A Database of MONOOXYGENASES

No.Name ENZYME BRENDALIGAND UM-BBDreaction catalyzedsynonymsclassgene sequence linkstructure linkreferences on NCBI
1 1-methoxypyrene 6,7-monooxygenase 1.4.-.- -- --e06001-Methoxypyrene = 1-Methoxypyrene-6,7-oxide ----
2 nitrilotriacetate monooxygenase 1.5.1.- ----e0388Nitrilotriacetate = Glyoxylate + Iminodiacetate----
3 ammonia monooxygenase 1.7.3.- ---- e0061Chloroethane = Acetaldehyde, Dimethyl ether = Methanol + Formaldehyde,Methyl fluoride = Formaldehyde
42-mercaptobenzothiazole monooxygenase 1.13.12.- ----e07382-Mercaptobenzothiazole = 6-Hydroxy-2-mercaptobenzothiazole
5hexadecyltrimethylammonium chloride monooxygenase 1.13.12.- ---- e0872Hexadecyltrimethylammonium chloride = Trimethylamine + Hexadecanal
66-hydroxy-2-mercaptobenzothiazole monooxygenase 1.13.12.-----e07396-Hydroxy-2-mercaptobenzothiazole = 6,7-Dihydroxy-2-mercaptobenzothiazole
7isooctane monooxygenase 1.13.12.-----e0795Isooctane = 2,4,4-Trimethyl-1-pentanol
82-(methylthio)benzothiazole monooxygenase 1.14.-.-----e0812Benzothiazole = 2-Hydroxybenzothiazole
94-chlorophenoxyacetate monooxygenase 1.14.-.- ----e03244-Chlorophenoxyacetate = Glyoxylate + 4-Chlorophenol
10pinacolone 5-monooxygenase 1.14.-.-----e08232,2-Dimethyl-3-pentanone = 1-Hydroxy-4,4-dimethylpentan-3-one
11alpha-pinene monooxygenase 1.14.-.-----e475alpha-Pinene = Pinocarveol
12phenylboronic acid monooxygenase 1.14.-.------e0630Phenylboronic acid -----> Phenol
13pyrene 4,5-monooxygenase 1.14.-.-----e0590Pyrene -----> Pyrene-4,5-oxide
14pyrene 1,2-monooxygenase 1.14.-.-----e0592Pyrene -----> Pyrene-1,2-oxide
153-hydroxy-2-naphthoate hydroxylase 1.14.-.-----e0893--
164-nitrophenol 2-monooxygenase 1.14.-.-----e0205p-Nitrophenol -----> 4-Nitrocatechol
171-hydroxypyrene 6,7-monooxygenase1.14.-.-----e0554Formamide -----> Formate
18benzothiazole monooxygenase1.14.-.-----e0812Benzothiazole -----> 2-Hydroxybenzothiazole
192,6-dihydroxybenzothiazole monooxygenase 1.14.-.-----e08152,6-Dihydroxybenzothiazole -----> 2,6,7-Trihydroxybenzothiazole
204-nitrocatechol 4-monooxygenase 1.14.-.-----e02064-Nitrocatechol -----> 1,2,4-Benzenetriol
212-hydroxyisobutyrate 3-monooxygenase 1.14.-.-----e04102-Hydroxyisobutyrate -----> 2,3-Dihydroxy-2-methyl propionate
221-hydroxypyrene 7,8-monooxygenase 1.14.-.-----e05961-Hydroxypyrene -----> 1-Hydroxypyrene-7,8-oxide
232-hydroxybenzothiazole monooxygenase 1.14.-.-----e08112-Hydroxybenzothiazole -----> 2,6-Dihydroxybenzothiazole
241-indanone monooxygenase 1.14.12.-----e02981-Indanone -----> 3,4-Dihydrocoumarin
252-indanone monooxygenase 1.14.12.-----e02992-Indanone -----> 3-Isochromanone
266-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase1.14.13.-----e00436-Hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline -----> 5,6-Dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline
271-hydroxy-2-oxolimonene 1,2-monooxygenase 1.14.13.-----e0464(1S,4R)-1-Hydroxy-2-oxolimonene -----> (3R)-3-Isopropenyl-6-oxoheptanoate
282-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase1.14.13.-----e03042-Oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA -----> delta2,5-3,4,4-Trimethylpimelyl-CoA
29ethionamide monooxygenase1.14.13.-----e0829Thiobenzamide -----> Thiobenzamide S-oxide, Thiobenzamide S-oxide -----> Thiobenzamide S,S-dioxide
30xylene monooxygenase1.14.13.-----e0172Toluene -----> Benzyl alcohol, m-Xylene -----> 3-Methylbenzyl alcohol, o-Xylene -----> 2-Methylbenzyl alcohol, p-Xylene -----> p-Methylbenzyl alcohol
31toluene 3-monooxygenase1.14.13.-----e02243-Hydroxytoluene -----> 3-Methylcatechol, Toluene -----> 3-Hydroxytoluene
32styrene monooxygenase 1.14.13.-----e0195Styrene -----> Styrene oxide
33toluene-4-sulfonate monooxygenase 1.14.13.-----e0243Toluene-4-sulfonate -----> 4-Hydroxytoluene
34salicylate 5-hydroxylase 1.14.13.-----e0644Salicylate -----> Gentisate
35toluene 4-monooxygenase1.14.13.-----e0225Toluene -----> 4-Hydroxytoluene
36DBT monooxygenase 1.14.13.-----e0214Benzyl sulfide -----> Benzyl sulfoxide, Benzyl sulfoxide -----> Benzyl sulfone, Dibenzothiophene -----> Dibenzothiophene-5-oxide, Dibenzothiophene-5-oxide -----> Dibenzothiophene-5,5-dioxide
37chlorophenol 4-monooxygenase 1.14.13.-----e0252--
38dibenzothiophene-5,5-dioxide monooxygenase 1.14.13.-----e0215Dibenzothiophene-5,5-dioxide -----> 2'-Hydroxybiphenyl-2-sulfinate
39
403-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase 1.14.13.-----e0042 3-Methyl-2-oxo-1,2-dihydroquinoline -----> 6-Hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline
41 trimethylamine monooxygenase 1.14.13.-----e0873Trimethylamine -----> Trimethylamine N-oxide
424-hydroxyacetophenone monooxygenase 1.14.13.-----e0479 4-Hydroxyacetophenone -----> 4-Hydroxyphenyl acetate
43phenanthrene 1,2-monooxygenase 1.14.13.-----e0333 Phenanthrene -----> Phenanthrene-1,2-oxide, Phenanthrene -----> 1-Phenanthrol
44branched-chain dodecylbenzene sulfonate monooxygenase 1.14.13.-----e0672Branched-chain dodecylbenzene sulfonate -----> Sulfurous acid + Branched-chain dodecyl-4-hydroxy-benzene
45limonene 1,2-monooxygenase1.14.13.-----e0462(+)-(4R)-Limonene -----> (4R)-Limonene-1,2-epoxide
46 toluene 2-monooxygenase 1.14.13.- ----e02222-Hydroxytoluene -----> 3-Methylcatechol, Toluene -----> 2-Hydroxytoluene, 1,1,2-Trichloroethylene -----> Trichloroethylene epoxide
47 methanesulfonic acid monooxygenase 1.14.13.-----e0264Methanesulfonic acid -----> Sulfurous acid + Formaldehyde
48toluenesulfonate methyl-monooxygenase1.14.13.-----e0238Toluene-4-sulfonate -----> 4-Sulfobenzyl alcohol
49alpha-pinene monooxygenase[NADH]1.14.13.-----e0443alpha-Pinene -----> alpha-Pinene oxide
50 phenanthrene 9,10-monooxygenase1.14.13.-----e0347Phenanthrene -----> Phenanthrene-3,4-oxide
51phenanthrene 3,4-monooxygenase1.14.13.-----e0334Phenanthrene -----> Phenanthrene-9,10-oxide
52dimethyl sulfide monooxygenase1.14.13.-----e0189Phenanthrene -----> Phenanthrene-9,10-oxide
53salicylate hydroxylase 1.14.13.11.14.13.11.14.13.1e0149Salicylate -----> Catechol
54 4-hydroxybenzoate 3-monooxygenase 1.14.13.21.14.13.21.14.13.2e00844-Hydroxybenzoate -----> 3,4-Dihydroxybenzoate
554-hydroxyphenylacetate 3-hydroxylase 1.14.13.31.14.13.31.14.13.3e01504-Hydroxyphenylacetate -----> 3,4-Dihydroxyphenylacetate
56 orcinol hydroxylase 1.14.13.61.14.13.61.14.13.6e0073Orcinol -----> 2,3,5-Trihydroxytoluene
57phenol 2-monooxygenase 1.14.13.71.14.13.71.14.13.7e0208Phenol -----> Catechol, Hydroquinone -----> 1,2,4-Benzenetriol, Resorcinol -----> 1,2,4-Benzenetriol
