protein_id=NP_002244.1] [location=303..4373]
Length = 4071
Score = 50.8 bits (120), Expect = 5e-07, Method: Compositional matrix adjust.
Identities = 38/143 (26%), Positives = 67/143 (46%), Gaps = 8/143 (5%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEV-VTLWYRSPEVLLGSA 404
R+ +HRDL +N+L+ +K +K+ DFGLAR + P V + + L + +PE +
Sbjct: 3064 RKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV 3243
Query: 405 RYSTPVDIWSIGTIFAEL----ATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 460
Y+ D+WS G + E+ A+ P D E + + + P+ +++
Sbjct: 3244 -YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTML 3420
Query: 461 DYKNTFPKWKP--GSLASHVKNL 481
D + P +P L H+ NL
Sbjct: 3421 DCWHGEPSQRPTFSELVEHLGNL 3489
>lcl|NM_032037.3_cdsid_NP_114426.1 [gene=TSSK6]
[protein=testis-specific serine/threonine-protein kinase
6] [protein_id=NP_114426.1] [location=234..1055]
Length = 822
Score = 50.4 bits (119), Expect = 6e-07, Method: Compositional matrix adjust.
Identities = 50/163 (30%), Positives = 73/163 (44%), Gaps = 3/163 (1%)
Frame = +1
Query: 349 VLHRDLKPQNLLID-DKGTIKLADFGLAR-AFGIPIRVYTHEVVTLWYRSPEVLLGSARY 406
++HRDLK +N+L+ D+ +KL DFG R A G P + T + Y SPEVLLG
Sbjct: 391 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYP-DLSTTYCGSAAYASPEVLLGIPYD 567
Query: 407 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 466
D+WS+G + + T F DS+I L R
Sbjct: 568 PKKYDVWSMGVVLYVMVTGCMPFD-DSDIAGLPR-------------------------- 666
Query: 467 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-GKMALN 508
+ K G L L E L++++L + P+ R S G++A N
Sbjct: 667 -RQKRGVLYPEGLELSERCKALIAELLQFSPSARPSAGQVARN 792
>lcl|NM_002447.2_cdsid_NP_002438.2 [gene=MST1R]
[protein=macrophage-stimulating protein receptor isoform
1 preproprotein] [protein_id=NP_002438.2]
[location=265..4467]
Length = 4203
Score = 50.4 bits (119), Expect = 7e-07, Method: Compositional matrix adjust.
Identities = 27/83 (32%), Positives = 49/83 (59%), Gaps = 4/83 (4%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLG 402
++ +HRDL +N ++D+ T+K+ADFGLAR ++ + H + + + + E L
Sbjct: 3604 QKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALES-LQ 3780
Query: 403 SARYSTPVDIWSIGTIFAELATK 425
+ R++T D+WS G + EL T+
Sbjct: 3781 TYRFTTKSDVWSFGVLLWELLTR 3849
>lcl|NM_005255.2_cdsid_NP_005246.2 [gene=GAK]
[protein=cyclin-G-associated kinase]
[protein_id=NP_005246.2] [location=200..4135]
Length = 3936
Score = 50.1 bits (118), Expect = 8e-07, Method: Compositional matrix adjust.
Identities = 40/145 (27%), Positives = 65/145 (44%), Gaps = 26/145 (17%)
Frame = +1
Query: 337 RLYQNRENWRRRVLHRDLKPQNLLIDDKGTIKLADFGLAR--------AFGIPIRVYTHE 388
R Q+ + ++HRDLK +NLL+ ++GTIKL DFG A ++ R E
Sbjct: 469 RAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 648
Query: 389 VVTL----WYRSPEV--LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI------- 435
+T YR+PE+ L + DIW++G I L ++ F +++
Sbjct: 649 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKY 828
Query: 436 -----DQLFRIFRALGTPNNEVWPE 455
D + +F +L +V PE
Sbjct: 829 SIPPHDTQYTVFHSLIRAMLQVNPE 903
>lcl|NM_017433.4_cdsid_NP_059129.3 [gene=MYO3A]
[protein=myosin-IIIa] [protein_id=NP_059129.3]
[location=361..5211]
Length = 4851
Score = 50.1 bits (118), Expect = 8e-07, Method: Compositional matrix adjust.
Identities = 44/175 (25%), Positives = 68/175 (38%), Gaps = 4/175 (2%)
Frame = +1
Query: 348 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR-- 405
+ +HRD+K N+L+ +G +KL DFG++ V T ++ +PEV+ +
Sbjct: 433 KTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLD 612
Query: 406 --YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 463
Y D WS+G EL P + LF+I R
Sbjct: 613 TTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPR-------------------- 732
Query: 464 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 518
N PK + L S N D +SK L D KR + L H + ++ +
Sbjct: 733 NPPPKLRQPELWSAEFN------DFISKCLTKDYEKRPTVSELLQHKFITQIEGK 879
>lcl|NM_000141.4_cdsid_NP_000132.3 [gene=FGFR2] [protein=fibroblast
growth factor receptor 2 isoform 1 precursor]
[protein_id=NP_000132.3] [location=648..3113]
Length = 2466
Score = 50.1 bits (118), Expect = 9e-07, Method: Compositional matrix adjust.
Identities = 43/166 (25%), Positives = 78/166 (46%), Gaps = 14/166 (8%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---THEVVTLWYRSPEVLLGS 403
++ +HRDL +N+L+ + +K+ADFGLAR I Y T+ + + + +PE L
Sbjct: 1858 QKCIHRDLAARNVLVTENNVMKIADFGLARDIN-NIDYYKKTTNGRLPVKWMAPEALFDR 2034
Query: 404 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA---LGTPNNEVWPEVESLQ 460
Y+ D+WS G + E+ T + +++LF++ + + P N ++
Sbjct: 2035 V-YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMR 2211
Query: 461 DYKNTFPKWKPGSLASHVKNLD--------ENGLDLLSKMLIYDPA 498
D + P +P + V++LD E LDL + Y P+
Sbjct: 2212 DCWHAVPSQRP-TFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 2346
>lcl|NM_005163.2_cdsid_NP_005154.2 [gene=AKT1] [protein=RAC-alpha
serine/threonine-protein kinase]
[protein_id=NP_005154.2] [location=555..1997]
Length = 1443
Score = 50.1 bits (118), Expect = 9e-07, Method: Compositional matrix adjust.
Identities = 49/175 (28%), Positives = 81/175 (46%), Gaps = 9/175 (5%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPEVLLGS 403
+ V++RDLK +NL++D G IK+ DFGL + G ++ + T Y +PEVL +
Sbjct: 802 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEVLEDN 972
Query: 404 ARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 462
Y VD W +G + E+ + P ++ D E +LF + +E ++
Sbjct: 973 D-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE--KLFELIL------------MEEIR-- 1101
Query: 463 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYF 512
FP+ +L K+ LLS +L DP +R+ G K + H +F
Sbjct: 1102---FPR----TLGPEAKS-------LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 1224
>lcl|NM_004203.4_cdsid_NP_004194.3 [gene=PKMYT1]
[protein=membrane-associated tyrosine- and
threonine-specific cdc2-inhibitory kinase isoform 1]
[protein_id=NP_004194.3] [location=510..2009]
Length = 1500
Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 35/114 (30%), Positives = 53/114 (46%)
Frame = +1
Query: 325 QILNYIKGNLNGRLYQNRENWRRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV 384
Q+ Y++ L + + + ++H D+KP N+ + +G KL DFGL G
Sbjct: 625 QVWGYLRDTLLALAHLHSQG----LVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAG 792
Query: 385 YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQL 438
E Y +PE+L GS Y T D++S+G E+A L HG QL
Sbjct: 793 EVQEGDPR-YMAPELLQGS--YGTAADVFSLGLTILEVACNMELPHGGEGWQQL 945
>lcl|NM_001013703.2_cdsid_NP_001013725.2 [gene=EIF2AK4]
[protein=eukaryotic translation initiation factor 2-alpha
kinase 4] [protein_id=NP_001013725.2] [location=51..5000]
Length = 4950
Score = 49.3 bits (116), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 51/179 (28%), Positives = 76/179 (42%), Gaps = 20/179 (11%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLAR---AFGI---------------PIRVYTHEVV 390
++HRDLKP N+ +D +K+ DFGLA AF P T V
Sbjct: 2530 MIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVG 2709
Query: 391 TLWYRSPEVLLGSAR--YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP 448
T Y SPEV GS + Y+ VD++S+G IF E++ +H + + L P
Sbjct: 2710 TALYVSPEV-QGSTKSAYNQKVDLFSLGIIFFEMS-----YHPMVTASERIFVLNQLRDP 2871
Query: 449 NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 507
+ +PE D+ + H K ++S +L +DPAKR + L
Sbjct: 2872 TSPKFPE-----DFDD----------GEHAKQ-----KSVISWLLNHDPAKRPTATELL 2988
>lcl|NM_001143677.1_cdsid_NP_001137149.1 [gene=SGK1]
[protein=serine/threonine-protein kinase Sgk1 isoform 3]
[protein_id=NP_001137149.1] [location=51..1430]
Length = 1380
Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 29/83 (34%), Positives = 43/83 (51%)
Frame = +1
Query: 349 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 408
+++RDLKP+N+L+D +G I L DFGL + + T Y +PEV L Y
Sbjct: 736 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEV-LHKQPYDR 912
Query: 409 PVDIWSIGTIFAELATKKPLFHG 431
VD W +G + E+ P F+
Sbjct: 913 TVDWWCLGAVLYEMLYGLPPFYS 981
>lcl|NM_145331.2_cdsid_NP_663304.1 [gene=MAP3K7]
[protein=mitogen-activated protein kinase kinase kinase
7 isoform B] [protein_id=NP_663304.1]
[location=419..2239]
Length = 1821
Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 37/100 (37%), Positives = 53/100 (53%), Gaps = 1/100 (1%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTI-KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 405
+ ++HRDLKP NLL+ GT+ K+ DFG A I + ++ W +PEV GS
Sbjct: 448 KALIHRDLKPPNLLLVAGGTVLKICDFGT--ACDIQTHMTNNKGSAAWM-APEVFEGS-N 615
Query: 406 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRAL 445
YS D++S G I E+ T++ F D FRI A+
Sbjct: 616 YSEKCDVFSWGIILWEVITRRKPF--DEIGGPAFRIMWAV 729
>lcl|NM_002019.4_cdsid_NP_002010.2 [gene=FLT1] [protein=vascular
endothelial growth factor receptor 1 isoform 1 precursor]
[protein_id=NP_002010.2] [location=286..4302]
Length = 4017
Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 27/78 (34%), Positives = 44/78 (56%), Gaps = 2/78 (2%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEV-VTLWYRSPEVLLGSA 404
R+ +HRDL +N+L+ + +K+ DFGLAR + P V + + L + +PE +
Sbjct: 3046 RKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKI 3225
Query: 405 RYSTPVDIWSIGTIFAEL 422
YST D+WS G + E+
Sbjct: 3226 -YSTKSDVWSYGVLLWEI 3276
>lcl|NM_198465.2_cdsid_NP_940867.2 [gene=NRK] [protein=nik-related
protein kinase] [protein_id=NP_940867.2]
[location=304..5052]
Length = 4749
Score = 48.5 bits (114), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 30/100 (30%), Positives = 47/100 (47%), Gaps = 4/100 (4%)
Frame = +1
Query: 348 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL----LGS 403
RV+HRD+K QN+L+ +KL DFG++ + T ++ +PEV+
Sbjct: 514 RVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPR 693
Query: 404 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 443
Y D+WS+G E+A P ++ LF I R
Sbjct: 694 RSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILR 813
>lcl|NM_001174066.1_cdsid_NP_001167537.1 [gene=FGFR1]
[protein=fibroblast growth factor receptor 1 isoform 3
precursor] [protein_id=NP_001167537.1]
[location=263..2464]
Length = 2202
Score = 48.5 bits (114), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 37/142 (26%), Positives = 71/142 (50%), Gaps = 6/142 (4%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---THEVVTLWYRSPEVLLGS 403
++ +HRDL +N+L+ + +K+ADFGLAR I Y T+ + + + +PE L
Sbjct: 1582 KKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH-IDYYKKTTNGRLPVKWMAPEALFDR 1758
Query: 404 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA---LGTPNNEVWPEVESLQ 460
Y+ D+WS G + E+ T + +++LF++ + + P+N ++
Sbjct: 1759 I-YTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 1935
Query: 461 DYKNTFPKWKPGSLASHVKNLD 482
D + P +P + V++LD
Sbjct: 1936 DCWHAVPSQRP-TFKQLVEDLD 1998
>lcl|NM_002744.4_cdsid_NP_002735.3 [gene=PRKCZ] [protein=protein
kinase C zeta type isoform 1] [protein_id=NP_002735.3]
[location=162..1940]
Length = 1779
Score = 48.1 bits (113), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 28/84 (33%), Positives = 44/84 (52%)
Frame = +1
Query: 346 RRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 405
R +++RDLK N+L+D G IKL D+G+ + P + T Y +PE+L G
Sbjct: 1105 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE-E 1281
Query: 406 YSTPVDIWSIGTIFAELATKKPLF 429
Y VD W++G + E+ + F
Sbjct: 1282 YGFSVDWWALGVLMFEMMAGRSPF 1353
>lcl|NM_022963.2_cdsid_NP_075252.2 [gene=FGFR4] [protein=fibroblast
growth factor receptor 4 isoform 2 precursor]
[protein_id=NP_075252.2] [location=54..2342]
Length = 2289
Score = 47.4 bits (111), Expect = 6e-06, Method: Compositional matrix adjust.
Identities = 30/100 (30%), Positives = 53/100 (53%), Gaps = 3/100 (3%)
Frame = +1
Query: 347 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---THEVVTLWYRSPEVLLGS 403
R+ +HRDL +N+L+ + +K+ADFGLAR I Y ++ + + + +PE L
Sbjct: 1696 RKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH-IDYYKKTSNGRLPVKWMAPEALFDR 1872
Query: 404 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 443
Y+ D+WS G + E+ T + +++LF + R
Sbjct: 1873 V-YTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLR 1989
>lcl|NM_005372.1_cdsid_NP_005363.1 [gene=MOS]
[protein=proto-oncogene serine/threonine-protein kinase
mos] [protein_id=NP_005363.1] [location=1..1041]
Length = 1041
Score = 47.4 bits (111), Expect = 6e-06, Method: Compositional matrix adjust.
Identities = 37/136 (27%), Positives = 62/136 (45%), Gaps = 17/136 (12%)
Frame = +1
Query: 316 DRNEPH-------RIQQILNYIKGNLNGRLYQNRENWRRRVLHRDLKPQNLLIDDKGTIK 368
D EPH + + L Y +NG L+ + ++ ++H DLKP N+LI ++ K
Sbjct: 481 DAGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQS----IVHLDLKPANILISEQDVCK 648
Query: 369 LADFGLAR------AFGIPIR----VYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTI 418
++DFG + F P YTH R+PE+L G + DI+S
Sbjct: 649 ISDFGCSEKLEDLLCFQTPSYPLGGTYTH-------RAPELLKGEG-VTPKADIYSFAIT 804
Query: 419 FAELATKKPLFHGDSE 434
++ TK+ + G+ +
Sbjct: 805 LWQMTTKQAPYSGERQ 852
>lcl|NM_004721.4_cdsid_NP_004712.1 [gene=MAP3K13]
[protein=mitogen-activated protein kinase kinase kinase
13 isoform 1] [protein_id=NP_004712.1]
[location=407..3307]
Length = 2901
Score = 47.4 bits (111), Expect = 6e-06, Method: Compositional matrix adjust.
Identities = 25/77 (32%), Positives = 39/77 (50%)
Frame = +1
Query: 348 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 407
+++HRDLK N+L+ +K++DFG ++ + W +PEV+ S
Sbjct: 820 KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWM-APEVIRNEP-VS 993
Query: 408 TPVDIWSIGTIFAELAT 424
VDIWS G + EL T
Sbjct: 994 EKVDIWSFGVVLWELLT 1044
BLAST Search Results
TBLASTN 2.2.20 [Feb-08-2009]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment:
Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schäffer, and Yi-Kuo Yu (2005) "Protein database
searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= g9.t1
(545 letters)
Database: taget.fasta
3914 sequences; 7,230,561 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
lcl|NM_004586.2_cdsid_NP_004577.1 [gene=RPS6KA3] [protein=riboso... 913 0.0
lcl|NM_003942.2_cdsid_NP_003933.1 [gene=RPS6KA4] [protein=riboso... 407 e-114
lcl|NM_001143677.1_cdsid_NP_001137149.1 [gene=SGK1] [protein=ser... 278 1e-75
lcl|NM_181690.2_cdsid_NP_859029.1 [gene=AKT3] [protein=RAC-gamma... 275 1e-74
lcl|NM_005163.2_cdsid_NP_005154.2 [gene=AKT1] [protein=RAC-alpha... 273 4e-74
lcl|NM_006255.3_cdsid_NP_006246.2 [gene=PRKCH] [protein=protein ... 250 4e-67
lcl|NM_212535.2_cdsid_NP_997700.1 [gene=PRKCB] [protein=protein ... 249 7e-67
lcl|NM_002737.2_cdsid_NP_002728.1 [gene=PRKCA] [protein=protein ... 248 1e-66
lcl|NM_002744.4_cdsid_NP_002735.3 [gene=PRKCZ] [protein=protein ... 238 2e-63
lcl|NM_007271.2_cdsid_NP_009202.1 [gene=STK38] [protein=serine/t... 222 1e-58
lcl|NM_004409.3_cdsid_NP_004400.4 [gene=DMPK] [protein=myotonin-... 198 2e-51
lcl|NM_001261816.1_cdsid_NP_001248745.1 [gene=PDPK1] [protein=3-... 184 4e-47
lcl|NM_032430.1_cdsid_NP_115806.1 [gene=BRSK1] [protein=serine/t... 154 3e-38
lcl|NM_003957.3_cdsid_NP_003948.2 [gene=BRSK2] [protein=serine/t... 147 3e-36
lcl|NM_172084.2_cdsid_NP_742081.1 [gene=CAMK2B] [protein=calcium... 142 1e-34
lcl|NM_004073.2_cdsid_NP_004064.2 [gene=PLK3] [protein=serine/th... 142 2e-34
lcl|NM_014586.1_cdsid_NP_055401.1 [gene=HUNK] [protein=hormonall... 137 5e-33
lcl|NM_033126.1_cdsid_NP_149117.1 [gene=PSKH2] [protein=serine/t... 135 2e-32
lcl|NM_053025.3_cdsid_NP_444253.3 [gene=MYLK] [protein=myosin li... 127 3e-30
lcl|NM_004734.4_cdsid_NP_004725.1 [gene=DCLK1] [protein=serine/t... 127 3e-30
lcl|NM_025164.3_cdsid_NP_079440.2 [gene=SIK3] [protein=serine/th... 125 1e-29
lcl|NM_004938.2_cdsid_NP_004929.2 [gene=DAPK1] [protein=death-as... 123 7e-29
lcl|NM_016457.4_cdsid_NP_057541.2 [gene=PRKD2] [protein=serine/t... 120 6e-28
lcl|NM_133494.2_cdsid_NP_598001.1 [gene=NEK7] [protein=serine/th... 112 1e-25
lcl|NM_006875.3_cdsid_NP_006866.2 [gene=PIM2] [protein=serine/th... 107 7e-24
lcl|NM_005876.4_cdsid_NP_005867.3 [gene=SPEG] [protein=striated ... 106 1e-23
lcl|NM_001128629.2_cdsid_NP_001122101.1 [gene=PAK6] [protein=ser... 105 2e-23
lcl|NM_004721.4_cdsid_NP_004712.1 [gene=MAP3K13] [protein=mitoge... 104 3e-23
lcl|NM_002578.3_cdsid_NP_002569.1 [gene=PAK3] [protein=serine/th... 103 5e-23
lcl|NM_002401.3_cdsid_NP_002392.2 [gene=MAP3K3] [protein=mitogen... 100 5e-22
lcl|NM_005546.3_cdsid_NP_005537.3 [gene=ITK] [protein=tyrosine-p... 99 2e-21
lcl|NM_004759.4_cdsid_NP_004750.1 [gene=MAPKAPK2] [protein=MAP k... 98 4e-21
lcl|NM_004203.4_cdsid_NP_004194.3 [gene=PKMYT1] [protein=membran... 97 7e-21
lcl|NM_172226.2_cdsid_NP_757380.1 [gene=CAMKK2] [protein=calcium... 96 1e-20
lcl|NM_001042600.1_cdsid_NP_001036065.1 [gene=MAP4K1] [protein=m... 96 1e-20
lcl|NM_133378.4_cdsid_NP_596869.4 [gene=TTN] [protein=titin isof... 95 2e-20
lcl|NM_198465.2_cdsid_NP_940867.2 [gene=NRK] [protein=nik-relate... 95 3e-20
lcl|NM_020975.4_cdsid_NP_066124.1 [gene=RET] [protein=proto-onco... 94 4e-20
lcl|NM_005109.2_cdsid_NP_005100.1 [gene=OXSR1] [protein=serine/t... 94 5e-20
lcl|NM_017433.4_cdsid_NP_059129.3 [gene=MYO3A] [protein=myosin-I... 93 1e-19
lcl|NM_020526.3_cdsid_NP_065387.1 [gene=EPHA8] [protein=ephrin t... 91 5e-19
lcl|NM_002031.2_cdsid_NP_002022.1 [gene=FRK] [protein=tyrosine-p... 90 8e-19
lcl|NM_001256196.1_cdsid_NP_001243125.1 [gene=ARAF] [protein=ser... 90 1e-18
lcl|NM_002446.3_cdsid_NP_002437.2 [gene=MAP3K10] [protein=mitoge... 89 1e-18
lcl|NM_032037.3_cdsid_NP_114426.1 [gene=TSSK6] [protein=testis-s... 89 2e-18
lcl|NM_002529.3_cdsid_NP_002520.2 [gene=NTRK1] [protein=high aff... 89 2e-18
lcl|NM_012395.2_cdsid_NP_036527.1 [gene=CDK14] [protein=cyclin-d... 88 4e-18
lcl|NM_145331.2_cdsid_NP_663304.1 [gene=MAP3K7] [protein=mitogen... 88 4e-18
lcl|NM_004444.4_cdsid_NP_004435.3 [gene=EPHB4] [protein=ephrin t... 87 6e-18
lcl|NM_000141.4_cdsid_NP_000132.3 [gene=FGFR2] [protein=fibrobla... 87 9e-18
lcl|NM_002596.3_cdsid_NP_002587.2 [gene=CDK18] [protein=cyclin-d... 86 1e-17
lcl|NM_004431.3_cdsid_NP_004422.2 [gene=EPHA2] [protein=ephrin t... 86 1e-17
lcl|NM_004438.3_cdsid_NP_004429.1 [gene=EPHA4] [protein=ephrin t... 84 5e-17
lcl|NM_001174168.1_cdsid_NP_001167639.1 [gene=SYK] [protein=tyro... 83 1e-16
lcl|NM_001174066.1_cdsid_NP_001167537.1 [gene=FGFR1] [protein=fi... 83 1e-16
lcl|NM_004439.5_cdsid_NP_004430.4 [gene=EPHA5] [protein=ephrin t... 82 1e-16
lcl|NM_000142.4_cdsid_NP_000133.1 [gene=FGFR3] [protein=fibrobla... 82 2e-16
lcl|NM_002314.3_cdsid_NP_002305.1 [gene=LIMK1] [protein=LIM doma... 80 8e-16
lcl|NM_000455.4_cdsid_NP_000446.1 [gene=STK11] [protein=serine/t... 80 1e-15
lcl|NM_004972.3_cdsid_NP_004963.1 [gene=JAK2] [protein=tyrosine-... 79 1e-15
lcl|NM_021643.3_cdsid_NP_067675.1 [gene=TRIB2] [protein=tribbles... 79 2e-15
lcl|NM_022963.2_cdsid_NP_075252.2 [gene=FGFR4] [protein=fibrobla... 79 2e-15
lcl|NM_001042599.1_cdsid_NP_001036064.1 [gene=ERBB4] [protein=re... 77 6e-15
lcl|NM_005204.3_cdsid_NP_005195.2 [gene=MAP3K8] [protein=mitogen... 76 1e-14
lcl|NM_000215.3_cdsid_NP_000206.2 [gene=JAK3] [protein=tyrosine-... 75 2e-14
lcl|NM_004560.3_cdsid_NP_004551.2 [gene=ROR2] [protein=tyrosine-... 75 3e-14
lcl|NM_002447.2_cdsid_NP_002438.2 [gene=MST1R] [protein=macropha... 74 4e-14
lcl|NM_006871.3_cdsid_NP_006862.2 [gene=RIPK3] [protein=receptor... 74 4e-14
lcl|NM_000208.2_cdsid_NP_000199.2 [gene=INSR] [protein=insulin r... 74 4e-14
lcl|NM_001012338.2_cdsid_NP_001012338.1 [gene=NTRK3] [protein=NT... 74 7e-14
lcl|NM_005417.3_cdsid_NP_005408.1 [gene=SRC] [protein=proto-onco... 73 1e-13
lcl|NM_002344.5_cdsid_NP_002335.2 [gene=LTK] [protein=leukocyte ... 73 1e-13
lcl|NM_000875.3_cdsid_NP_000866.1 [gene=IGF1R] [protein=insulin-... 72 3e-13
lcl|NM_006648.3_cdsid_NP_006639.3 [gene=WNK2] [protein=serine/th... 71 4e-13
lcl|NM_002747.3_cdsid_NP_002738.2 [gene=MAPK4] [protein=mitogen-... 71 4e-13
lcl|NM_005248.2_cdsid_NP_005239.1 [gene=FGR] [protein=tyrosine-p... 71 5e-13
lcl|NM_020639.2_cdsid_NP_065690.2 [gene=RIPK4] [protein=receptor... 70 8e-13
lcl|NM_002019.4_cdsid_NP_002010.2 [gene=FLT1] [protein=vascular ... 70 9e-13
lcl|NM_004304.4_cdsid_NP_004295.2 [gene=ALK] [protein=ALK tyrosi... 70 1e-12
lcl|NM_012119.4_cdsid_NP_036251.2 [gene=CDK20] [protein=cyclin-d... 67 5e-12
lcl|NM_015076.3_cdsid_NP_055891.1 [gene=CDK19] [protein=cyclin-d... 67 6e-12
lcl|NM_139355.2_cdsid_NP_647612.1 [gene=MATK] [protein=megakaryo... 67 7e-12
lcl|NM_002020.4_cdsid_NP_002011.2 [gene=FLT4] [protein=vascular ... 67 9e-12
lcl|NM_004071.3_cdsid_NP_004062.2 [gene=CLK1] [protein=dual spec... 65 2e-11
lcl|NM_024652.3_cdsid_NP_078928.3 [gene=LRRK1] [protein=leucine-... 65 2e-11
lcl|NM_001024847.2_cdsid_NP_001020018.1 [gene=TGFBR2] [protein=T... 65 3e-11
lcl|NM_032387.4_cdsid_NP_115763.2 [gene=WNK4] [protein=serine/th... 65 4e-11
lcl|NM_005781.4_cdsid_NP_005772.3 [gene=TNK2] [protein=activated... 63 1e-10
lcl|NM_014215.2_cdsid_NP_055030.1 [gene=INSRR] [protein=insulin ... 63 1e-10
lcl|NM_002253.2_cdsid_NP_002244.1 [gene=KDR] [protein=vascular e... 62 2e-10
lcl|NM_005372.1_cdsid_NP_005363.1 [gene=MOS] [protein=proto-onco... 62 3e-10
lcl|NM_001013703.2_cdsid_NP_001013725.2 [gene=EIF2AK4] [protein=... 59 2e-09
lcl|NM_001025243.1_cdsid_NP_001020414.1 [gene=IRAK1] [protein=in... 57 6e-09
lcl|NM_001160367.1_cdsid_NP_001153839.1 [gene=CDK10] [protein=cy... 57 8e-09
lcl|NM_005211.3_cdsid_NP_005202.2 [gene=CSF1R] [protein=macropha... 57 8e-09
lcl|NM_000222.2_cdsid_NP_000213.1 [gene=KIT] [protein=mast/stem ... 56 1e-08
lcl|NM_018571.5_cdsid_NP_061041.2 [gene=STRADB] [protein=STE20-r... 55 2e-08
lcl|NM_004119.2_cdsid_NP_004110.2 [gene=FLT3] [protein=receptor-... 54 6e-08
lcl|NM_014238.1_cdsid_NP_055053.1 [gene=KSR1] [protein=kinase su... 53 1e-07
lcl|NM_014916.3_cdsid_NP_055731.2 [gene=LMTK2] [protein=serine/t... 52 2e-07
lcl|NM_173598.4_cdsid_NP_775869.3 [gene=KSR2] [protein=kinase su... 52 3e-07
lcl|NM_005255.2_cdsid_NP_005246.2 [gene=GAK] [protein=cyclin-G-a... 50 9e-07
lcl|NM_032538.1_cdsid_NP_115927.1 [gene=TTBK1] [protein=tau-tubu... 49 2e-06
>lcl|NM_004586.2_cdsid_NP_004577.1 [gene=RPS6KA3] [protein=ribosomal
protein S6 kinase alpha-3] [protein_id=NP_004577.1]
[location=1..2223]
Length = 2223
Score = 913 bits (2360), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 437/541 (80%), Positives = 490/541 (90%), Gaps = 2/541 (0%)
Frame = +1
Query: 1 MVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRK 60
++DEPM E E + +E +KEI ITHHVKEG+EKADP+QFELLKVLGQGSFGKVFLV+K
Sbjct: 82 IMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKK 261
Query: 61 KTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLIL 120
+G DA QLYAMKVLKKA+LKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLIL
Sbjct: 262 ISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLIL 441
Query: 121 DFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHI 180
DFLRGGD+FTRLSKEV+FTEEDVKFYLAELALALDHLH LGI+YRDLKPENILLDE GHI
Sbjct: 442 DFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI 621
Query: 181 KLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLP 240
KLTDFGLSKES+D EKKAYSFCGTVEYMAPEVVNRRGH+QSADWWS+GVLMFEMLTGTLP
Sbjct: 622 KLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLP 801
Query: 241 FQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF 298
FQGKDR ETM MILKAKLGMPQFLS EAQSLLRMLFKRNPANRLG+ +GVEEIKRH FF
Sbjct: 802 FQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF 981
Query: 299 ANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSF 358
+ IDW+KLY+RE+ PPFKPA+G+P+DTF FDPEFTAKTPKDSPG+P SANAHQLF+GFSF
Sbjct: 982 STIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSF 1161
Query: 359 VATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNM 418
VA + +E + + + + Q++ N+ QF + YE+KEDIGVGSYSVCKRCIH TNM
Sbjct: 1162VAITSDDESQAMQTVGVHSI-VQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNM 1338
Query: 419 EFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRIL 478
EFAVKIIDKSKRDP+EEIEIL+RYGQHPNIITLKDV+DDG+YVY+VT+LMKGGELLD+IL
Sbjct: 1339EFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKIL 1518
Query: 479 KQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
+QK FSEREAS +L+ I+KTV+YLH QGVVHRDLKPSNILY+DES + +SIRICDFGFAK
Sbjct: 1519RQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK 1698
Query: 539 Q 539
Q
Sbjct: 1699Q 1701
Score = 110 bits (276), Expect = 5e-25, Method: Compositional matrix adjust.
