| DB ID | MyCo_6932 |
| Title | Circulating microRNA sequencing revealed miRNome patterns in hematology and oncology patients aiding the prognosis of invasive aspergillosis |
| Year | 2022 |
| PMID | 35504997 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Hematological malignancy |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The study protocol was approved by the Ethics Committee of the University Hospitals of Debrecen, Hungary (MK-JA/50/0096-01/2017) and carried out in accordance with the approved guidelines. Informed consent was obtained from the participants in the study. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Hsa-miR-20a-5p |
| Biomarker Full Name | Hsa-miR-20a-5p |
| Biomarker Type | Diagnostic |
| Biomolecule | miRNA |
| Geographical Location | Hungary |
| Cohort | This retrospective case–control study was performed from May 2017 to November 2020 and involved two hematology centers in Hungary: the University of Debrecen, Faculty of Medicine, Institute of Internal Medicine, Debrecen, Hungary; and the Institute of András Jósa County and Teaching Hospital, Division of Hematology, Nyíregyháza, Hungary. The patient population comprised 26 adults: 16 males, with a median age of 63 (range 33–71) years, and 10 females, with a median age of 40 (range 25–52) years, with different hematological malignancies (mainly acute leukemia: 73.08%) receiving stem cell transplantation and intensive chemotherapy (neutrophil count < 0.5 × 109 cells/L). |
| Cohort No. | 26 Patients and 24 control |
| Age Group | 25-71 |
| P Value | p<0.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Underscoring the burden of invasive aspergillosis (IA), a marked increase in disease prevalence was observed due to improved diagnostics, an overall escalation in the use of immunosuppressive therapies, and an increased number of organ transplantations performed in recent ¬ decades. IA remains a major issue among patients who have undergone either stem cell or solid organ transplantation, with a prevalence of over 10%. |
| Technique | Bioinformatics analysis |
| Analysis Method | Insilico bioinformatics based highthroughput small transcriptome sequencing |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Insilico bioinformatics based highthroughput small transcriptome sequencing, qRT-PCR |
| Up Regulation Down Regulation | Down regulated |
| Sequence Data | None |
| External Link | None |