582,6-dihydroxypyridine oxidase 1.14.13.101.14.13.101.14.13.10e03402,6-Dihydroxypyridine -----> 2,3,6-Trihydroxypyridine
59benzoate 4-monooxygenase 1.14.13.121.14.13.121.14.13.12e0414Benzoate -----> 4-Hydroxybenzoate
60 4-hydroxyphenylacetate 1-hydroxylase 1.14.13.181.14.13.181.14.13.18e01514-Hydroxyphenylacetate -----> Homogentisate
612,4-dichlorophenol hydroxylase 1.14.13.201.14.13.201.14.13.20e01524-Chlorophenol -----> 4-Chlorocatecho, 2,4-Dichlorophenol -----> 3,5-Dichlorocatechol
62cyclohexanone 1,2-monooxygenase 1.14.13.221.14.13.221.14.13.22e0166Cyclohexanone -----> 1-Oxa-2-oxocycloheptane
633-hydroxybenzoate 4-hydroxylase 1.14.13.23 1.14.13.221.14.13.23e01093-Hydroxybenzoate -----> 3,4-Dihydroxybenzoate
643-hydroxybenzoate 6-hydroxylase 1.14.13.24 1.14.13.241.14.13.24e02893-Hydroxybenzoate -----> Gentisate
65soluble methane monooxygenase 1.14.13.251.14.13.251.14.13.25e0007Methane -----> Methanol
664-aminobenzoate hydroxylase1. 1.14.13.271.14.13.271.14.13.27e04004-Aminobenzoate -----> p-Aminophenol
67anthranilate 3-monooxygenase 1.14.13.351.14.13.351.14.13.35e03822-Aminobenzoate -----> 2,3-Dihydroxybenzoate
68anthraniloyl-CoA monooxygenase 1.14.13.401.14.13.401.14.13.40e03702-Aminobenzoyl-CoA -----> 2-Amino-5-oxo-cyclohex-1-enecarboxy-CoA
692-hydroxybiphenyl 3-monooxygenase 1.14.13.441.14.13.441.14.13.44e08962-Hydroxybiphenyl -----> 2,3-Dihydroxybiphenyl
70limonene 3-monooxygenase 1.14.13.471.14.13.471.14.13.47e0467Limonene -----> Isopiperitenol
71limonene 6-monooxygenase 1.14.13.481.14.13.481.14.13.48e0445Limonene -----> Carveol
72limonene 7-monooxygenase 1.14.13.491.14.13.491.14.13.49e0458Limonene -----> Perillyl alcohol
73pentachlorophenol 4-monooxygenase 1.14.13.501.14.13.501.14.13.50e0148Pentachlorophenol -----> 2,3,5,6-Tetrachlorohydroquinone,Bromoxynil -----> 2,6-Dibromohydroquinone
74alkene monooxygenase 1.14.13.691.14.13.691.14.13.69e0039Ethylene -----> Ethylene Oxide, Propylene -----> (R)-1,2-Epoxypropane, Propylene -----> (S)-1,2-Epoxypropane
75vanillate monooxygenase 1.14.13.821.14.13.821.14.13.82e0117Vanillate -----> 3,4-Dihydroxybenzoate + Formaldehyde
76pyrrole-2-carboxylate monooxygenase 1.14.14.-----e0611Pyrrole-2-carboxylate -----> 5-Hydroxypyrrole-2-carboxylate
77endosulfan sulfate monooxygenase 1.14.14.-----e08574-Methoxybenzoate -----> 4-Hydroxybenzoate + Formaldehyde
78unspecific monooxygenase 1.14.14.1----e0551Benzyl sulfoxide -----> Benzyl sulfone,1,3-Dinitro-1,2,3,4-tetrahydro-1,3,5-triazine -----> 1-Nitro-1,2-dihydro-1,3,5-triazine,Hexahydro-1,3,5-trinitro-1,3,5-triazine -----> 1,3-Dinitro-1,2,3,4-tetrahydro-1,3,5-triazine
79deethylatrazine monooxygenase 1.14.15.-----e0098Deethylatrazine -----> Deisopropyldeethylatrazine
80 deisopropylatrazine monooxygenas 1.14.15.-----e0094Deisopropylatrazine -----> Deisopropyldeethylatrazine
81butane monooxygenase 1.14.15.-----e0661Cyclohexane -----> Cyclohexanol
82atrazine monooxygenase 1.14.15.-----e0090Atrazine -----> Deethylatrazine, Atrazine -----> Deisopropylatrazine
83camphor 5-monooxygenase 1.14.15.1----e0300(+)-Camphor -----> 5-exo-Hydroxycamphor
84camphor 1,2-monooxygenase 1.14.15.2----e0302(+)-bornane-2,5-dione ----> 5-oxo-1,2-campholide 2,5 diketocamphane 1,2-monooxygenase, 3,6-diketocamphane 1,6-monooxygenase.
