| DB ID | MyCo_6289 |
| Title | Labeled quantitative mass spectrometry to study the host response during aspergillosis in the common bottlenose dolphin (Tursiops truncatus) |
| Year | 2019 |
| PMID | 31030843 |
| Fungal Diseases involved | Aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Animal |
| Host Common name | Bottlenose dolphin |
| Host Scientific name | Tursiops truncatus |
| Biomarker Name | Prepronociceptin (Fragment) |
| Biomarker Full Name | Prepronociceptin (Fragment) |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Over 15 years, 115 blood samples were opportunistically collected during routine or clinical health assessments from 87 common bot- tlenose dolphins (Tursiops truncatus) under human care (from 2002 to 2016 (except for four samples obtained in 1991, 1993, 1993, and 1995), but 62.8% obtained over the last three years). |
| Cohort No. | 87 |
| Age Group | 18.4– 26.5 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | 0.191 fold |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillosis is an airborne fungal infection caused by saprophytic ubiquitous molds that belong to the Aspergillus genus. It is responsible for several distinct respiratory diseases in both humans and animals. In marine mammals, Aspergillus-related disease is assumed to be rare, but it has been reported with increasing incidence: 66.7% of the 18 reported cases have been published after the year 2000. Aspergillosis can involve the lungs and brain in cetaceans. The major species responsible for infection belong to the Fumigati section, Nigri section and Terrei section in which A. fumigatus stricto sensu (ss), A. niger ss and A. terreus ss are the most frequently isolated, respectively. |
| Technique | Bioinformatics analysis |
| Analysis Method | Proteomics Approach |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Proteomics Approach |
| Up Regulation Down Regulation | Down regulated |
| Sequence Data | Uniprot ID: G5CYG5 , GenBank ID: PNOC |
| External Link | None |
