| DB ID | MyCo_6538 |
| Title | Evaluation of the diagnostic performance of a semi-quantitative lateral flow assay for the detection of Cryptococcus antigen in serum and cerebrospinal fluid specimens |
| Year | 2024 |
| PMID | 39657327 |
| Fungal Diseases involved | Cryptococcosis |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | spp. |
| Organism | Cryptococcus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Cerebrospinal fluid (CSF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CrAg |
| Biomarker Full Name | Cryptococcus antigen |
| Biomarker Type | Prognostic |
| Biomolecule | Protein |
| Geographical Location | Colombia |
| Cohort | Here tested sera and CSF specimens from patients with sus-pected cryptococcosis. From a total of 613 stored specimens, here determined a sample size of 151 specimens, comprising 85 sera and 66 CSF speci-mens. |
| Cohort No. | 151 |
| Age Group | None |
| P Value | None |
| Sensitivity | 0.84 |
| Specificity | 1 |
| Positive Predictive Value | 0.9 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcosis is a severe fungal infection usually observed in individuals with immunosuppression, particularly those with advanced HIV disease (AHD).The disease is caused by yeasts belonging to the Cryptococcus genus,and most infections are associated with C. neoformans and C. gattii complexes. This fungus can invade various organs following a primary respi-ratory infection; however, it exhibits a pronounced predilec- tion for the central nervous system (CNS), often resulting in meningitis, which is associated with high mortality, particu- larly if cryptococcosis diagnosis and antifungal therapy are delayed. |
| Technique | Assay |
| Analysis Method | Semi-quantitative lateral flow assay |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Semi-quantitative lateral flow assay |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