Identities = 80/280 (28%), Positives = 147/280 (52%), Gaps = 14/280 (5%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEV-N 99
+E+ + +G GS+ + ++ +A+K++ K+ RD E +IL+
Sbjct: 1264 YEVKEDIGVGSYS---VCKRCIHKATNMEFAVKIIDKSK---RDPTE---EIEILLRYGQ 1416
Query: 100 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 159
HP I+ L + +Y++ + ++GG++ ++ ++ F+E + L + +++LH
Sbjct: 1417 HPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHA 1596
Query: 160 LGIVYRDLKPENIL-LDEIGH---IKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR 215
G+V+RDLKP NIL +DE G+ I++ DFG +K+ + + C T ++APEV+ R
Sbjct: 1597 QGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR 1776
Query: 216 RGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQF---------LSA 266
+G+ + D WS GVL++ MLTG PF ++T IL A++G +F +S
Sbjct: 1777 QGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEIL-ARIGSGKFSLSGGYWNSVSD 1950
Query: 267 EAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKL 306
A+ L+ + +P RL + V RH + + WD+L
Sbjct: 1951 TAKDLVSKMLHVDPHQRLTAALV---LRHPWI--VHWDQL 2055
>lcl|NM_003942.2_cdsid_NP_003933.1 [gene=RPS6KA4] [protein=ribosomal
protein S6 kinase alpha-4 isoform a]
[protein_id=NP_003933.1] [location=84..2402]
Length = 2319
Score = 407 bits (1047), Expect = e-114, Method: Compositional matrix adjust.
Identities = 249/562 (44%), Positives = 344/562 (61%), Gaps = 27/562 (4%)
Frame = +1
Query: 7 EEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDA 66
+E + +SC E + E +T H EK FELLKVLG G++GKVFLVRK G DA
Sbjct: 7 DEDDDESCAVELRITEANLTGH----EEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDA 174
Query: 67 GQLYAMKVLKKASLKVRDRVR--TKMERDILVEVNH-PFIVKLHYAFQTEGKLYLILDFL 123
G+LYAMKVL+KA+L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD++
Sbjct: 175 GKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYV 354
Query: 124 RGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLT 183
GG++FT L + F E +V+ Y E+ LAL+HLH+LGI+YRDLK EN+LLD GHI LT
Sbjct: 355 SGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLT 534
Query: 184 DFGLSKESVDQEK-KAYSFCGTVEYMAPEVV-NRRGHSQSADWWSYGVLMFEMLTGTLPF 241
DFGLSKE + +EK + +SFCGT+EYMAPE++ ++ GH ++ DWWS G+L+FE+LTG PF
Sbjct: 535 DFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF 714
Query: 242 QGK-DRN---ETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRH 295
+ +RN E ILK P + AQ LL+ L ++P RLG+ +G +E++ H
Sbjct: 715 TLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNH 894
Query: 296 LFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKG 355
FF +DW L R++ PF+P D F EFT P SP ++F+G
Sbjct: 895 PFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQG 1074
Query: 356 FSFVATSIAEEYKITPITSANVLPIVQIN-GNAA----------QFGEVYEL---KEDIG 401
+SFVA SI ++ +T P G AA F + YEL + +G
Sbjct: 1075YSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALG 1254
Query: 402 VGSYSVCKRCIHATTNMEFAVKIIDKS-KRDPSEEIEILMRYGQHPNIITLKDVFDDGRY 460
GS+SVC+RC + EFAVKI+ + + + E+ L HPN++ L +V D +
Sbjct: 1255QGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLH 1434
Query: 461 VYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ-GVVHRDLKPSNILY 519
YLV +L++GGELL+ I K++ FSE EAS IL + V ++H + GVVHRDLKP NILY
Sbjct: 1435TYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILY 1614
Query: 520 MDESASADSIRICDFGFAKQPP 541
D++ A ++I DFGFA+ P
Sbjct: 1615ADDTPGA-PVKIIDFGFARLRP 1677
Score = 111 bits (278), Expect = 3e-25, Method: Compositional matrix adjust.
Identities = 86/263 (32%), Positives = 140/263 (53%), Gaps = 19/263 (7%)
Frame = +1
Query: 46 VLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDIL---VEVNHPF 102
LGQGSF R++ +GQ +A+K+L + R+ +R++ + +HP
Sbjct: 1246 ALGQGSFSVCRRCRQR---QSGQEFAVKILSR-------RLEANTQREVAALRLCQSHPN 1395
Query: 103 IVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ-LG 161
+V LH + YL+L+ LRGG++ + K+ F+E + L L A+ +H+ G
Sbjct: 1396 VVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAG 1575
Query: 162 IVYRDLKPENILL--DEIGH-IKLTDFGLSK-ESVDQEKKAYSFCGTVEYMAPEVVNRRG 217
+V+RDLKPENIL D G +K+ DFG ++ + C T++Y APE++ ++G
Sbjct: 1576 VVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQG 1755
Query: 218 HSQSADWWSYGVLMFEMLTGTLPFQGKDRN-------ETMNMILKAKLGMP----QFLSA 266
+ +S D WS GV+++ ML+G +PFQG E M I + + + Q +S
Sbjct: 1756 YDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSE 1935
Query: 267 EAQSLLRMLFKRNPANRLGSEGV 289
EA+ L+R L +PA RL EG+
Sbjct: 1936 EAKELVRGLLTVDPAKRLKLEGL 2004
>lcl|NM_001143677.1_cdsid_NP_001137149.1 [gene=SGK1]
[protein=serine/threonine-protein kinase Sgk1 isoform 3]
[protein_id=NP_001137149.1] [location=51..1430]
Length = 1380
Score = 278 bits (712), Expect = 1e-75, Method: Compositional matrix adjust.
Identities = 150/339 (44%), Positives = 211/339 (62%), Gaps = 12/339 (3%)
Frame = +1
Query: 36 ADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDI 94
A P+ F LKV+G+GSFGKV L R K YA+KVL KKA LK ++ ER++
Sbjct: 361 AKPSDFHFLKVIGKGSFGKVLLARHKA---EEVFYAVKVLQKKAILKKKEEKHIMSERNV 531
Query: 95 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALA 153
L++ V HPF+V LH++FQT KLY +LD++ GG++F L +E F E +FY AE+A A
Sbjct: 532 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 711
Query: 154 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVV 213
L +LH L IVYRDLKPENILLD GHI LTDFGL KE+++ +FCGT EY+APEV+
Sbjct: 712 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 891
Query: 214 NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLR 273
+++ + ++ DWW G +++EML G PF ++ E + IL L + ++ A+ LL
Sbjct: 892 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 1071
Query: 274 MLFKRNPANRLGS-EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEF 332
L +++ RLG+ + EIK H+FF+ I+WD L +++ PPF P P+D FDPEF
Sbjct: 1072GLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEF 1251
Query: 333 T--------AKTPKDSPGLPASAN-AHQLFKGFSFVATS 362
T K+P DS + AS A + F GFS+ +
Sbjct: 1252TEEPVPNSIGKSP-DSVLVTASVKEAAEAFLGFSYAPPT 1365
Score = 72.8 bits (177), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 46/147 (31%), Positives = 72/147 (48%), Gaps = 7/147 (4%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHPNIITLK 452
IG GS+ H + +AVK++ K ++ E +L++ +HP ++ L
Sbjct: 394 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 573
Query: 453 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 512
F +Y V D + GGEL + +++CF E A I+ + YLH +V+RDL
Sbjct: 574 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 753
Query: 513 KPSNILYMDESASADSIRICDFGFAKQ 539
KP NIL +D S I + DFG K+
Sbjct: 754 KPENIL-LD---SQGHIVLTDFGLCKE 822
>lcl|NM_181690.2_cdsid_NP_859029.1 [gene=AKT3] [protein=RAC-gamma
serine/threonine-protein kinase isoform 2]
[protein_id=NP_859029.1] [location=113..1510]
Length = 1398
Score = 275 bits (703), Expect = 1e-74, Method: Compositional matrix adjust.
Identities = 138/319 (43%), Positives = 204/319 (63%), Gaps = 3/319 (0%)
Frame = +1
Query: 26 THHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDR 85
THH ++ F+ LK+LG+G+FGKV LVR+K +G+ YAMK+LKK + +D
Sbjct: 412 THHKRKTMN-----DFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVIIAKDE 567
Query: 86 V-RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVK 144
V T E +L HPF+ L Y+FQT+ +L +++++ GG++F LS+E +F+E+ +
Sbjct: 568 VAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTR 747
Query: 145 FYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGT 204
FY AE+ ALD+LH IVYRDLK EN++LD+ GHIK+TDFGL KE + +FCGT
Sbjct: 748 FYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT 927
Query: 205 VEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFL 264
EY+APEV+ + ++ DWW GV+M+EM+ G LPF +D + +IL + P+ L
Sbjct: 928 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTL 1107
Query: 265 SAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKP 322
S++A+SLL L ++P RLG + +EI RH FF+ ++W +Y +++ PPFKP
Sbjct: 1108SSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSE 1287
Query: 323 DDTFCFDPEFTAKTPKDSP 341
DT FD EFTA+T +P
Sbjct: 1288TDTRYFDEEFTAQTITITP 1344
Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 38/146 (26%), Positives = 69/146 (47%), Gaps = 6/146 (4%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI------EILMRYGQHPNIITLKD 453
+G G++ + +A+KI+ K +E+ +++ +HP + +LK
Sbjct: 460 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKY 639
Query: 454 VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK 513
F + V + + GGEL + +++ FSE I +DYLH +V+RDLK
Sbjct: 640 SFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLK 819
Query: 514 PSNILYMDESASADSIRICDFGFAKQ 539
N++ +D+ I+I DFG K+
Sbjct: 820 LENLM-LDKDG---HIKITDFGLCKE 885
>lcl|NM_005163.2_cdsid_NP_005154.2 [gene=AKT1] [protein=RAC-alpha
serine/threonine-protein kinase]
[protein_id=NP_005154.2] [location=555..1997]
Length = 1443
Score = 273 bits (699), Expect = 4e-74, Method: Compositional matrix adjust.
Identities = 144/335 (42%), Positives = 209/335 (62%), Gaps = 10/335 (2%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEV 98
+FE LK+LG+G+FGKV LV++K G+ YAMK+LKK + +D V T E +L
Sbjct: 445 EFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 615
Query: 99 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 158
HPF+ L Y+FQT +L ++++ GG++F LS+E +F+E+ +FY AE+ ALD+LH
Sbjct: 616 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 795
Query: 159 -QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRG 217
+ +VYRDLK EN++LD+ GHIK+TDFGL KE + +FCGT EY+APEV+
Sbjct: 796 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 975
Query: 218 HSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFK 277
+ ++ DWW GV+M+EM+ G LPF +D + +IL ++ P+ L EA+SLL L K
Sbjct: 976 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 1155
Query: 278 RNPANRL--GSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAK 335
++P RL GSE +EI +H FFA I W +Y++++ PPFKP DT FD EFTA+
Sbjct: 1156KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQ 1335
Query: 336 ----TPKDSPGLPASANAHQL--FKGFSFVATSIA 364
TP D ++ + F FS+ A+ A
Sbjct: 1336MITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 1440
Score = 53.5 bits (127), Expect = 9e-08, Method: Compositional matrix adjust.
Identities = 41/147 (27%), Positives = 69/147 (46%), Gaps = 7/147 (4%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI------EILMRYGQHPNIITLKD 453
+G G++ T +A+KI+ K +E+ +++ +HP + LK
Sbjct: 466 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 645
Query: 454 VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ-GVVHRDL 512
F + V + GGEL + +++ FSE A I +DYLH + VV+RDL
Sbjct: 646 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 825
Query: 513 KPSNILYMDESASADSIRICDFGFAKQ 539
K N++ +D+ I+I DFG K+
Sbjct: 826 KLENLM-LDKDG---HIKITDFGLCKE 894
>lcl|NM_006255.3_cdsid_NP_006246.2 [gene=PRKCH] [protein=protein
kinase C eta type] [protein_id=NP_006246.2]
[location=306..2357]
Length = 2052
Score = 250 bits (638), Expect = 4e-67, Method: Compositional matrix adjust.
Identities = 134/330 (40%), Positives = 192/330 (58%), Gaps = 9/330 (2%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM-ERDIL-VE 97
FE ++VLG+GSFGKV L R K + G LYA+KVLKK + D V M E+ IL +
Sbjct: 1060 NFEFIRVLGKGSFGKVMLARVK---ETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLA 1230
Query: 98 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHL 157
NHPF+ +L FQT +L+ +++F+ GGD+ + K F E +FY AE+ AL L
Sbjct: 1231 RNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 1410
Query: 158 HQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRG 217
H GI+YRDLK +N+LLD GH KL DFG+ KE + +FCGT +Y+APE++
Sbjct: 1411 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 1590
Query: 218 HSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFK 277
+ + DWW+ GVL++EML G PF+ ++ ++ IL ++ P +L +A +L+
Sbjct: 1591 YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT 1770
Query: 278 RNPANRLGS---EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTA 334
+NP RLGS G I RH FF IDW +L R+++PPF+P +D FDP+F
Sbjct: 1771 KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIK 1950
Query: 335 K----TPKDSPGLPASANAHQLFKGFSFVA 360
+ TP D LP F+ FS+V+
Sbjct: 1951 EEPVLTPIDEGHLPMINQDE--FRNFSYVS 2034
Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 40/153 (26%), Positives = 67/153 (43%), Gaps = 7/153 (4%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIE-------ILMRYGQHP 446
+E +G GS+ T +AVK++ K +++E IL HP
Sbjct: 1063 FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHP 1242
Query: 447 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 506
+ L F ++ V + + GG+L+ I K + F E A I + +LH +G
Sbjct: 1243 FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKG 1422
Query: 507 VVHRDLKPSNILYMDESASADSIRICDFGFAKQ 539
+++RDLK N+L E ++ DFG K+
Sbjct: 1423 IIYRDLKLDNVLLDHEG----HCKLADFGMCKE 1509
>lcl|NM_212535.2_cdsid_NP_997700.1 [gene=PRKCB] [protein=protein
kinase C beta type isoform 1] [protein_id=NP_997700.1]
[location=198..2213]
Length = 2016
Score = 249 bits (636), Expect = 7e-67, Method: Compositional matrix adjust.
Identities = 133/327 (40%), Positives = 197/327 (60%), Gaps = 8/327 (2%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM--ERDILVEV 98
F L VLG+GSFGKV L +K G D +LYA+K+LKK + D V M +R + +
Sbjct: 1024 FNFLMVLGKGSFGKVMLSERK-GTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 1194
Query: 99 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 158
PF+ +LH FQT +LY +++++ GGD+ + + F E FY AE+A+ L L
Sbjct: 1195 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 1374
Query: 159 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 218
GI+YRDLK +N++LD GHIK+ DFG+ KE++ +FCGT +Y+APE++ + +
Sbjct: 1375 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 1554
Query: 219 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKR 278
+S DWW++GVL++EML G PF+G+D +E I++ + P+ +S EA ++ + L +
Sbjct: 1555 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 1734
Query: 279 NPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAK- 335
+P RLG EG +IK H FF IDW+KL ++E+QPP+KP + DT FD EFT +
Sbjct: 1735 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQP 1914
Query: 336 ---TPKDSPGLPASANAHQLFKGFSFV 359
TP D L F GFS+
Sbjct: 1915 VELTPTDK--LFIMNLDQNEFAGFSYT 1989
Score = 51.2 bits (121), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 49/207 (23%), Positives = 88/207 (42%), Gaps = 8/207 (3%)
Frame = +1
Query: 341 PGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEV-YELKED 399
P P + A++ + F I++ K+ + N + NGN + +
Sbjct: 865 PVPPEGSEANEELRQ-KFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMV 1041
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIE-------ILMRYGQHPNIITLK 452
+G GS+ T+ +AVKI+ K +++E +L G+ P + L
Sbjct: 1042 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 1221
Query: 453 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 512
F +Y V + + GG+L+ I + F E A I+ + +L +G+++RDL
Sbjct: 1222 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 1401
Query: 513 KPSNILYMDESASADSIRICDFGFAKQ 539
K N++ E I+I DFG K+
Sbjct: 1402 KLDNVMLDSEG----HIKIADFGMCKE 1470
>lcl|NM_002737.2_cdsid_NP_002728.1 [gene=PRKCA] [protein=protein
kinase C alpha type] [protein_id=NP_002728.1]
[location=45..2063]
Length = 2019
Score = 248 bits (634), Expect = 1e-66, Method: Compositional matrix adjust.
Identities = 137/326 (42%), Positives = 198/326 (60%), Gaps = 7/326 (2%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM-ERDILVEVN 99
F L VLG+GSFGKV L +K +LYA+K+LKK + D V M E+ +L ++
Sbjct: 1015 FNFLMVLGKGSFGKVMLADRKG---TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 1185
Query: 100 HP-FIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 158
P F+ +LH FQT +LY +++++ GGD+ + + F E FY AE+++ L LH
Sbjct: 1186 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLH 1365
Query: 159 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 218
+ GI+YRDLK +N++LD GHIK+ DFG+ KE + +FCGT +Y+APE++ + +
Sbjct: 1366 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY 1545
Query: 219 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKR 278
+S DWW+YGVL++EML G PF G+D +E I++ + P+ LS EA S+ + L +
Sbjct: 1546 GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTK 1725
Query: 279 NPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKP-ASGKPDDTFCFDPEFTAK 335
+PA RLG EG +++ H FF IDW+KL RE+QPPFKP GK + FD FT
Sbjct: 1726 HPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAEN--FDKFFTRG 1899
Query: 336 TPK-DSPGLPASANAHQL-FKGFSFV 359
P P AN Q F+GFS+V
Sbjct: 1900 QPVLTPPDQLVIANIDQSDFEGFSYV 1977
Score = 50.8 bits (120), Expect = 5e-07, Method: Compositional matrix adjust.
Identities = 39/147 (26%), Positives = 67/147 (45%), Gaps = 7/147 (4%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIE-------ILMRYGQHPNIITLK 452
+G GS+ T +A+KI+ K +++E +L + P + L
Sbjct: 1033 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 1212
Query: 453 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 512
F +Y V + + GG+L+ I + F E +A IS + +LH +G+++RDL
Sbjct: 1213 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDL 1392
Query: 513 KPSNILYMDESASADSIRICDFGFAKQ 539
K N++ E I+I DFG K+
Sbjct: 1393 KLDNVMLDSEG----HIKIADFGMCKE 1461
>lcl|NM_002744.4_cdsid_NP_002735.3 [gene=PRKCZ] [protein=protein
kinase C zeta type isoform 1] [protein_id=NP_002735.3]
[location=162..1940]
Length = 1779
Score = 238 bits (607), Expect = 2e-63, Method: Compositional matrix adjust.
Identities = 128/335 (38%), Positives = 198/335 (59%), Gaps = 16/335 (4%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEVN 99
F+L++V+G+GS+ KV LVR K Q+YAMKV+KK + + + + E+ + + +
Sbjct: 754 FDLIRVIGRGSYAKVLLVRLKKN---DQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 924
Query: 100 -HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 158
+PF+V LH FQT +L+L+++++ GGD+ + ++ EE +FY AE+ +AL+ LH
Sbjct: 925 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 1104
Query: 159 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 218
+ GI+YRDLK +N+LLD GHIKLTD+G+ KE + +FCGT Y+APE++ +
Sbjct: 1105 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 1284
Query: 219 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMN-------MILKAKLGMPQFLSAEAQSL 271
S DWW+ GVLMFEM+ G PF N MN +IL+ + +P+FLS +A +
Sbjct: 1285 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 1464
Query: 272 LRMLFKRNPANRLGSE---GVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCF 328
L+ ++P RLG G +IK H FF +IDWD L K++ PPF+P F
Sbjct: 1465 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 1644
Query: 329 DPEFTAK----TPKDSPGLPASANAHQLFKGFSFV 359
D +FT++ TP D + + F+GF ++
Sbjct: 1645 DTQFTSEPVQLTPDDEDAIKRIDQSE--FEGFEYI 1743
Score = 52.8 bits (125), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 38/154 (24%), Positives = 74/154 (48%), Gaps = 8/154 (5%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIE-------ILMRYGQHP 446
++L IG GSY+ + +A+K++ K E+I+ + + +P
Sbjct: 754 FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP 933
Query: 447 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 506
++ L F ++LV + + GG+L+ + +Q+ E A I +++LH +G
Sbjct: 934 FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG 1113
Query: 507 VVHRDLKPSNILYMDESASADS-IRICDFGFAKQ 539
+++RDLK N+L AD I++ D+G K+
Sbjct: 1114IIYRDLKLDNVLL-----DADGHIKLTDYGMCKE 1200
>lcl|NM_007271.2_cdsid_NP_009202.1 [gene=STK38]
[protein=serine/threonine-protein kinase 38]
[protein_id=NP_009202.1] [location=287..1684]
Length = 1398
Score = 222 bits (565), Expect = 1e-58, Method: Compositional matrix adjust.
Identities = 130/328 (39%), Positives = 192/328 (58%), Gaps = 39/328 (11%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEVN 99
FE LKV+G+G+FG+V LV+KK D G +YAMK+L+KA + +++V + ERDILVE +
Sbjct: 265 FESLKVIGRGAFGEVRLVQKK---DTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 435
Query: 100 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 159
++VK+ Y+FQ + LYLI++FL GGD+ T L K+ TEE+ +FY+AE LA+D +HQ
Sbjct: 436 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 615
Query: 160 LGIVYRDLKPENILLDEIGHIKLTDFGL------------------------------SK 189
LG ++RD+KP+N+LLD GH+KL+DFGL SK
Sbjct: 616 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 795
Query: 190 ESVDQEKK-----AYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGK 244
+ K+ A+S GT +Y+APEV + G+++ DWWS GV+M+EML G PF +
Sbjct: 796 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 975
Query: 245 DRNETMNMILKAKLGM---PQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANI 301
ET ++ K + P+ +E L + F +R+G+ GVEEIK + FF +
Sbjct: 976 TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGV 1155
Query: 302 DWDKLYKREVQPPFKPASGKPDDTFCFD 329
DW+ + +R + S DDT FD
Sbjct: 1156DWEHIRERPAAISIEIKS--IDDTSNFD 1233
Score = 52.0 bits (123), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 34/145 (23%), Positives = 68/145 (46%), Gaps = 7/145 (4%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI-------EILMRYGQHPNIITLK 452
IG G++ + T +A+KI+ K+ E++ +IL+ ++ +
Sbjct: 283 IGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-ADSLWVVKMF 459
Query: 453 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 512
F D +YL+ + + GG+++ ++K+ +E E + +D +H G +HRD+
Sbjct: 460 YSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDI 639
Query: 513 KPSNILYMDESASADSIRICDFGFA 537
KP N+L S +++ DFG
Sbjct: 640 KPDNLLL----DSKGHVKLSDFGLC 702
>lcl|NM_004409.3_cdsid_NP_004400.4 [gene=DMPK]
[protein=myotonin-protein kinase isoform 2]
[protein_id=NP_004400.4] [location=206..2095]
Length = 1890
Score = 198 bits (503), Expect = 2e-51, Method: Compositional matrix adjust.
Identities = 124/324 (38%), Positives = 179/324 (55%), Gaps = 18/324 (5%)
Frame = +1
Query: 24 PITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVR 83
PI +KE + D FE+LKV+G+G+F +V +V+ K GQ+YAMK++ K + R
Sbjct: 166 PIVVRLKEVRLQRD--DFEILKVIGRGAFSEVAVVKMK---QTGQVYAMKIMNKWDMLKR 330
Query: 84 DRVRT-KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTE-- 140
V + ERD+LV + +I +LH+AFQ E LYL++++ GGD+ T LSK F E
Sbjct: 331 GEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSK---FGERI 501
Query: 141 --EDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLS-KESVDQEKK 197
E +FYLAE+ +A+D +H+LG V+RD+KP+NILLD GHI+L DFG K D +
Sbjct: 502 PAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVR 681
Query: 198 AYSFCGTVEYMAPEVVN-------RRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETM 250
+ GT +Y++PE++ + DWW+ GV +EM G PF ET
Sbjct: 682 SLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETY 861
Query: 251 NMIL--KAKLGMP---QFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDK 305
I+ K L +P + + EA+ ++ L P RLG G + + H FF +DWD
Sbjct: 862 GKIVHYKEHLSLPLVDEGVPEEARDFIQRLLC-PPETRLGRGGAGDFRTHPFFFGLDWDG 1038
Query: 306 LYKREVQPPFKPASGKPDDTFCFD 329
L R+ PPF P DT FD
Sbjct: 1039L--RDSVPPFTPDFEGATDTCNFD 1104
Score = 58.9 bits (141), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 52/153 (33%), Positives = 76/153 (49%), Gaps = 11/153 (7%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKS---KRDP----SEEIEILMRYGQHP 446
+E+ + IG G++S T +A+KI++K KR EE ++L+ G
Sbjct: 211 FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN-GDRR 387
Query: 447 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDI----LYVISKTVDYL 502
I L F D Y+YLV + GG+LL + K F ER +++ L I +D +
Sbjct: 388 WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSK---FGERIPAEMARFYLAEIVMAIDSV 558
Query: 503 HCQGVVHRDLKPSNILYMDESASADSIRICDFG 535
H G VHRD+KP NIL +D IR+ DFG
Sbjct: 559 HRLGYVHRDIKPDNIL-LDRCG---HIRLADFG 645
>lcl|NM_001261816.1_cdsid_NP_001248745.1 [gene=PDPK1]
[protein=3-phosphoinositide-dependent protein kinase 1
isoform 3] [protein_id=NP_001248745.1]
[location=150..1514]
Length = 1365
Score = 184 bits (466), Expect = 4e-47, Method: Compositional matrix adjust.
