| DB ID | MyCo_6243 |
| Title | Circulatory Inflammatory Proteins as Early Diagnostic Biomarkers for Invasive Aspergillosis in Patients with Hematologic Malignancies-an Exploratory Study |
| Year | 2024 |
| PMID | 38407673 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Hematologic Malignancies |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | This prospective, noninterventional, systematic sampling was approved by the institutional ethics committee under the number S61797. All patients provided written informed consent before inclusion. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-17C |
| Biomarker Full Name | Interleukin-17C |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Portugal |
| Cohort | For the discovery cohort, we retrospectively evaluated longitudinal serum samples from 33 cases with proven or probable IA and 66 matched controls from two matched control cohorts (an infected and a non-infected cohort) without IMI. Patients were classified as per EORTC-MSGERC consensus definitions. |
| Cohort No. | 33 Patients and 66 Control |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive mold infections (IMI) remain associated with high mortality rates, with a 1-year mortality of 32% (even higher in certain populations), requiring early diagnosis and prompt initiation of appropriate treatment to increase odds of survival. The early diagnosis of invasive aspergillosis (IA), the most frequent IMI, is a challenge, with signs and symptoms being either unspecific or appearing at a very late disease phase. Histopathological identification of fungal elements within a typical tissue reaction remains the gold-standard method, but the material is rarely accessible, and fungal culture form respiratory specimens has a low sensitivity. |
| Technique | Bioinformatics analysis |
| Analysis Method | Proteomics Approach |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Proteomics Approach |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
