| DB ID | MyCo_5955 |
| Title | New restriction fragment length polymorphism (RFLP) markers for Aspergillus fumigatus |
| Year | 2001 |
| PMID | 11476976 |
| Fungal Diseases involved | Aspergillus fumigatus infection |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Biopsy |
| Sample source | Extracted DNA |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | R108 DNA Fragment |
| Biomarker Full Name | R108 DNA Fragment |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | USA |
| Cohort | Seventeen clinical isolates of Aspergillus fumigatus were obtained from sputum expectorants or bronchial lavage of four di¡erent patients colonized with A. fumigatus. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillus fumigatus is an important cause of nosoco- mial infection in immunocompromised patients and has a high associated mortality rate. Recently, Debeaupuis et al. suggested, based on high intraspecies genetic var- iability, that any environmental strain of A. fumigatus is a putative infectious strain that can cause invasive aspergil- losis when it encounters an immunosuppressed host. Although A. fumigatus can be cultured from sequential sputum samples, it is not known whether colonization of the respiratory tract with A. fumigatus is due to one or several strains or whether frequent re-colonization takes place, especially after therapy. |
| Technique | PCR |
| Analysis Method | PCR-based RAPD and RFLP |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | PCR-based RAPD and RFLP |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