Identities = 105/300 (35%), Positives = 175/300 (58%), Gaps = 12/300 (4%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEVN 99
F+ K+LG+GSF V L R+ + YA+K+L+K + ++V ERD++ ++
Sbjct: 244 FKFGKILGEGSFSTVVLARELA---TSREYAIKILEKRHIIKENKVPYVTRERDVMSRLD 414
Query: 100 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 159
HPF VKL++ FQ + KLY L + + G++ + K F E +FY AE+ AL++LH
Sbjct: 415 HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHG 594
Query: 160 LGIVYRDLKPENILLDEIGHIKLTDFG----LSKESVDQEKKAYSFCGTVEYMAPEVVNR 215
GI++RDLKPENILL+E HI++TDFG LS ES ++ +A SF GT +Y++PE++
Sbjct: 595 KGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPES--KQARANSFVGTAQYVSPELLTE 768
Query: 216 RGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRML 275
+ +S+D W+ G ++++++ G PF+ + I+K + P+ +A+ L+ L
Sbjct: 769 KSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKL 948
Query: 276 FKRNPANRLGSEGVE---EIKRHLFFANIDWDKLYKREVQPP----FKPASGKPDDTFCF 328
+ RLG E +E +K H FF ++ W+ L+++ PP + PA + DD C+
Sbjct: 949 LVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPPKLTAYLPAMSE-DDEDCY 1119
Score = 69.3 bits (168), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 50/154 (32%), Positives = 75/154 (48%), Gaps = 7/154 (4%)
Frame = +1
Query: 392 EVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDK-----SKRDP--SEEIEILMRYGQ 444
E ++ + +G GS+S T+ E+A+KI++K + P + E +++ R
Sbjct: 238 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 414
Query: 445 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHC 504
HP + L F D +Y K GELL I K F E I ++YLH
Sbjct: 415 HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHG 594
Query: 505 QGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
+G++HRDLKP NIL ++ I+I DFG AK
Sbjct: 595 KGIIHRDLKPENILLNEDM----HIQITDFGTAK 684
>lcl|NM_032430.1_cdsid_NP_115806.1 [gene=BRSK1]
[protein=serine/threonine-protein kinase BRSK1]
[protein_id=NP_115806.1] [location=278..2614]
Length = 2337
Score = 154 bits (390), Expect = 3e-38, Method: Compositional matrix adjust.
Identities = 94/284 (33%), Positives = 154/284 (54%), Gaps = 3/284 (1%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI--LVEV 98
+ L K LG+G G LV+ GQ A+K++ + K+ + V K+ER+I L +
Sbjct: 100 YRLEKTLGKGQTG---LVKLGVHCITGQKVAIKIVNRE--KLSESVLMKVEREIAILKLI 264
Query: 99 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 158
HP ++KLH ++ + LYL+L+ + GG++F L K+ T ++ + + ++ ALD H
Sbjct: 265 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCH 444
Query: 159 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 218
I +RDLKPEN+LLDE +I++ DFG++ V S CG+ Y PEV+ +
Sbjct: 445 SYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETS-CGSPHYACPEVIKGEKY 621
Query: 219 -SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFK 277
+ AD WS GV++F +L G LPF + + + + + MP F+ + QSLLR + +
Sbjct: 622 DGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIE 801
Query: 278 RNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGK 321
P RL +E+I++H ++ K E P +PA G+
Sbjct: 802 VEPEKRL---SLEQIQKHPWYLG------GKHEPDPCLEPAPGR 906
Score = 98.2 bits (243), Expect = 3e-21, Method: Compositional matrix adjust.
Identities = 55/156 (35%), Positives = 90/156 (57%), Gaps = 6/156 (3%)
Frame = +1
Query: 388 AQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPS------EEIEILMR 441
AQ+ Y L++ +G G + K +H T + A+KI+++ K S EI IL +
Sbjct: 82 AQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAIL-K 258
Query: 442 YGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDY 501
+HP+++ L DV+++ +Y+YLV + + GGEL D ++K+ + +EA I +D+
Sbjct: 259 LIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDF 438
Query: 502 LHCQGVVHRDLKPSNILYMDESASADSIRICDFGFA 537
H + HRDLKP N+L +DE ++IRI DFG A
Sbjct: 439 CHSYSICHRDLKPENLL-LDEK---NNIRIADFGMA 534
>lcl|NM_003957.3_cdsid_NP_003948.2 [gene=BRSK2]
[protein=serine/threonine-protein kinase BRSK2 isoform
2] [protein_id=NP_003948.2] [location=387..2393]
Length = 2007
Score = 147 bits (372), Expect = 3e-36, Method: Compositional matrix adjust.
Identities = 89/263 (33%), Positives = 147/263 (55%), Gaps = 5/263 (1%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI--LVEV 98
+ L K LG+G G LV+ Q A+K++ + K+ + V K+ER+I L +
Sbjct: 55 YRLEKTLGKGQTG---LVKLGVHCVTCQKVAIKIVNRE--KLSESVLMKVEREIAILKLI 219
Query: 99 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 158
HP ++KLH ++ + LYL+L+ + GG++F L K+ T ++ + + ++ ALD H
Sbjct: 220 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 399
Query: 159 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 218
I +RDLKPEN+LLDE +I++ DFG++ V S CG+ Y PEV+ RG
Sbjct: 400 SHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETS-CGSPHYACPEVI--RGE 570
Query: 219 ---SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRML 275
+ AD WS GV++F +L G LPF + + + + + MP F+ + QSLLR +
Sbjct: 571 KYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGM 750
Query: 276 FKRNPANRLGSEGVEEIKRHLFF 298
+ + A RL +E I++H+++
Sbjct: 751 IEVDAARRL---TLEHIQKHIWY 810
Score = 98.2 bits (243), Expect = 2e-21, Method: Compositional matrix adjust.
Identities = 55/156 (35%), Positives = 90/156 (57%), Gaps = 6/156 (3%)
Frame = +1
Query: 388 AQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPS------EEIEILMR 441
AQ+ Y L++ +G G + K +H T + A+KI+++ K S EI IL +
Sbjct: 37 AQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAIL-K 213
Query: 442 YGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDY 501
+HP+++ L DV+++ +Y+YLV + + GGEL D ++K+ + +EA I +D+
Sbjct: 214 LIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDF 393
Query: 502 LHCQGVVHRDLKPSNILYMDESASADSIRICDFGFA 537
H + HRDLKP N+L +DE ++IRI DFG A
Sbjct: 394 CHSHSICHRDLKPENLL-LDEK---NNIRIADFGMA 489
>lcl|NM_172084.2_cdsid_NP_742081.1 [gene=CAMK2B]
[protein=calcium/calmodulin-dependent protein kinase
type II subunit beta isoform 8] [protein_id=NP_742081.1]
[location=211..1560]
Length = 1350
Score = 142 bits (358), Expect = 1e-34, Method: Compositional matrix adjust.
Identities = 77/254 (30%), Positives = 136/254 (53%), Gaps = 7/254 (2%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVN 99
+++L + +G+G+F +VR+ G YA K++ L RD + + E I +
Sbjct: 37 EYQLYEDIGKGAFS---VVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLK 207
Query: 100 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 159
H IV+LH + EG YL+ D + GG++F + ++E D + ++ A+ H HQ
Sbjct: 208 HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 387
Query: 160 LGIVYRDLKPENILLDEI---GHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRR 216
+G+V+RDLKPEN+LL +KL DFGL+ E ++ + F GT Y++PEV+ +
Sbjct: 388 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKE 567
Query: 217 GHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQ----FLSAEAQSLL 272
+ + D W+ GV+++ +L G PF +D+++ I P ++ EA++L+
Sbjct: 568 AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 747
Query: 273 RMLFKRNPANRLGS 286
+ NPA R+ +
Sbjct: 748 NQMLTINPAKRITA 789
Score = 107 bits (267), Expect = 5e-24, Method: Compositional matrix adjust.
Identities = 58/157 (36%), Positives = 91/157 (57%), Gaps = 5/157 (3%)
Frame = +1
Query: 386 NAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEI-----LM 440
+F + Y+L EDIG G++SV +RC+ T E+A KII+ K + ++ +
Sbjct: 16 TCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARIC 195
Query: 441 RYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVD 500
R +H NI+ L D + + YLV DL+ GGEL + I+ ++ +SE +AS + I + V
Sbjct: 196 RLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 375
Query: 501 YLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFA 537
+ H GVVHRDLKP N+L + A ++++ DFG A
Sbjct: 376 HCHQMGVVHRDLKPENLLLASKCKGA-AVKLADFGLA 483
>lcl|NM_004073.2_cdsid_NP_004064.2 [gene=PLK3]
[protein=serine/threonine-protein kinase PLK3]
[protein_id=NP_004064.2] [location=101..2041]
Length = 1941
Score = 142 bits (357), Expect = 2e-34, Method: Compositional matrix adjust.
Identities = 79/255 (30%), Positives = 136/255 (53%), Gaps = 1/255 (0%)
Frame = +1
Query: 45 KVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL-KVRDRVRTKMERDILVEVNHPFI 103
++LG+G F + + + T + G YA+KV+ ++ + K R + E ++ ++ H I
Sbjct: 196 RLLGKGGFARCY---EATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHI 366
Query: 104 VKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIV 163
V+ + F+ +Y+ L+ + E +V++YL ++ L +LHQ GI+
Sbjct: 367 VRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGIL 546
Query: 164 YRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSAD 223
+RDLK N + E +K+ DFGL+ E++ + CGT Y+APEV+ R+GH AD
Sbjct: 547 HRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEAD 726
Query: 224 WWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANR 283
WS G +M+ +L G+ PF+ D ET I + +P LS A+ LL + + +P +R
Sbjct: 727 VWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDR 906
Query: 284 LGSEGVEEIKRHLFF 298
+++I RH FF
Sbjct: 907 ---PSIDQILRHDFF 942
Score = 56.2 bits (134), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 43/160 (26%), Positives = 69/160 (43%), Gaps = 8/160 (5%)
Frame = +1
Query: 391 GEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSK-RDPSEEIEIL-----MRYGQ 444
G Y +G G ++ C T +AVK+I +S+ P + +IL R Q
Sbjct: 175 GRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQ 354
Query: 445 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHC 504
H +I+ F+D +Y+ +L L + E E L I + YLH
Sbjct: 355 HRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQ 534
Query: 505 QGVVHRDLKPSNILYMDESASADSIRICDFGFAK--QPPD 542
+G++HRDLK N + +++ DFG A +PP+
Sbjct: 535 RGILHRDLKLGNFFITENM----ELKVGDFGLAARLEPPE 642
>lcl|NM_014586.1_cdsid_NP_055401.1 [gene=HUNK] [protein=hormonally
up-regulated neu tumor-associated kinase]
[protein_id=NP_055401.1] [location=361..2505]
Length = 2145
Score = 137 bits (345), Expect = 5e-33, Method: Compositional matrix adjust.
Identities = 87/244 (35%), Positives = 133/244 (54%), Gaps = 7/244 (2%)
Frame = +1
Query: 47 LGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVE--VNHPFIV 104
LG+GSF KV R+ G+ A+KV+ K K V + R+ ++ + HP I
Sbjct: 202 LGEGSFAKV---REGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNIT 372
Query: 105 KLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVY 164
+L +TE YL+++ GG++ ++ ++ E + + Y+ +L A++HLH+ G+V+
Sbjct: 373 QLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVH 552
Query: 165 RDLKPENILLDEIGHIKLTDFGLSKES--VDQEKKAYSFCGTVEYMAPEVVNRRGHSQSA 222
RDLK EN+LLDE +IKL DFGLS + + + CG+ Y APE++ R+ +
Sbjct: 553 RDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKI 732
Query: 223 DWWSYGVLMFEMLTGTLPFQGKD---RNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRN 279
D WS GV M+ MLTGTLPF + R M+ K +P LS A S LR L + +
Sbjct: 733 DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPD 912
Query: 280 PANR 283
P R
Sbjct: 913 PVKR 924
Score = 83.6 bits (205), Expect = 8e-17, Method: Compositional matrix adjust.
Identities = 51/145 (35%), Positives = 80/145 (55%), Gaps = 7/145 (4%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI-EILMRYGQ------HPNIITLK 452
+G GS++ + +H T + A+K+IDK + + + L R GQ HPNI L
Sbjct: 202 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 381
Query: 453 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 512
D+ + YLV +L GG L+ +I ++K E EA + + V++LH GVVHRDL
Sbjct: 382 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 561
Query: 513 KPSNILYMDESASADSIRICDFGFA 537
K N+L +DE ++I++ DFG +
Sbjct: 562 KIENLL-LDED---NNIKLIDFGLS 624
>lcl|NM_033126.1_cdsid_NP_149117.1 [gene=PSKH2]
[protein=serine/threonine-protein kinase H2]
[protein_id=NP_149117.1] [location=1..1158]
Length = 1158
Score = 135 bits (339), Expect = 2e-32, Method: Compositional matrix adjust.
Identities = 82/232 (35%), Positives = 137/232 (59%), Gaps = 9/232 (3%)
Frame = +1
Query: 35 KADP---AQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKME 91
K DP A++++ ++G GSF +V V +KT + +A+KV++ + R+ +++
Sbjct: 160 KFDPRVLARYDIKALIGTGSFSRVVRVEQKT---TKKPFAIKVMETREREGREACVSEL- 327
Query: 92 RDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELA 151
+L V+H +IV+L F+TE ++Y++++ GG++F RL + FTE D L +A
Sbjct: 328 -SVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVA 504
Query: 152 LALDHLHQLGIVYRDLKPENILLDEIGH---IKLTDFGLS---KESVDQEKKAYSFCGTV 205
+ +LH L I +R+LKPEN+L G I +TDFGL+ K+S D K + CGT
Sbjct: 505 DGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMK--TLCGTP 678
Query: 206 EYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAK 257
EY+APEV+ R+ ++ + D W+ GV+ + +L+G LPF + + ILK K
Sbjct: 679 EYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGK 834
Score = 103 bits (257), Expect = 7e-23, Method: Compositional matrix adjust.
Identities = 56/148 (37%), Positives = 84/148 (56%), Gaps = 4/148 (2%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSE----EIEILMRYGQHPNII 449
Y++K IG GS+S R TT FA+K+++ +R+ E E+ +L R H I+
Sbjct: 187 YDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRV-SHRYIV 363
Query: 450 TLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVH 509
L ++F+ VY+V +L GGEL DR++ Q F+ER+A IL +++ + YLH + H
Sbjct: 364 QLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITH 543
Query: 510 RDLKPSNILYMDESASADSIRICDFGFA 537
R+LKP N+LY I I DFG A
Sbjct: 544 RNLKPENLLYY-HPGEESKILITDFGLA 624
>lcl|NM_053025.3_cdsid_NP_444253.3 [gene=MYLK] [protein=myosin light
chain kinase, smooth muscle isoform 1]
[protein_id=NP_444253.3] [location=283..6027]
Length = 5745
Score = 127 bits (320), Expect = 3e-30, Method: Compositional matrix adjust.
Identities = 81/252 (32%), Positives = 144/252 (57%), Gaps = 8/252 (3%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVF-LVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVN 99
+++ + LG G FG+VF LV KKT +++A K K S K ++ +R E I+ ++
Sbjct: 4390 YDIEERLGSGKFGQVFRLVEKKTR----KVWAGKFFKAYSAKEKENIR--QEISIMNCLH 4551
Query: 100 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVL-FTEEDVKFYLAELALALDHLH 158
HP +V+ AF+ + + ++L+ + GG++F R+ E TE + Y+ +++ ++++H
Sbjct: 4552 HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIH 4731
Query: 159 QLGIVYRDLKPENIL-LDEIG-HIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRR 216
+ GIV+ DLKPENI+ +++ G IKL DFGL++ ++ GT E++APEV+N
Sbjct: 4732 KQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARR-LENAGSLKVLFGTPEFVAPEVINYE 4908
Query: 217 GHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMP----QFLSAEAQSLL 272
+ D WS GV+ + +++G PF G + NET+ + A +S +A+ +
Sbjct: 4909 PIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFI 5088
Query: 273 RMLFKRNPANRL 284
L K++ NRL
Sbjct: 5089 SNLLKKDMKNRL 5124
Score = 82.4 bits (202), Expect = 1e-16, Method: Compositional matrix adjust.
Identities = 51/164 (31%), Positives = 90/164 (54%), Gaps = 5/164 (3%)
Frame = +1
Query: 381 VQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIID----KSKRDPSEEI 436
V IN + + Y+++E +G G + R + T +A K K K + +EI
Sbjct: 4354 VTIN-TEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEI 4530
Query: 437 EILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKC-FSEREASDILYVI 495
I M HP ++ D F++ + +V +++ GGEL +RI+ + +ERE + I
Sbjct: 4531 SI-MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQI 4707
Query: 496 SKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQ 539
S+ V+Y+H QG+VH DLKP NI+ ++++ + I++ DFG A++
Sbjct: 4708 SEGVEYIHKQGIVHLDLKPENIMCVNKTGT--RIKLIDFGLARR 4833
>lcl|NM_004734.4_cdsid_NP_004725.1 [gene=DCLK1]
[protein=serine/threonine-protein kinase DCLK1 isoform 1]
[protein_id=NP_004725.1] [location=284..2473]
Length = 2190
Score = 127 bits (320), Expect = 3e-30, Method: Compositional matrix adjust.
Identities = 77/247 (31%), Positives = 134/247 (54%), Gaps = 10/247 (4%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVN 99
++++ + +G G+F +V++ + YA+K++KK+ + ++ + + E IL V
Sbjct: 1165 RYKVGRTIGDGNFA---VVKECVERSTAREYALKIIKKSKCRGKEHM-IQNEVSILRRVK 1332
Query: 100 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 159
HP IV L +LYL+++ ++GGD+F ++ +TE D L LA A+ +LH
Sbjct: 1333 HPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHS 1512
Query: 160 LGIVYRDLKPENILL----DEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR 215
L IV+RD+KPEN+L+ D +KL DFGL + + Y+ CGT Y+APE++
Sbjct: 1513 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGL---ATIVDGPLYTVCGTPTYVAPEIIAE 1683
Query: 216 RGHSQSADWWSYGVLMFEMLTGTLPFQGK--DRNETMNMILKAKLGMPQ----FLSAEAQ 269
G+ D W+ GV+ + +L G PF+G D+ + IL ++ P +S A+
Sbjct: 1684 TGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAK 1863
Query: 270 SLLRMLF 276
L+ M+
Sbjct: 1864 ELITMML 1884
Score = 115 bits (288), Expect = 2e-26, Method: Compositional matrix adjust.
Identities = 63/162 (38%), Positives = 95/162 (58%), Gaps = 5/162 (3%)
Frame = +1
Query: 388 AQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSE-----EIEILMRY 442
A E Y++ IG G+++V K C+ +T E+A+KII KSK E E+ IL R
Sbjct: 1150 ATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRV 1329
Query: 443 GQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYL 502
+HPNI+ L + D +YLV +L+KGG+L D I ++ER+AS +LY ++ + YL
Sbjct: 1330 -KHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYL 1506
Query: 503 HCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQPPDPL 544
H +VHRD+KP N+L + + S+++ DFG A PL
Sbjct: 1507 HSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPL 1632
>lcl|NM_025164.3_cdsid_NP_079440.2 [gene=SIK3]
[protein=serine/threonine-protein kinase SIK3]
[protein_id=NP_079440.2] [location=37..3828]
Length = 3792
Score = 125 bits (315), Expect = 1e-29, Method: Compositional matrix adjust.
Identities = 77/270 (28%), Positives = 137/270 (50%), Gaps = 1/270 (0%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNH 100
+E+ + +G+G+F +V++ T A+K++ K L + + E I+ + H
Sbjct: 22 YEIDRTIGKGNFA---VVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 192
Query: 101 PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQL 160
P I++L+ +TE +YL+ ++ GG++F L E++ + ++ A+ H
Sbjct: 193 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 372
Query: 161 GIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH-S 219
IV+RDLK EN+LLD +IK+ DFG S + ++CG+ Y APE+ + +
Sbjct: 373 NIVHRDLKAENLLLDANLNIKIADFGFSN-LFTPGQLLKTWCGSPPYAAPELFEGKEYDG 549
Query: 220 QSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRN 279
D WS GV+++ ++ G LPF G +L K +P F+S E + L+R + +
Sbjct: 550 PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLD 729
Query: 280 PANRLGSEGVEEIKRHLFFANIDWDKLYKR 309
P RL +E+I +H + D D + R
Sbjct: 730 PNKRL---SMEQICKHKWMKLGDADPNFDR 810
Score = 100 bits (250), Expect = 5e-22, Method: Compositional matrix adjust.
Identities = 57/151 (37%), Positives = 86/151 (56%), Gaps = 6/151 (3%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSE------EIEILMRYGQHPN 447
YE+ IG G+++V KR H T + A+KIIDK++ D E++I M+ HP+
Sbjct: 22 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQI-MKMLCHPH 198
Query: 448 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGV 507
II L V + R +YLVT+ GGE+ D ++ +E+EA I V + HC+ +
Sbjct: 199 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 378
Query: 508 VHRDLKPSNILYMDESASADSIRICDFGFAK 538
VHRDLK N+L +D + +I+I DFGF+
Sbjct: 379 VHRDLKAENLL-LDANL---NIKIADFGFSN 459
>lcl|NM_004938.2_cdsid_NP_004929.2 [gene=DAPK1]
[protein=death-associated protein kinase 1]
[protein_id=NP_004929.2] [location=376..4668]
Length = 4293
Score = 123 bits (308), Expect = 7e-29, Method: Compositional matrix adjust.
Identities = 83/250 (33%), Positives = 132/250 (52%), Gaps = 12/250 (4%)
Frame = +1
Query: 47 LGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDR--VRTKMERD--ILVEVNHPF 102
LG G F V R+K+ G YA K +KK K R R +ER+ IL E+ HP
Sbjct: 55 LGSGQFAVVKKCREKS---TGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPN 225
Query: 103 IVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGI 162
++ LH ++ + + LIL+ + GG++F L+++ TEE+ +L ++ + +LH L I
Sbjct: 226 VITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQI 405
Query: 163 VYRDLKPENILLDEIG----HIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 218
+ DLKPENI+L + IK+ DFGL+ + +D + + GT E++APE+VN
Sbjct: 406 AHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK-IDFGNEFKNIFGTPEFVAPEIVNYEPL 582
Query: 219 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMP----QFLSAEAQSLLRM 274
AD WS GV+ + +L+G PF G + ET+ + SA A+ +R
Sbjct: 583 GLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRR 762
Query: 275 LFKRNPANRL 284
L ++P R+
Sbjct: 763 LLVKDPKKRM 792
Score = 105 bits (263), Expect = 1e-23, Method: Compositional matrix adjust.
Identities = 56/154 (36%), Positives = 88/154 (57%), Gaps = 10/154 (6%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDK----------SKRDPSEEIEILMRYG 443
Y+ E++G G ++V K+C +T +++A K I K S+ D E+ IL
Sbjct: 37 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEI- 213
Query: 444 QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLH 503
QHPN+ITL +V+++ V L+ +L+ GGEL D + +++ +E EA++ L I V YLH
Sbjct: 214 QHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLH 393
Query: 504 CQGVVHRDLKPSNILYMDESASADSIRICDFGFA 537
+ H DLKP NI+ +D + I+I DFG A
Sbjct: 394 SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLA 495
>lcl|NM_016457.4_cdsid_NP_057541.2 [gene=PRKD2]
[protein=serine/threonine-protein kinase D2 isoform A]
[protein_id=NP_057541.2] [location=758..3394]
Length = 2637
Score = 120 bits (301), Expect = 6e-28, Method: Compositional matrix adjust.
Identities = 84/245 (34%), Positives = 128/245 (52%), Gaps = 5/245 (2%)
Frame = +1
Query: 3 DEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVR-KK 61
D P G A H + + ++E + A Q +VLG G FG V+ + +K
Sbjct: 1543 DAPSAPGHAP--HRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRK 1716
Query: 62 TGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILD 121
TG D A+KV+ K + + + E IL + HP IV L F+T K++++++
Sbjct: 1717 TGRDV----AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 1884
Query: 122 FLRGGDVFTRLSKEV-LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILL---DEI 177
L G + LS E E KF + ++ +AL HLH IV+ DLKPEN+LL D
Sbjct: 1885 KLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF 2064
Query: 178 GHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTG 237
+KL DFG ++ + ++ S GT Y+APEV+ +G+++S D WS GV+M+ L+G
Sbjct: 2065 PQVKLCDFGFAR-IIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSG 2241
Query: 238 TLPFQ 242
T PF
Sbjct: 2242 TFPFN 2256
Score = 70.5 bits (171), Expect = 7e-13, Method: Compositional matrix adjust.
Identities = 58/211 (27%), Positives = 97/211 (45%), Gaps = 10/211 (4%)
Frame = +1
Query: 338 KDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELK 397
+D+P P A Q S + I E I T + P
Sbjct: 1540 QDAPSAPGHAPHRQASLSISVSNSQIQENVDIA--TVYQIFP-----------------D 1662
Query: 398 EDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEI-----LMRYGQHPNIITLK 452
E +G G + V H T + AVK+IDK + +E ++ +++ +HP I+ L+
Sbjct: 1663 EVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLE 1842
Query: 453 DVFDDGRYVYLVTDLMKGGELLDRILKQKC--FSEREASDILYVISKTVDYLHCQGVVHR 510
+F+ V++V + + G ++L+ IL + ER ++ I + +LH + +VH
Sbjct: 1843 CMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHC 2019
Query: 511 DLKPSNILYMDESASAD---SIRICDFGFAK 538
DLKP N+L ASAD +++CDFGFA+
Sbjct: 2020 DLKPENVLL----ASADPFPQVKLCDFGFAR 2100
>lcl|NM_133494.2_cdsid_NP_598001.1 [gene=NEK7]
[protein=serine/threonine-protein kinase Nek7]
[protein_id=NP_598001.1] [location=328..1236]
Length = 909
Score = 112 bits (281), Expect = 1e-25, Method: Compositional matrix adjust.
Identities = 66/214 (30%), Positives = 110/214 (51%), Gaps = 5/214 (2%)
Frame = +1
Query: 39 AQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEV 98
A F + K +G+G F +V+ R D + KV + + R E D+L ++
Sbjct: 94 ANFRIEKKIGRGQFSEVY--RAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL 267
Query: 99 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEV-----LFTEEDVKFYLAELALA 153
NHP ++K + +F + +L ++L+ GD+ +R+ K L E V Y +L A
Sbjct: 268 NHPNVIKYYASFIEDNELNIVLELADAGDL-SRMIKHFKKQKRLIPERTVWKYFVQLCSA 444
Query: 154 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVV 213
L+H+H +++RD+KP N+ + G +KL D GL + + A+S GT YM+PE +
Sbjct: 445 LEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 624
Query: 214 NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRN 247
+ G++ +D WS G L++EM PF G N
Sbjct: 625 HENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMN 726
Score = 48.1 bits (113), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 35/157 (22%), Positives = 74/157 (47%), Gaps = 12/157 (7%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIID-------KSKRDPSEEIEILMRYGQHP 446
+ +++ IG G +S R + A+K + K++ D +EI++L + HP
Sbjct: 100 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN-HP 276
Query: 447 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILK-----QKCFSEREASDILYVISKTVDY 501
N+I F + + +V +L G+L R++K ++ ER + +++
Sbjct: 277 NVIKYYASFIEDNELNIVLELADAGDL-SRMIKHFKKQKRLIPERTVWKYFVQLCSALEH 453
Query: 502 LHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
+H + V+HRD+KP+N+ + +++ D G +
Sbjct: 454 MHSRRVMHRDIKPANVFI----TATGVVKLGDLGLGR 552
>lcl|NM_006875.3_cdsid_NP_006866.2 [gene=PIM2]
[protein=serine/threonine-protein kinase pim-2]
[protein_id=NP_006866.2] [location=303..1238]
Length = 936
Score = 107 bits (266), Expect = 7e-24, Method: Compositional matrix adjust.
