| DB ID | MyCo_5924 |
| Title | Circular RNA PRKCI and microRNA-545 relate to sepsis risk, disease severity and 28-day mortality |
| Year | 2020 |
| PMID | 32985287 |
| Fungal Diseases involved | Sepsis |
| Associated Medical Condition | None |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | This study was approved by the Institutional Ethics Committees of The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | circ-PRKCI |
| Biomarker Full Name | Circular RNA protein kinase C iota |
| Biomarker Type | Diagnostic |
| Biomolecule | miRNA |
| Geographical Location | China |
| Cohort | In total, 121 sepsis patients and 60 healthy controls (HCs) were enrolled in this study. Sepsis patients were recruited from our hospital between January 2018 and February 2020, and HCs were prospectively recruited from health examination center in our hospital between March 2020 and April 2020. The inclusion criteria of sepsis patients were: (1) diagnosed as sepsis according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3); (2) age 18 years old; (3) without other fatal diseases (such as hematologic malignancies, solid tumors, pre-existing immunodeficiency or autoimmune diseases). |
| Cohort No. | 121 |
| Age Group | > 18 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Sepsis is a clinical syndrome triggered by a systemic response to infection that causes the immune system to attack the body’s own tissues, subsequently causing organ failure (e.g. severe sepsis), hypotension (e.g. septic shock), and even death. Despite great improvements in disease management, including numerous antibiotics (e.g. penicillin) and supportive therapies for organ dysfunctions accompanying sepsis (e.g. dialysis, ventilators, extracorporeal membrane oxygenation), the treatment outcomes of sepsis are disappointing and sepsis is still the leading cause of death repre- senting 15–25% mortality. Thus far, no magic drugs exist for sepsis. |
| Technique | PCR |
| Analysis Method | RT-qPCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | RT-qPCR |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
