| DB ID | MyCo_5962 |
| Title | Recombinant allergens combined with biological markers in the diagnosis of allergic bronchopulmonary aspergillosis in cystic fibrosis patients |
| Year | 2010 |
| PMID | 20631331 |
| Fungal Diseases involved | Allergic bronchopulmonary aspergillosis |
| Associated Medical Condition | Cystic fibrosis |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | None |
| Site of Infection | Lungs |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | rAspf4 IgE |
| Biomarker Full Name | A. fumigatus recombinant allergens rAspf4 Immunoglobulin E |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | France |
| Cohort | In our retrospective study, a total of 133 sera from 65 patients (30 males and 35 females; mean age, 13.2 9.9 years; range, 1 to 53 years of age) with cystic fibrosis, regularly followed up at the Grenoble cystic fibrosis center between 1997 and 2008, were analyzed. |
| Cohort No. | 65 |
| Age Group | 1 to 53 years of age |
| P Value | p<0.05 |
| Sensitivity | 0.923 |
| Specificity | 0.937 |
| Positive Predictive Value | 0.8 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Allergic bronchopulmonary aspergillosis (ABPA) is a frequent complication in patients with cystic fibrosis that causes significant respiratory morbidity. The exact prevalence of ABPA is not clearly known; however, it ranges from 2 to 25% in patients with cystic fibrosis. ABPA may lead to acute worsening of the respiratory condition and ongoing decline in lung function. Without adequate treatment, ABPA ultimately progresses to a chronic state with lung fibrosis. ABPA is a hypersensitivity pulmonary disease associated with inflammatory destruction of airways in response to Aspergillus allergens. Thus, chronic airway colonization with Aspergillus induces strong inflammatory responses with high IgE levels. The factors leading to ABPA are not clearly understood, but it is believed that Aspergillus-specific, IgE mediated type I hypersensitivity reactions and specific IgG-mediated type III hypersensitivity reactions play central roles in the pathogenesis of ABPA. Furthermore, host factors, including individual susceptibility, may contribute to the immunopathogenesis of ABPA. Early diagnosis and treatment of ABPA are important to prevent serious and potentially irreversible lung damage. |
| Technique | Analytic |
| Analysis Method | Pharmacia UniCAP Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Pharmacia UniCAP method, ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