Identities = 80/265 (30%), Positives = 141/265 (53%), Gaps = 11/265 (4%)
Frame = +1
Query: 30 KEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL----KVRDR 85
+E +E A++ L +LG+G FG VF + T D Q+ A+KV+ + + + D
Sbjct: 73 REAFE----AEYRLGPLLGKGGFGTVFAGHRLT--DRLQV-AIKVIPRNRVLGWSPLSDS 231
Query: 86 VRTKMERDILVEVN----HPFIVKLHYAFQTEGKLYLILDF-LRGGDVFTRLSKEVLFTE 140
V +E +L +V HP +++L F+T+ L+L+ L D+F ++++ E
Sbjct: 232 VTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGE 411
Query: 141 EDVKFYLAELALALDHLHQLGIVYRDLKPENILLD-EIGHIKLTDFGLSKESVDQEKKAY 199
+ + ++ A+ H H G+V+RD+K ENIL+D G KL DFG ++ ++
Sbjct: 412 GPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG--SGALLHDEPYT 585
Query: 200 SFCGTVEYMAPEVVNRRG-HSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKL 258
F GT Y PE ++R H+ A WS G+L+++M+ G +PF+ +D+ IL+A+L
Sbjct: 586 DFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFE-RDQE-----ILEAEL 747
Query: 259 GMPQFLSAEAQSLLRMLFKRNPANR 283
P +S + +L+R P++R
Sbjct: 748 HFPAHVSPDCCALIRRCLAPKPSSR 822
>lcl|NM_005876.4_cdsid_NP_005867.3 [gene=SPEG] [protein=striated
muscle preferentially expressed protein kinase isoform 1]
[protein_id=NP_005867.3] [location=1..9804]
Length = 9804
Score = 106 bits (264), Expect = 1e-23, Method: Compositional matrix adjust.
Identities = 73/247 (29%), Positives = 120/247 (48%), Gaps = 4/247 (1%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNH 100
+ L+ +G FG V R+ G+ + K++ A+ R R E ++L ++H
Sbjct: 8896 YTFLEEKARGRFGVVRACRENA---TGRTFVAKIVPYAAEGKR---RVLQEYEVLRTLHH 9057
Query: 101 PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQL 160
I+ LH A+ T L LI + ++ LS ++E+DV Y+ +L LD+LH
Sbjct: 9058 ERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGH 9237
Query: 161 GIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSF-CGTVEYMAPEVVNRRGHS 219
+++ D+KP+N+LL +K+ DFG ++ Q + GT+E+MAPE+V
Sbjct: 9238 HVLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIG 9417
Query: 220 QSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQS---LLRMLF 276
+ D W GVL + ML+G PF D ET I+ + Q +QS LR +
Sbjct: 9418 SATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVL 9597
Query: 277 KRNPANR 283
+P +R
Sbjct: 9598 SVHPWSR 9618
Score = 91.7 bits (226), Expect = 3e-19, Method: Compositional matrix adjust.
Identities = 57/217 (26%), Positives = 115/217 (52%), Gaps = 5/217 (2%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNH 100
+++ + +G+G+F +R+ +G +A K + + + + + E +L + H
Sbjct: 4801 YDIHQEIGRGAFS---YLRRIVERSSGLEFAAKFIPS---QAKPKASARREARLLARLQH 4962
Query: 101 PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQL 160
++ H AF+ L ++ + L ++ R++++ E +++ Y+ ++ + +LHQ
Sbjct: 4963 DCVLYFHEAFERRRGLVIVTE-LCTEELLERIARKPTVCESEIRAYMRQVLEGIHYLHQS 5139
Query: 161 GIVYRDLKPENILLDEIG----HIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRR 216
+++ D+KPEN+L+ + +++ DFG ++E E + Y GT E++APE+VN+
Sbjct: 5140 HVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQ-YCQYGTPEFVAPEIVNQS 5316
Query: 217 GHSQSADWWSYGVLMFEMLTGTLPFQGK-DRNETMNM 252
S D W GV+ F LTG PF G+ DR MN+
Sbjct: 5317 PVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNI 5427
Score = 88.2 bits (217), Expect = 3e-18, Method: Compositional matrix adjust.
Identities = 51/160 (31%), Positives = 87/160 (54%), Gaps = 5/160 (3%)
Frame = +1
Query: 389 QFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIID---KSKRDPSEEIEILMRYGQH 445
+ + Y++ ++IG G++S +R + ++ +EFA K I K K E +L R QH
Sbjct: 4786 RLSDFYDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASARREARLLARL-QH 4962
Query: 446 PNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ 505
++ + F+ R + +VT+L ELL+RI ++ E E + + + + YLH
Sbjct: 4963 DCVLYFHEAFERRRGLVIVTELCTE-ELLERIARKPTVCESEIRAYMRQVLEGIHYLHQS 5139
Query: 506 GVVHRDLKPSNILYMDESASADSIRICDFGFAKQ--PPDP 543
V+H D+KP N+L D +A +RICDFG A++ P +P
Sbjct: 5140 HVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEP 5259
Score = 67.0 bits (162), Expect = 7e-12, Method: Compositional matrix adjust.
Identities = 46/153 (30%), Positives = 77/153 (50%), Gaps = 3/153 (1%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIID---KSKRDPSEEIEILMRYGQHPNIIT 450
Y E+ G + V + C T F KI+ + KR +E E+L R H I++
Sbjct: 8896 YTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRRVLQEYEVL-RTLHHERIMS 9072
Query: 451 LKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHR 510
L + + RY+ L+ + ELL + + +SE + + + + + +DYLH V+H
Sbjct: 9073 LHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHVLHL 9252
Query: 511 DLKPSNILYMDESASADSIRICDFGFAKQPPDP 543
D+KP N+L ++A ++I DFG A QP +P
Sbjct: 9253 DIKPDNLLLAPDNA----LKIVDFGSA-QPYNP 9336
>lcl|NM_001128629.2_cdsid_NP_001122101.1 [gene=PAK6]
[protein=serine/threonine-protein kinase PAK 6 isoform 1]
[protein_id=NP_001122101.1] [location=358..2403]
Length = 2046
Score = 105 bits (262), Expect = 2e-23, Method: Compositional matrix adjust.
Identities = 72/258 (27%), Positives = 133/258 (51%), Gaps = 6/258 (2%)
Frame = +1
Query: 47 LGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM---ERDILVEVNHPFI 103
+G+GS G V L R+K +G+ A+K++ +R + R ++ E I+ + H +
Sbjct: 1237 IGEGSTGIVCLAREK---HSGRQVAVKMMD-----LRKQQRRELLFNEVVIMRDYQHFNV 1392
Query: 104 VKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIV 163
V+++ ++ +L+++++FL+GG T + +V EE + + AL +LH G++
Sbjct: 1393 VEMYKSYLVGEELWVLMEFLQGG-ALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVI 1569
Query: 164 YRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSAD 223
+RD+K ++ILL G +KL+DFG + K S GT +MAPEV++R ++ D
Sbjct: 1570 HRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVD 1749
Query: 224 WWSYGVLMFEMLTGTLPFQGKDRNETMNMILKA---KLGMPQFLSAEAQSLLRMLFKRNP 280
WS G+++ EM+ G P+ + M + + KL +S + L + R+P
Sbjct: 1750 IWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDP 1929
Query: 281 ANRLGSEGVEEIKRHLFF 298
R + +E+ H F
Sbjct: 1930 QERATA---QELLDHPFL 1974
Score = 67.0 bits (162), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 40/143 (27%), Positives = 75/143 (52%), Gaps = 3/143 (2%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI---EILMRYGQHPNIITLKDVFD 456
IG GS + + + AVK++D K+ E + ++MR QH N++ + +
Sbjct: 1237 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL 1416
Query: 457 DGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSN 516
G ++++ + ++GG L D I+ Q +E + + + + + + YLH QGV+HRD+K +
Sbjct: 1417 VGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDS 1593
Query: 517 ILYMDESASADSIRICDFGFAKQ 539
IL + +++ DFGF Q
Sbjct: 1594 ILLTLDG----RVKLSDFGFCAQ 1650
>lcl|NM_004721.4_cdsid_NP_004712.1 [gene=MAP3K13]
[protein=mitogen-activated protein kinase kinase kinase
13 isoform 1] [protein_id=NP_004712.1]
[location=407..3307]
Length = 2901
Score = 104 bits (260), Expect = 3e-23, Method: Compositional matrix adjust.
Identities = 74/245 (30%), Positives = 125/245 (51%), Gaps = 5/245 (2%)
Frame = +1
Query: 44 LKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI--LVEVNHP 101
L+ LG G+ G VFL G+ A +V K +VR + E DI L ++ HP
Sbjct: 511 LQWLGSGAQGAVFL---------GKFRAEEVAIK-------KVREQNETDIKHLRKLKHP 642
Query: 102 FIVKLHYAFQTEGKLY-LILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQL 160
I+ T+ Y +I+++ G ++ L T + + +A +++LH
Sbjct: 643 NIIAFK-GVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLH 819
Query: 161 GIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQ 220
I++RDLK N+L+ +K++DFG SKE D+ K SF GTV +MAPEV+ S+
Sbjct: 820 KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK-MSFAGTVAWMAPEVIRNEPVSE 996
Query: 221 SADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEA--QSLLRMLFKR 278
D WS+GV+++E+LTG +P++ D + + + L +P + + L++ ++
Sbjct: 997 KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQS 1176
Query: 279 NPANR 283
P NR
Sbjct: 1177KPRNR 1191
Score = 55.1 bits (131), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 30/103 (29%), Positives = 51/103 (49%)
Frame = +1
Query: 440 MRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTV 499
+R +HPNII K V ++ + G+L + + + + R D I+ +
Sbjct: 622 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGM 801
Query: 500 DYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQPPD 542
+YLH ++HRDLK N+L D+++I DFG +K+ D
Sbjct: 802 NYLHLHKIIHRDLKSPNVLV----THTDAVKISDFGTSKELSD 918
>lcl|NM_002578.3_cdsid_NP_002569.1 [gene=PAK3]
[protein=serine/threonine-protein kinase PAK 3 isoform a]
[protein_id=NP_002569.1] [location=622..2256]
Length = 1635
Score = 103 bits (258), Expect = 5e-23, Method: Compositional matrix adjust.
Identities = 71/255 (27%), Positives = 125/255 (49%), Gaps = 3/255 (1%)
Frame = +1
Query: 47 LGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKL 106
+GQG+ G V+ GQ A+K + ++ + ++ ++ E +P IV
Sbjct: 820 IGQGASGTVYTALDIA---TGQEVAIKQMNLQQQPKKELIINEIL--VMRENKNPNIVNY 984
Query: 107 HYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRD 166
++ +L++++++L GG T + E E + E ALD LH +++RD
Sbjct: 985 LDSYLVGDELWVVMEYLAGGS-LTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRD 1161
Query: 167 LKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWS 226
+K +NILL G +KLTDFG + ++ K + GT +MAPEVV R+ + D WS
Sbjct: 1162 IKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWS 1341
Query: 227 YGVLMFEMLTGTLPFQGKDRNETMNMIL---KAKLGMPQFLSAEAQSLLRMLFKRNPANR 283
G++ EM+ G P+ ++ + +I +L P+ LSA + L + + +R
Sbjct: 1342 LGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMD-VDR 1518
Query: 284 LGSEGVEEIKRHLFF 298
GS +E+ +H F
Sbjct: 1519 RGS--AKELLQHPFL 1557
Score = 72.8 bits (177), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 47/150 (31%), Positives = 77/150 (51%), Gaps = 4/150 (2%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI--EIL-MRYGQHPNIIT 450
Y E IG G+ + T E A+K ++ ++ E I EIL MR ++PNI+
Sbjct: 802 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN 981
Query: 451 LKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHR 510
D + G +++V + + GG L D ++ + C E + + + + +D+LH V+HR
Sbjct: 982 YLDSYLVGDELWVVMEYLAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHR 1158
Query: 511 DLKPSNILY-MDESASADSIRICDFGFAKQ 539
D+K NIL MD S+++ DFGF Q
Sbjct: 1159DIKSDNILLGMD-----GSVKLTDFGFCAQ 1233
>lcl|NM_002401.3_cdsid_NP_002392.2 [gene=MAP3K3]
[protein=mitogen-activated protein kinase kinase kinase 3
isoform 2] [protein_id=NP_002392.2] [location=320..2200]
Length = 1881
Score = 100 bits (249), Expect = 5e-22, Method: Compositional matrix adjust.
Identities = 74/252 (29%), Positives = 121/252 (48%), Gaps = 13/252 (5%)
Frame = +1
Query: 38 PAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLK---KASLKVRDRVRTKMERDI 94
P + K+LGQG+FG+V+L D G+ A K ++ + ++ + E +
Sbjct: 1075 PINWRRGKLLGQGAFGRVYLCYDV---DTGRELASKQVQFDPDSPETSKEVSALECEIQL 1245
Query: 95 LVEVNHPFIVKLHYAFQ--TEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELAL 152
L + H IV+ + + E L + ++++ GG V +L TE + Y ++
Sbjct: 1246 LKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILE 1425
Query: 153 ALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSK--ESVDQEKKAY-SFCGTVEYMA 209
+ +LH IV+RD+K NIL D G++KL DFG SK +++ S GT +M+
Sbjct: 1426 GMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMS 1605
Query: 210 PEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILK-----AKLGMPQFL 264
PEV++ G+ + AD WS G + EMLT P+ E M I K +P +
Sbjct: 1606 PEVISGEGYGRKADVWSLGCTVVEMLTEKPPWA---EYEAMAAIFKIATQPTNPQLPSHI 1776
Query: 265 SAEAQSLLRMLF 276
S + LR +F
Sbjct: 1777 SEHGRDFLRRIF 1812
Score = 49.3 bits (116), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 40/150 (26%), Positives = 68/150 (45%), Gaps = 10/150 (6%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKII-------DKSKRDPSEEIEI-LMRYGQHPNIITL 451
+G G++ C T E A K + + SK + E EI L++ QH I+
Sbjct: 1102 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 1281
Query: 452 KDVFDDG--RYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVH 509
D + + + + M GG + D++ +E I + + YLH +VH
Sbjct: 1282 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVH 1461
Query: 510 RDLKPSNILYMDESASADSIRICDFGFAKQ 539
RD+K +NIL SA ++++ DFG +K+
Sbjct: 1462 RDIKGANIL----RDSAGNVKLGDFGASKR 1539
>lcl|NM_005546.3_cdsid_NP_005537.3 [gene=ITK]
[protein=tyrosine-protein kinase ITK/TSK]
[protein_id=NP_005537.3] [location=83..1945]
Length = 1863
Score = 98.6 bits (244), Expect = 2e-21, Method: Compositional matrix adjust.
Identities = 66/273 (24%), Positives = 142/273 (52%), Gaps = 10/273 (3%)
Frame = +1
Query: 21 KEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKV----FLVRKKTGPDAGQLYAMKVLK 76
++ P+T ++ G DP++ ++ +G G FG V +L + K A+K ++
Sbjct: 1027 QKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKV--------AIKTIR 1182
Query: 77 KASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRL-SKE 135
+ ++ D + E +++++++HP +V+L+ + + L+ +F+ G + L ++
Sbjct: 1183 EGAMSEEDFIE---EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQR 1353
Query: 136 VLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQE 195
LF E + ++ + +L + +++RDL N L+ E IK++DFG+++ +D +
Sbjct: 1354 GLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ 1533
Query: 196 KKAYSFCGT---VEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMN 251
S GT V++ +PEV + +S +D WS+GVLM+E+ + G +P++ + +E +
Sbjct: 1534 YT--SSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVE 1707
Query: 252 MILKA-KLGMPQFLSAEAQSLLRMLFKRNPANR 283
I +L P+ S ++ +K P +R
Sbjct: 1708 DISTGFRLYKPRLASTHVYQIMNHCWKERPEDR 1806
>lcl|NM_004759.4_cdsid_NP_004750.1 [gene=MAPKAPK2] [protein=MAP
kinase-activated protein kinase 2 isoform 1]
[protein_id=NP_004750.1] [location=211..1323]
Length = 1113
Score = 97.8 bits (242), Expect = 4e-21, Method: Compositional matrix adjust.
Identities = 74/258 (28%), Positives = 125/258 (48%), Gaps = 18/258 (6%)
Frame = +1
Query: 45 KVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIV 104
+VLG G GKV + K + L ++ KA +V R P IV
Sbjct: 202 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS---------QCPHIV 354
Query: 105 KLHYAFQT--EGK--LYLILDFLRGGDVFTRLSK--EVLFTEEDVKFYLAELALALDHLH 158
++ ++ G+ L ++++ L GG++F+R+ + FTE + + + A+ +LH
Sbjct: 355 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 534
Query: 159 QLGIVYRDLKPENILLDEI---GHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR 215
+ I +RD+KPEN+L +KLTDFG +KE+ + C T Y+APEV+
Sbjct: 535 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGP 711
Query: 216 RGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQF---------LSA 266
+ +S D WS GV+M+ +L G PF + ++ +K ++ M Q+ +S
Sbjct: 712 EKYDKSCDMWSLGVIMYILLCGYPPFYS-NHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 888
Query: 267 EAQSLLRMLFKRNPANRL 284
E + L+R L K P R+
Sbjct: 889 EVKMLIRNLLKTEPTQRM 942
Score = 85.1 bits (209), Expect = 2e-17, Method: Compositional matrix adjust.
Identities = 50/146 (34%), Positives = 85/146 (58%), Gaps = 6/146 (4%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDD-- 457
+G+G + + T +FA+K++ + E+E+ R Q P+I+ + DV+++
Sbjct: 208 LGLGINGKVLQIFNKRTQEKFALKMLQDCPK-ARREVELHWRASQCPHIVRIVDVYENLY 384
Query: 458 -GRYVYL-VTDLMKGGELLDRILKQ--KCFSEREASDILYVISKTVDYLHCQGVVHRDLK 513
GR L V + + GGEL RI + + F+EREAS+I+ I + + YLH + HRD+K
Sbjct: 385 AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVK 564
Query: 514 PSNILYMDESASADSIRICDFGFAKQ 539
P N+LY + +A +++ DFGFAK+
Sbjct: 565 PENLLYTSKRPNA-ILKLTDFGFAKE 639
>lcl|NM_004203.4_cdsid_NP_004194.3 [gene=PKMYT1]
[protein=membrane-associated tyrosine- and
threonine-specific cdc2-inhibitory kinase isoform 1]
[protein_id=NP_004194.3] [location=510..2009]
Length = 1500
Score = 97.1 bits (240), Expect = 7e-21, Method: Compositional matrix adjust.
Identities = 87/270 (32%), Positives = 128/270 (47%), Gaps = 12/270 (4%)
Frame = +1
Query: 32 GYEKADP-----AQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV 86
GY+ + P F+ L LG GS+G+VF VR K + G+LYA+K +DR
Sbjct: 286 GYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSK---EDGRLYAVKRSMSPFRGPKDRA 456
Query: 87 RTKMERDILVEVN-HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKE--VLFTEEDV 143
R E +V HP V+L A++ G LYL + G + + E V
Sbjct: 457 RKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELC--GPSLQQHCEAWGASLPEAQV 630
Query: 144 KFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCG 203
YL + LAL HLH G+V+ D+KP NI L G KL DFGL E + G
Sbjct: 631 WGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVE-LGTAGAGEVQEG 807
Query: 204 TVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGT-LPFQGKDRNETMNMILKAKLGMPQ 262
YMAPE++ + + +AD +S G+ + E+ LP G+ + L P+
Sbjct: 808 DPRYMAPELL-QGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLP-----PE 969
Query: 263 F---LSAEAQSLLRMLFKRNPANRLGSEGV 289
F LS+E +S+L M+ + +P R +E +
Sbjct: 970 FTAGLSSELRSVLVMMLEPDPKLRATAEAL 1059
>lcl|NM_172226.2_cdsid_NP_757380.1 [gene=CAMKK2]
[protein=calcium/calmodulin-dependent protein kinase
kinase 2 isoform 2] [protein_id=NP_757380.1]
[location=176..1801]
Length = 1626
Score = 96.3 bits (238), Expect = 1e-20, Method: Compositional matrix adjust.
Identities = 83/288 (28%), Positives = 138/288 (47%), Gaps = 32/288 (11%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRD--------------- 84
Q+ L +G+GS+G V L + + YAMKVL K L +R
Sbjct: 490 QYTLKDEIGKGSYGVVKLAYNE---NDNTYYAMKVLSKKKL-IRQAGFPRRPPPRGTRPA 657
Query: 85 -----RVRTKMER-----DILVEVNHPFIVKLHYAFQ--TEGKLYLILDFLRGGDVFTRL 132
+ R +E+ IL +++HP +VKL E LY++ + + G V
Sbjct: 658 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVP 837
Query: 133 SKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESV 192
+ + L +E+ +FY +L +++LH I++RD+KP N+L+ E GHIK+ DFG+S E
Sbjct: 838 TLKPL-SEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 1014
Query: 193 DQEKKAYSFCGTVEYMAPEVVN--RRGHSQSA-DWWSYGVLMFEMLTGTLPFQGKDRNET 249
+ + GT +MAPE ++ R+ S A D W+ GV ++ + G PF +
Sbjct: 1015GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 1194
Query: 250 MNMILKAKLGMPQF--LSAEAQSLLRMLFKRNPANRLGSEGVEEIKRH 295
+ I L P ++ + + L+ + +NP +R+ V EIK H
Sbjct: 1195HSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRI---VVPEIKLH 1329
Score = 75.5 bits (184), Expect = 2e-14, Method: Compositional matrix adjust.
Identities = 55/178 (30%), Positives = 88/178 (49%), Gaps = 32/178 (17%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSK------------------------ 429
Y LK++IG GSY V K + N +A+K++ K K
Sbjct: 493 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 672
Query: 430 --RDPSE----EIEILMRYGQHPNIITLKDVFDDGR--YVYLVTDLMKGGELLDRILKQK 481
R P E EI IL + HPN++ L +V DD ++Y+V +L+ G +++ + K
Sbjct: 673 QPRGPIEQVYQEIAILKKL-DHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLK 846
Query: 482 CFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQ 539
SE +A + K ++YLH Q ++HRD+KPSN+L ++ I+I DFG + +
Sbjct: 847 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDG----HIKIADFGVSNE 1008
>lcl|NM_001042600.1_cdsid_NP_001036065.1 [gene=MAP4K1]
[protein=mitogen-activated protein kinase kinase kinase
kinase 1 isoform 1] [protein_id=NP_001036065.1]
[location=109..2574]
Length = 2466
Score = 95.9 bits (237), Expect = 1e-20, Method: Compositional matrix adjust.
Identities = 60/200 (30%), Positives = 107/200 (53%), Gaps = 5/200 (2%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILV--E 97
++LL+ LG G++G+VF R K +G L A+K++K ++ D V T ++++IL+
Sbjct: 46 HYDLLQRLGGGTYGEVFKARDKV---SGDLVALKMVK---MEPDDDVST-LQKEILILKT 204
Query: 98 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHL 157
H IV H ++ KL++ ++F G + +E + + E+ L +L
Sbjct: 205 CRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYL 384
Query: 158 HQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVN--- 214
H ++RD+K NIL+++ G ++L DFG+S + + SF GT +MAPEV
Sbjct: 385 HSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVAL 564
Query: 215 RRGHSQSADWWSYGVLMFEM 234
+ G+++ D WS G+ E+
Sbjct: 565 KGGYNELCDIWSLGITAIEL 624
Score = 52.8 bits (125), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 37/152 (24%), Positives = 71/152 (46%), Gaps = 6/152 (3%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEIL------MRYGQHPN 447
Y+L + +G G+Y + + A+K++ K +P +++ L ++ +H N
Sbjct: 49 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMV---KMEPDDDVSTLQKEILILKTCRHAN 219
Query: 448 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGV 507
I+ + + +++ + G L D SE + S + + + + YLH Q
Sbjct: 220 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 399
Query: 508 VHRDLKPSNILYMDESASADSIRICDFGFAKQ 539
+HRD+K +NIL D A +R+ DFG + Q
Sbjct: 400 IHRDIKGANILIND----AGEVRLADFGISAQ 483
>lcl|NM_133378.4_cdsid_NP_596869.4 [gene=TTN] [protein=titin isoform
N2-A] [protein_id=NP_596869.4] [location=226..100497]
Length = 100272
Score = 95.1 bits (235), Expect = 2e-20, Method: Compositional matrix adjust.
Identities = 76/270 (28%), Positives = 130/270 (48%), Gaps = 8/270 (2%)
Frame = +1
Query: 29 VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT 88
KE YEK + + + LG+G FG +V + + + Y K +K +K D+V
Sbjct: 93730 TKELYEK-----YMIAEDLGRGEFG---IVHRCVETSSKKTYMAKFVK---VKGTDQVLV 93876
Query: 89 KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVL-FTEEDVKFYL 147
K E IL H I+ LH +F++ +L +I +F+ G D+F R++ E ++ Y+
Sbjct: 93877 KKEISILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYV 94056
Query: 148 AELALALDHLHQLGIVYRDLKPENILLD--EIGHIKLTDFGLSKESVDQEKKAYSFCGTV 205
++ AL LH I + D++PENI+ IK+ +FG +++ + F
Sbjct: 94057 HQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAP- 94233
Query: 206 EYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQ--- 262
EY APEV S + D WS G L++ +L+G PF + + + I+ A+ +
Sbjct: 94234 EYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAF 94413
Query: 263 -FLSAEAQSLL-RMLFKRNPANRLGSEGVE 290
+S EA + R+L K + SE ++
Sbjct: 94414 KEISIEAMDFVDRLLVKERKSRMTASEALQ 94503
Score = 70.5 bits (171), Expect = 6e-13, Method: Compositional matrix adjust.
Identities = 40/160 (25%), Positives = 81/160 (50%), Gaps = 4/160 (2%)
Frame = +1
Query: 384 NGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDP---SEEIEILM 440
+ + + E Y + ED+G G + + RC+ ++ + K + D +EI IL
Sbjct: 93721 HSSTKELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISIL- 93897
Query: 441 RYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKC-FSEREASDILYVISKTV 499
+H NI+ L + F+ + ++ + + G ++ +RI +ERE ++ + + +
Sbjct: 93898 NIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEAL 94077
Query: 500 DYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQ 539
+LH + H D++P NI+Y +S +I+I +FG A+Q
Sbjct: 94078 QFLHSHNIGHFDIRPENIIYQTRRSS--TIKIIEFGQARQ 94191
>lcl|NM_198465.2_cdsid_NP_940867.2 [gene=NRK] [protein=nik-related
protein kinase] [protein_id=NP_940867.2]
[location=304..5052]
Length = 4749
Score = 94.7 bits (234), Expect = 3e-20, Method: Compositional matrix adjust.
