| DB ID | MyCo_7031 |
| Title | Transcriptomic biomarker pathways associated with death in HIV-infected patients with cryptococcal meningitis |
| Year | 2021 |
| PMID | 33863324 |
| Fungal Diseases involved | Cryptococcal meningitis |
| Associated Medical Condition | HIV-AIDS |
| Genus | Cryptococcus |
| Species | spp. |
| Organism | Cryptococcus spp. |
| Ethical Statement | The COAT trial was approved by the Uni- versity of Minnesota IRB (# 0810M49622), Uganda National Council for Science and Technology, and local Ethics Committees in Kampala, Uganda from Mulago Hospital and Makerere University. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted RNA |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | NOTCH2 |
| Biomarker Full Name | NOTCH2 |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | USA |
| Cohort | During the trial period, 115 HIV-infected patients with CM were randomized approximately one week post diagnosis to early versus differed ART and were then followed up for 26 weeks |
| Cohort No. | 115 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcal meningitis (CM) is the most prevalent fun- gal opportunistic infection in persons living with AIDS with CD4 + T cell counts of less than 100 cells/uL. HIV- associated cryptococcal infections account for nearly one-fifth of the million deaths annually worldwide, with the majority occurred in the Sub-Saharan region. |
| Technique | Bioinformatics analysis |
| Analysis Method | Transcriptomics approach |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Transcriptomics approach |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
