| DB ID | MyCo_7172 |
| Title | Phenotypic and functional characterization of NK cells in human immune response against the dimorphic fungus Paracoccidioides brasiliensis |
| Year | 2012 |
| PMID | 22723518 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | In accordance with the rules of the Medical Research Ethics Committee at the Faculty of Medical Sciences, State University of Cam- pinas, all individuals signed a voluntary consent form agreeing to partic-ipate in the study. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CD56+granulysin+ |
| Biomarker Full Name | CD56+granulysin+ |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Peripheral venous blood was collected from healthy donors and PCM patients, the latter being divided into two groups: patients with active disease selected before or within the first month of treatment, and patients who had received treatment and had negative serological tests for P. bra- siliensis and no clinical signs of the disease. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Infections caused by fungi are currently among the most life- threatening diseases. Paracoccidioidomycosis (PCM), a dis- ease caused by the dimorphic fungus Paracoccidioides bra-siliensis, is the major cause of systemic mycosis in Latin America. The disease presents a wide spectrum of clinical and immu- nological manifestations, varying from benign and localized forms to severe and disseminated forms. The pattern of the immune response to P. brasiliensis is thought to be a determinant of disease progression and clinical outcome. Effective defense against P. brasiliensis depends mainly upon Th1 response, where TNF-a and IFN-g play a particularly prominent role. |
| Technique | Analytic |
| Analysis Method | Western blotting |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA, Flow Cytometry Analysis, qRT-PCR, Western blotting |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
