| DB ID | MyCo_7041 |
| Title | Seasonal airway microbiome and transcriptome interactions promote childhood asthma exacerbations |
| Year | 2022 |
| PMID | 35149044 |
| Fungal Diseases involved | Fungal infection |
| Associated Medical Condition | Asthma exacerbation |
| Genus | Malassezia |
| Species | spp. |
| Organism | Malassezia spp. |
| Ethical Statement | This study was approved by the institutional review boards of all institutions. All participants or their legal guardians provided written informed consent before enrollment onto the study. |
| Site of Infection | Lungs |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Nasal blow samples |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | SMAD3 |
| Biomarker Full Name | SMAD3 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Samples obtained from children enrolled onto the Mechanisms Underlying Asthma Exacerbations Prevented and Persistent with Immune-based therapy (MUPPITS-1; NCT02502890) trial were used for this study, which was part of the Inner-City Asthma Consortium.10 Children enrolled onto this study lived in 1 of 9 inner-city study sites in the United States within Boston, Chicago, Cincinnati, Dallas, Denver, Detroit, New York, St Louis, and Washington, DC; were between 6 and 17 years old; had doctor-diagnosed asthma; had experienced at least 2 exacerbations in the previous year; and had eosinophil counts greater than 150 cells/mm3. |
| Cohort No. | 181 |
| Age Group | Jun-17 |
| P Value | p=0.01 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Bioinformatics analysis |
| Analysis Method | Transcriptomics Approach |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Transcriptomics Approach |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
