| DB ID | MyCo_6522 |
| Title | Significantly higher procalcitonin levels could differentiate Gram-negative sepsis from Gram-positive and fungal sepsis |
| Year | 2012 |
| PMID | 22644264 |
| Fungal Diseases involved | Fungal sepsis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | spp. |
| Organism | Candida spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | PCT |
| Biomarker Full Name | Procalcitonin |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Czech Republic |
| Cohort | Here performed a retrospective study of plasma PCT and CRP levels in ICU patients with positive blood cultures during the six-month period. One hundred and sixty-six (166) patients with positive blood cultures were assessed. The clinical status of patients was classified according to the Sepsis Definition Conference criteria. |
| Cohort No. | 166 |
| Age Group | 55-76 |
| P Value | p<0.00001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Sepsis, a systemic inflammatory response to noxious infection, is a relatively frequent and serious complication in critically ill patients. Mean sepsis incidence of around 30–40 % in intensive care units (ICU) patients is com- monly reported: for instance, the SOAP study (Sepsis Occurrence in Acutely Ill Patients), which evaluated data from 3147 ICU patients from 198 centers, reported sepsis during hospitalization in 38 % of patients, whereas mor- tality of these septic patients was 27 % compared to 14 % in non-septic ICU cohort. Early and accurate diagnostics of sepsis with rapid initiation of adequate therapy is crucial for patients’ surviving. |
| Technique | Immunological assay |
| Analysis Method | Sandwich electrochemiluminescence immunoassay |
| ELISA kits | sandwich electrochemiluminescence immunoassay (Cobas ECLIA,Japan) |
| Assay Data | None |
| Validation Techniques used | Sandwich electrochemiluminescence immunoassay |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
