| DB ID | MyCo_6466 |
| Title | Targeted removal of macrophage-secreted interleukin-1 receptor antagonist protects against lethal Candida albicans sepsis |
| Year | 2023 |
| PMID | 37478856 |
| Fungal Diseases involved | Candidemia |
| Associated Medical Condition | Sepsis |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | All procedures were performed in accordance with ethical guidelines and approved animal license protocols of the Canton of Bern (BE3/18 and BE31/2021). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Kidney Tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | IL-1Ra |
| Biomarker Full Name | Interleukin-1 receptor antagonist |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Switzerland |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Candida albicans represents the most common cause of fungal bloodstream infection; and despite adequate antifungal treatment, the overall mortality is 30%–40%, exceeding 60% in critically ill patients. C. albicans is normally contained by epithelial barrier immunity and occurs as commensal in half of the population. Inborn errors of immunity highlight the importance of interleukin (IL)-17-mediated pathways to avert mucocutaneous colonization, whereas functional neutrophil responses are critical to prevent systemic infec- tion. Accordingly, individuals with immunosuppression due to hematologic malignancies, organ transplantation, AIDS, or prolonged intensive care hospitalization are highly susceptible to invasive candidiasis. However, preceding systemic viral infections, or medical interventions that compromise physiological barrier function, such as indwelling devices, parenteral nutrition, and abdominal surgery, may predispose otherwise im- muno-competent hosts to disseminated Candida infection. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR, Flow Cytometry, Phagocytosis assay, Western blot, Immunohistochemistry and immunofluorescence |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
