| DB ID | MyCo_6701 |
| Title | Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents |
| Year | 2022 |
| PMID | 35134165 |
| Fungal Diseases involved | Invasive candidiasis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | spp. |
| Organism | Candida spp. |
| Ethical Statement | Clinical Trials Registration. NCT02220790 |
| Site of Infection | Bloodstream |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | T2Candida |
| Biomarker Full Name | T2Candida Assay |
| Biomarker Type | Diagnostic |
| Biomolecule | None |
| Geographical Location | USA |
| Cohort | Eligible participants were aged >120 days and <18 years with clinical characteristics concerning for IC. Participants were ineligible if they (1) had possible, probable, or proven in¬vasive fungal disease according to European Organization for Research and Treatment of Cancer/Mycoses Study Group cri¬teria within the past 30 days; (2) had been previously included in the study; (3) weighed <4 kg, disallowing sufficient phle¬botomy; or (4) were receiving empirical or targeted antifungal therapy. |
| Cohort No. | 500 Patients |
| Age Group | patients aged >120 days and <18 years |
| P Value | None |
| Sensitivity | 0.792 |
| Specificity | 0.971 |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive candidiasis (IC) is a common cause of bloodstream infections in hospitalized patients and associated with in¬creased hospital lengths of stay, charges, and all-cause mortality rates. These infections can be particularly severe in chil¬dren with cancer and after organ or hematopoietic cell transplantation [6–8]. Diagnosing IC in pediatric patients is challenging. Cultures are insensitive and often take >24 hours for a preliminary positive result, delaying initial therapy and leading to in¬creased mortality rate. A single-center prediction rule to identify candidemia in pediatric intensive care unit patients found that multiple factors had a predictive probability of 46%. However, an independent multicenter study failed to vali¬date the model. |
| Technique | ELISA |
| Analysis Method | T2Candida ELISA Assay Based [FDA Approved] |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | FDA Approved ELISA |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
