| DB ID | MyCo_6016 |
| Title | Selection of a surrogate agent (fluconazole or voriconazole) for initial susceptibility testing of posaconazole against Candida spp.: results from a global antifungal surveillance program |
| Year | 2007 |
| PMID | 18094129 |
| Fungal Diseases involved | Candida infection |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | dubliniensis |
| Organism | Candida dubliniensis |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Fluconazole MIC |
| Biomarker Full Name | Fluconazole MIC |
| Biomarker Type | Predictive-surrogate |
| Biomolecule | None |
| Geographical Location | USA |
| Cohort | A total of 10,807 clinical isolates of Candida spp. submitted by more than 100 medical centers worldwide from January 2001 to December 2006 were tested. The collection included 5,827 Candida albicans isolates, 1,542 Candida parapsilosis isolates, 1,517 Candida glabrata isolates, 1,198 Candida tropicalis isolates, 305 Candida krusei isolates, 138 Candida guilliermondii isolates, 133 Candida lusitaniae isolates, 51 Candida kefyr isolates, 31 Candida pelliculosa isolates, 19 Candida famata isolates, 13 Candida rugosa isolates, 12 Candida dubliniensis isolates, 12 Candida lipolytica isolates, and 8 Candida zeylanoides isolates. All of these isolates were incident isolates from individual patients and were obtained from blood or other normally sterile body fluids. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | 0.25 µg/ml |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Assay |
| Analysis Method | Posaconazole Broth Microdilution Antifungal Susceptibility Testing |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Posaconazole Broth Microdilution Antifungal Susceptibility Testing |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |