| DB ID | MyCo_7181 |
| Title | Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways |
| Year | 2019 |
| PMID | 31170201 |
| Fungal Diseases involved | Pneumocystis |
| Associated Medical Condition | None |
| Genus | Pneumocystis |
| Species | spp. |
| Organism | Pneumocystis spp. |
| Ethical Statement | The institutional Animals Welfare Bioethics Committee of the University of Chile, Faculty of Medicine approved the protocol under number CBA #0715. Studies were conducted in accor- dance with the Animal Protection Law of Chile (Law 20.380) and the Guide for the Care and Use of Laboratory Animals (8th Edition, National Academies Press, Washington DC). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Homogenized Lungs tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | Muc5B |
| Biomarker Full Name | Mucin-encoding gene Muc5B |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | Chile |
| Cohort | Thirty five female Sprague Dawley rats of 250 g weight derived from a sin- gle colony were obtained from University of Chile, Faculty of Medicine, Animal Research Facility, and subjected to standard housing conditions and HEPA filtered environment (Lab- Products Inc, USA). Fifteen female Sprague Dawley, 250 grams rats were used as seeding rats, and 30 rats from the same colony were timed-pregnant and exposed to seeding rats, following the same protocol of experiment 1. |
| Cohort No. | 35 and 15 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Analytic |
| Analysis Method | Western Blotting |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR, Western Blotting |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
