| DB ID | MyCo_5889 |
| Title | Renal allograft recipients fail to increase interferon-γ during invasive fungal diseases |
| Year | 2012 |
| PMID | 22974244 |
| Fungal Diseases involved | Invasive fungal infection |
| Associated Medical Condition | Renal Allograft Recipients |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | All clinical studies were approved by the UK National Research Ethics Committee. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IFN-γ |
| Biomarker Full Name | Interferon gamma |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | UK |
| Cohort | Patients were recruited from the West London Renal Transplant Centre at Imperial College Healthcare NHS Trust, UK. Ten renal allograft recipients with proven or probable invasive fungal diseases were studied over a 5-year pe-riod. |
| Cohort No. | 10 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive fungal diseases are a major cause of morbidity and mortality in renal allograft recipients. This clinical problem is a consequence of an increasing requirement for organ transplantation, and the aggressive immunosup- pression treatment protocols required to sustain allogeneic transplant programs. Transplant immunosuppressive drug regimens primarily target T cell mediated graft re- jection, and it is notable that solid organ transplant recipi- ents develop invasive fungal diseases without neutropenia being a major risk factor. This clinical observation sug- gests that T cell-based immune responses are important for protective immunity against invasive fungal diseases in this patient population, and it draws parallels with the emergence of invasive fungal diseases in patients with late-stage AIDS. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
