| DB ID | MyCo_6097 |
| Title | Translational proteomic study to address host protein changes during aspergillosis |
| Year | 2018 |
| PMID | 30040865 |
| Fungal Diseases involved | Aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The authors applied the regulations of Declaration of Helsinki. They complied with the BRISQ guidelines. The rat model of invasive aspergillosis was approved by the General Direction for Research and Innovation, French Ministry of Higher Education and Research through the accreditation number No. 01901.01, and by the Ethics Committee for Animal Experimentation of the Val-de-Loire region through the accreditation number No. C37-261-3. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Homogenized lungs tissue |
| Host Group | Animal |
| Host Common name | Rat |
| Host Scientific name | Rattus norvegicus |
| Biomarker Name | GRIP and coiled-coil domain- containing protein 2 |
| Biomarker Full Name | GRIP and coiled-coil domain- containing protein 2 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Blood samples and lung parenchyma specimens were obtained from 6–8 week-old male neutropenic rats (Rattusnorvegicus, N1 = 46). |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | ≥ 4.0 fold |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillosis is a fungal airborne infection due to saprophytic ubiquitous molds that belong to Aspergillus genus. It is responsible for several distinct respiratory diseases in both animals and humans. For example, aspergillosis is subacute or chronic in penguins under human care in zoos, and its incidence was estimated to 20.2% in a rehabilitation center in Brazil. In such birds, it implies adaptive immunity and develops progressively at the inner surface of air sacs. In humans, the invasive form is rather encountered during severe neutropenia and is more acute; its incidence raised to 5% after intensive chemotherapy or allogenic hematopoi- etic stem-cell transplantation. Invasive aspergillosis causes high morbidity, and mortality rates have been estimated as 30–70%, depending on the underlying medical conditions, the site of infection and the degree of dissemination. The Aspergillusspecies of the Fumigati section are those which have been primarily isolated from most of the human and animal clini- cal specimens. Species belonging to Flavi, Nigrior Terrei sections have been less frequently cul- tured. |
| Technique | Bioinformatics analysis |
| Analysis Method | Proteomics Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Proteomics Analysis |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | Access. number (UniProt) G5CB89 |
| External Link | None |