Identities = 84/304 (27%), Positives = 137/304 (45%), Gaps = 48/304 (15%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFL-VRKKTGPDAGQLYAMKVL--KKASL-KVRDRVRTKM------ 90
F L K +G G++G+++L + +KTG A+KV+ +K L ++ RVR
Sbjct: 73 FSLDKTIGLGTYGRIYLGLHEKTG----AFTAVKVMNARKTPLPEIGRRVRVNKYQKSVG 240
Query: 91 ------ERDILVEVN-------HPFIVKLHYAF------QTEGKLYLILDFLRGGDV--F 129
E D+ E+N H IV + AF +L+++++ G V
Sbjct: 241 WRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDV 420
Query: 130 TRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSK 189
R++ E+ + + E+ L HLH +++RD+K +N+LL +KL DFG+S
Sbjct: 421 VRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSA 600
Query: 190 ESVDQEKKAYSFCGTVEYMAPEVVN-----RRGHSQSADWWSYGVLMFEMLTGTLPFQGK 244
+ + SF GT +MAPEV++ RR + +D WS G+ EM G P
Sbjct: 601 QVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNL 780
Query: 245 DRNETMNMILKAKLGMPQFLSA----------EAQSLLRMLFKRNPANRLGSEGVEEIK- 293
E + +IL+ P S+ E ++ LF+ AN L V +IK
Sbjct: 781 QPLEALFVILRE--SAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDIKN 954
Query: 294 -RHL 296
RH+
Sbjct: 955 ERHV 966
Score = 51.6 bits (122), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 40/182 (21%), Positives = 73/182 (40%), Gaps = 35/182 (19%)
Frame = +1
Query: 393 VYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSK----------------------- 429
++ L + IG+G+Y +H T AVK+++ K
Sbjct: 70 IFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSVGWRY 249
Query: 430 ----RDPSEEIEILMRYGQHPNIITLKDVF------DDGRYVYLVTDLMKGGELLD--RI 477
D E+ +L +Y H NI++ F +++V +L G + D R+
Sbjct: 250 SDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVRM 429
Query: 478 LKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFA 537
+ E + I I + + +LH V+HRD+K N+L + +++ DFG +
Sbjct: 430 TSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNA----EVKLVDFGVS 597
Query: 538 KQ 539
Q
Sbjct: 598 AQ 603
>lcl|NM_020975.4_cdsid_NP_066124.1 [gene=RET] [protein=proto-oncogene
tyrosine-protein kinase receptor Ret isoform a precursor]
[protein_id=NP_066124.1] [location=191..3535]
Length = 3345
Score = 94.4 bits (233), Expect = 4e-20, Method: Compositional matrix adjust.
Identities = 76/276 (27%), Positives = 140/276 (50%), Gaps = 35/276 (12%)
Frame = +1
Query: 43 LLKVLGQGSFGKV-----FLVRKKTGPDAGQLYAMKVLKK--ASLKVRDRVRTKMERDIL 95
L K LG+G FGKV F ++ + G A+K+LK+ + ++RD + E ++L
Sbjct: 2176 LGKTLGEGEFGKVVKATAFHLKGRAG---YTTVAVKMLKENASPSELRDLLS---EFNVL 2337
Query: 96 VEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDV--FTRLSKEV----------------- 136
+VNHP ++KL+ A +G L LI+++ + G + F R S++V
Sbjct: 2338 KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLD 2517
Query: 137 -----LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKES 191
T D+ + +++ + +L ++ +V+RDL NIL+ E +K++DFGLS++
Sbjct: 2518 HPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV 2697
Query: 192 VDQEKKAYSFCG--TVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNE 248
+++ G V++MA E + ++ +D WS+GVL++E++T G P+ G
Sbjct: 2698 YEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPER 2877
Query: 249 TMNMILKA-KLGMPQFLSAEAQSLLRMLFKRNPANR 283
N++ ++ P S E L+ +K+ P R
Sbjct: 2878 LFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 2985
>lcl|NM_005109.2_cdsid_NP_005100.1 [gene=OXSR1]
[protein=serine/threonine-protein kinase OSR1]
[protein_id=NP_005100.1] [location=343..1926]
Length = 1584
Score = 94.0 bits (232), Expect = 5e-20, Method: Compositional matrix adjust.
Identities = 53/165 (32%), Positives = 88/165 (53%), Gaps = 14/165 (8%)
Frame = +1
Query: 91 ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLS--------KEVLFTEED 142
E + + +HP IV + +F + +L+L++ L GG V + K + E
Sbjct: 187 EIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEST 366
Query: 143 VKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSK-----ESVDQEKK 197
+ L E+ L++LH+ G ++RD+K NILL E G +++ DFG+S + + K
Sbjct: 367 IATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 546
Query: 198 AYSFCGTVEYMAPEVVNR-RGHSQSADWWSYGVLMFEMLTGTLPF 241
+F GT +MAPEV+ + RG+ AD WS+G+ E+ TG P+
Sbjct: 547 RKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPY 681
Score = 68.2 bits (165), Expect = 3e-12, Method: Compositional matrix adjust.
Identities = 50/157 (31%), Positives = 77/157 (49%), Gaps = 13/157 (8%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPS-----EEIEILMRYGQHPNI 448
YEL+E IG G+ +V + A + A+K I+ K S +EI+ M HPNI
Sbjct: 49 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQA-MSQCHHPNI 225
Query: 449 ITLKDVFDDGRYVYLVTDLMKGGELLDRIL--------KQKCFSEREASDILYVISKTVD 500
++ F ++LV L+ GG +LD I K E + IL + + ++
Sbjct: 226 VSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLE 405
Query: 501 YLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFA 537
YLH G +HRD+K NIL ++ S++I DFG +
Sbjct: 406 YLHKNGQIHRDVKAGNILLGEDG----SVQIADFGVS 504
>lcl|NM_017433.4_cdsid_NP_059129.3 [gene=MYO3A]
[protein=myosin-IIIa] [protein_id=NP_059129.3]
[location=361..5211]
Length = 4851
Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust.
Identities = 82/293 (27%), Positives = 134/293 (45%), Gaps = 27/293 (9%)
Frame = +1
Query: 37 DPA-QFELLKVLGQGSFGKVF-LVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI 94
DP+ +E+ + +G+G++GKVF ++ KK G +KA++K+ D + ++ +I
Sbjct: 46 DPSDTWEITETIGKGTYGKVFKVLNKKNG------------QKAAVKILDPIH-DIDEEI 186
Query: 95 LVEVN-------HPFIVKLHYAF----QTEG-KLYLILDFLRGGDVFTRLSKEVL----- 137
E N HP +V+ + + + G KL+L+L+ GG V T L K L
Sbjct: 187 EAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSV-TDLVKGFLKRGER 363
Query: 138 FTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKK 197
+E + + L E + L HLH ++RD+K NILL G +KL DFG+S + +
Sbjct: 364 MSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHR 543
Query: 198 AYSFCGTVEYMAPEVVN-----RRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNM 252
+ GT +MAPEV+ + D WS G+ E+ G P +
Sbjct: 544 RNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFK 723
Query: 253 ILK---AKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANID 302
I + KL P+ SAE + ++ R V E+ +H F I+
Sbjct: 724 IPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKR---PTVSELLQHKFITQIE 873
Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 48/161 (29%), Positives = 80/161 (49%), Gaps = 13/161 (8%)
Frame = +1
Query: 392 EVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIE----ILMRYGQHPN 447
+ +E+ E IG G+Y + ++ + AVKI+D D EEIE IL HPN
Sbjct: 55 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPI-HDIDEEIEAEYNILKALSDHPN 231
Query: 448 IITLKDVF-----DDGRYVYLVTDLMKGGELLDRI---LKQ-KCFSEREASDILYVISKT 498
++ ++ +G ++LV +L GG + D + LK+ + SE + IL+
Sbjct: 232 VVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMG 411
Query: 499 VDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQ 539
+ +LH +HRD+K +NIL E +++ DFG + Q
Sbjct: 412 LQHLHNNKTIHRDVKGNNILLTTEGG----VKLVDFGVSAQ 522
>lcl|NM_020526.3_cdsid_NP_065387.1 [gene=EPHA8] [protein=ephrin type-A
receptor 8 isoform 1 precursor] [protein_id=NP_065387.1]
[location=126..3143]
Length = 3018
Score = 90.9 bits (224), Expect = 5e-19, Method: Compositional matrix adjust.
Identities = 70/240 (29%), Positives = 118/240 (49%), Gaps = 12/240 (5%)
Frame = +1
Query: 37 DPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILV 96
+ ++ + K++G G G+V R + A+K LK A R R E I+
Sbjct: 1891 EASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALK-AGYTERQRRDFLSEASIMG 2067
Query: 97 EVNHPFIVKLHYAFQTEGKLYLIL-DFLRGG--DVFTRLSKEVLFTEEDVKFYLAELALA 153
+ +HP I++L T G+L +I+ +++ G D F R + + FT + L +
Sbjct: 2068 QFDHPNIIRLE-GVVTRGRLAMIVTEYMENGSLDTFLR-THDGQFTIMQLVGMLRGVGAG 2241
Query: 154 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCG---TVEYMAP 210
+ +L LG V+RDL N+L+D K++DFGLS+ D AY+ G + + AP
Sbjct: 2242 MRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAP 2421
Query: 211 EVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMI-----LKAKLGMPQFL 264
E + R S ++D WS+GV+M+E+L G P+ + ++ + L A +G P L
Sbjct: 2422 EAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHAL 2601
Score = 50.8 bits (120), Expect = 5e-07, Method: Compositional matrix adjust.
Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 5/118 (4%)
Frame = +1
Query: 426 DKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQK--CF 483
++ +RD E I+ ++ HPNII L+ V GR +VT+ M+ G LD L+ F
Sbjct: 2023 ERQRRDFLSEASIMGQF-DHPNIIRLEGVVTRGRLAMIVTEYMENGS-LDTFLRTHDGQF 2196
Query: 484 SEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRIC---DFGFAK 538
+ + +L + + YL G VHRDL N+L DS +C DFG ++
Sbjct: 2197 TIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVL-------VDSNLVCKVSDFGLSR 2349
>lcl|NM_002031.2_cdsid_NP_002022.1 [gene=FRK]
[protein=tyrosine-protein kinase FRK]
[protein_id=NP_002022.1] [location=448..1965]
Length = 1518
Score = 90.1 bits (222), Expect = 8e-19, Method: Compositional matrix adjust.
Identities = 69/239 (28%), Positives = 118/239 (49%), Gaps = 13/239 (5%)
Frame = +1
Query: 37 DPAQFELLKVLGQGSFGKVFL-VRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDIL 95
D +LLK LG G FG+V+ + T P A+K LK S+ D +R E I+
Sbjct: 688 DRNSIQLLKRLGSGQFGEVWEGLWNNTTP-----VAVKTLKPGSMDPNDFLR---EAQIM 843
Query: 96 VEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYL-------A 148
+ HP +++L+ E +Y+I + +R G + +E L + K +L A
Sbjct: 844 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSL-----QEYLQNDTGSKIHLTQQVDMAA 1008
Query: 149 ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE-SVDQE---KKAYSFCGT 204
++A + +L ++RDL N+L+ E K+ DFGL++ VD E + +
Sbjct: 1009QVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLP 1188
Query: 205 VEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKAKLGMPQ 262
V++ APE + S +D WS+G+L++E++T G +P+ G + + M L +PQ
Sbjct: 1189VKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQM-LAQNYRLPQ 1362
>lcl|NM_001256196.1_cdsid_NP_001243125.1 [gene=ARAF]
[protein=serine/threonine-protein kinase A-Raf isoform 2]
[protein_id=NP_001243125.1] [location=212..2041]
Length = 1830
Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust.
Identities = 68/221 (30%), Positives = 109/221 (49%), Gaps = 12/221 (5%)
Frame = +1
Query: 33 YEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMER 92
Y + P++ +LLK +G GSFG VF R + D A+KVLK + K E
Sbjct: 913 YWEVPPSEVQLLKRIGTGSFGTVF--RGRWHGDV----AVKVLKVSQPTAEQAQAFKNEM 1074
Query: 93 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAEL-- 150
+L + H I+ L F T +I + G ++ L D +F + +L
Sbjct: 1075 QVLRKTRHVNIL-LFMGFMTRPGFAIITQWCEGSSLYHHLHVA------DTRFDMVQLID 1233
Query: 151 -----ALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLS--KESVDQEKKAYSFCG 203
A +D+LH I++RDLK NI L E +K+ DFGL+ K + G
Sbjct: 1234 VARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSG 1413
Query: 204 TVEYMAPEVVNRRG---HSQSADWWSYGVLMFEMLTGTLPF 241
+V +MA EV+ + +S +D ++YGV+++E++TG+LP+
Sbjct: 1414 SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPY 1536
>lcl|NM_002446.3_cdsid_NP_002437.2 [gene=MAP3K10]
[protein=mitogen-activated protein kinase kinase kinase
10] [protein_id=NP_002437.2] [location=289..3153]
Length = 2865
Score = 89.4 bits (220), Expect = 1e-18, Method: Compositional matrix adjust.
Identities = 68/233 (29%), Positives = 118/233 (50%), Gaps = 11/233 (4%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVN 99
+ +L +++G G FGKV+ + A + + K ++ + E + +
Sbjct: 289 ELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAE---QVCQEARLFGALQ 459
Query: 100 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 159
HP I+ L A L L++++ RGG + L+ + V + + ++A +++LH
Sbjct: 460 HPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAV-QVARGMNYLHN 636
Query: 160 ---LGIVYRDLKPENILLDEI--GH------IKLTDFGLSKESVDQEKKAYSFCGTVEYM 208
+ I++RDLK NIL+ E H +K+TDFGL++E K S GT +M
Sbjct: 637 DAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTK--MSAAGTYAWM 810
Query: 209 APEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMP 261
APEV+ S+S+D WS+GVL++E+LTG +P++ D + KL +P
Sbjct: 811 APEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLP 969
Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 44/158 (27%), Positives = 77/158 (48%), Gaps = 13/158 (8%)
Frame = +1
Query: 395 ELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYG------QHPNI 448
+L+E IGVG + R + + +D K DP+ E + + QHPNI
Sbjct: 295 QLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEK-DPAVTAEQVCQEARLFGALQHPNI 471
Query: 449 ITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG-- 506
I L+ + ++ LV + +GG L R+L + + +++ ++YLH
Sbjct: 472 IALRGACLNPPHLCLVMEYARGGA-LSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPV 648
Query: 507 -VVHRDLKPSNILYMDESAS---ADSI-RICDFGFAKQ 539
++HRDLK NIL ++ + AD++ +I DFG A++
Sbjct: 649 PIIHRDLKSINILILEAIENHNLADTVLKITDFGLARE 762
>lcl|NM_032037.3_cdsid_NP_114426.1 [gene=TSSK6]
[protein=testis-specific serine/threonine-protein kinase
6] [protein_id=NP_114426.1] [location=234..1055]
Length = 822
Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust.
Identities = 74/260 (28%), Positives = 129/260 (49%), Gaps = 17/260 (6%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTK---------ME 91
++L + +G+GS+ KV + K K ++KV DR R E
Sbjct: 34 YKLGRTIGEGSYSKVKVATSK-----------KYKGTVAIKVVDRRRAPPDFVNKFLPRE 180
Query: 92 RDILVEVNHPFIVKLHYAFQT-EGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAEL 150
IL V HP IV + + GKLY++++ D+ + + + A++
Sbjct: 181 LSILRGVRHPHIVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQI 357
Query: 151 ALALDHLHQLGIVYRDLKPENILL--DEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYM 208
A A+ +LH +V+RDLK EN+LL DE +KLTDFG +++ + ++CG+ Y
Sbjct: 358 AGAVRYLHDHHLVHRDLKCENVLLSPDE-RRVKLTDFGFGRQAHGYPDLSTTYCGSAAYA 534
Query: 209 APEVVNRRGHS-QSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGM--PQF-- 263
+PEV+ + + D WS GV+++ M+TG +PF D ++ + + K G+ P+
Sbjct: 535 SPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPF---DDSDIAGLPRRQKRGVLYPEGLE 705
Query: 264 LSAEAQSLLRMLFKRNPANR 283
LS ++L+ L + +P+ R
Sbjct: 706 LSERCKALIAELLQFSPSAR 765
Score = 60.5 bits (145), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 46/155 (29%), Positives = 76/155 (49%), Gaps = 9/155 (5%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPS-------EEIEILMRYGQHP 446
Y+L IG GSYS K A+K++D+ + P E+ IL R +HP
Sbjct: 34 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSIL-RGVRHP 210
Query: 447 NIITLKDVFD--DGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHC 504
+I+ + + + +G+ +Y+V + +LL + + +A D+ I+ V YLH
Sbjct: 211 HIVHVFEFIEVCNGK-LYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHD 384
Query: 505 QGVVHRDLKPSNILYMDESASADSIRICDFGFAKQ 539
+VHRDLK N+L S +++ DFGF +Q
Sbjct: 385 HHLVHRDLKCENVLL---SPDERRVKLTDFGFGRQ 480
>lcl|NM_002529.3_cdsid_NP_002520.2 [gene=NTRK1] [protein=high affinity
nerve growth factor receptor isoform 2 precursor]
[protein_id=NP_002520.2] [location=57..2447]
Length = 2391
Score = 88.6 bits (218), Expect = 2e-18, Method: Compositional matrix adjust.
Identities = 73/259 (28%), Positives = 129/259 (49%), Gaps = 22/259 (8%)
Frame = +1
Query: 47 LGQGSFGKVFLVR-KKTGPDAGQ-LYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIV 104
LG+G+FGKVFL P+ + L A+K LK+AS R + E ++L + H IV
Sbjct: 1546 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDF--QREAELLTMLQHQHIV 1719
Query: 105 KLHYAFQTEGK-LYLILDFLRGGDVFTRLSK-----EVLFTEEDVK----------FYLA 148
+ + TEG+ L ++ +++R GD+ L ++L EDV +
Sbjct: 1720 RF-FGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVAS 1896
Query: 149 ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE--SVDQEKKAYSFCGTVE 206
++A + +L L V+RDL N L+ + +K+ DFG+S++ S D + +
Sbjct: 1897 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 2076
Query: 207 YMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKAK-LGMPQFL 264
+M PE + R + +D WS+GV+++E+ T G P+ E ++ I + + L P+
Sbjct: 2077 WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC 2256
Query: 265 SAEAQSLLRMLFKRNPANR 283
E +++R ++R P R
Sbjct: 2257 PPEVYAIMRGCWQREPQQR 2313
>lcl|NM_012395.2_cdsid_NP_036527.1 [gene=CDK14]
[protein=cyclin-dependent kinase 14]
[protein_id=NP_036527.1] [location=145..1500]
Length = 1356
Score = 87.8 bits (216), Expect = 4e-18, Method: Compositional matrix adjust.
Identities = 69/233 (29%), Positives = 115/233 (49%), Gaps = 3/233 (1%)
Frame = +1
Query: 33 YEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMER 92
+ KAD +E L+ LG+GS+ V+ + K G+L A+KV++ + + E
Sbjct: 331 FGKAD--SYEKLEKLGEGSYATVYKGKSKVN---GKLVALKVIRLQEEEGTPFTAIR-EA 492
Query: 93 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVL-FTEEDVKFYLAELA 151
+L + H IV LH T+ L L+ +++ D+ + K ++VK +L +L
Sbjct: 493 SLLKGLKHANIVLLHDIIHTKETLTLVFEYVHT-DLCQYMDKHPGGLHPDNVKLFLFQLL 669
Query: 152 LALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPE 211
L ++HQ I++RDLKP+N+L+ + G +KL DFGL++ + T+ Y P+
Sbjct: 670 RGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPD 849
Query: 212 V-VNRRGHSQSADWWSYGVLMFEMLTGTLPFQG-KDRNETMNMILKAKLGMPQ 262
V + +S D W G + EM+ G F G KD + + I LG P
Sbjct: 850 VLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLV-LGTPN 1005
Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 17/172 (9%)
Frame = +1
Query: 389 QFGEV--YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEI----LMRY 442
+FG+ YE E +G GSY+ + A+K+I + + + I L++
Sbjct: 328 KFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKG 507
Query: 443 GQHPNIITLKDVFDDGRYVYLV-----TDLMK------GGELLDRILKQKCFSEREASDI 491
+H NI+ L D+ + LV TDL + GG D + K F
Sbjct: 508 LKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNV---KLF-------- 654
Query: 492 LYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQPPDP 543
L+ + + + Y+H + ++HRDLKP N+L D +++ DFG A+ P
Sbjct: 655 LFQLLRGLSYIHQRYILHRDLKPQNLLISD----TGELKLADFGLARAKSVP 798
>lcl|NM_145331.2_cdsid_NP_663304.1 [gene=MAP3K7]
[protein=mitogen-activated protein kinase kinase kinase
7 isoform B] [protein_id=NP_663304.1]
[location=419..2239]
Length = 1821
Score = 87.8 bits (216), Expect = 4e-18, Method: Compositional matrix adjust.
Identities = 76/287 (26%), Positives = 141/287 (49%), Gaps = 17/287 (5%)
Frame = +1
Query: 33 YEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMER 92
+E+ D + E+ +V+G+G+FG V + + + A+K ++ S +R +E
Sbjct: 82 FEEIDYKEIEVEEVVGRGAFGVVCKAKWR-----AKDVAIKQIESES----ERKAFIVEL 234
Query: 93 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELAL 152
L VNHP IVKL+ A + L++++ GG ++ VL E + +Y A A+
Sbjct: 235 RQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYN-----VLHGAEPLPYYTAAHAM 393
Query: 153 A--------LDHLHQL---GIVYRDLKPENILLDEIGHI-KLTDFGLSKESVDQEKKAYS 200
+ + +LH + +++RDLKP N+LL G + K+ DFG + D + +
Sbjct: 394 SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA---CDIQTHMTN 564
Query: 201 FCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQ--GKDRNETMNMILKA-K 257
G+ +MAPEV +S+ D +S+G++++E++T PF G M + +
Sbjct: 565 NKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTR 744
Query: 258 LGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHL--FFANID 302
+ + L +SL+ + ++P+ R E + +I HL +F D
Sbjct: 745 PPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGAD 885
>lcl|NM_004444.4_cdsid_NP_004435.3 [gene=EPHB4] [protein=ephrin type-B
receptor 4 precursor] [protein_id=NP_004435.3]
[location=492..3455]
Length = 2964
Score = 87.0 bits (214), Expect = 6e-18, Method: Compositional matrix adjust.
Identities = 65/233 (27%), Positives = 115/233 (49%), Gaps = 8/233 (3%)
Frame = +1
Query: 29 VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT 88
V+E ++ D + ++ +V+G G FG+V R K A+K LK + R R
Sbjct: 1807 VREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTE-RQRREF 1983
Query: 89 KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG--DVFTRLSKEVLFTEEDVKFY 146
E I+ + HP I++L + ++ +F+ G D F RL+ + FT +
Sbjct: 1984 LSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLN-DGQFTVIQLVGM 2160
Query: 147 LAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSK---ESVDQEKKAYSFCG 203
L +A + +L ++ V+RDL NIL++ K++DFGLS+ E+ S G
Sbjct: 2161 LRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGG 2340
Query: 204 TV--EYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMI 253
+ + APE + R + ++D WSYG++M+E+++ G P+ + +N I
Sbjct: 2341 KIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI 2499
Score = 51.6 bits (122), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 43/153 (28%), Positives = 73/153 (47%), Gaps = 9/153 (5%)
Frame = +1
Query: 395 ELKEDIGVGSYS-VCKRCIHATTNMEFAVKI-------IDKSKRDPSEEIEILMRYGQHP 446
+++E IG G + VC+ + A E V I ++ +R+ E I+ ++ +HP
Sbjct: 1846 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQF-EHP 2022
Query: 447 NIITLKDVFDDGRYVYLVTDLMKGGELLDRI-LKQKCFSEREASDILYVISKTVDYLHCQ 505
NII L+ V + V ++T+ M+ G L + L F+ + +L I+ + YL
Sbjct: 2023 NIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEM 2202
Query: 506 GVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
VHRDL NIL S ++ DFG ++
Sbjct: 2203 SYVHRDLAARNILV----NSNLVCKVSDFGLSR 2289
>lcl|NM_000141.4_cdsid_NP_000132.3 [gene=FGFR2] [protein=fibroblast
growth factor receptor 2 isoform 1 precursor]
[protein_id=NP_000132.3] [location=648..3113]
Length = 2466
Score = 86.7 bits (213), Expect = 9e-18, Method: Compositional matrix adjust.
Identities = 72/270 (26%), Positives = 133/270 (49%), Gaps = 26/270 (9%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRK----KTGPDAGQLYAMKVLKK-ASLKVRDRVRTKMERDI 94
+ L K LG+G FG+V + K P A+K+LK A+ K + ++ME
Sbjct: 1438 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 1617
Query: 95 LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDV-----------------FTRLSKEVL 137
++ H I+ L A +G LY+I+++ G++ R+ +E +
Sbjct: 1618 MIG-KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 1794
Query: 138 FTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE--SVDQE 195
T +D+ +LA +++L ++RDL N+L+ E +K+ DFGL+++ ++D
Sbjct: 1795 -TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 1971
Query: 196 KKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMIL 254
KK + V++MAPE + R ++ +D WS+GVLM+E+ T G P+ G E ++
Sbjct: 1972 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 2151
Query: 255 KA-KLGMPQFLSAEAQSLLRMLFKRNPANR 283
+ ++ P + E ++R + P+ R
Sbjct: 2152 EGHRMDKPANCTNELYMMMRDCWHAVPSQR 2241
>lcl|NM_002596.3_cdsid_NP_002587.2 [gene=CDK18]
[protein=cyclin-dependent kinase 18 isoform b]
[protein_id=NP_002587.2] [location=345..1769]
Length = 1425
Score = 86.3 bits (212), Expect = 1e-17, Method: Compositional matrix adjust.
Identities = 66/222 (29%), Positives = 108/222 (48%), Gaps = 4/222 (1%)
Frame = +1
Query: 44 LKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI--LVEVNHP 101
L LG+G++ VF R K + + LK+ L+ + R++ L + H
Sbjct: 439 LDKLGEGTYATVFKGRSKLTEN------LVALKEIRLEHEEGAPCTAIREVSLLKNLKHA 600
Query: 102 FIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEEDVKFYLAELALALDHLHQL 160
IV LH T+ L L+ ++L D+ L L + +VK ++ +L L + H
Sbjct: 601 NIVTLHDLIHTDRSLTLVFEYL-DSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 777
Query: 161 GIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEV-VNRRGHS 219
I++RDLKP+N+L++E G +KL DFGL++ K + T+ Y P+V + +S
Sbjct: 778 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 957
Query: 220 QSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMP 261
D W G + +EM TG F G E +++I + LG P
Sbjct: 958 TPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRL-LGTP 1080
Score = 48.5 bits (114), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 42/157 (26%), Positives = 70/157 (44%), Gaps = 10/157 (6%)
Frame = +1
Query: 392 EVYELKEDIGVGSYSVCKRCIHATTNMEFAVKII--DKSKRDPSEEIE--ILMRYGQHPN 447
E Y + +G G+Y+ + T A+K I + + P I L++ +H N
Sbjct: 424 ETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHAN 603
Query: 448 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQ------KCFSEREASDILYVISKTVDY 501
I+TL D+ R + LV E LD LKQ S ++ + + + Y
Sbjct: 604 IVTLHDLIHTDRSLTLVF------EYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAY 765
Query: 502 LHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
H + ++HRDLKP N+L + +++ DFG A+
Sbjct: 766 CHHRKILHRDLKPQNLLINERG----ELKLADFGLAR 864
>lcl|NM_004431.3_cdsid_NP_004422.2 [gene=EPHA2] [protein=ephrin type-A
receptor 2 precursor] [protein_id=NP_004422.2]
[location=156..3086]
Length = 2931
Score = 86.3 bits (212), Expect = 1e-17, Method: Compositional matrix adjust.
