| DB ID | MyCo_6004 |
| Title | Detailed β-(1→3)-D-glucan and mannan antigen kinetics in patients with candidemia |
| Year | 2023 |
| PMID | 37823667 |
| Fungal Diseases involved | Candidemia |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | tropicalis |
| Organism | Candida tropicalis |
| Ethical Statement | The study was approved by the ethics committee of the University Freiburg (277/13) and Erlangen (5_17Bc). The need for informed consent was waived. Standards for Reporting Diagnostic Accuracy (STARD) were followed. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Mn |
| Biomarker Full Name | Mannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | During the study period, 138 patients with candidemia were screened. Nine patients were excluded because less than three sera were available. In total, 129 patients with 131 candidemia episodes and 15 candidemia relapses were included and 1,243 sera (range 3–27 per patient) were tested. |
| Cohort No. | 129 |
| Age Group | None |
| P Value | p=0.627 |
| Sensitivity | 0.351 |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Candida species account for approximately 10% of bloodstream infections in intensive care units (ICUs) and are associated with an in-hospital mortality rate of 30%. Since bacteremia and candidemia are clinically indistinguishable, empirical anti-infective therapy for patients later diagnosed with candidemia includes an antifungal agent in less than 6% of cases. Instead, antifungal therapy is usually started at the time of blood culture (BC)-positivity, i.e., with a delay of 2–3 days after the onset of symptoms. However, a delay in the initiation of adequate treatment is associated with an increased mortality. Therefore, antifungal therapy should be guided by a pre-emptive approach using rapid diagnostic tests. |
| Technique | Immunological assay |
| Analysis Method | Platelia Candida Ag-Plus assay |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Platelia Candida Ag-Plus assay |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
