| DB ID | MyCo_6966 |
| Title | Antibody ligation of CEACAM1, CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans |
| Year | 2022 |
| PMID | 34847408 |
| Fungal Diseases involved | Invasive candidiasis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | This study was conducted according to the principles expressed in the Declaration of Helsinki. The blood donation protocol and use of blood for this study were reviewed and approved by the institutional ethics committee of the University Hospital Jena (permission number 5070-02/17). The participants provided their written informed consent to participate in this study. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CEACAM6 |
| Biomarker Full Name | CEACAM6 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive candidiasis is the most common fungal disease among hospitalized patients in the developed world, and the fourth most common bloodstream infection in intensive care units. Invasive candidiasis is a major threat to immunosuppressed or critically ill patients and results in mortality rates as high as 40%, even when patients receive antifungal therapy; Candida albicans causes the majority of these infections. |
| Technique | Bioinformatics analysis |
| Analysis Method | Transcriptomics Approach |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Transcriptomics Approach |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