Identities = 69/254 (27%), Positives = 123/254 (48%), Gaps = 8/254 (3%)
Frame = +1
Query: 38 PAQFELLKVLGQGSFGKVFLVRKKTGPDAGQL-YAMKVLKKASLKVRDRVRTKMERDILV 96
P+ KV+G G FG+V+ KT ++ A+K LK A + RV E I+
Sbjct: 1828 PSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLK-AGYTEKQRVDFLGEAGIMG 2004
Query: 97 EVNHPFIVKLHYAFQTEGKLYLILDFLRGG--DVFTRLSKEVLFTEEDVKFYLAELALAL 154
+ +H I++L + +I +++ G D F R K+ F+ + L +A +
Sbjct: 2005 QFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLR-EKDGEFSVLQLVGMLRGIAAGM 2181
Query: 155 DHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCG---TVEYMAPE 211
+L + V+RDL NIL++ K++DFGLS+ D + Y+ G + + APE
Sbjct: 2182 KYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPE 2361
Query: 212 VVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKA-KLGMPQFLSAEAQ 269
++ R + ++D WS+G++M+E++T G P+ +E M I +L P +
Sbjct: 2362 AISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIY 2541
Query: 270 SLLRMLFKRNPANR 283
L+ +++ A R
Sbjct: 2542 QLMMQCWQQERARR 2583
Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 46/156 (29%), Positives = 73/156 (46%), Gaps = 4/156 (2%)
Frame = +1
Query: 387 AAQFGEVYE--LKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQ 444
A +FGEVY+ LK G V + + A +K + D E I+ ++
Sbjct: 1861 AGEFGEVYKGMLKTSSGKKEVPVAIKTLKA--------GYTEKQRVDFLGEAGIMGQFSH 2016
Query: 445 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKC--FSEREASDILYVISKTVDYL 502
H NII L+ V + + ++T+ M+ G L D+ L++K FS + +L I+ + YL
Sbjct: 2017 H-NIIRLEGVISKYKPMMIITEYMENGAL-DKFLREKDGEFSVLQLVGMLRGIAAGMKYL 2190
Query: 503 HCQGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
VHRDL NIL S ++ DFG ++
Sbjct: 2191 ANMNYVHRDLAARNILV----NSNLVCKVSDFGLSR 2286
>lcl|NM_004438.3_cdsid_NP_004429.1 [gene=EPHA4] [protein=ephrin type-A
receptor 4 precursor] [protein_id=NP_004429.1]
[location=43..3003]
Length = 2961
Score = 84.3 bits (207), Expect = 5e-17, Method: Compositional matrix adjust.
Identities = 63/231 (27%), Positives = 112/231 (48%), Gaps = 6/231 (2%)
Frame = +1
Query: 29 VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT 88
V+E ++ D + ++ KV+G G FG+V R K A+K LK A + R
Sbjct: 1825 VREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLK-AGYTDKQRRDF 2001
Query: 89 KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG--DVFTRLSKEVLFTEEDVKFY 146
E I+ + +HP I+ L + +I +++ G D F R + FT +
Sbjct: 2002 LSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLR-KNDGRFTVIQLVGM 2178
Query: 147 LAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCG--- 203
L + + +L + V+RDL NIL++ K++DFG+S+ D + AY+ G
Sbjct: 2179 LRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKI 2358
Query: 204 TVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMI 253
+ + APE + R + ++D WSYG++M+E+++ G P+ + + I
Sbjct: 2359 PIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI 2511
Score = 51.2 bits (121), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 46/154 (29%), Positives = 72/154 (46%), Gaps = 10/154 (6%)
Frame = +1
Query: 395 ELKEDIGVGSYS-VCKRCIHATTNMEFAVKI-------IDKSKRDPSEEIEILMRYGQHP 446
++++ IGVG + VC + E V I DK +RD E I+ ++ HP
Sbjct: 1864 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQF-DHP 2040
Query: 447 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQK--CFSEREASDILYVISKTVDYLHC 504
NII L+ V + V ++T+ M+ G LD L++ F+ + +L I + YL
Sbjct: 2041 NIIHLEGVVTKCKPVMIITEYMENGS-LDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSD 2217
Query: 505 QGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
VHRDL NIL S ++ DFG ++
Sbjct: 2218 MSYVHRDLAARNILV----NSNLVCKVSDFGMSR 2307
>lcl|NM_001174168.1_cdsid_NP_001167639.1 [gene=SYK]
[protein=tyrosine-protein kinase SYK isoform 2]
[protein_id=NP_001167639.1] [location=123..1961]
Length = 1839
Score = 82.8 bits (203), Expect = 1e-16, Method: Compositional matrix adjust.
Identities = 55/213 (25%), Positives = 110/213 (51%), Gaps = 5/213 (2%)
Frame = +1
Query: 91 ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAEL 150
E +++ ++++P+IV++ + E + L+++ G + L + ++++ + ++
Sbjct: 1189 EANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV 1365
Query: 151 ALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE-SVDQEKKAYSFCGT--VEY 207
++ + +L + V+RDL N+LL + K++DFGLSK D+ G V++
Sbjct: 1366 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 1545
Query: 208 MAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKA-KLGMPQFLS 265
APE +N S +D WS+GVLM+E + G P++G +E M+ K ++G P
Sbjct: 1546 YAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP 1725
Query: 266 AEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFF 298
E L+ + + + NR G VE R+ ++
Sbjct: 1726 REMYDLMNLCWTYDVENRPGFAAVELRLRNYYY 1824
>lcl|NM_001174066.1_cdsid_NP_001167537.1 [gene=FGFR1]
[protein=fibroblast growth factor receptor 1 isoform 3
precursor] [protein_id=NP_001167537.1]
[location=263..2464]
Length = 2202
Score = 82.8 bits (203), Expect = 1e-16, Method: Compositional matrix adjust.
Identities = 70/266 (26%), Positives = 130/266 (48%), Gaps = 25/266 (9%)
Frame = +1
Query: 43 LLKVLGQGSFGKVFLVRK----KTGPDAGQLYAMKVLKK-ASLKVRDRVRTKMERDILVE 97
L K LG+G FG+V L K P+ A+K+LK A+ K + ++ME ++
Sbjct: 1171 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 1350
Query: 98 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRL----------------SKEVLFTEE 141
H I+ L A +G LY+I+++ G++ L + E + +
Sbjct: 1351 -KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSK 1527
Query: 142 DVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE--SVDQEKKAY 199
D+ ++A +++L ++RDL N+L+ E +K+ DFGL+++ +D KK
Sbjct: 1528 DLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 1707
Query: 200 SFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKA-K 257
+ V++MAPE + R ++ +D WS+GVL++E+ T G P+ G E ++ + +
Sbjct: 1708 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 1887
Query: 258 LGMPQFLSAEAQSLLRMLFKRNPANR 283
+ P + E ++R + P+ R
Sbjct: 1888 MDKPSNCTNELYMMMRDCWHAVPSQR 1965
>lcl|NM_004439.5_cdsid_NP_004430.4 [gene=EPHA5] [protein=ephrin type-A
receptor 5 isoform a precursor] [protein_id=NP_004430.4]
[location=194..3307]
Length = 3114
Score = 82.4 bits (202), Expect = 1e-16, Method: Compositional matrix adjust.
Identities = 60/203 (29%), Positives = 106/203 (52%), Gaps = 6/203 (2%)
Frame = +1
Query: 45 KVLGQGSFGKVFLVRKKTGPDAGQL-YAMKVLKKASLKVRDRVRTKMERDILVEVNHPFI 103
+V+G G FG+V R K P +L A+K LK + + R E I+ + +HP I
Sbjct: 2035 RVIGAGEFGEVCSGRLKL-PGKRELPVAIKTLKVGYTE-KQRRDFLGEASIMGQFDHPNI 2208
Query: 104 VKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEEDVKFYLAELALALDHLHQLGI 162
+ L + ++ +++ G + T L K + FT + L ++ + +L +G
Sbjct: 2209 IHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGY 2388
Query: 163 VYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCG---TVEYMAPEVVNRRGHS 219
V+RDL NIL++ K++DFGLS+ D + AY+ G + + APE + R +
Sbjct: 2389 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFT 2568
Query: 220 QSADWWSYGVLMFEMLT-GTLPF 241
++D WSYG++M+E+++ G P+
Sbjct: 2569 SASDVWSYGIVMWEVVSYGERPY 2637
Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 48/149 (32%), Positives = 69/149 (46%), Gaps = 10/149 (6%)
Frame = +1
Query: 400 IGVGSYS-VCKRCIHATTNMEFAVKI-------IDKSKRDPSEEIEILMRYGQHPNIITL 451
IG G + VC + E V I +K +RD E I+ ++ HPNII L
Sbjct: 2041 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQF-DHPNIIHL 2217
Query: 452 KDVFDDGRYVYLVTDLMKGGELLDRILKQK--CFSEREASDILYVISKTVDYLHCQGVVH 509
+ V + V +VT+ M+ G LD LK+ F+ + +L IS + YL G VH
Sbjct: 2218 EGVVTKSKPVMIVTEYMENGS-LDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVH 2394
Query: 510 RDLKPSNILYMDESASADSIRICDFGFAK 538
RDL NIL S ++ DFG ++
Sbjct: 2395 RDLAARNILI----NSNLVCKVSDFGLSR 2469
>lcl|NM_000142.4_cdsid_NP_000133.1 [gene=FGFR3] [protein=fibroblast
growth factor receptor 3 isoform 1 precursor]
[protein_id=NP_000133.1] [location=257..2677]
Length = 2421
Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust.
Identities = 81/315 (25%), Positives = 148/315 (46%), Gaps = 34/315 (10%)
Frame = +1
Query: 22 EIPITHHVKEGYEKADP------AQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVL 75
E P +V E ADP A+ L K LG+G FG+V + + G D + A K +
Sbjct: 1339 EGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMA-EAIGIDKDR--AAKPV 1509
Query: 76 KKASLKVRDRVRTKMERDILVEV-------NHPFIVKLHYAFQTEGKLYLILDFLRGGDV 128
A ++D K D++ E+ H I+ L A G LY+++++ G++
Sbjct: 1510 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL 1689
Query: 129 --FTRLSK--------------EVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENI 172
F R + E T +D+ ++A +++L ++RDL N+
Sbjct: 1690 REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 1869
Query: 173 LLDEIGHIKLTDFGLSKE--SVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVL 230
L+ E +K+ DFGL+++ ++D KK + V++MAPE + R ++ +D WS+GVL
Sbjct: 1870 LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 2049
Query: 231 MFEMLT-GTLPFQGKDRNETMNMILKA-KLGMPQFLSAEAQSLLRMLFKRNPANRLG-SE 287
++E+ T G P+ G E ++ + ++ P + + ++R + P+ R +
Sbjct: 2050 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 2229
Query: 288 GVEEIKRHLFFANID 302
VE++ R L + D
Sbjct: 2230 LVEDLDRVLTVTSTD 2274
Score = 48.1 bits (113), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 41/170 (24%), Positives = 75/170 (44%), Gaps = 21/170 (12%)
Frame = +1
Query: 390 FGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKII-----DKSKRDPSEEIEILMRYGQ 444
FG+V + E IG+ K + AVK++ DK D E+E++ G+
Sbjct: 1447 FGQVV-MAEAIGIDKDRAAK-------PVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGK 1602
Query: 445 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQK----------C------FSEREA 488
H NII L G +Y++ + G L + + ++ C + ++
Sbjct: 1603 HKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDL 1782
Query: 489 SDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
Y +++ ++YL Q +HRDL N+L +++ ++I DFG A+
Sbjct: 1783 VSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV----MKIADFGLAR 1920
>lcl|NM_002314.3_cdsid_NP_002305.1 [gene=LIMK1] [protein=LIM domain
kinase 1 isoform 1] [protein_id=NP_002305.1]
[location=215..2158]
Length = 1944
Score = 80.1 bits (196), Expect = 8e-16, Method: Compositional matrix adjust.
Identities = 52/207 (25%), Positives = 107/207 (51%), Gaps = 16/207 (7%)
Frame = +1
Query: 45 KVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM-ERDILVEVNHPFI 103
+VLG+G FG+ V + + G++ MK L + + + RT + E ++ + HP +
Sbjct: 1027 EVLGKGCFGQAIKVTHR---ETGEVMVMKELIRFDEETQ---RTFLKEVKVMRCLEHPNV 1188
Query: 104 VKLHYAFQTEGKLYLILDFLRGGDVFTRL-SKEVLFTEEDVKFYLAELALALDHLHQLGI 162
+K + +L I ++++GG + + S + + + ++A + +LH + I
Sbjct: 1189 LKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNI 1368
Query: 163 VYRDLKPENILLDEIGHIKLTDFGLSKESVDQE--------------KKAYSFCGTVEYM 208
++RDL N L+ E ++ + DFGL++ VD++ KK Y+ G +M
Sbjct: 1369 IHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWM 1548
Query: 209 APEVVNRRGHSQSADWWSYGVLMFEML 235
APE++N R + + D +S+G+++ E++
Sbjct: 1549 APEMINGRSYDEKVDVFSFGIVLCEII 1629
Score = 47.4 bits (111), Expect = 5e-06, Method: Compositional matrix adjust.
Identities = 36/148 (24%), Positives = 72/148 (48%), Gaps = 7/148 (4%)
Frame = +1
Query: 398 EDIGVGSYSVCKRCIHATTN----MEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKD 453
E +G G + + H T M+ ++ ++++R +E+++ MR +HPN++
Sbjct: 1027 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKV-MRCLEHPNVLKFIG 1203
Query: 454 VFDDGRYVYLVTDLMKGGEL---LDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHR 510
V + + +T+ +KGG L + + Q +S+R + I+ + YLH ++HR
Sbjct: 1204 VLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVS--FAKDIASGMAYLHSMNIIHR 1377
Query: 511 DLKPSNILYMDESASADSIRICDFGFAK 538
DL N L + ++ + DFG A+
Sbjct: 1378 DLNSHNCLVRENK----NVVVADFGLAR 1449
>lcl|NM_000455.4_cdsid_NP_000446.1 [gene=STK11]
[protein=serine/threonine-protein kinase STK11]
[protein_id=NP_000446.1] [location=1116..2417]
Length = 1302
Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust.
Identities = 67/270 (24%), Positives = 121/270 (44%), Gaps = 17/270 (6%)
Frame = +1
Query: 46 VLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKV----RDRVRTKMERDILVEVNHP 101
+LG+GS+GKV V D+ L V K+ K E +L + H
Sbjct: 160 LLGEGSYGKVKEVL-----DSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHK 324
Query: 102 FIVKLHYAFQTE--GKLYLILDFLRGGDVFTRLSKEVLFTEEDVKF-------YLAELAL 152
+++L E K+Y+++++ G +E+L + + +F Y +L
Sbjct: 325 NVIQLVDVLYNEEKQKMYMVMEYCVCG------MQEMLDSVPEKRFPVCQAHGYFCQLID 486
Query: 153 ALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSK--ESVDQEKKAYSFCGTVEYMAP 210
L++LH GIV++D+KP N+LL G +K++D G+++ + + G+ + P
Sbjct: 487 GLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPP 666
Query: 211 EVVNRRGHSQS--ADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEA 268
E+ N D WS GV ++ + TG PF+G + + I K +P
Sbjct: 667 EIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPL 846
Query: 269 QSLLRMLFKRNPANRLGSEGVEEIKRHLFF 298
LL+ + + PA R + +I++H +F
Sbjct: 847 SDLLKGMLEYEPAKRF---SIRQIRQHSWF 927
Score = 55.5 bits (132), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 46/157 (29%), Positives = 81/157 (51%), Gaps = 12/157 (7%)
Frame = +1
Query: 394 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIID--------KSKRDPSEEIEILMRYGQH 445
Y + + +G GSY K + + T AVKI+ + + +EI++L R +H
Sbjct: 145 YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL-RH 321
Query: 446 PNIITLKDVF--DDGRYVYLVTDLMKGG--ELLDRILKQKCFSEREASDILYVISKTVDY 501
N+I L DV ++ + +Y+V + G E+LD + +K F +A + ++Y
Sbjct: 322 KNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV-PEKRFPVCQAHGYFCQLIDGLEY 498
Query: 502 LHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
LH QG+VH+D+KP N+L + +++I D G A+
Sbjct: 499 LHSQGIVHKDIKPGNLLL----TTGGTLKISDLGVAE 597
>lcl|NM_004972.3_cdsid_NP_004963.1 [gene=JAK2]
[protein=tyrosine-protein kinase JAK2]
[protein_id=NP_004963.1] [location=495..3893]
Length = 3399
Score = 79.3 bits (194), Expect = 1e-15, Method: Compositional matrix adjust.
Identities = 67/220 (30%), Positives = 115/220 (52%), Gaps = 15/220 (6%)
Frame = +1
Query: 32 GYEKADPAQFE-----LLKVLGQGSFGKVFLVRKKTGPD-AGQLYAMKVLKKASLK-VRD 84
+E DP QFE L+ LG+G+FG V + R D G++ A+K L+ ++ + +RD
Sbjct: 2503 AFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRD 2682
Query: 85 RVRTKMERDILVEVNHPFIVKLHYAFQTEGK--LYLILDFLRGGDVFTRLSKEVLFTEED 142
R E +IL + H IVK + G+ L LI+++L G + L K +
Sbjct: 2683 FER---EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDH- 2850
Query: 143 VKF--YLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYS 200
+K Y +++ +++L ++RDL NIL++ +K+ DFGL+K + Q+K+ Y
Sbjct: 2851 IKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTK-VLPQDKEYYK 3027
Query: 201 FCGTVE----YMAPEVVNRRGHSQSADWWSYGVLMFEMLT 236
E + APE + S ++D WS+GV+++E+ T
Sbjct: 3028 VKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT 3147
Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 60/217 (27%), Positives = 110/217 (50%), Gaps = 26/217 (11%)
Frame = +1
Query: 47 LGQGSFGKVFL-VRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMER------DILVEVN 99
LGQG+F K+F VR++ G D GQL+ +VL LKV D+ ++ +++
Sbjct: 1651 LGQGTFTKIFKGVRREVG-DYGQLHETEVL----LKVLDKAHRNYSESFFEAASMMSKLS 1815
Query: 100 HPFIVKLHYAFQTEG-KLYLILDFLRGGDVFTRLSK-----EVLFTEEDVKFYLAELALA 153
H +V L+Y G + L+ +F++ G + T L K +L+ E K +LA A
Sbjct: 1816 HKHLV-LNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAK----QLAWA 1980
Query: 154 LDHLHQLGIVYRDLKPENILL-----DEIGH---IKLTDFGLS----KESVDQEKKAYSF 201
+ L + +++ ++ +NILL + G+ IKL+D G+S + + QE+
Sbjct: 1981 MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER----- 2145
Query: 202 CGTVEYMAPEVV-NRRGHSQSADWWSYGVLMFEMLTG 237
+ ++ PE + N + + + D WS+G ++E+ +G
Sbjct: 2146 ---IPWVPPECIENPKNLNLATDKWSFGTTLWEICSG 2247
Score = 46.6 bits (109), Expect = 9e-06, Method: Compositional matrix adjust.
Identities = 57/195 (29%), Positives = 89/195 (45%), Gaps = 25/195 (12%)
Frame = +1
Query: 372 ITSANVLPIVQING----------NAAQFGEVY-ELKEDIGVGSYSVCKRC----IHATT 416
+T ++LP ++I + QF E + + + +G G++ + C + T
Sbjct: 2446 LTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNT 2625
Query: 417 NMEFAVKIIDKSK----RDPSEEIEILMRYGQHPNIITLKDV-FDDGRY-VYLVTDLMKG 470
AVK + S RD EIEIL + QH NI+ K V + GR + L+ + +
Sbjct: 2626 GEVVAVKKLQHSTEEHLRDFEREIEIL-KSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPY 2802
Query: 471 GELLDRILKQKCFSER--EASDILYV--ISKTVDYLHCQGVVHRDLKPSNILYMDESASA 526
G L D + K K ER + Y I K ++YL + +HRDL NIL +E
Sbjct: 2803 GSLRDYLQKHK---ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE---- 2961
Query: 527 DSIRICDFGFAKQPP 541
+ ++I DFG K P
Sbjct: 2962 NRVKIGDFGLTKVLP 3006
>lcl|NM_021643.3_cdsid_NP_067675.1 [gene=TRIB2] [protein=tribbles
homolog 2] [protein_id=NP_067675.1]
[location=1437..2468]
Length = 1032
Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust.
Identities = 53/181 (29%), Positives = 91/181 (50%), Gaps = 6/181 (3%)
Frame = +1
Query: 126 GDV--FTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILL--DEIGHIK 181
GD+ F R K++ EE+ ++A A+ H H G+V RDLK + +E +K
Sbjct: 403 GDMHSFVRTCKKL--REEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVK 576
Query: 182 LTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH--SQSADWWSYGVLMFEMLTGTL 239
L + + G Y++PE++N G ++AD WS GV+++ ML G
Sbjct: 577 LESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRY 756
Query: 240 PFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFA 299
PF + + + I + + +P+ LS +A+ L+R + +R P+ RL S +EI H +F+
Sbjct: 757 PFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTS---QEILDHPWFS 927
Query: 300 N 300
Sbjct: 928 T 930
>lcl|NM_022963.2_cdsid_NP_075252.2 [gene=FGFR4] [protein=fibroblast
growth factor receptor 4 isoform 2 precursor]
[protein_id=NP_075252.2] [location=54..2342]
Length = 2289
Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust.
Identities = 72/266 (27%), Positives = 125/266 (46%), Gaps = 25/266 (9%)
Frame = +1
Query: 43 LLKVLGQGSFGKVFLVRK----KTGPDAGQLYAMKVLK-KASLKVRDRVRTKMERDILVE 97
L K LG+G FG+V PD A+K+LK AS K + ++ME L+
Sbjct: 1285 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 1464
Query: 98 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDV--FTRLSKEV---------LFTEEDVKFY 146
H I+ L EG LY+I++ G++ F R + +E + F
Sbjct: 1465 -RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFP 1641
Query: 147 LA-----ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSK--ESVDQEKKAY 199
+ ++A + +L ++RDL N+L+ E +K+ DFGL++ +D KK
Sbjct: 1642 VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS 1821
Query: 200 SFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKA-K 257
+ V++MAPE + R ++ +D WS+G+L++E+ T G P+ G E +++ + +
Sbjct: 1822 NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHR 2001
Query: 258 LGMPQFLSAEAQSLLRMLFKRNPANR 283
+ P E L+R + P+ R
Sbjct: 2002 MDRPPHCPPELYGLMRECWHAAPSQR 2079
>lcl|NM_001042599.1_cdsid_NP_001036064.1 [gene=ERBB4]
[protein=receptor tyrosine-protein kinase erbB-4 isoform
JM-a/CVT-2 precursor] [protein_id=NP_001036064.1]
[location=99..3977]
Length = 3879
Score = 77.4 bits (189), Expect = 6e-15, Method: Compositional matrix adjust.
Identities = 59/235 (25%), Positives = 115/235 (48%), Gaps = 11/235 (4%)
Frame = +1
Query: 39 AQFELLKVLGQGSFGKVFL-VRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVE 97
+ + +KVLG G+FG V+ + G A+K+L + + + V E I+
Sbjct: 2146 TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETT-GPKANVEFMDEALIMAS 2322
Query: 98 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFT-------RLSKEVLFTEEDVKFYLAEL 150
++HP +V+L + L+ + G + + ++L + ++
Sbjct: 2323 MDHPHLVRL-LGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN------WCVQI 2481
Query: 151 ALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSK--ESVDQEKKAYSFCGTVEYM 208
A + +L + +V+RDL N+L+ H+K+TDFGL++ E ++E A +++M
Sbjct: 2482 AKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWM 2661
Query: 209 APEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKAKLGMPQ 262
A E ++ R + +D WSYGV ++E++T G P+ G E +++ K + +PQ
Sbjct: 2662 ALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGER-LPQ 2823
>lcl|NM_005204.3_cdsid_NP_005195.2 [gene=MAP3K8]
[protein=mitogen-activated protein kinase kinase kinase
8] [protein_id=NP_005195.2] [location=613..2016]
Length = 1404
Score = 75.9 bits (185), Expect = 1e-14, Method: Compositional matrix adjust.
Identities = 56/195 (28%), Positives = 91/195 (46%), Gaps = 2/195 (1%)
Frame = +1
Query: 49 QGSFGKVFLVR--KKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKL 106
+G+FGKV+L + K A +L + K + ++++ R H I +L
Sbjct: 436 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFR------------HENIAEL 579
Query: 107 HYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRD 166
+ A ++L ++ GG V +L E ++ + + LD LH +++ D
Sbjct: 580 YGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHD 759
Query: 167 LKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWS 226
+KP NI+ + L DFGLS + + GT YM+PEV+ RGHS AD +S
Sbjct: 760 IKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYS 936
Query: 227 YGVLMFEMLTGTLPF 241
G + M TGT P+
Sbjct: 937 LGATLIHMQTGTPPW 981
Score = 56.2 bits (134), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 49/154 (31%), Positives = 76/154 (49%), Gaps = 4/154 (2%)
Frame = +1
Query: 390 FGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSE-EIEILMRYGQHPNI 448
FG+VY L +DI T A K+I + PS+ EI+ R H NI
Sbjct: 445 FGKVY-LAQDI--------------KTKKRMACKLIPVDQFKPSDVEIQACFR---HENI 570
Query: 449 ITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYV---ISKTVDYLHCQ 505
L G V+L + +GG +L+++ + C RE +I++V + K +D+LH +
Sbjct: 571 AELYGAVLWGETVHLFMEAGEGGSVLEKL--ESCGPMREF-EIIWVTKHVLKGLDFLHSK 741
Query: 506 GVVHRDLKPSNILYMDESASADSIRICDFGFAKQ 539
V+H D+KPSNI++M A + DFG + Q
Sbjct: 742 KVIHHDIKPSNIVFMSTKAV-----LVDFGLSVQ 828
>lcl|NM_000215.3_cdsid_NP_000206.2 [gene=JAK3]
[protein=tyrosine-protein kinase JAK3]
[protein_id=NP_000206.2] [location=101..3475]
Length = 3375
Score = 75.1 bits (183), Expect = 2e-14, Method: Compositional matrix adjust.
Identities = 74/280 (26%), Positives = 128/280 (45%), Gaps = 29/280 (10%)
Frame = +1
Query: 33 YEKADPAQFE-----LLKVLGQGSFGKVFLVR-KKTGPDAGQLYAMKVLKKASL-KVRDR 85
Y DP FE + LG+G+FG V L R G + G L A+K L+ + + RD
Sbjct: 2425 YACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDF 2604
Query: 86 VRTKMERDILVEVNHPFIVKLHYAFQTEGK--LYLILDFLRGGDVFTRLSK-EVLFTEED 142
R E IL ++ FIVK G+ L L++++L G + L +
Sbjct: 2605 QR---EIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASR 2775
Query: 143 VKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSK-ESVDQEKKAYSF 201
+ Y +++ +++L V+RDL NIL++ H+K+ DFGL+K +D++
Sbjct: 2776 LLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVRE 2955
Query: 202 CGT--VEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGT----------LPFQGKDRN-- 247
G + + APE ++ S+ +D WS+GV+++E+ T L G +R+
Sbjct: 2956 PGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVP 3135
Query: 248 ----ETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANR 283
+ +L P AE L+++ + +P +R
Sbjct: 3136 ALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDR 3255
>lcl|NM_004560.3_cdsid_NP_004551.2 [gene=ROR2]
[protein=tyrosine-protein kinase transmembrane receptor
ROR2 precursor] [protein_id=NP_004551.2]
[location=200..3031]
Length = 2832
Score = 74.7 bits (182), Expect = 3e-14, Method: Compositional matrix adjust.
Identities = 76/287 (26%), Positives = 132/287 (45%), Gaps = 25/287 (8%)
Frame = +1
Query: 22 EIP-ITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAG---QLYAMKVLK- 76
E+P I H + ++ + ++ LG+ FGKV+ GP G Q A+K LK
Sbjct: 1357 EMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVY-KGHLFGPAPGEQTQAVAIKTLKD 1533
Query: 77 KASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD-----VFTR 131
KA +R+ R E + + HP +V L + L +I + GD V
Sbjct: 1534 KAEGPLREEFRH--EAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRS 1707
Query: 132 LSKEVLFTEED--VKFYL---------AELALALDHLHQLGIVYRDLKPENILLDEIGHI 180
+V T++D VK L A++A +++L +V++DL N+L+ + ++
Sbjct: 1708 PHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNV 1887
Query: 181 KLTDFGLSKE--SVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-G 237
K++D GL +E + D K + + +MAPE + S +D WSYGV+++E+ + G
Sbjct: 1888 KISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYG 2067
Query: 238 TLPFQGKDRNETMNMILKAK-LGMPQFLSAEAQSLLRMLFKRNPANR 283
P+ G + + MI + L P A +L+ + P+ R
Sbjct: 2068 LQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRR 2208
>lcl|NM_002447.2_cdsid_NP_002438.2 [gene=MST1R]
[protein=macrophage-stimulating protein receptor isoform
1 preproprotein] [protein_id=NP_002438.2]
[location=265..4467]
Length = 4203
Score = 74.3 bits (181), Expect = 4e-14, Method: Compositional matrix adjust.