85alkane 1-monooxygenase 1.14.15.3----e0022n-Octane -----> 1-OctanolAlkane 1-hydroxylase; omega-Hydroxylase; Fatty acid omega-hydroxylase
866-hydroxypseudooxynicotine monooxygenase 1.14.18.-----e03426-Hydroxypseudooxynicotine -----> 2,6-Dihydroxypseudooxynicotine
874-methoxybenzoate monooxygenase 1.14.99.15----e01034-Methoxybenzoate -----> 4-Hydroxybenzoate + Formaldehyde
88thiophene-2-carboxyl-CoA monooxygenase 1.14.99.35----e0775Thiophene-2-carboxyl-CoA -----> 5-Oxo-4,5-dihydrothiophene-2-carboxyl-CoA
892,4,6-Trichlorophenol -4-Monooxygenases1.14.13.-------2,4,6-Trichlorophenol (2,4,6-TCP) -----> 2,6-Dichlorohydroquinone
90
91EDTA monooxygenase--------EDTA---->Glycoxylate
922-Nitrophenol-2-Monooxygenase 1.14.31.311.14.13.311.14.13.31--2-nitrophenol ----> catechol + nitrite
93methyl tert-butyl ether (MTBE) Monooxygenase--------methyl tert-butyl ether----->tert-butyl alcohol (TBA) + formaldehyde
942,4-dichlorophenoxyacetate monooxygenase--------2,4-dichlorophenoxyacetate monooxygenase----->2,4-dichlrophenol
95 particulate methane monooxygenase(p-MMO)--------methane---->merthanol
96mecoprop monooxygenase--------R)-(+)-2(2-methyl-4-chlorophenoxy)propionic------>4-chloro-2-methylphenol(MCP) acid (mecoprop)
974-chloro-2-methylphenol(MCP) Monooxygenase--------4-chloro-2-methylphenol(MCP)----> subsituted catechol
98cyclododecane monooxygenase--------cyclododecane---->cyclododecanol
99aliphatic ether terminal monooxygenase--------aliphatic ether------>alcohol
1004-Nitrophenol-2-monooxygenase 1.14.31.291.14.13.291.14.13.29e02054-nitrophenol----->4-NitroCatechol
101
102
103Cyclopentanone monooxygenase--------Cyclopentanone------>valerolactone
104Cyclododecanone monooxygenase--------cyclododecanone----->lauryl lactone
1054-hydroxybenzoate 3-monooxygenase (NAD(P)H) 1.14.13.33------4-hydroxybenzoate ------> 3,4-dihydroxybenzoate
106propane monooxygenase--------propane----->1-prpanol, propane----->2-propanol, propane-----> 1-propanol + 2-propanol
107dibensothiophene-monooxygenase--------Dibenzothiophene----->DBT sulfoxide----->DBT sulfone
108sulfoxide monooxygenase--------Dibenzothiophene----->DBT sulfoxide----->DBT sulfone
109dibenzothiophene (DBT) sulfone monooxygenase--------DBT sulfone----->2-(2-hydroxyphenyl)benzenesulfinate (HPBS)
110Methylhydroquinone-Metabolizing oxygenase--------methylhydroquinone------>trihydroxytolune
111phenylacetone monooxygenase 1.14.13.92------Phenylacetone + NADPH -----> benzyl acetate
1122,5 diketocamphane 1,2-monooxygenase
1133,6-diketocamphane 1,6-monooxygenase<
114
1154-Methyl-5-Nitrocatechol oxygenase(MNC monooxygenase) 1.13.12.- ------4-methyl-5-nitrocatechol-------> 2-hydroxy-5-methylquinone
116Pentachloronitrobenze-4-monooxygenase--------Pentachloronitrobenzene------->Pentachlorophenol
1172-chloro-4-nitrophenol-4-monooxygenase--------2-chloro-4-nitrophenol------->2-chlorohydroquinone
118Toluene-o-xylene monooxygenase--------Nitrobenzene---------> 4-Nitrophenol + 2-Nitrophenol