| DB ID | MyCo_6700 |
| Title | Development of SERS-based immunoassay for the detection of cryptococcosis biomarker |
| Year | 2022 |
| PMID | 35441260 |
| Fungal Diseases involved | Cryptococcosis |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | spp. |
| Organism | Cryptococcus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GXM |
| Biomarker Full Name | Glucuronoxylomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Metabolite |
| Geographical Location | China |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcosis is one of the most common opportunistic systemic fungal infections among human immune-deficiency virus/acquired immune-deficiency syndrome (HIV/AIDS) patients and other immune-suppressed individuals resulted from cancer chemotherapy, diabetes mellitus, steroid therapy, renal transplantation, etc.. Nonetheless, up to 20% of cases occur in phenotypically “normal” or clinically immunocompetent patients. The most common etiological agents of cryptococcosis is Cryptococcus neoformans (C. neoformans), which is ubiquitously found in soil and the feces of birds. Upon inhalation of infectious propagules, C. neoformans penetrate the lung tissue, causing pulmonary cryptococcosis, and possibility leading to the dissemination to other organs, most commonly the brain. Therefore, the early clinical diagnosis of cryptococcosis infection is very essential in improving the curative and survival rates. |
| Technique | ELISA |
| Analysis Method | Surface-enhanced Raman scattering (SERS) - ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA, Transmission electron microscopy (TEM), |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