Identities = 71/304 (23%), Positives = 141/304 (46%), Gaps = 27/304 (8%)
Frame = +1
Query: 45 KVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVE-VNHPFI 103
+V+G+G FG V+ A+K L + + +V + +L+ +NHP +
Sbjct: 3256 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR--ITEMQQVEAFLREGLLMRGLNHPNV 3429
Query: 104 VKL-HYAFQTEGKLYLILDFLRGGDV--FTRLSKEVLFTEEDVKFYLAELALALDHLHQL 160
+ L EG +++L ++ GD+ F R + ++ + F L ++A +++L +
Sbjct: 3430 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGL-QVARGMEYLAEQ 3606
Query: 161 GIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQE----KKAYSFCGTVEYMAPEVVNRR 216
V+RDL N +LDE +K+ DFGL+++ +D+E ++ V++MA E +
Sbjct: 3607 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTY 3786
Query: 217 GHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKA-KLGMPQFLSAEAQSLLRM 274
+ +D WS+GVL++E+LT G P++ D + + + + +L P++ +++
Sbjct: 3787 RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQ 3966
Query: 275 LFKRNPANR-----------------LGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKP 317
++ +PA R LG V+ ++ ++ R QP F P
Sbjct: 3967 CWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQFSP 4146
Query: 318 ASGK 321
G
Sbjct: 4147 MPGN 4158
>lcl|NM_006871.3_cdsid_NP_006862.2 [gene=RIPK3]
[protein=receptor-interacting serine/threonine-protein
kinase 3] [protein_id=NP_006862.2] [location=211..1767]
Length = 1557
Score = 74.3 bits (181), Expect = 4e-14, Method: Compositional matrix adjust.
Identities = 58/206 (28%), Positives = 106/206 (51%), Gaps = 8/206 (3%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVR-KKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEV 98
+ E +++G+G FG VF + +K G D A+K++ ++ + ++ + ++ +
Sbjct: 58 ELENQELVGKGGFGTVFRAQHRKWGYDV----AVKIVNSKAISREVKAMASLDNEFVLRL 225
Query: 99 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 158
I K+++ + K L+ F+ G + L + + L E+ L + +LH
Sbjct: 226 EG-VIEKVNW--DQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLH 396
Query: 159 QLG--IVYRDLKPENILLDEIGHIKLTDFGLSK--ESVDQEKKAYSFCGTVEYMAPEV-- 212
+++RDLKP N+LLD H+KL DFGLS + GT+ Y+APE+
Sbjct: 397 DQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFV 576
Query: 213 -VNRRGHSQSADWWSYGVLMFEMLTG 237
VNR+ S ++D +S+G+LM+ +L G
Sbjct: 577 NVNRKA-STASDVYSFGILMWAVLAG 651
>lcl|NM_000208.2_cdsid_NP_000199.2 [gene=INSR] [protein=insulin
receptor isoform Long preproprotein]
[protein_id=NP_000199.2] [location=110..4258]
Length = 4149
Score = 74.3 bits (181), Expect = 4e-14, Method: Compositional matrix adjust.
Identities = 65/276 (23%), Positives = 126/276 (45%), Gaps = 16/276 (5%)
Frame = +1
Query: 24 PITHHVKEGYEKADPAQFELLKVLGQGSFGKVF--LVRKKTGPDAGQLYAMKVLKKASLK 81
P + +V + +E + + LL+ LGQGSFG V+ R +A A+K + + S
Sbjct: 3019 PCSVYVPDEWEVSR-EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNE-SAS 3192
Query: 82 VRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK------- 134
+R+R+ E ++ +V+L ++++ + GD+ + L
Sbjct: 3193 LRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAEN 3372
Query: 135 ---EVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE- 190
T +++ AE+A + +L+ V+RDL N ++ +K+ DFG++++
Sbjct: 3373 NPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI 3552
Query: 191 -SVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNE 248
D +K V +MAPE + + S+D WS+GV+++E+ + P+QG +
Sbjct: 3553 YETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQ 3732
Query: 249 TMNMILKAK-LGMPQFLSAEAQSLLRMLFKRNPANR 283
+ ++ L P L+RM ++ NP R
Sbjct: 3733 VLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMR 3840
>lcl|NM_001012338.2_cdsid_NP_001012338.1 [gene=NTRK3] [protein=NT-3
growth factor receptor isoform a precursor]
[protein_id=NP_001012338.1] [location=307..2826]
Length = 2520
Score = 73.6 bits (179), Expect = 7e-14, Method: Compositional matrix adjust.
Identities = 71/286 (24%), Positives = 125/286 (43%), Gaps = 36/286 (12%)
Frame = +1
Query: 43 LLKVLGQGSFGKVFLVR-KKTGPDAGQ-LYAMKVLKKASLKVRDRVRTKMERDILVEVNH 100
L + LG+G+FGKVFL P + L A+K LK +L R + E ++L + H
Sbjct: 1618 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDF--QREAELLTNLQH 1791
Query: 101 PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKE----VLFTEEDVKFYLAELALA--- 153
IVK + L ++ ++++ GD+ L ++ + + EL L+
Sbjct: 1792 EHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQML 1971
Query: 154 ---------LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE--SVDQEK----KA 198
+ +L V+RDL N L+ +K+ DFG+S++ S D +
Sbjct: 1972 HIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSG 2151
Query: 199 YSFCGTVE----------YMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRN 247
FC E +M PE + R + +D WS+GV+++E+ T G P+
Sbjct: 2152 NDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNT 2331
Query: 248 ETMNMILKAK-LGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEI 292
E + I + + L P+ E ++ ++R P RL + + +I
Sbjct: 2332 EVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKI 2469
>lcl|NM_005417.3_cdsid_NP_005408.1 [gene=SRC] [protein=proto-oncogene
tyrosine-protein kinase Src] [protein_id=NP_005408.1]
[location=450..2060]
Length = 1611
Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 62/244 (25%), Positives = 119/244 (48%), Gaps = 7/244 (2%)
Frame = +1
Query: 47 LGQGSFGKVFLVRKKTGPDAGQL-YAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVK 105
LGQG FG+V++ G G A+K LK ++ ++ E ++ ++ H +V+
Sbjct: 826 LGQGCFGEVWM-----GTWNGTTRVAIKTLKPGTMSPEAFLQ---EAQVMKKLRHEKLVQ 981
Query: 106 LHYAFQTEGKLYLILDFLRGGDVFTRLSKEV---LFTEEDVKFYLAELALALDHLHQLGI 162
L YA +E +Y++ +++ G + L E L + V A++A + ++ ++
Sbjct: 982 L-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM-AAQIASGMAYVERMNY 1155
Query: 163 VYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCG-TVEYMAPEVVNRRGHSQS 221
V+RDL+ NIL+ E K+ DFGL++ D E A +++ APE +
Sbjct: 1156 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 1335
Query: 222 ADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKA-KLGMPQFLSAEAQSLLRMLFKRN 279
+D WS+G+L+ E+ T G +P+ G E ++ + + ++ P L+ +++
Sbjct: 1336 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 1515
Query: 280 PANR 283
P R
Sbjct: 1516 PEER 1527
>lcl|NM_002344.5_cdsid_NP_002335.2 [gene=LTK] [protein=leukocyte
tyrosine kinase receptor isoform 1 precursor]
[protein_id=NP_002335.2] [location=179..2773]
Length = 2595
Score = 72.8 bits (177), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 67/275 (24%), Positives = 127/275 (46%), Gaps = 20/275 (7%)
Frame = +1
Query: 29 VKEGYEKADPAQFELLKVLGQGSFGKVF--LVRKKTGPDAGQLYAMKVLKKASLKVRDRV 86
+ G + PA LL+ LG G+FG+V+ LV G + A+K L + +D +
Sbjct: 1492 LPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELC-SPQDEL 1668
Query: 87 RTKMERDILVEVNHPFIVK-LHYAFQTEGKLYLILDFLRGGDV--FTRLSKEVL-----F 138
ME I+ + H IV+ + + + +L ++L+ + GGD+ F R S+ L
Sbjct: 1669 DFLMEALIISKFRHQNIVRCVGLSLRATPRL-ILLELMSGGDMKSFLRHSRPHLGQPSPL 1845
Query: 139 TEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGH---IKLTDFGLSKESVDQE 195
D+ ++A +L + ++RD+ N LL G K+ DFG+++ D
Sbjct: 1846 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMAR---DIY 2016
Query: 196 KKAYSFCG-----TVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNET 249
+ +Y G V++M PE + D WS+GVL++E+ + G +P+ G+ E
Sbjct: 2017 RASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEV 2196
Query: 250 MNMIL-KAKLGMPQFLSAEAQSLLRMLFKRNPANR 283
++ ++ ++ P+ ++ ++ P R
Sbjct: 2197 LDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELR 2301
>lcl|NM_000875.3_cdsid_NP_000866.1 [gene=IGF1R] [protein=insulin-like
growth factor 1 receptor precursor]
[protein_id=NP_000866.1] [location=51..4154]
Length = 4104
Score = 71.6 bits (174), Expect = 3e-13, Method: Compositional matrix adjust.
Identities = 62/253 (24%), Positives = 117/253 (46%), Gaps = 16/253 (6%)
Frame = +1
Query: 47 LGQGSFGKVF--LVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIV 104
LGQGSFG V+ + + + A+K + +A+ +R+R+ E ++ E N +V
Sbjct: 3013 LGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAA-SMRERIEFLNEASVMKEFNCHHVV 3189
Query: 105 KLHYAFQTEGKLYLILDFLRGGDVFTRL--------SKEVLFTEEDVKF--YLAELALAL 154
+L +I++ + GD+ + L + VL K E+A +
Sbjct: 3190 RLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGM 3369
Query: 155 DHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE--SVDQEKKAYSFCGTVEYMAPEV 212
+L+ V+RDL N ++ E +K+ DFG++++ D +K V +M+PE
Sbjct: 3370 AYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPES 3549
Query: 213 VNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKAK-LGMPQFLSAEAQS 270
+ + +D WS+GV+++E+ T P+QG + + +++ L P
Sbjct: 3550 LKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFE 3729
Query: 271 LLRMLFKRNPANR 283
L+RM ++ NP R
Sbjct: 3730 LMRMCWQYNPKMR 3768
>lcl|NM_006648.3_cdsid_NP_006639.3 [gene=WNK2]
[protein=serine/threonine-protein kinase WNK2]
[protein_id=NP_006639.3] [location=1..6654]
Length = 6654
Score = 71.2 bits (173), Expect = 4e-13, Method: Compositional matrix adjust.
Identities = 56/202 (27%), Positives = 101/202 (50%), Gaps = 7/202 (3%)
Frame = +1
Query: 47 LGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKL 106
LG+GSF V+ K + A L+ L +R R K E ++L + HP IV+
Sbjct: 601 LGRGSFKTVY---KGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRF 771
Query: 107 HYAFQTEGK----LYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLG- 161
+ +++ K + L+ + + G + T L + + + ++ + ++ L LH
Sbjct: 772 YDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTP 951
Query: 162 -IVYRDLKPENILLD-EIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHS 219
I++RDLK +NI + G +K+ D GL+ ++ + A S GT E+MAPE+ +
Sbjct: 952 PIIHRDLKCDNIFITGPTGSVKIGDLGLA--TLKRASFAKSVIGTPEFMAPEMYEEH-YD 1122
Query: 220 QSADWWSYGVLMFEMLTGTLPF 241
+S D +++G+ M EM T P+
Sbjct: 1123ESVDVYAFGMCMLEMATSEYPY 1188
Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 42/151 (27%), Positives = 68/151 (45%), Gaps = 12/151 (7%)
Frame = +1
Query: 399 DIGVGSYSVCKRCIHATTNMEFAV------KIIDKSKRDPSEEIEILMRYGQHPNIITLK 452
++G GS+ + + T +E A K+ ++ EE E+L QHPNI+
Sbjct: 598 ELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGL-QHPNIVRFY 774
Query: 453 DVFDDG----RYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG-- 506
D ++ R + LVT+LM G L + + K + I K + +LH +
Sbjct: 775 DFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPP 954
Query: 507 VVHRDLKPSNILYMDESASADSIRICDFGFA 537
++HRDLK NI + S++I D G A
Sbjct: 955 IIHRDLKCDNIFI---TGPTGSVKIGDLGLA 1038
>lcl|NM_002747.3_cdsid_NP_002738.2 [gene=MAPK4]
[protein=mitogen-activated protein kinase 4]
[protein_id=NP_002738.2] [location=1001..2764]
Length = 1764
Score = 71.2 bits (173), Expect = 4e-13, Method: Compositional matrix adjust.
Identities = 66/246 (26%), Positives = 113/246 (45%), Gaps = 17/246 (6%)
Frame = +1
Query: 47 LGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKL 106
LG G G V + D+ + V K A R E I+ ++H IVK+
Sbjct: 76 LGFGVNGLVL-----SAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKV 240
Query: 107 HYAFQTEGK-----------LYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 155
+ +G Y++ +++ RL ++ EE K ++ +L L
Sbjct: 241 YEVLGPKGTDLQGELFKFSVAYIVQEYMETD--LARLLEQGTLAEEHAKLFMYQLLRGLK 414
Query: 156 HLHQLGIVYRDLKPENILLD-EIGHIKLTDFGLSKESVDQ--EKKAYSFCGTVE--YMAP 210
++H +++RDLKP NI + E +K+ DFGL++ VDQ K Y G V Y +P
Sbjct: 415 YIHSANVLHRDLKPANIFISTEDLVLKIGDFGLAR-IVDQHYSHKGYLSEGLVTKWYRSP 591
Query: 211 E-VVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQ 269
+++ ++++ D W+ G ++ EMLTG + F G E M +IL+ +P +
Sbjct: 592 RLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILET---IPVIREEDKD 762
Query: 270 SLLRML 275
LLR++
Sbjct: 763 ELLRVM 780
Score = 51.6 bits (122), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 42/154 (27%), Positives = 70/154 (45%), Gaps = 15/154 (9%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKIID----KSKRDPSEEIEILMRYGQHPNIITLKDVF 455
+G G + + + + AVK I +S + EI+I+ R H NI+ + +V
Sbjct: 76 LGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRL-DHDNIVKVYEVL 252
Query: 456 DDG-----------RYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHC 504
Y+V + M+ L R+L+Q +E A +Y + + + Y+H
Sbjct: 253 GPKGTDLQGELFKFSVAYIVQEYMETD--LARLLEQGTLAEEHAKLFMYQLLRGLKYIHS 426
Query: 505 QGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
V+HRDLKP+NI E ++I DFG A+
Sbjct: 427 ANVLHRDLKPANIFISTEDL---VLKIGDFGLAR 519
>lcl|NM_005248.2_cdsid_NP_005239.1 [gene=FGR]
[protein=tyrosine-protein kinase Fgr]
[protein_id=NP_005239.1] [location=229..1818]
Length = 1590
Score = 70.9 bits (172), Expect = 5e-13, Method: Compositional matrix adjust.
Identities = 61/256 (23%), Positives = 123/256 (48%), Gaps = 11/256 (4%)
Frame = +1
Query: 39 AQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEV 98
+ L + LG G FG V+L + A+K LK ++ + + E ++ +
Sbjct: 781 SSITLERRLGTGCFGDVWLGTW----NGSTKVAVKTLKPGTMSPKAFLE---EAQVMKLL 939
Query: 99 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKF-----YLAELALA 153
H +V+L YA +E +Y++ +F+ G + L +D++ A++A
Sbjct: 940 RHDKLVQL-YAVVSEEPIYIVTEFMCHGSLLDFLKNP---EGQDLRLPQLVDMAAQVAEG 1107
Query: 154 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFC-GT---VEYMA 209
+ ++ ++ ++RDL+ NIL+ E K+ DFGL++ D E Y+ C G+ +++ A
Sbjct: 1108 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDE---YNPCQGSKFPIKWTA 1278
Query: 210 PEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKA-KLGMPQFLSAE 267
PE + +D WS+G+L+ E++T G +P+ G ++ E + + + + P A
Sbjct: 1279 PEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPAS 1458
Query: 268 AQSLLRMLFKRNPANR 283
+ ++ +P R
Sbjct: 1459 LYEAMEQTWRLDPEER 1506
>lcl|NM_020639.2_cdsid_NP_065690.2 [gene=RIPK4]
[protein=receptor-interacting serine/threonine-protein
kinase 4] [protein_id=NP_065690.2] [location=49..2403]
Length = 2355
Score = 70.1 bits (170), Expect = 8e-13, Method: Compositional matrix adjust.
Identities = 62/235 (26%), Positives = 111/235 (47%), Gaps = 12/235 (5%)
Frame = +1
Query: 37 DPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILV 96
D +F + +G G FG+V+ VR + + SL V DR R ++L
Sbjct: 52 DAGEFTGWEKVGSGGFGQVYKVRH-----VHWKTWLAIKCSPSLHVDDRERM----ELLE 204
Query: 97 EVNHPFIVKLHYAFQTEG----KLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLA-ELA 151
E + K Y G + L+++++ G + L+ E L D++F + E A
Sbjct: 205 EAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPL--PWDLRFRIIHETA 378
Query: 152 LALDHLHQLG--IVYRDLKPENILLDEIGHIKLTDFGLSK---ESVDQEKKAYSFCGTVE 206
+ ++ LH + +++ DLKP NILLD H+K++DFGL+K S + GT+
Sbjct: 379 VGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIA 558
Query: 207 YMAPEVVNRRGH--SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLG 259
Y+ PE + + D +S+ ++++ +LT PF D +++++K G
Sbjct: 559 YLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFA--DEKNILHIMVKVVKG 717
>lcl|NM_002019.4_cdsid_NP_002010.2 [gene=FLT1] [protein=vascular
endothelial growth factor receptor 1 isoform 1 precursor]
[protein_id=NP_002010.2] [location=286..4302]
Length = 4017
Score = 70.1 bits (170), Expect = 9e-13, Method: Compositional matrix adjust.
Identities = 50/172 (29%), Positives = 89/172 (51%), Gaps = 6/172 (3%)
Frame = +1
Query: 139 TEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE---SVDQE 195
T ED+ Y ++A ++ L ++RDL NILL E +K+ DFGL+++ + D
Sbjct: 2983 TMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYV 3162
Query: 196 KKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMIL 254
+K + +++MAPE + + +S +D WSYGVL++E+ + G P+ G +E L
Sbjct: 3163 RKGDTRL-PLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRL 3339
Query: 255 KAKLGM--PQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWD 304
+ + M P++ + E ++ + R+P R + E L AN+ D
Sbjct: 3340 REGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQD 3495
>lcl|NM_004304.4_cdsid_NP_004295.2 [gene=ALK] [protein=ALK tyrosine
kinase receptor precursor] [protein_id=NP_004295.2]
[location=953..5815]
Length = 4863
Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 59/257 (22%), Positives = 114/257 (44%), Gaps = 16/257 (6%)
Frame = +1
Query: 43 LLKVLGQGSFGKVFLVRKKTGP-DAGQL-YAMKVLKKASLKVRDRVRTKMERDILVEVNH 100
L++ LG G+FG+V+ + P D L A+K L + + +D + ME I+ + NH
Sbjct: 3352 LIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSE-QDELDFLMEALIISKFNH 3528
Query: 101 PFIVKLHYAFQTEGKLYLILDFLRGGDVFT-------RLSKEVLFTEEDVKFYLAELALA 153
IV+ +++L+ + GGD+ + R S+ D+ ++A
Sbjct: 3529 QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACG 3708
Query: 154 LDHLHQLGIVYRDLKPENILLDEIGH---IKLTDFGLSKESVDQEKKAYSFCG--TVEYM 208
+L + ++RD+ N LL G K+ DFG++++ C V++M
Sbjct: 3709 CQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWM 3888
Query: 209 APEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILK-AKLGMPQFLSA 266
PE + D WS+GVL++E+ + G +P+ K E + + ++ P+
Sbjct: 3889 PPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG 4068
Query: 267 EAQSLLRMLFKRNPANR 283
++ ++ P +R
Sbjct: 4069 PVYRIMTQCWQHQPEDR 4119
>lcl|NM_012119.4_cdsid_NP_036251.2 [gene=CDK20]
[protein=cyclin-dependent kinase 20 isoform 2]
[protein_id=NP_036251.2] [location=335..1312]
Length = 978
Score = 67.4 bits (163), Expect = 5e-12, Method: Compositional matrix adjust.
Identities = 62/225 (27%), Positives = 103/225 (45%), Gaps = 3/225 (1%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI--LVE 97
Q+ +L +G+G+ G VF K + G++ A+K K A ++ D + R+I L E
Sbjct: 7 QYCILGRIGEGAHGIVF---KAKHVETGEIVALK--KVALRRLEDGFPNQALREIKALQE 171
Query: 98 V-NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDH 156
+ ++ ++V+L F G L +F+ + + VK YL L +
Sbjct: 172 MEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAF 351
Query: 157 LHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRR 216
H IV+RDLKP N+L+ G +K+ DFGL++ + Y+ +V R
Sbjct: 352 CHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTH---------QVATR- 501
Query: 217 GHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMP 261
S G +M E+L G+ F GK+ E + +L+ LG P
Sbjct: 502 ---------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRI-LGTP 606
Score = 53.5 bits (127), Expect = 8e-08, Method: Compositional matrix adjust.
Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 8/147 (5%)
Frame = +1
Query: 400 IGVGSYSVCKRCIHATTNMEFAVKII------DKSKRDPSEEIEILMRYGQHPNIITLKD 453
IG G++ + + H T A+K + D EI+ L + ++ LK
Sbjct: 28 IGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKA 207
Query: 454 VFDDGRYVYLVTDLMKGGELLDRILK--QKCFSEREASDILYVISKTVDYLHCQGVVHRD 511
VF G L + M L +++ Q+ ++ + L ++ K V + H +VHRD
Sbjct: 208 VFPHGGGFVLAFEFMLSD--LAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRD 381
Query: 512 LKPSNILYMDESASADSIRICDFGFAK 538
LKP+N+L +++ ++I DFG A+
Sbjct: 382 LKPANLLI----SASGQLKIADFGLAR 450
>lcl|NM_015076.3_cdsid_NP_055891.1 [gene=CDK19]
[protein=cyclin-dependent kinase 19]
[protein_id=NP_055891.1] [location=74..1582]
Length = 1509
Score = 67.0 bits (162), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 61/226 (26%), Positives = 108/226 (47%), Gaps = 18/226 (7%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVN 99
++E KV G+G++G V+ R+K G D + YA+K ++ + + E +L E+
Sbjct: 61 EYEGCKV-GRGTYGHVYKARRKDGKDEKE-YALKQIEGTGISMS----ACREIALLRELK 222
Query: 100 HPFIVKLHYAF--QTEGKLYLILDF----LRGGDVFTRLSKE----VLFTEEDVKFYLAE 149
HP ++ L F ++ K++L+ D+ L F R SK + VK L +
Sbjct: 223 HPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQ 402
Query: 150 LALALDHLHQLGIVYRDLKPENILL----DEIGHIKLTDFGLSKESVDQEKKAYSF---C 202
+ + +LH +++RDLKP NIL+ E G +K+ D G ++ K
Sbjct: 403 ILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVV 582
Query: 203 GTVEYMAPE-VVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRN 247
T Y APE ++ R ++++ D W+ G + E+LT F + +
Sbjct: 583 VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 720
Score = 63.9 bits (154), Expect = 7e-11, Method: Compositional matrix adjust.
Identities = 51/159 (32%), Positives = 73/159 (45%), Gaps = 13/159 (8%)
Frame = +1
Query: 400 IGVGSYSVC--KRCIHATTNMEFAVKIIDKSKRDPSEEIEI-LMRYGQHPNIITLKDVF- 455
+G G+Y R E+A+K I+ + S EI L+R +HPN+I L+ VF
Sbjct: 79 VGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFL 258
Query: 456 -DDGRYVYLVTD--------LMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 506
R V+L+ D ++K K +LY I + YLH
Sbjct: 259 SHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANW 438
Query: 507 VVHRDLKPSNILYMDESASADSIRICDFGFAKQPPDPLQ 545
V+HRDLKP+NIL M E ++I D GFA+ PL+
Sbjct: 439 VLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLK 555
>lcl|NM_139355.2_cdsid_NP_647612.1 [gene=MATK]
[protein=megakaryocyte-associated tyrosine-protein
kinase isoform a] [protein_id=NP_647612.1]
[location=401..1924]
Length = 1524
Score = 67.0 bits (162), Expect = 7e-12, Method: Compositional matrix adjust.
Identities = 64/245 (26%), Positives = 110/245 (44%), Gaps = 8/245 (3%)
Frame = +1
Query: 47 LGQGSFGKVFLVRKKTGPDAGQLYAMKVLK----KASLKVRDRVRTKMERDILVEVNHPF 102
+G+G FG V G GQ A+K +K + V TKM+ + LV +
Sbjct: 721 IGEGEFGAVL-----QGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRL---L 876
Query: 103 IVKLHYAFQTEGKLYLILDFLRGGDV--FTRLSKEVLFTEEDVKFYLAELALALDHLHQL 160
V LH LY++++ + G++ F R L + + +A +++L
Sbjct: 877 GVILHQG------LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESK 1038
Query: 161 GIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQ 220
+V+RDL NIL+ E K++DFGL+K + K S V++ APE + +
Sbjct: 1039KLVHRDLAARNILVSEDLVAKVSDFGLAKA---ERKGLDSSRLPVKWTAPEALKHGKFTS 1209
Query: 221 SADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKA-KLGMPQFLSAEAQSLLRMLFKR 278
+D WS+GVL++E+ + G P+ E + K ++ P+ L+ ++
Sbjct: 1210KSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEA 1389
Query: 279 NPANR 283
PA R
Sbjct: 1390EPARR 1404
>lcl|NM_002020.4_cdsid_NP_002011.2 [gene=FLT4] [protein=vascular
endothelial growth factor receptor 3 isoform 2 precursor]
[protein_id=NP_002011.2] [location=80..3976]
Length = 3897
Score = 66.6 bits (161), Expect = 9e-12, Method: Compositional matrix adjust.
