| DB ID | MyCo_6580 |
| Title | Serological profiling of a Candida albicans protein microarray reveals permanent host-pathogen interplay and stage-specific responses during candidemia |
| Year | 2010 |
| PMID | 20361054 |
| Fungal Diseases involved | Candida albicans infection |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | Human sera from candidemia patients and hospitalized patients were collected from SH-UF under protocols approved and created by the UF Institutional Review Board. Sera from healthy individuals were obtained from volunteers at the General Clinical Research Center at the University of California, Irvine. Written, informed consent was obtained from participants. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Cdc19 |
| Biomarker Full Name | Pyruvate kinase |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Here collected sera from 21 patients with candidemia where the etiological agent was C. albicans. Here also used sera from 12 hospital patients and 50 healthy individuals who had no evidence of candidiasis as our negative control groups. |
| Cohort No. | 21 Patients and 62 control |
| Age Group | None |
| P Value | p=0.0061 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | The yeast Candida albicans exists in a dichotomist relationship with the human host. C. albicans is frequently found as a commensal organism on the human skin, gastrointestinal (GI) tract and the vulvovaginal tract. Close to 60% of healthy individuals carry C. albicans as a commensal in the oral cavity. Colonic and rectal colonization is even higher, ranging from 45% to 75% among patient groups. Alterations in the host immunity, physiology, or normal microflora rather than the acquisition of novel or hypervirulent factors associated with C. albicans, are suggested to lead to the development of candidiasis. Both neutrophils and mucosal integrity of the GI tract, are critical in preventing hematogenously disseminated candidiasis. |
| Technique | Analytic |
| Analysis Method | Serological Profiling |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Serological Profiling |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