Identities = 86/346 (24%), Positives = 146/346 (42%), Gaps = 84/346 (24%)
Frame = +1
Query: 22 EIPITHHVKEGYEKADPAQFE-------LLKVLGQGSFGKV-----FLVRKKTGPDAGQL 69
E+P+ + Y D +Q+E L +VLG G+FGKV F + K + D
Sbjct: 2461 EVPLEEQCE--YLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDT--- 2625
Query: 70 YAMKVLKKASLKVRDRVRTKMERDILVEV-NHPFIVKLHYAF-QTEGKLYLIL------- 120
A+K+LK+ + R E IL+ + NH +V L A + +G L +I+
Sbjct: 2626 VAVKMLKEGATASEHRALMS-ELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGN 2802
Query: 121 --DFLRGG-DVFT--------------------RL-------SKEVLF------------ 138
+FLR D F+ RL S VLF
Sbjct: 2803 LSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARR 2982
Query: 139 ---------------TEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLT 183
T ED+ Y ++A ++ L ++RDL NILL E +K+
Sbjct: 2983 ASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKIC 3162
Query: 184 DFGLSKE---SVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTL 239
DFGL+++ D +K + +++MAPE + + ++ +D WS+GVL++E+ + G
Sbjct: 3163 DFGLARDIYKDPDYVRKGSARL-PLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGAS 3339
Query: 240 PFQGKDRNETMNMILK--AKLGMPQFLSAEAQSLLRMLFKRNPANR 283
P+ G NE L+ ++ P+ + + ++ + +P R
Sbjct: 3340 PYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKAR 3477
>lcl|NM_004071.3_cdsid_NP_004062.2 [gene=CLK1] [protein=dual
specificity protein kinase CLK1 isoform 1]
[protein_id=NP_004062.2] [location=182..1636]
Length = 1455
Score = 65.5 bits (158), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 62/251 (24%), Positives = 113/251 (45%), Gaps = 25/251 (9%)
Frame = +1
Query: 39 AQFELLKVLGQGSFGKVF-LVRKKTGPDAGQLYAMKVLKKASL---KVRDRVRTKMERDI 94
A++E++ LG+G+FGKV + K G G+ A+K++K R ++ +E
Sbjct: 475 ARYEIVDTLGEGAFGKVVECIDHKAG---GRHVAVKIVKNVDRYCEAARSEIQV-LEHLN 642
Query: 95 LVEVNHPF-IVKLHYAFQTEGKLYLILDFLRGGDV-FTRLSKEVLFTEEDVKFYLAELAL 152
+ N F V++ F+ G + ++ + L F + + + F + ++ ++
Sbjct: 643 TTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICK 822
Query: 153 ALDHLHQLGIVYRDLKPENILLDEIGH-------------------IKLTDFGLSKESVD 193
+++ LH + + DLKPENIL + + IK+ DFG + + D
Sbjct: 823 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA--TYD 996
Query: 194 QEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMI 253
E + + T Y APEV+ G SQ D WS G ++ E G F D E + M+
Sbjct: 997 DEHHS-TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMM 1173
Query: 254 LKAKLGMPQFL 264
+ +P+ +
Sbjct: 1174ERILGPLPKHM 1206
>lcl|NM_024652.3_cdsid_NP_078928.3 [gene=LRRK1] [protein=leucine-rich
repeat serine/threonine-protein kinase 1]
[protein_id=NP_078928.3] [location=320..6367]
Length = 6048
Score = 65.5 bits (158), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 77/287 (26%), Positives = 128/287 (44%), Gaps = 35/287 (12%)
Frame = +1
Query: 46 VLGQGSFGKV-FLVRKKTGPDAGQLYAMKVLKKAS----------LKVRDRVRT----KM 90
VLGQG G V + R + P A + + +K K + L+ D ++ +
Sbjct: 3739 VLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQ 3918
Query: 91 ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFY---- 146
E +L + HP IV L + L L+ + T LS+ D F
Sbjct: 3919 EASMLHALQHPCIVAL--IGISIHPLCFALELAPLSSLNTVLSENA----RDSSFIPLGH 4080
Query: 147 ------LAELALALDHLHQLGIVYRDLKPENIL---LDEIGHI--KLTDFGLSKESVDQE 195
++A L +LH+ I++ DLK +NIL LD HI KL+D+G+S++S +
Sbjct: 4081 MLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHE- 4257
Query: 196 KKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMI-- 253
A GT Y APE+ R + + D +SYG++++E+L+G P G + + +
Sbjct: 4258 -GALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSK 4434
Query: 254 -LKAKLGMPQFLS-AEAQSLLRMLFKRNPANR-LGSEGVEEIKRHLF 297
++ LG P+ + Q+L+ + P R L V ++K F
Sbjct: 4435 GIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTF 4575
>lcl|NM_001024847.2_cdsid_NP_001020018.1 [gene=TGFBR2]
[protein=TGF-beta receptor type-2 isoform A precursor]
[protein_id=NP_001020018.1] [location=383..2161]
Length = 1779
Score = 64.7 bits (156), Expect = 3e-11, Method: Compositional matrix adjust.
Identities = 62/223 (27%), Positives = 108/223 (48%), Gaps = 27/223 (12%)
Frame = +1
Query: 41 FELLKVLGQGSFGKVFLVR-KKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVN 99
EL ++G+G F +V+ + K+ + + A+K+ + K E+DI ++N
Sbjct: 805 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP-----YEEYASWKTEKDIFSDIN 969
Query: 100 --HPFIVKLHYAFQTEGKL----YLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALA 153
H I++ A + + +L +LI F G++ L++ V+ + ED++ + LA
Sbjct: 970 LKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVI-SWEDLRKLGSSLARG 1146
Query: 154 LDHLH---------QLGIVYRDLKPENILLDEIGHIKLTDFGLSKE-----SVDQEKKAY 199
+ HLH ++ IV+RDLK NIL+ L DFGLS SVD +
Sbjct: 1147 IAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSG 1326
Query: 200 SFCGTVEYMAPEVVNRRGHSQS------ADWWSYGVLMFEMLT 236
GT YMAPEV+ R + ++ D +S ++++EM +
Sbjct: 1327 QV-GTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTS 1452
>lcl|NM_032387.4_cdsid_NP_115763.2 [gene=WNK4]
[protein=serine/threonine-protein kinase WNK4]
[protein_id=NP_115763.2] [location=69..3800]
Length = 3732
Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust.
Identities = 52/202 (25%), Positives = 102/202 (50%), Gaps = 7/202 (3%)
Frame = +1
Query: 47 LGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKL 106
+G+GSF V+ + D A L+ L +R R E ++L + HP IV+
Sbjct: 538 IGRGSFKTVY---RGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRF 708
Query: 107 HYAFQT--EGKLYLIL--DFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQL-- 160
+ ++++ G++ ++L + + G + T L + ++ + ++ L LH
Sbjct: 709 YDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVP 888
Query: 161 GIVYRDLKPENILLD-EIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHS 219
I++RDLK +N+ + G +K+ D GL+ ++ + A S GT E+MAPE+ + +
Sbjct: 889 PILHRDLKCDNVFITGPTGSVKIGDLGLA--TLKRASFAKSVIGTPEFMAPEMYEEK-YD 1059
Query: 220 QSADWWSYGVLMFEMLTGTLPF 241
++ D +++G+ M EM T P+
Sbjct: 1060EAVDVYAFGMCMLEMATSEYPY 1125
Score = 52.8 bits (125), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 43/151 (28%), Positives = 72/151 (47%), Gaps = 12/151 (7%)
Frame = +1
Query: 399 DIGVGSYSVCKRCIHATTNMEFA-----VKIIDKSKRDP-SEEIEILMRYGQHPNII--- 449
+IG GS+ R + T +E A + + +++R SEE+E+L + QHPNI+
Sbjct: 535 EIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEML-KGLQHPNIVRFY 711
Query: 450 -TLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ--G 506
+ K V + LVT+LM G L + + + R I + + +LH +
Sbjct: 712 DSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPP 891
Query: 507 VVHRDLKPSNILYMDESASADSIRICDFGFA 537
++HRDLK N+ + S++I D G A
Sbjct: 892 ILHRDLKCDNVFI---TGPTGSVKIGDLGLA 975
>lcl|NM_005781.4_cdsid_NP_005772.3 [gene=TNK2] [protein=activated
CDC42 kinase 1 isoform 1] [protein_id=NP_005772.3]
[location=544..3660]
Length = 3117
Score = 62.8 bits (151), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 71/294 (24%), Positives = 126/294 (42%), Gaps = 37/294 (12%)
Frame = +1
Query: 27 HHVKEGYEKADPA--------------------QFELLKVLGQGSFGKVFLVRKKTGPDA 66
HH + + K PA LL+ LG GSFG V R + +
Sbjct: 274 HHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVV--RRGEWDAPS 447
Query: 67 GQLY--AMKVLKKASLK----VRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLIL 120
G+ A+K LK L + D +R E + + ++H +++L Y + ++
Sbjct: 448 GKTVSVAVKCLKPDVLSQPEAMDDFIR---EVNAMHSLDHRNLIRL-YGVVLTPPMKMVT 615
Query: 121 DFLRGGDVFTRLSK-EVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGH 179
+ G + RL K + F + Y ++A + +L ++RDL N+LL
Sbjct: 616 ELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDL 795
Query: 180 IKLTDFGLSK-------ESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMF 232
+K+ DFGL + V QE + F + APE + R S ++D W +GV ++
Sbjct: 796 VKIGDFGLMRALPQNDDHYVMQEHRKVPFA----WCAPESLKTRTFSHASDTWMFGVTLW 963
Query: 233 EMLT-GTLPFQGKDRNETMNMILK--AKLGMPQFLSAEAQSLLRMLFKRNPANR 283
EM T G P+ G + ++ ++ I K +L P+ + +++ + P +R
Sbjct: 964 EMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDR 1125
>lcl|NM_014215.2_cdsid_NP_055030.1 [gene=INSRR] [protein=insulin
receptor-related protein precursor]
[protein_id=NP_055030.1] [location=300..4193]
Length = 3894
Score = 62.8 bits (151), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 59/264 (22%), Positives = 114/264 (43%), Gaps = 20/264 (7%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVF--LVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVE 97
Q +++ LGQGSFG V+ L R + A+K + + + R+ + E ++
Sbjct: 2932 QISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELA-SPRECIEFLKEASVMKA 3108
Query: 98 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKF----------YL 147
+V+L +I++ + GD+ + L E +
Sbjct: 3109 FKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMA 3288
Query: 148 AELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE--SVDQEKKAYSFCGTV 205
E+A + +L V+RDL N ++ + +K+ DFG++++ D +K V
Sbjct: 3289 GEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPV 3468
Query: 206 EYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKAKL-----G 259
+MAPE + + +D WS+GV+++E++T P+QG + + ++ + G
Sbjct: 3469 RWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEG 3648
Query: 260 MPQFLSAEAQSLLRMLFKRNPANR 283
P L Q L+ ++ NP R
Sbjct: 3649 CPLQL----QELMSRCWQPNPRLR 3708
>lcl|NM_002253.2_cdsid_NP_002244.1 [gene=KDR] [protein=vascular
endothelial growth factor receptor 2 precursor]
[protein_id=NP_002244.1] [location=303..4373]
Length = 4071
Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 50/175 (28%), Positives = 87/175 (49%), Gaps = 7/175 (4%)
Frame = +1
Query: 137 LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE---SVD 193
T E + Y ++A ++ L ++RDL NILL E +K+ DFGL+++ D
Sbjct: 2995 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 3174
Query: 194 QEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNM 252
+K + +++MAPE + R ++ +D WS+GVL++E+ + G P+ G +E
Sbjct: 3175 YVRKGDARL-PLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCR 3351
Query: 253 ILK--AKLGMPQFLSAEAQSLLRMLFKRNPANRLG-SEGVEEIKRHLFFANIDWD 304
LK ++ P + + E + + P+ R SE VE + +L AN D
Sbjct: 3352 RLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLG-NLLQANAQQD 3513
>lcl|NM_005372.1_cdsid_NP_005363.1 [gene=MOS]
[protein=proto-oncogene serine/threonine-protein kinase
mos] [protein_id=NP_005363.1] [location=1..1041]
Length = 1041
Score = 61.6 bits (148), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 3/105 (2%)
Frame = +1
Query: 146 YLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQ---EKKAYSFC 202
Y ++ L LH IV+ DLKP NIL+ E K++DFG S++ D + +Y
Sbjct: 541 YSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLEDLLCFQTPSYPLG 720
Query: 203 GTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRN 247
GT + APE++ G + AD +S+ + +++M T P+ G+ ++
Sbjct: 721 GTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGERQH 855
>lcl|NM_001013703.2_cdsid_NP_001013725.2 [gene=EIF2AK4]
[protein=eukaryotic translation initiation factor 2-alpha
kinase 4] [protein_id=NP_001013725.2] [location=51..5000]
Length = 4950
Score = 58.5 bits (140), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 20/106 (18%)
Frame = +1
Query: 149 ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESV---------------- 192
E+ L ++H+ G+++RDLKP NI LD H+K+ DFGL+ + +
Sbjct: 2491 EILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLI 2670
Query: 193 --DQEKKAYSFCGTVEYMAPEV--VNRRGHSQSADWWSYGVLMFEM 234
D GT Y++PEV + ++Q D +S G++ FEM
Sbjct: 2671 KSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEM 2808
Score = 52.0 bits (123), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 32/110 (29%), Positives = 56/110 (50%), Gaps = 4/110 (3%)
Frame = +1
Query: 88 TKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFL----RGGDVFTRLSKEVLFTEEDV 143
T+ E + LV+++HP +V+ E +++D L G + LS +
Sbjct: 1027 TETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQL 1206
Query: 144 KFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVD 193
+ Y A+L LD+LH +V++ L N+L+D G +K+TD+ +SK D
Sbjct: 1207 RRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLAD 1356
>lcl|NM_001025243.1_cdsid_NP_001020414.1 [gene=IRAK1]
[protein=interleukin-1 receptor-associated kinase 1
isoform 3] [protein_id=NP_001020414.1]
[location=80..1981]
Length = 1902
Score = 57.0 bits (136), Expect = 6e-09, Method: Compositional matrix adjust.
Identities = 61/214 (28%), Positives = 95/214 (44%), Gaps = 23/214 (10%)
Frame = +1
Query: 47 LGQGSFGKVF-LVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEV------N 99
+G+G FG V+ V + T +YA+K LK+ + D T +++ L EV
Sbjct: 652 IGEGGFGCVYRAVMRNT------VYAVKRLKENA----DLEWTAVKQSFLTEVEQLSRFR 801
Query: 100 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEV-----LFTEEDVKFYLAELALAL 154
HP IV G L+ FL G + RL + L + + L A A+
Sbjct: 802 HPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGT-ARAI 978
Query: 155 DHLHQ--LGIVYRDLKPENILLDEIGHIKLTDFGLSK------ESVDQEK---KAYSFCG 203
LHQ +++ D+K N+LLDE KL DFGL++ S Q + + G
Sbjct: 979 QFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRG 1158
Query: 204 TVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTG 237
T+ Y+ E + + D +S+GV++ E L G
Sbjct: 1159TLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 1260
Score = 53.5 bits (127), Expect = 9e-08, Method: Compositional matrix adjust.
Identities = 50/176 (28%), Positives = 81/176 (46%), Gaps = 14/176 (7%)
Frame = +1
Query: 377 VLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKS-------- 428
P+ +I+ F E ELK IG G + R + N +AVK + ++
Sbjct: 595 CWPLCEISRGTHNFSE--ELK--IGEGGFGCVYRAV--MRNTVYAVKRLKENADLEWTAV 756
Query: 429 KRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRI--LKQKC--FS 484
K+ E+E L R+ +HPNI+ + LV + G L DR+ Q C S
Sbjct: 757 KQSFLTEVEQLSRF-RHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLS 933
Query: 485 EREASDILYVISKTVDYLH--CQGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
+ DIL ++ + +LH ++H D+K SN+L +DE + ++ DFG A+
Sbjct: 934 WPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVL-LDERLTP---KLGDFGLAR 1089
>lcl|NM_001160367.1_cdsid_NP_001153839.1 [gene=CDK10]
[protein=cyclin-dependent kinase 10 isoform d]
[protein_id=NP_001153839.1] [location=219..1088]
Length = 870
Score = 57.0 bits (136), Expect = 8e-09, Method: Compositional matrix adjust.
Identities = 45/174 (25%), Positives = 82/174 (47%), Gaps = 3/174 (1%)
Frame = +1
Query: 91 ERDILVEVNHPFIVKLHYAFQTEG--KLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLA 148
E +L+ + HP IV+L ++L++ + + F+E VK +
Sbjct: 43 EITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVL 222
Query: 149 ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYM 208
++ L +LH+ I++RDLK N+L+ + G +K DFGL++ K T+ Y
Sbjct: 223 QVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYR 402
Query: 209 APE-VVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMP 261
APE ++ + S D W+ G ++ E+L G +++I++ LG P
Sbjct: 403 APELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQL-LGTP 561
Score = 50.8 bits (120), Expect = 6e-07, Method: Compositional matrix adjust.
Identities = 35/108 (32%), Positives = 58/108 (53%), Gaps = 4/108 (3%)
Frame = +1
Query: 435 EIEILMRYGQHPNIITLKDVF--DDGRYVYLVTDLMKG--GELLDRILKQKCFSEREASD 490
EI +L+R +HPNI+ LK+V + ++LV + LL+ + FSE +
Sbjct: 43 EITLLLRL-RHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM--PTPFSEAQVKC 213
Query: 491 ILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAK 538
I+ + + + YLH ++HRDLK SN+L D+ ++ DFG A+
Sbjct: 214 IVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGC----VKTADFGLAR 345
>lcl|NM_005211.3_cdsid_NP_005202.2 [gene=CSF1R] [protein=macrophage
colony-stimulating factor 1 receptor precursor]
[protein_id=NP_005202.2] [location=293..3211]
Length = 2919
Score = 57.0 bits (136), Expect = 8e-09, Method: Compositional matrix adjust.
Identities = 39/150 (26%), Positives = 77/150 (51%), Gaps = 8/150 (5%)
Frame = +1
Query: 142 DVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHI-KLTDFGLSKESVDQEKKAYS 200
D+ + +++A + L ++RD+ N+LL GH+ K+ DFGL+++ ++ Y
Sbjct: 2260 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-GHVAKIGDFGLARDIMNDSN--YI 2430
Query: 201 FCGT----VEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILK 255
G V++MAPE + ++ +D WSYG+L++E+ + G P+ G N ++K
Sbjct: 2431 VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 2610
Query: 256 --AKLGMPQFLSAEAQSLLRMLFKRNPANR 283
++ P F S+++ + P +R
Sbjct: 2611 DGYQMAQPAFAPKNIYSIMQACWALEPTHR 2700
>lcl|NM_000222.2_cdsid_NP_000213.1 [gene=KIT] [protein=mast/stem cell
growth factor receptor Kit isoform 1 precursor]
[protein_id=NP_000213.1] [location=88..3018]
Length = 2931
Score = 56.2 bits (134), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 37/142 (26%), Positives = 69/142 (48%), Gaps = 7/142 (4%)
Frame = +1
Query: 149 ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGT---- 204
++A + L ++RDL NILL K+ DFGL+++ + Y G
Sbjct: 2323 QVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSN--YVVKGNARLP 2496
Query: 205 VEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMNMILKAKLGM--P 261
V++MAPE + ++ +D WSYG+ ++E+ + G+ P+ G + ++K M P
Sbjct: 2497 VKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSP 2676
Query: 262 QFLSAEAQSLLRMLFKRNPANR 283
+ AE +++ + +P R
Sbjct: 2677 EHAPAEMYDIMKTCWDADPLKR 2742
>lcl|NM_018571.5_cdsid_NP_061041.2 [gene=STRADB]
[protein=STE20-related kinase adapter protein beta
isoform 1] [protein_id=NP_061041.2] [location=366..1622]
Length = 1257
Score = 55.5 bits (132), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 38/134 (28%), Positives = 65/134 (48%), Gaps = 9/134 (6%)
Frame = +1
Query: 394 YELKEDIGVG--SYSVCKRCIHATTNMEFAVKIID-----KSKRDPSEEIEILMRYGQHP 446
YEL+ +IG G + + H T +KI + + + ++ IL + +HP
Sbjct: 172 YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 351
Query: 447 NIITLKDVFDDGRYVYLVTDLMKGGEL--LDRILKQKCFSEREASDILYVISKTVDYLHC 504
NI T VF G ++++++ M G L R + SE +IL+ + ++YLH
Sbjct: 352 NITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQ 531
Query: 505 QGVVHRDLKPSNIL 518
G +HR +K S+IL
Sbjct: 532 NGCIHRSIKASHIL 573
>lcl|NM_004119.2_cdsid_NP_004110.2 [gene=FLT3] [protein=receptor-type
tyrosine-protein kinase FLT3] [protein_id=NP_004110.2]
[location=83..3064]
Length = 2982
Score = 53.9 bits (128), Expect = 6e-08, Method: Compositional matrix adjust.
Identities = 35/131 (26%), Positives = 67/131 (51%), Gaps = 5/131 (3%)
Frame = +1
Query: 137 LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEK 196
+ T ED+ + ++A ++ L V+RDL N+L+ +K+ DFGL+++ +
Sbjct: 2344 VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSN 2523
Query: 197 KAYSFCGT----VEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLPFQGKDRNETMN 251
Y G V++MAPE + ++ +D WSYG+L++E+ + G P+ G +
Sbjct: 2524 --YVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY 2697
Query: 252 MILKAKLGMPQ 262
+++ M Q
Sbjct: 2698 KLIQNGFKMDQ 2730
>lcl|NM_014238.1_cdsid_NP_055053.1 [gene=KSR1] [protein=kinase
suppressor of Ras 1] [protein_id=NP_055053.1]
[location=446..2734]
Length = 2289
Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 62/246 (25%), Positives = 110/246 (44%), Gaps = 19/246 (7%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVN 99
Q EL + +GQG +G+V R G A +L M + LK+ K E +
Sbjct: 1423 QVELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKL-----FKKEVMNYRQTR 1584
Query: 100 HPFIVKLHYAFQTEGKLYLILDFLRGGDV--FTRLSKEVLFTEEDVKFYLAELALALDHL 157
H +V A L +I F +G + F R K L + + E+ + +L
Sbjct: 1585 HENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINK-TRQIAQEIIKGMGYL 1761
Query: 158 HQLGIVYRDLKPENILLDEIGHIKLTDFGL--------SKESVDQEKKAYSFCGTVEYMA 209
H GIV++DLK +N+ D G + +TDFGL +Q K ++ + + Y+A
Sbjct: 1762 HAKGIVHKDLKSKNVFYDN-GKVVITDFGLFGISGVVREGRRENQLKLSHDW---LCYLA 1929
Query: 210 PEVV---------NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGM 260
PE+V ++ S++AD +++G + +E+ P + + ++ I + GM
Sbjct: 1930 PEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGE-GM 2106
Query: 261 PQFLSA 266
+ L++
Sbjct: 2107 KRVLTS 2124
>lcl|NM_014916.3_cdsid_NP_055731.2 [gene=LMTK2]
[protein=serine/threonine-protein kinase LMTK2
precursor] [protein_id=NP_055731.2] [location=294..4805]
Length = 4512
Score = 52.4 bits (124), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 61/277 (22%), Positives = 114/277 (41%), Gaps = 24/277 (8%)
Frame = +1
Query: 44 LKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFI 103
++ +G G FGKV L TG ++ ++ A+ K +D E +++ HP I
Sbjct: 418 IQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQ--HPNI 591
Query: 104 VKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYL-----AELALALDHLH 158
++ L+ +F GD+ L E D + L E+A L +H
Sbjct: 592 LQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMH 771
Query: 159 QLGIVYRDLKPENILLDEIGHIKLTDFGL--SKESVD----QEKKAYSFCGTVEYMAPEV 212
+L ++ DL N L ++K+ D+G+ S+ D +KK + + + APE+
Sbjct: 772 KLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFP----LRWTAPEL 939
Query: 213 VNR-------RGHSQSADWWSYGVLMFEML-TGTLPFQGKDRNETMNMILK---AKLGMP 261
V ++ ++ WS GV ++E+ P+ + +N +++ KL P
Sbjct: 940 VTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKP 1119
Query: 262 QFLSAEAQSLLRML--FKRNPANRLGSEGVEEIKRHL 296
Q + +L +P R +E V + +L
Sbjct: 1120QLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYL 1230
>lcl|NM_173598.4_cdsid_NP_775869.3 [gene=KSR2] [protein=kinase
suppressor of Ras 2] [protein_id=NP_775869.3]
[location=56..2821]
Length = 2766
Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 48/222 (21%), Positives = 105/222 (47%), Gaps = 17/222 (7%)
Frame = +1
Query: 40 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILV--E 97
Q E+ +++G+G FG+V+ R G A +L ++ + LK +R+++ +
Sbjct: 1906 QLEIGELIGKGRFGQVYHGRWH-GEVAIRLIDIERDNEDQLKA-------FKREVMAYRQ 2061
Query: 98 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRL-SKEVLFTEEDVKFYLAELALALDH 156
H +V A + L +I +G +++ + +++ + E+ + +
Sbjct: 2062 TRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGY 2241
Query: 157 LHQLGIVYRDLKPENILLDEIGHIKLTDFGLSK-----ESVDQEKKAYSFCGTVEYMAPE 211
LH GI+++DLK +N+ D G + +TDFGL ++ +E K G + ++APE
Sbjct: 2242 LHAKGILHKDLKSKNVFYDN-GKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPE 2418
Query: 212 VV---------NRRGHSQSADWWSYGVLMFEMLTGTLPFQGK 244
++ ++ S+ +D ++ G + +E+ PF+ +
Sbjct: 2419 IIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQ 2544
Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 41/152 (26%), Positives = 70/152 (46%), Gaps = 7/152 (4%)
Frame = +1
Query: 392 EVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEI----LMRYGQ--H 445
E E+ E IG G + + H + E A+++ID +RD ++++ +M Y Q H
Sbjct: 1903 EQLEIGELIGKGRFG---QVYHGRWHGEVAIRLID-IERDNEDQLKAFKREVMAYRQTRH 2070
Query: 446 PNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSE-REASDILYVISKTVDYLHC 504
N++ ++ ++T L KG L + K + + I I K + YLH
Sbjct: 2071 ENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHA 2250
Query: 505 QGVVHRDLKPSNILYMDESASADSIRICDFGF 536
+G++H+DLK N+ Y + I DFG
Sbjct: 2251 KGILHKDLKSKNVFY-----DNGKVVITDFGL 2331
>lcl|NM_005255.2_cdsid_NP_005246.2 [gene=GAK]
[protein=cyclin-G-associated kinase]
[protein_id=NP_005246.2] [location=200..4135]
Length = 3936
Score = 50.1 bits (118), Expect = 9e-07, Method: Compositional matrix adjust.
Identities = 46/160 (28%), Positives = 75/160 (46%), Gaps = 12/160 (7%)
Frame = +1
Query: 390 FGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNII 449
F VYE +D+G G KR + +N E + R +E+ + + HPNI+
Sbjct: 151 FAFVYE-AQDVGSGREYALKRLL---SNEE-------EKNRAIIQEVCFMKKLSGHPNIV 297
Query: 450 TL-------KDVFDDGRYVYLV-TDLMKGG--ELLDRILKQKCFSEREASDILYVISKTV 499
K+ D G+ +L+ T+L KG E L ++ + S I Y + V
Sbjct: 298 QFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAV 477
Query: 500 DYLHCQG--VVHRDLKPSNILYMDESASADSIRICDFGFA 537
++H Q ++HRDLK N+L ++ +I++CDFG A
Sbjct: 478 QHMHRQKPPIIHRDLKVENLLLSNQG----TIKLCDFGSA 585
>lcl|NM_032538.1_cdsid_NP_115927.1 [gene=TTBK1] [protein=tau-tubulin
kinase 1] [protein_id=NP_115927.1] [location=280..4245]
Length = 3966
Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 61/256 (23%), Positives = 104/256 (40%), Gaps = 34/256 (13%)
Frame = +1
Query: 32 GYEKAD--PAQF------ELLKVLGQGSFGKVF-----LVRK------KTGPDAGQLYAM 72
G E+AD PA + ++LK +G G FG+++ L R+ ++ Q+ M
Sbjct: 49 GGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM 228
Query: 73 KVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFT-- 130
+V L+ +D V R I N F + Q +G+ L + FT
Sbjct: 229 EVAVLKKLQGKDHVC----RFIGCGRNEKFN---YVVMQLQGRNLADLRRSQPRGTFTLS 387
Query: 131 ---RLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIK----LT 183
RL K++L + ++ +H +G ++RD+KP N + + +
Sbjct: 388 TTLRLGKQILES--------------IEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYML 525
Query: 184 DFGLSKE------SVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTG 237
DFGL+++ V + F GTV Y + R + D WS ++ E G
Sbjct: 526 DFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVG 705
Query: 238 TLPFQGKDRNETMNMI 253
LP++ E + MI
Sbjct: 706 QLPWRKIKDKEQVGMI 753
Database: taget.fasta
Posted date: Jul 3, 2013 6:49 PM
Number of letters in database: 7,230,561
Number of sequences in database: 3914
Lambda K H
0.312 0.130 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 3914
Number of Hits to DB: 76,873,871
Number of extensions: 1563295
Number of successful extensions: 50023
Number of sequences better than 1.0e-05: 188
Number of HSP's gapped: 30084
Number of HSP's successfully gapped: 630
Length of database: 2,410,187
Neighboring words threshold: 13
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.4 bits)
S2: 42 (20.8 bits)